Antitumor activity of crude polysaccharides isolated from Solanum nigrum Linne on U14 cervical carcinoma bearing mice

Phytotherapy Research

Volumn 21, Issue 9, 2007, Pages 832-840

  Li, Jian ^a   Li, Qingwang ^a,b   Feng, Tao ^b   Zhang, Tao ^c   Li, Kun ^a,c   Zhao, Rui ^a   Han, Zengsheng ^a   Gao, Dawei ^a  

^a YANSHAN UNIVERSITY   (China)

^b NORTHWEST A F UNIVERSITY   (China)

^c JIAMUSI UNIVERSITY   (China)

Author keywords

Anticancer activity; Apoptosis; Polysaccharides; Solanum nigrum Linne; TNF ; TUNEL

Indexed keywords

CYCLOPHOSPHAMIDE; POLYSACCHARIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SOLANUM NIGRUM EXTRACT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASCITES TUMOR; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER TISSUE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG MEGADOSE; DRUG SYNTHESIS; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LOW DRUG DOSE; MICROSCOPY; MOUSE; MUTANT; NICK END LABELING; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SOLANUM NIGRUM; TRANSMISSION ELECTRON MICROSCOPY; TREATMENT DURATION; TUMOR CELL; TUMOR NECROSIS; ULTRASTRUCTURE; UPREGULATION; UTERINE CERVIX CARCINOMA;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; FEMALE; KIDNEY; LIVER; MICE; MICE, INBRED STRAINS; PHYTOTHERAPY; PLANT EXTRACTS; POLYSACCHARIDES; SOLANUM NIGRUM; UTERINE CERVICAL NEOPLASMS;

MUS; SOLANUM NIGRUM;

EID: 34548657463     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2163     Document Type: Article

References (36)

1. Baell JB, Huang DC. 2002. Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs. Biochem Pharmacol 64: 851-863.
2. Balkwill F. 2002. Tumor necrosis factor or tumor promoting factor? Cytokine Growth Factor Rev 13: 135-141.
3. Chen YY, Chang HM. 2004. Antiproliferative and differentiating effects of polysaccharide fraction from fu-ling (Poria cocox) on human leukemic U937 and HL-60 cells. Food Chem Toxicol 42: 759-769.
4. Cheng YL, Chang WL, Lee SC et al. 2004. Acetone extract of Angelica sinensis inhibits proliferation of human cancer cells via inducing cell cycle arrest and apoptosis. Life Sci 75: 1579-1594.
5. Chresta CM, Masters JRW, Hickman JA. 1996. Hypersensitivity of human testicular tumours to etoposide-induced apoptosis is associated with functional p53 and high Bax: Bcl2 ratio. Cancer Res 56: 1834-1841.
6. Dixon SC, Soriano BJ, Lush RM, Rorner MM, Figg WD. 1997. Apoptosis: its role in the development of malignancies and its potential as a novel therapeutic target. Ann Pharmacother 31: 76-82.
7. Evan GI, Vousden KH. 2001. Proliferation, cell cycle and apoptosis in cancer. Nature 411(6835): 342-348.
8. Goodsell DS. 2002. The molecular perspective: Bcl-2 and apoptosis. Stem Cells 20: 355-356.
9. Gupta S, Hastak K, Ahmad N, Lewin JS, Mukhtar H. 2001. Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols. Proc Natl Acad Sci USA 98: 10350-10355.
10. Haupt S, Haupt Y. 2004. Manipulation of the tumor suppressor p53 for potentiating cancer therapy. Seminars in Cancer Biology 14: 244-252.
11. Hu K, Kobayashi H, Dong A, Jing Y, Iwasaki S, Yao X. 1999. Antineoplastic agents III: steroidal glycosides from Solanum nigrum. Planta Med 65: 35-38.
12. Johnson VL, Ko SC, Holmstrom TH, Eriksson JE, Chow SC. 2000. Effector caspases are dispensable for the early nuclear morphological changes during chemical-induced apoptosis. J Cell Sci 113: 2941-2953.
13. Kawada M, Ohno Y, Ri Y et al. 2001. Anti-tumor effect of gallic acid on LL-2 cancer cells transplanted in mice. Anticancer Drugs 12: 847-852.
14. Lee SJ, Lim KT. 2006. 150KDa glycoprotein isolated from Solanum nigrum Linne stimulates caspase-3 activation and reduces inducible nitric oxide production in HCT-116 cells. Toxicol In Vitro 20: 1088-1097.
15. Levine AJ. 1997. p53, the cellular gatekeeper for growth and division. Cell 88: 323-331.
16. Locksley RM, Killeen N, Lenardo MJ. 2001.The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104: 487-501.
17. 22 hepatocellular carcinoma. Yakugaku Zasshi 125: 665-670.
18. Lucken-Ardjomande S, Martinou JC. 2005. Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane. C R Biol 328: 616-631.
19. Luo J, Soh JW, Xing WQ, Mao Y, Matsuno T, Weinstein IB. 2001. PM-3, a benzo-gamma-pyran derivative isolated from propolis, inhibits growth of MCF-7 human breast cancer cells. Anticancer Res 21: 1665-1771.
20. Moalic S, Liagre B, Corbiere C et al. 2001. A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cell. FEBS Lett 506: 225-230.
21. Nergard CS, Diallo D, Michaelsen TE et al. 2004. Isolation, partial characterization and immunomodulating activities of polysaccharides from Vernonia kotschyana Sch. Bip. ex Walp. J Ethnopharmacol 91: 141-152.
22. Park HJ, Jeong MH, Lim YJ et al. 2001. Szygium aromaticum (L.) Merr. Et Perry (Myrtaceae) flower bud induces apoptosis of p815 mastocytoma cell line. Life Sci 69: 553-566.
23. Prashanth KV, Shashidhara S, Kumar MM, Sridhara BY. 2001. Cytoprotective role of Solanum nigrum against gentamicin-induced kidney cell (Vero cells) damage in vitro. Fitoterapia 72: 481-486.
24. Prozesky EA, Meyer JJ, Louw AI. 2001. In vitro antiplasmodial activity and cytotoxicity of ethnobotanically selected South African plants. J Ethnopharmacol 76: 239-245.
25. Sakamoto S, Kudo H, Kuwa K et al. 1991. Anticancer effects of a Chinese herbal medicine, juzen-taiho-to, in combination with or without 5-fluorouracil derivative on DNA-synthesizing enzymes in 1,2-dimethylhydrazine induced colonic cancer in rats. Am J Chin Med 19: 233-241.
26. Sang BH, Young HK, Chang WL et al. 1998. Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai. Immunopharmacology 40: 39-48.
27. Schulte-Hermann R, Grasl-Kraupp B, Bursch W. 1994. Tumor development and apoptosis. Int Arch Allergy Immunol 105: 363-367.
28. Schwartsmann G, Ratain MJ, Cragg GM et al. 2002. Anticancer drug discovery and development throughout the world. J Clin Oncol 20: 47S-59S.
29. Son YO, Kim J, Lim JC, Chung Y, Chung GH, Lee JC. 2003. Ripe fruits of Solanum nigrum L. inhibits cell growth and induces apoptosis in MCF-7 cells. Food Chem Toxicol 41: 1427-1428.
30. Sultana S, Perwaiz S, Iqbal M, Athar M. 1995. Crude extracts of hepatoprotective plants, Solanum nigrum and Cichorium intybus inhibit free radical-mediated DNA damage. J Ethnopharmacol 45: 189-192.
31. Szlosarek P, Charles KA, Balkwill FR. 2006. Tumor necrosis factor-a as a tumor promoter. Eur J Cancer 42: 745-759.
32. Tselepis C, Perry I, Dawson C. 2002. Tumour necrosis factor-a in Barrett's oesophagus: a potential novel mechanism of action. Oncogene 21: 6071-6081.
33. van Engeland M, Nieland LJ, Ramaekers FC, Schutte B, Reutelingsperger CP. 1998. Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 31: 1-9.
34. Vickers A. 2002. Botanical medicines for the treatment of cancer: rationale, overview of current data, and methodological considerations for phase I and II trials. Cancer Invest 20: 1069-1079.
35. Zhang M, Chen HX, Huang J, Li Z, Zhu CP, Zhang SH. 2005. Effect of Lyceum barbarum polysaccharide on human hepatoma QGY7703 cells: Inhibition of proliferation and induction of apoptosis. Life Sci 76: 2115-2124.
36. Zhivotovsky B, Orrenius S, Brustugun OT, Doskeland SO. 1998. Injected cytochrome c induces apoptosis. Nature 391: 449-450.