Antitumor effects of total alkaloids isolated from Solanum nigrum in vitro and in vivo

Pharmazie

Volumn 63, Issue 7, 2008, Pages 534-538

  Li, Jian ^a   Li, Qing Wang ^a,b   Gao, Da Wei ^a   Han, Zeng Sheng ^a   Li, Kun ^a  

^a YANSHAN UNIVERSITY   (China)

^b NORTHWEST A F UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SOLANUM ALKALOID; SOLANUM NIGRUM EXTRACT; SOLANUM NIGRUM LINNE EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BAX GENE; BCL 2 GENE; CANCER INHIBITION; CELL DEATH; CHINESE HERB; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; HELA CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTOTOXICITY; MOUSE; NICK END LABELING; NONHUMAN; NUDE MOUSE; ONCOGENE; P53 GENE; SOLANUM NIGRUM; STAINING; UTERINE CERVIX CANCER;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL PROLIFERATION; DNA FRAGMENTATION; FEMALE; GENES, BCL-2; GENES, P53; HELA CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LYMPHOCYTES; MICE; MICE, INBRED BALB C; SOLANUM NIGRUM;

EID: 48249135417     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2008.7789     Document Type: Article

References (22)

1. Antonsson B, Martinou J (2000) The Bcl-2 protein family. Exp Cell Res 56: 50-57.
2. Arends MJ, Wyllie AH (1991) Apoptosis: Mechanisms and roles in pathology. Int Rev Exp Pathol 32: 223-254.
3. Baell JB, Huang DC (2002) Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs. Biochem Pharmacol 64: 851-863.
4. Cheng BL (2000) The culture technology of animal cells. South China University of Technology Press, Guangzhou, p. 131-132.
5. Darzynkiewicz Z, Bruno S, del Bino G, Garczyca W, Holz MA, Lassota P, Traganos F (1992) Features of apoptotic cells measured by flow cytometry. Cytometry 13: 795-808.
6. Dive C, Gregory CD, Phipps DJ, Evans DL, Milner AE, Wyllie AH (1992) Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry. Biochim Biophys Acta 1133: 275-285.
7. Dong Y, Yang MM, Kwan CY (1997) In vitro inhibition of proliferation of HL-60 cells by tetrandrine and coriolus versicolor peptide derived from Chinese medicinal herbs. Life Sci 60: PL135-140.
8. Goodsell DS (2002) The molecular perspective: Bcl-2 and apoptosis. Stem Cells 20: 355-356.
9. Haupt S, Louria-Hayon I, Haupt Y (2003) p53 licensed to kill? Operating the assassin. J Cell Biochem 88: 76-82.
10. Hu K, Kobayashi H, Dong A, Jing Y, Iwasaki S, Yao X (1999) Antineoplastic agents: steroidal glycosides from Solanum nigrum. Planta Med 65: 35-38.
11. Lee SJ, Lim KT (2006) 150KDa glycoprotein isolated from Solanum nigrum Linne stimulates caspase-3 activation and reduces inducible nitric oxide production in HCT-116 cells. Toxicol in vitro 20: 1088-1097.
12. Lucken-Ardjomande S, Matinou JC (2005) Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane. CR Biology 328: 616-631.
13. Ma J, Fu NY, Peng WL, Wu WY, Xu AL (2001) Apoptosis induced by isoliquiritigenin in human gastric cancer MGC-803 cells. Planta Med 67: 754-757.
14. Prashanth KV, Shashidhara S, Kumar MM (2001) Cytoprotective role of Solanum nigrum against gentamicin-induced kidney cell (Vero cells) damage in vitro. Fitoterapia 72: 481-486.
15. Reed JC (1997) Double identity for the proteins of the Bcl-2 family. Nature 387: 773-776.
16. Schulte-Hermann R, Grasl-Kraupp B, Bursch W (1994) Tumor development and apoptosis. Int Arch Allergy Immunol 105: 363-367.
17. Son YO, Kim J, Lim JC, Chung Y, Chung GH, Lee JC (2003) Ripe fruits of Solanum nigrum inhibit cell growth and induce apoptosis in MCF-7 cells. Food Chem Toxicol 41: 1421-1428.
18. Sultana S, Perwaiz S, Iqbal M, Athar M (1995) Crude extracts of hepatoprotective plants, Solanum nigrum and Cichorium intybus inhibit free radical-mediated DNA damage. J Ethnopharmacol 45: 189-192.
19. Tanizawa A, Fujimori A, Fujimori Y, Pommier Y (1994) Comparison of topoisomerase I inhibition, DNA damage and cytotoxicity of camptothecin derivatives presently in clinical trials. J Natl Cancer Inst 86: 836-842.
20. Tropp BE (1997) Steroid hormones. In: Biochemistry - Concepts and Applications (Ed. Tropp BE) Brooks/Cole, Pacific Grove p. 492-494.
21. Zhang GQ, Ren RG, Kong QY et al., (1997) Effects of radix salviae miltiorrhizae on proliferation, apoptosis and c-myc protein expression of fibroblast in culture of kidney with lupus nephritis. Chin J Integrated Traditional Western Med 17: 473-475.
22. Zhang X, Yang XP, Pan QC (1998) Studies on the anticancer effect and apoptosis in human liver cancer cell line BEL-7402 by sodium artesunate. Chin J Herbal Drugs 29: 467.