HPLC and tandem detection to monitor conformational properties of biopharmaceuticals

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 821, Issue 1, 2005, Pages 45-52

  Luykx, Dion M A M ^a   Goerdayal, S S ^a   Dingemanse, P J ^a   Jiskoot, W ^b   Jongen, Peter M J M ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

(Reversed phase) HPLC; Anti tetanus immunoglobulin; Biopharmaceuticals; Circular dichroism; Human growth hormone; Human serum albumin; Interferon alfa; Intrinsic fluorescence; Protein conformation; Tandem detection

Indexed keywords

CONFORMATIONS; DRUG PRODUCTS; FLUORESCENCE; IMPURITIES; MONOMERS; PROTEINS; SIZE EXCLUSION CHROMATOGRAPHY; ULTRAVIOLET DETECTORS;

BIOPHARMACEUTICALS; CIRCULAR DICHROISM (CD); INTRINSIC FLUORESCENCE DETECTION; MONOMERIC PROTEINS;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

RECOMBINANT ALPHA2B INTERFERON;

ACCURACY; ANALYTIC METHOD; ARTICLE; CIRCULAR DICHROISM; DRUG CONFORMATION; FLUORESCENCE; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LINEAR SYSTEM; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET SPECTROSCOPY;

CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; HUMANS; INTERFERON ALFA-2B; PHARMACEUTICAL PREPARATIONS; PROTEIN CONFORMATION; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 20344361924     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2005.04.005     Document Type: Article

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