Recurrent deletions at 6q in early age of onset non-HNPCC- and non-FAP-associated intestinal carcinomas. Evidence for a novel cancer susceptibility locus at 6q14-q22

Genes Chromosomes and Cancer

Volumn 47, Issue 2, 2008, Pages 159-164

  Bläker, Hendrik ^a   Mechtersheimer, Gunhild ^a   Sutter, Christian ^a   Hertkorn, Christian ^b   Kern, Michael A ^a   Rieker, Ralf J ^a   Penzel, Roland ^a   Schirmacher, Peter ^a   Kloor, Matthias ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b TUMOR BIOLOGY CENTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADENOMATOUS POLYP; ADULT; ALLELIC IMBALANCE; ARTICLE; CHROMOSOME 6; CHROMOSOME 6Q; CHROMOSOME DELETION; CLINICAL ARTICLE; COLON CANCER; COLORECTAL CANCER; COMPARATIVE GENOMIC HYBRIDIZATION; ENTERITIS; FEMALE; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENETIC MARKER; GENETIC PREDISPOSITION; HETEROZYGOSITY LOSS; HUMAN; INTESTINE CARCINOMA; MALE; ONSET AGE; PRIORITY JOURNAL; SMALL INTESTINE CANCER;

ADENOMATOUS POLYPOSIS COLI; ADULT; AGE OF ONSET; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 6; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MICROSATELLITE INSTABILITY; TUMOR MARKERS, BIOLOGICAL;

EID: 38049051401     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20516     Document Type: Article

References (27)

1. Baudis M, Cleary M. 2001. Progenetix.net: An online repository for molecular cytogenetic aberration data. Bioinformatics 17:1228-1229.
2. Bläker H, von Herbay A, Penzel R, Gross S, Otto HF. 2002. Genetics of adenocarcinomas of the small intestine: Frequent deletions at chromosome 18q and mutations of the SMAD4 gene. Oncogene 21:158-164.
3. Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, Meltzer SJ, Rodriguez-Bigas MA, Fodde R, Ranzani GN, Srivastava S. 1998. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58:5248-5257.
4. Camps J, Armengol G, del Rey J, Lozano JJ, Vauhkonen H, Prat E, Egozcue J, Sumoy L, Knuutila S, Miro R. 2006. Genome-wide differences between microsatellite stable and unstable colorectal tumors. Carcinogenesis 27:419-428.
5. Fearnhead N, Britton M, Bodmer W. 2001. The ABC of APC. Hum Mol Genet 10:721-733.
6. Fearon ER, Vogelstein B. 1990. A genetic model for colorectal tumorigenesis. Cell 61:759-767.
7. Findeisen P, Kloor M, Merx S, Sutter C, Woerner SM, Dostmann N, Benner A, Dondog B, Pawlita M, Dippold W, Wagner R, Gebert J, von Knebel Doebetitz M. 2005. T25 repeat in the 3′ untranslated tegion of the CASP2 gene: A sensitive and specific marker for microsatellite instability in colorectal cancer. Cancer Res 65:8072-8078.
8. Iacobuzio-Donahue CA, van der Heijden MS, Baumgartner MR, Troup WJ, Romm JM, Doheny K, Pugh E, Yeo CJ, Goggins MG, Hruban RH, Kern SF. 2004. Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss. Cancer Res 64:871-875.
9. Isola J, DeVries S, Chu L, Ghazvini S, Waldman F. 1994. Analysis of changes in DNA sequence copy number by comparative genomic hybridization in archival paraffin-embedded tumor samples. Am J Pathol 145:1301-1308.
10. Lamlum H, Ilyas M, Rowan A, Clark S, Johnson V, Bell J, Frayling I, Efstathiou J, Pack K, Payne S, Roylancc R, Gorman P, Sheer D, Neale K, Phillips R, Talbot I, Bodmer W, Tomlinson I. 1999. The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: A new facet to Knudson's 'two-hit' hypothesis. Nat Med 5:1071-1075.
11. Losi L, Di Gregorio C, Pedroni M, Ponti G, Roncucci L, Scarcelli A, Genuardi M, Baglioni S, Marino M, Rossi G, Benatti P, Maffei SA, Menigatti M, Rincarri B, Ponz de Leon M. 2005. Molecular genetic alterations and clinical features in early-onset colorectal carcinomas and their role for the recognition of hereditary cancer syndromes. Am J Gastroenterol 100:2280-2287.
12. Lynch HT, Watson P. 1998. AFAP: Variety is the spice of life. Gut 43:451-452.
13. Miyaki M, Konishi M, Kikuchi-Yanoshita R, Enomoto M, Igari T, Tanaka K, Muraoka M, Takahashi H, Amada Y, Fukayama M. 1994. Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res 54:3011-3020.
14. Niessen RC, Berends MJ, Wu Y, Sijmons RH, Hollema H, Ligtenberg MJ, de Walle HE, de Vries EG, Karrenbeld A, Buys CH, van der Zee AG, Hofstra RM, Kleibeuker JH. 2006. Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non-polyposis colorectal cancer. Gut 55:1781-1788.
15. Offerhaus GJ, Giardiello FM, Krush AJ, Booker SV, Tersmette AC, Kelley NC, Hamilton SR. 1992. The risk of upper gastrointestinal cancer in familial adenomatous polyposis. Gastroenterol 102:1980-1982.
16. Postma C, Hermsen MA, Coffa J, Baak JP, Mueller JD, Mueller E, Bethke B, Schouten JP, Stolte M, Meijer GA. 2005. Chromosomal instability in flat adenomas and carcinomas of the colon. J Pathol 205:514-521.
17. Rijken AM, Hu J, Perlman EJ, Morsberger LA, Long P, Kern SE, Hruban RH, Yeo CJ, Griffin CA. 1999. Genomic alterations in distal bile duct carcinoma by comparative genomic hybridization and karyotype analysis. Genes Chromosomes Cancer 26:185-191.
18. Rodriguez-Bigas MA, Boland CR, Hamilton SR, Henson DE, Jass JR, Khan PM, Lynch H, Perucho M, Smyrk T, Sobin L, Srivastava S. 1997. A National Cancer Institute Workshop on hereditary nonpolyposis colorectal cancer syndrome: Meeting highlights and Bethesda guidelines. J Natl Cancer Inst 89:1758-1762.
19. Southey MC, Jenkins MA, Mead L, Whitty J, Trivett M, Tesoriero A, Smith LD, Jennings K, Grubb G, Royce SG, Walsh MD, Barker MA, Young JP, Jass JR, St. John DJ, Macrae FA, Giles GG, Hopper JL. 2005. Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer. J Clin Oncol 23:6524-6532.
20. Tibiletti MG, Sessa F, Bernasconi B, Cerutti R, Broggi B, Furlan D, Acquati F, Bianchi M, Russo A, Capella C, Taramelli R. 2000. A large 6q deletion is a common cytogenetic alteration in fibroadenomas, pre-malignant lesions, and carcinomas of the breast. Clin Cancer Res 6:1422-1431.
21. Tomlinson I, Sasieni P, Bodmer W. 2002. How many mutations in a cancer? Am J Pathol 160:755-758.
22. Umar A, Boland CR, Terdiman JP, Syngal S, de la Chapelle A, Ruschoff J, Fishel R, Lindor NM, Burgart LJ, Hamelin R, Hamilton SR, Hlatt RA, Jass J, Lindblom A, Lynch HT, Peltomaki P, Ramsey SD, Rodriguez-Bigas MA, Vasen HF, Hawk ET, Barrett JC, Freedman AN, Srivastava S. 2004. Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96:261-268.
23. Verhagen PC, Hermans KG, Brok MO, van Weerden WM, Tilanus MG, de Weger RA, Boon TA, Trapman J. 2002. Deletion of chromosomal region 6q14-16 in prostate cancer. Int J Cancer 102:142-147.
24. Vogelstein B, Fearon ER, Kern SE, Hamilton SR, Preisinger AC, Nakamura Y, White R. 1989. Allelotype of colorectal carcinomas. Science 244:207-211.
25. Wildrick DM, Alfaro SR, Gope R, Boman BM. 1992. A study of chromosome 6 allele loss in human colorectal carcinomas. Anticancer Res 12:1717-1719.
26. Yuen ST, Chan TL, Ho JW, Chan AS, Chung LP, Lam PW, Tse CW, Wyllie AH, Leung SY. 2002. Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers. Oncogene 21:7585-7592.
27. Zhang J, Lindroos A, Ollila S, Russell A, Marra G, Mueller H, Peltomaki P, Plasilova M, Heinimann K. 2006. Gene conversion is a frequent mechanism of inactivation of the wild-type allele in cancers from MLH1/MSH2 deletion carriers. Cancer Res 66:659-664.