Dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4+ T cells

Nature Medicine

Volumn 6, Issue 10, 2000, Pages 1154-1159

  Kikuchi, Toshiaki ^a   Worgall, Stefan ^a   Singh, Ravi ^a   Moore, Malcolm A S ^b   Crystal, Ronald G ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; VIRUS VECTOR;

ANTIBODY SPECIFICITY; ANTIGEN SPECIFICITY; ARTICLE; BACTERICIDAL ACTIVITY; BINDING AFFINITY; CELL INTERACTION; DENDRITIC CELL; HELPER CELL; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; LIGAND BINDING; PRIORITY JOURNAL; PSEUDOMONAS;

ANIMALS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; COCULTURE TECHNIQUES; CYTOKINES; DENDRITIC CELLS; FEMALE; GENETIC ENGINEERING; GENETIC VECTORS; IMMUNIZATION; MICE; MICE, INBRED C57BL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 0033782795     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/80498     Document Type: Article

References (34)

1. Dendritic cells and the control of immunity
2. CD40 and CD154 in cell-mediated immunity
3. CD40-CD40 ligand: A multifunctional receptor-ligand pair
4. The role of dendritic cells in the induction and regulation of immunity to microbial infection
5. Dendritic cell vaccines for cancer immunotherapy
6. How B and T cells talk to each other
7. Biochemistry of B lymphocyte activation
8. Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II presentation to cells
9. Prophylaxis against opportunistic infections in patients with human immunodeficiency virus infection
10. Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection
11. Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
12. Dendritic cells pulsed with Pseudomonas protect against lethal pulmonary Pseudomonas infection in mice
13. Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes
14. Human dendritic cells skew isotype switching of CD40-activated naive B cells towards IgA1 and IgA2
15. Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes
16. Dendritic cells modified to express CD40 ligand elicit therapeutic immunity against pre-existing murine tumors
17. Enhanced in vivo immune responses to bacterial lipopolysaccharide by exogenous CD40 stimulation
18. Enhancement of T cell-independent immune responses in vivo by CD40 antibodies
19. The induction of a protective response in Leishmania major-infected BALB/c mice with anti-CD40 mAb
20. CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge
21. Recombinant CD40L treatment protects allogeneic murine bone marrow transplant recipients from death caused by herpes simplex virus-1 infection
22. Exogenous CD40 ligand induces a pulmonary inflammation response
23. Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice
24. Human gene therapy
25. Transfer of genes to humans: Early lessons and obstacles to success
26. Adenoviruses as gene-delivery vehicles
27. Anti-tumor immunity induced by in vivo adenovirus vector-mediated expression of CD40 ligand in tumor cells
28. Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector
29. Adenovirus-mediated transfer of a recombinant alpha 1 - Antitrypsin gene to the lung epithelium in vivo
30. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium
31. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis
32. Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity
33. In vitro and in vivo T cell responses in mice during bronchopulmonary infection with mucoid Pseudomonas aeruginosa
34. A mouse model of chronic pulmonary infection with Pseudomonas aeruginosa and Pseudomonas cepacia