The effect of pH, hydrogen peroxide and temperature on the stability of human monoclonal antibody

Journal of Pharmaceutical and Biomedical Analysis

Volumn 14, Issue 8-10, 1996, Pages 1133-1140

  Usami, A ^a   Ohtsu, A ^a   Takahama, S ^a   Fujii, T ^a  

^a TEIJIN LTD   (Japan)

Author keywords

Electrophoresis; Liquid chromatography; Matrix assisted laser desorption ionization time of flight mass spectrometry; Monoclonal antibody; Stability; Virus neutralization assay

Indexed keywords

HYDROGEN PEROXIDE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY C 23; UNCLASSIFIED DRUG;

CONFERENCE PAPER; CYTOMEGALOVIRUS INFECTION; DEAMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN CYTOMEGALOVIRUS; ISOELECTRIC FOCUSING; MASS SPECTROMETRY; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; TEMPERATURE SENSITIVITY; TURBIDITY; VIRUS NEUTRALIZATION;

EID: 0030176302     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(96)01721-9     Document Type: Conference Paper

References (10)

1. Jiskoot W., Beuvery E.C., de Koning A.A.M., Herron J.N., Crommelin D.J.A. Pharm. Res. 7:1990;1234-1241.
2. Y.J. Wang and R. Pearlman, Plenum Press, New York, 1993, pp. 135-158.
3. Kroon D.J., Baldwin-Ferro A., Lalan P. Pharm. Res. 9:1992;1386-1393.
4. Tsai P.K., Bruner M.W., Irwin J.I., Yu Ip C.C., Oliver C.N., Nelson R.W., Volkin D.B., Middaugh C.R. Pharm. Res. 10:1993;1580-1586.
5. Robinson D.K., Chan C.P., Yu Ip C., Tsai P.K., Tung J., Seamans T.C., Lenny A.B., Lee D.K., Irwin J., Silberklang M. Biotechnol. Bioeng. 44:1994;727-735.
6. Paborji M., Pochopin N.L., Coppola W.P., Bogardus J.B. Pharm. Res. 11:1994;764-771.
7. Matsumoto Y., Sugano T., Miyamoto C., Masuho Y. Biochem. Biophys. Res. Commun. 137:1986;273-280.
8. Laemmli U.K. Nature. 227:1970;680-685.
9. Yoshioka S., Aso Y., Izutsu K., Terao T. J. Pharm. Sci. 83:1994;454-456.
10. Manning M.C., Patel K., Borchardt R.T. Pharm. Res. 6:1989;903-918.