Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci

Molecular Cancer

Volumn 9, Issue , 2010, Pages

  Berg, Marianne ^a,b   Ågesen, Trude H ^a,b   Thiis Evensen, Espen ^a   Merok, Marianne A ^a,b,c,d   Teixeira, Manuel R ^b,e   Vatn, Morten H ^a,d,f   Nesbakken, Arild ^b,c,d   Skotheim, Rolf I ^a,b   Lothe, Ragnhild A ^a,b,d  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c AKER UNIVERSITY HOSPITAL   (Norway)

^d UNIVERSITY OF OSLO   (Norway)

^e PORTUGUESE ONCOLOGY INSTITUTE   (Portugal)

^f AKERSHUS UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; INITIATION FACTOR 4E; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 4; MESSENGER RNA; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 GROUP 12A; PROTEIN CLC; PROTEIN P53; PROTEIN PPAT; PROTEIN RG9MTD2; PROTEIN ZNF574; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ADULT; AGE DISTRIBUTION; ARTICLE; CANCER RISK; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CHROMOSOME GAIN; CHROMOSOME LOSS; CLINICAL ARTICLE; COLORECTAL CANCER; FEMALE; GENE DOSAGE; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; GENOMICS; HUMAN; HUMAN TISSUE; MALE; MUTATIONAL ANALYSIS; ONSET AGE;

EID: 77951811915     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-9-100     Document Type: Article

References (66)

1. de la Chapella A. Genetic predisposition to colorectal cancer. Nat Rev Cancer 2004, 4:769-780. 10.1038/nrc1453, 15510158.
2. Rustgi AK. The genetics of hereditary colon cancer. Genes Dev 2007, 21:2525-2538. 10.1101/gad.1593107, 17938238.
3. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K. Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000, 343:78-85. 10.1056/NEJM200007133430201, 10891514.
4. Jaeger E, Webb E, Howarth K, Carvajal-Carmona L, Rowan A, Broderick P, Walther A, Spain S, Pittman A, Kemp Z, Sullivan K, Heinimann K, Lubbe S, Domingo E, Barclay E, Martin L, Gorman M, Chandler I, Vijayakrishnan J, Wood W, Papaemmanuil E, Penegar S, Qureshi M, Farrington S, Tenesa A, Cazier JB, Kerr D, Gray R, Peto J, Dunlop M, et al. Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. Nat Genet 2008, 40:26-28. 10.1038/ng.2007.41, 18084292.
5. Zanke BW, Greenwood CM, Rangrej J, Kustra R, Tenesa A, Farrington SM, Prendergast J, Olschwang S, Chiang T, Crowdy E, Ferretti V, Laflamme P, Sundararajan S, Roumy S, Olivier JF, Robidoux F, Sladek R, Montpetit A, Campbell P, Bezieau S, O'Shea AM, Zogopoulos G, Cotterchio M, Newcomb P, McLaughlin J, Younghusband B, Green R, Green J, Porteous ME, Campbell H, et al. Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet 2007, 39:989-994. 10.1038/ng2089, 17618283.
6. Tomlinson I, Webb E, Carvajal-Carmona L, Broderick P, Kemp Z, Spain S, Penegar S, Chandler I, Gorman M, Wood W, Barclay E, Lubbe S, Martin L, Sellick G, Jaeger E, Hubner R, Wild R, Rowan A, Fielding S, Howarth K, Silver A, Atkin W, Muir K, Logan R, Kerr D, Johnstone E, Sieber O, Gray R, Thomas H, Peto J, et al. A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet 2007, 39:984-988. 10.1038/ng2085, 17618284.
7. Tomlinson IP, Webb E, Carvajal-Carmona L, Broderick P, Howarth K, Pittman AM, Spain S, Lubbe S, Walther A, Sullivan K, Jaeger E, Fielding S, Rowan A, Vijayakrishnan J, Domingo E, Chandler I, Kemp Z, Qureshi M, Farrington SM, Tenesa A, Prendergast JG, Barnetson RA, Penegar S, Barclay E, Wood W, Martin L, Gorman M, Thomas H, Peto J, Bishop DT, et al. A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet 2008, 40:623-630. 10.1038/ng.111, 18372905.
8. Broderick P, Carvajal-Carmona L, Pittman AM, Webb E, Howarth K, Rowan A, Lubbe S, Spain S, Sullivan K, Fielding S, Jaeger E, Vijayakrishnan J, Kemp Z, Gorman M, Chandler I, Papaemmanuil E, Penegar S, Wood W, Sellick G, Qureshi M, Teixeira A, Domingo E, Barclay E, Martin L, Sieber O, Kerr D, Gray R, Peto J, Cazier JB, Tomlinson I, et al. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nat Genet 2007, 39:1315-1317. 10.1038/ng.2007.18, 17934461.
9. Tenesa A, Farrington SM, Prendergast JG, Porteous ME, Walker M, Haq N, Barnetson RA, Theodoratou E, Cetnarskyj R, Cartwright N, Semple C, Clark AJ, Reid FJ, Smith LA, Kavoussanakis K, Koessler T, Pharoah PD, Buch S, Schafmayer C, Tepel J, Schreiber S, Volzke H, Schmidt CO, Hampe J, Chang-Claude J, Hoffmeister M, Brenner H, Wilkening S, Canzian F, Capella G, et al. Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet 2008, 40:631-637. 10.1038/ng.133, 2778004, 18372901.
10. Houlston RS, Webb E, Broderick P, Pittman AM, Di Bernardo MC, Lubbe S, Chandler I, Vijayakrishnan J, Sullivan K, Penegar S, Carvajal-Carmona L, Howarth K, Jaeger E, Spain SL, Walther A, Barclay E, Martin L, Gorman M, Domingo E, Teixeira AS, Kerr D, Cazier JB, Niittymaki I, Tuupanen S, Karhu A, Aaltonen LA, Tomlinson IP, Farrington SM, Tenesa A, Prendergast JG, et al. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet 2008, 40:1426-1435. 10.1038/ng.262, 2836775, 19011631.
11. Mourra N, Zeitoun G, Buecher B, Finetti P, Lagarde A, Adelaide J, Birnbaum D, Thomas G, Olschwang S. High frequency of chromosome 14 deletion in early-onset colon cancer. Dis Colon Rectum 2007, 50:1881-1886. 10.1007/s10350-007-9040-3, 17726634.
12. Grady WM, Carethers JM. Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology 2008, 135:1079-1099. 10.1053/j.gastro.2008.07.076, 2866182, 18773902.
13. Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature 1997, 386:623-627. 10.1038/386623a0, 9121588.
14. Lothe RA. Microsatellite instability in human solid tumors. Mol Med Today 1997, 3:61-68. 10.1016/S1357-4310(96)10055-1, 9060003.
15. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990, 61:759-767. 10.1016/0092-8674(90)90186-I, 2188735.
16. Hoglund M, Gisselsson D, Hansen GB, Sall T, Mitelman F, Nilbert M. Dissecting karyotypic patterns in colorectal tumors: two distinct but overlapping pathways in the adenoma-carcinoma transition. Cancer Res 2002, 62:5939-5946.
17. Carvalho B, Postma C, Mongera S, Hopmans E, Diskin S, Wiel MA, Van CW, Thas O, Matthai A, Cuesta MA, Terhaar Sive Droste JS, Craanen M, Schrock E, Ylstra B, Meijer GA. Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression. Gut 2009, 58:79-89. 10.1136/gut.2007.143065, 18829976.
18. Grade M, Becker H, Liersch T, Ried T, Ghadimi BM. Molecular cytogenetics: genomic imbalances in colorectal cancer and their clinical impact. Cell Oncol 2006, 28:71-84.
19. Diep CB, Kleivi K, Ribeiro FR, Teixeira MR, Lindgjaerde OC, Lothe RA. The order of genetic events associated with colorectal cancer progression inferred from meta-analysis of copy number changes. Genes Chromosomes Cancer 2006, 45:31-41. 10.1002/gcc.20261, 16145679.
20. Hemminki A, Tomlinson I, Markie D, Jarvinen H, Sistonen P, Bjorkqvist AM, Knuutila S, Salovaara R, Bodmer W, Shibata D, de la CA, Aaltonen LA. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat Genet 1997, 15:87-90. 10.1038/ng0197-87, 8988175.
21. Poynter JN, Figueiredo JC, Conti DV, Kennedy K, Gallinger S, Siegmund KD, Casey G, Thibodeau SN, Jenkins MA, Hopper JL, Byrnes GB, Baron JA, Goode EL, Tiirikainen M, Lindor N, Grove J, Newcomb P, Jass J, Young J, Potter JD, Haile RW, Duggan DJ, Le ML. Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry. Cancer Res 2007, 67:11128-11132. 10.1158/0008-5472.CAN-07-3239, 18056436.
22. Valle L, Serena-Acedo T, Liyanarachchi S, Hampel H, Comeras I, Li Z, Zeng Q, Zhang HT, Pennison MJ, Sadim M, Pasche B, Tanner SM, de la Chapelle A. Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer. Science 2008, 321:1361-1365. 10.1126/science.1159397, 2672914, 18703712.
23. Wiesner GL, Daley D, Lewis S, Ticknor C, Platzer P, Lutterbaugh J, MacMillen M, Baliner B, Willis J, Elston RC, Markowitz SD. A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2. Proc Natl Acad Sci USA 2003, 100:12961-12965. 10.1073/pnas.2132286100, 240727, 14566058.
24. Neklason DW, Kerber RA, Nilson DB, nton-Culver H, Schwartz AG, Griffin CA, Lowery JT, Schildkraut JM, Evans JP, Tomlinson GE, Strong LC, Miller AR, Stopfer JE, Finkelstein DM, Nadkarni PM, Kasten CH, Mineau GP, Burt RW. Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis. Cancer Res 2008, 68:8993-8997. 10.1158/0008-5472.CAN-08-1376, 18974144.
25. Daley D, Lewis S, Platzer P, MacMillen M, Willis J, Elston RC, Markowitz SD, Wiesner GL. Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study. Am J Hum Genet 2008, 82:723-736. 10.1016/j.ajhg.2008.01.007, 2427227, 18313025.
26. Tenesa A, Dunlop MG. New insights into the aetiology of colorectal cancer from genome-wide association studies. Nat Rev Genet 2009, 10:353-358. 10.1038/nrg2574, 19434079.
27. Hong Y, Ho KS, Eu KW, Cheah PY. A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis. Clin Cancer Res 2007, 13:1107-1114. 10.1158/1078-0432.CCR-06-1633, 17317818.
28. Tomlinson IP, Dunlop M, Campbell H, Zanke B, Gallinger S, Hudson T, Koessler T, Pharoah PD, Niittymakix I, Tuupanenx S, Aaltonen LA, Hemminki K, Lindblom A, Forsti A, Sieber O, Lipton L, van WT, Morreau H, Wijnen JT, Devilee P, Matsuda K, Nakamura Y, Castellvi-Bel S, Ruiz-Ponte C, Castells A, Carracedo A, Ho JW, Sham P, Hofstra RM, Vodicka P, et al. COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer. Br J Cancer 2009, 102:447-454. 10.1038/sj.bjc.6605338, 19920828.
29. Pinkel D, Segraves R, Sudar D, Clark S, Poole I, Kowbel D, Collins C, Kuo WL, Chen C, Zhai Y, Dairkee SH, Ljung BM, Gray JW, Albertson DG. High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat Genet 1998, 20:207-211. 10.1038/2524, 9771718.
30. Wu Q, Lothe RA, Ahlquist T, Silins I, Trope CG, Micci F, Nesland JM, Suo Z, Lind GE. DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets. Mol Cancer 2007, 6:45-55. 10.1186/1476-4598-6-45, 1964763, 17623056.
31. Selzer RR, Richmond TA, Pofahl NJ, Green RD, Eis PS, Nair P, Brothman AR, Stallings RL. Analysis of chromosome breakpoints in neuroblastoma at sub-kilobase resolution using fine-tiling oligonucleotide array CGH. Genes Chromosomes Cancer 2005, 44:305-319. 10.1002/gcc.20243, 16075461.
32. McCormick MR, Selzer RR, Richmond TA. Methods in high-resolution, array-based comparative genomic hybridization. Methods Mol Biol 2007, 381:189-211. full_text, 17984520.
33. Baba Y, Nosho K, Shima K, Irahara N, Kure S, Toyoda S, Kirkner GJ, Goel A, Fuchs CS, Ogino S. Aurora-A expression is independently associated with chromosomal instability in colorectal cancer. Neoplasia 2009, 11:418-425. 2671854, 19412426.
34. Yu X, Harris SL, Levine AJ. The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res 2006, 66:4795-4801. 10.1158/0008-5472.CAN-05-4579, 16651434.
35. Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE. The colorectal microRNAome. Proc Natl Acad Sci USA 2006, 103:3687-3692. 10.1073/pnas.0511155103, 1450142, 16505370.
36. Hermsen M, Postma C, Baak J, Weiss M, Rapallo A, Sciutto A, Roemen G, Arends JW, Williams R, Giaretti W, De GA, Meijer G. Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability. Gastroenterology 2002, 123:1109-1119. 10.1053/gast.2002.36051, 12360473.
37. Camps J, Grade M, Nguyen QT, Hormann P, Becker S, Hummon AB, Rodriguez V, Chandrasekharappa S, Chen Y, Difilippantonio MJ, Becker H, Ghadimi BM, Ried T. Chromosomal breakpoints in primary colon cancer cluster at sites of structural variants in the genome. Cancer Res 2008, 68:1284-1295. 10.1158/0008-5472.CAN-07-2864, 18316590.
38. Nakao K, Mehta KR, Fridlyand J, Moore DH, Jain AN, Lafuente A, Wiencke JW, Terdiman JP, Waldman FM. High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization. Carcinogenesis 2004, 25:1345-1357. 10.1093/carcin/bgh134, 15001537.
39. Hertz S, Rothamel T, Skawran B, Giere C, Steinemann D, Flemming P, Becker T, Flik J, Wiese B, Soudah B, Kreipe H, Schlegelberger B, Wilkens L. Losses of chromosome arms 4q, 8p, 13q and gain of 8q are correlated with increasing chromosomal instability in hepatocellular carcinoma. Pathobiology 2008, 75:312-322. 10.1159/000151712, 18931534.
40. Cetin E, Cengiz B, Gunduz E, Gunduz M, Nagatsuka H, Bekir-Beder L, Fukushima K, Pehlivan D, MO N, Nishizaki K, Shimizu K, Nagai N. Deletion mapping of chromosome 4q22-35 and identification of four frequently deleted regions in head and neck cancers. Neoplasma 2008, 55:299-304.
41. Krona C, Caren H, Sjoberg RM, Sandstedt B, Laureys G, Kogner P, Martinsson T. Analysis of neuroblastoma tumour progression; loss of PHOX2B on 4p13 and 17q gain are early events in neuroblastoma tumourigenesis. Int J Oncol 2008, 32:575-583.
42. Shivapurkar N, Sood S, Wistuba II, Virmani AK, Maitra A, Milchgrub S, Minna JD, Gazdar AF. Multiple regions of chromosome 4 demonstrating allelic losses in breast carcinomas. Cancer Res 1999, 59:3576-3580.
43. Polascik TJ, Cairns P, Chang WY, Schoenberg MP, Sidransky D. Distinct regions of allelic loss on chromosome 4 in human primary bladder carcinoma. Cancer Res 1995, 55:5396-5399.
44. Ried T, Knutzen R, Steinbeck R, Blegen H, Schrock E, Heselmeyer K, du MS, Auer G. Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors. Genes Chromosomes Cancer 1996, 15:234-245. 10.1002/(SICI)1098-2264(199604)15:4<234::AID-GCC5>3.0.CO;2-2, 8703849.
45. Jiang LX, Xu J, Wang ZW, Li DP, Peng ZH, Gao JJ, He L, Zheng HT. Tumor suppress genes screening analysis on 4q in sporadic colorectal carcinoma. World J Gastroenterol 2008, 14:5606-5611. 10.3748/wjg.14.5606, 2746351, 18810782.
46. Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, et al. The DNA sequence and biology of human chromosome 19. Nature 2004, 428:529-535. 10.1038/nature02399, 15057824.
47. Vermeersch P, Zachee P, Brusselmans C. Acute myeloid leukemia with bone marrow necrosis and Charcot Leyden crystals. Am J Hematol 2007, 82:1029. 10.1002/ajh.20907, 17617789.
48. Xu Y, Pasche B. TGF-beta signaling alterations and susceptibility to colorectal cancer. Hum Mol Genet 2007, 16:R14-R20. 10.1093/hmg/ddl486, 2637552, 17613544.
49. Oklu R, Hesketh R. The latent transforming growth factor beta binding protein (LTBP) family. Biochem J 2000, 352:601-610. 10.1042/0264-6021:3520601, 1221494, 11104663.
50. Siegel PM, Massague J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 2003, 3:807-821. 10.1038/nrc1208, 14557817.
51. Mauel S, Kruse B, Etschmann B, Schulenburg AG, Schaerig M, Stovesand K, Wilcken B, Sterner-Kock A. Latent transforming growth factor binding protein 4 (LTBP-4) is downregulated in human mammary adenocarcinomas in vitro and in vivo. APMIS 2007, 115:687-700. 10.1111/j.1600-0463.2007.apm_453.x, 17550376.
52. Sterner-Kock A, Thorey IS, Koli K, Wempe F, Otte J, Bangsow T, Kuhlmeier K, Kirchner T, Jin S, Keski-Oja J, von MH. Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. Genes Dev 2002, 16:2264-2273. 10.1101/gad.229102, 186672, 12208849.
53. Mounier CM, Wendum D, Greenspan E, Flejou JF, Rosenberg DW, Lambeau G. Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate. Br J Cancer 2008, 98:587-595. 10.1038/sj.bjc.6604184, 2243149, 18212756.
54. Laye JP, Gill JH. Phospholipase A2 expression in tumours: a target for therapeutic intervention?. Drug Discov Today 2003, 8:710-716. 10.1016/S1359-6446(03)02754-5, 12927514.
55. Morioka Y, Ikeda M, Saiga A, Fujii N, Ishimoto Y, Arita H, Hanasaki K. Potential role of group × secretory phospholipase A(2) in cyclooxygenase-2-dependent PGE(2) formation during colon tumorigenesis. FEBS Lett 2000, 487:262-266. 10.1016/S0014-5793(00)02350-4, 11150521.
56. Burke JE, Dennis EA. Phospholipase A2 structure/function, mechanism, and signaling. J Lipid Res 2009, 50(Suppl):S237-S242. 10.1194/jlr.R800033-JLR200, 2674709, 19011112.
57. Fan S, Ramalingam SS, Kauh J, Xu Z, Khuri FR, Sun SY. Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues. Cancer Biol Ther 2009, 8:1463-1469.
58. Martin ME, Perez MI, Redondo C, Alvarez MI, Salinas M, Fando JL. 4E binding protein 1 expression is inversely correlated to the progression of gastrointestinal cancers. Int J Biochem Cell Biol 2000, 32:633-642. 10.1016/S1357-2725(00)00007-8, 10785360.
59. Feng Z, Hu W, de SE, Teresky AK, Jin S, Lowe S, Levine AJ. The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res 2007, 67:3043-3053. 10.1158/0008-5472.CAN-06-4149, 17409411.
60. Wessels LF, van WT, Hart AA, van't Veer LJ, Reinders MJ, Nederlof PM. Molecular classification of breast carcinomas by comparative genomic hybridization: a specific somatic genetic profile for BRCA1 tumors. Cancer Res 2002, 62:7110-7117.
61. Jonsson G, Naylor TL, Vallon-Christersson J, Staaf J, Huang J, Ward MR, Greshock JD, Luts L, Olsson H, Rahman N, Stratton M, Ringner M, Borg A, Weber BL. Distinct genomic profiles in hereditary breast tumors identified by array-based comparative genomic hybridization. Cancer Res 2005, 65:7612-7621.
62. Peltomaki P, Lothe RA, Aaltonen LA, Pylkkanen L, Nystrom-Lahti M, Seruca R, David L, Holm R, Ryberg D, Haugen A. Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome. Cancer Res 1993, 53:5853-5855.
63. Blaker H, Mechtersheimer G, Sutter C, Hertkorn C, Kern MA, Rieker RJ, Penzel R, Schirmacher P, Kloor M. Recurrent deletions at 6q in early age of onset non-HNPCC- and non-FAP-associated intestinal carcinomas. Evidence for a novel cancer susceptibility locus at 6q14-q22. Genes Chromosomes Cancer 2008, 47:159-164. 10.1002/gcc.20516, 18008368.
64. Skoglund J, Djureinovic T, Zhou XL, Vandrovcova J, Renkonen E, Iselius L, Bisgaard ML, Peltomaki P, Lindblom A. Linkage analysis in a large Swedish family supports the presence of a susceptibility locus for adenoma and colorectal cancer on chromosome 9q22.32-31.1. J Med Genet 2006, 43:e7. 10.1136/jmg.2005.033928, 2564647, 16467217.
65. Gruber SB, Moreno V, Rozek LS, Rennerts HS, Lejbkowicz F, Bonner JD, Greenson JK, Giordano TJ, Fearson ER, Rennert G. Genetic variation in 8q24 associated with risk of colorectal cancer. Cancer Biol Ther 2007, 6:1143-1147. 10.1158/1535-7163.MCT-06-0555, 17630503.
66. Haiman CA, Le ML, Yamamato J, Stram DO, Sheng X, Kolonel LN, Wu AH, Reich D, Henderson BE. A common genetic risk factor for colorectal and prostate cancer. Nat Genet 2007, 39:954-956. 10.1038/ng2098, 2391283, 17618282.