The dynamic changes of T-bet+/GATA-3+ and RORγt+/FOXP3+ cells in recipient spleens and grafts after rat orthotopic liver transplantation

Transplant Immunology

Volumn 22, Issue 3-4, 2010, Pages 165-171

  Xu, Min ^a,b   Tan, Changjun ^a,b   Zhou, Jian ^b   Huang, Xiaowu ^b   Dai, Zhi ^b   Zhu, Huaqi ^b   Zhao, Yiming ^b   Gu, Fangming ^b   Zhou, Shaolai ^b   Fan, Jia ^b  

^a Department of Pathology   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Acute rejection model; Orthotopic liver transplantation; T bet GATA 3; ROR t FOXP3

Indexed keywords

EOSIN; HEMATOXYLIN; ORPHAN NUCLEAR RECEPTOR; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN NORWAY RAT; CD4+ T LYMPHOCYTE; CELL INTERACTION; CELL TYPE; CONTROLLED STUDY; DISEASE SEVERITY; GRAFT RECIPIENT; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; INBRED STRAIN; LEWIS RAT; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LYMPHOCYTE COUNT; MALE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY T LYMPHOCYTE; SPLEEN; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL COUNT; CELLS, CULTURED; DISEASE PROGRESSION; FORKHEAD TRANSCRIPTION FACTORS; GATA3 TRANSCRIPTION FACTOR; GRAFT REJECTION; IMMUNOHISTOCHEMISTRY; LIVER; LIVER TRANSPLANTATION; MALE; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; RATS; RATS, INBRED LEW; SPLEEN; T-BOX DOMAIN PROTEINS;

EID: 77951667687     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2009.11.003     Document Type: Article

References (49)

1. McAlister V.C., Haddad E., Renouf E., Malthaner R.A., Kjaer M.S., Gluud L.L. Cyclosporine versus tacrolimus as primary immunosuppression after liver transplantation: a meta analysis. Am J Transplant 2006, 6:1578-1585.
2. Larsen C.P., Elwood E.T., Alexander D.Z., Ritchie S.C., Hendrix R., Tucker-Burden C., et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996, 381:434-438.
3. Kirk A.D., Burkly L.C., Batty D.S., Baumgartner R.E., Berning J.D., Buchanan K., et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med 1999, 5:686-693.
4. Wang C., Sun J., Sheil A.G., McCaughan G.W., Bishop G.A. A short course of methylprednisolone immunosuppression inhibits both rejection and spontaneous acceptance of rat liver allografts. Transplantation 2001, 72:44-51.
5. Constant S.L., Bottomly K. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol 1997, 15:297-322.
6. Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., Glimcher L.H. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000, 100:655-669.
7. Szabo S.J., Sullivan B.M., Stemmann C., Satoskar A.R., Sleckman B.P., Glimcher L.H. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 2002, 295:338-342.
8. Zheng W., Flavell R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997, 89:587-596.
9. Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006, 126:1121-1133.
10. Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nature Immunol 2003, 4:330-336.
11. Wan Y.Y., Flavell R.A. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc Natl Acad Sci USA 2005, 102:5126-5131.
12. Mottram P.L., Han W.R., Purcell L.J., McKenzie I.F., Hancock W.W. Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-gamma in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy. Transplantation 1995, 59:559-565.
13. Thai N.L., Fu F., Qian S., Sun H., Gao L., Wang S.C., et al. Cytokine mRNA profiles in mouse orthotopic liver transplantation. Graft rejection is associated with augmented TH1 function. Transplantation 1995, 59:274-281.
14. Loong C.C., Hsieh H.G., Lui W.Y., Chen A., Lin C.Y. Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection. J Pathol 2002, 197:322-332.
15. Bettelli E., Korn T., Oukka M., Kuchroo V.K. Induction and effector functions of T(H)17 cells. Nature 2008, 453:1051-1057.
16. Kamada N., Calne R.Y. Orthotopic liver transplantation in the rat. Technique using cuff for portal vein anastomosis and biliary drainage. Transplantation 1979, 28:47-50.
17. Shi S.R., Key M.E., Kalra K.L. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 1991, 39:741-748.
18. Cattoretti G., Pileri S., Parravicini C., Becker M.H., Poggi S., Bifulco C., et al. Antigen unmasking on formalin-fixed, paraffin-embedded tissue sections. J Pathol 1993, 171:83-98.
19. Demetris A.J., Batts K.P., Dhillon A.P., Fung L.F., Geller S.A., Hart J., et al. Banff schema for grading liver allograft rejection: an international consensus document. Hepatology 1997, 25:658-663.
20. Höroldt B.S., Burattin M., Gunson B.K., Bramhall S.R., Nightingale P., Hübscher S.G., et al. Does the Banff rejection activity index predict outcome in patients with early acute cellular rejection following liver transplantation?. Liver Transpl 2006, 12:1144-1151.
21. Malmhall C., Bossios A., Pullerits T., Lotvall J. Effects of pollen and nasal glucocorticoid on FOXP3+, GATA-3+ and T-bet+ cells in allergic rhinitis. Allergy 2007, 62:1007-1013.
22. Mullen A.C., High F.A., Hutchins A.S., Lee H.W., Villarino A.V., Livingston D.M., et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 2001, 292:1907-1910.
23. Pillai V., Ortega S.B., Wang C.K., Karandikar N.J. Transient regulatory T-cells: a state attained by all activated human T-cells. Clin Immunol 2007, 123:18-29.
24. Wang J., Ioan-Facsinay A., van der Voort E.I., Huizinga T.W., Toes R.E. Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells. Eur J Immunol 2007, 37:129-138.
25. Walsh P.T., Taylor D.K., Turka L.A. Tregs and transplantation tolerance. J Clin Invest 2004, 114:1398-1403.
26. Lechler R., Ng W.F., Steinman R.M. Dendritic cells in transplantation-friend or foe?. Immunity 2001, 14:357-368.
27. Starzl T.E., Zinkernagel R.M. Transplantation tolerance from a historical perspective. Nat Rev Immunol 2001, 1:233-239.
28. Soulillou J.P., Giral M. Controlling the incidence of infection and malignancy by modifying immunosuppression. Transplantation 2001, 72(12 Suppl):S89-S93.
29. Hjelmesaeth J., Hartmann A., Kofstad J., Egeland T., Stenstrom J., Fauchald P. Tapering off prednisolone and cyclosporin the first year after renal transplantation: the effect on glucose tolerance. Nephrol Dial Transplant 2001, 16:829-835.
30. Weaver C.T., Harrington L.E., Mangan P.R., Gavrieli M., Murphy K.M. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 2006, 24:677-688.
31. Ring G.H., Saleem S., Dai Z., Hassan A.T., Konieczny B.T., Baddoura F.K., et al. Interferon-gamma is necessary for initiating the acute rejection of major histocompatibility complex class II-disparate skin allografts. Transplantation 1999, 67:1362-1365.
32. Coito A.J., Shaw G.D., Li J., Ke B., Ma J., Busuttil R.W., et al. Selectin-mediated interactions regulate cytokine networks and macrophage heme oxygenase-1 induction in cardiac allograft recipients. Lab Invest 2002, 82:61-70.
33. Lin M.L., Zhan Y., Nutt S.L., Brady J., Wojtasiak M., Brooks A.G., et al. NK cells promote peritoneal xenograft rejection through an IFN-gamma-dependent mechanism. Xenotransplantation 2006, 13:536-546.
34. de Waal Malefyt R., Haanen J., Spits H., Roncarolo M.G., te Velde A., Figdor C., Johnson K., et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 1991, 174:915-924.
35. Boehler A., Bai X.H., Liu M., Cassivi S., Chamberlain D., Slutsky A.S., et al. Upregulation of T-helper 1 cytokines and chemokine expression in post-transplant airway obliteration. Am J Respir Crit Care Med 1999, 159:1910-1917.
36. Ding Y., Chen D., Tarcsafalvi A., Su R., Qin L., Bromberg J.S. Suppressor of cytokine signaling 1 inhibits IL-10-mediated immune responses. J Immunol 2003, 170:1383-1391.
37. Maloy K.J., Salaun L., Cahill R., Dougan G., Saunders N.J., Powrie F. CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med 2003, 197:111-119.
38. Fossiez F., Djossou O., Chomarat P., Flores-Romo L., Ait-Yahia S., Maat C., et al. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med 1996, 183:2593-2603.
39. Ye P., Rodriguez F.H., Kanaly S., Stocking K.L., Schurr J., Schwarzenberger P., et al. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med 2001, 194:519-527.
40. Ruddy M.J., Wong G.C., Liu X.K., Yamamoto H., Kasayama S., Kirkwood K.L., et al. Functional cooperation between interleukin-17 and tumor necrosis factor-alpha is mediated by CCAAT/enhancer-binding protein family members. J Biol Chem 2004, 279:2559-2567.
41. Albanesi C., Scarponi C., Cavani A., Federici M., Nasorri F., Girolomoni G., et al. IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-gamma and TNF-alpha. J Immunol 1999, 162:494-502.
42. Witowski J., Pawlaczyk K., Breborowicz A., Scheuren A., Kuzlan-Pawlaczyk M., Wisniewska J., et al. IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells. J Immunol 2000, 165:5814-5821.
43. Dieckmann D., Plottner H., Berchtold S., Berger T., Schuler G. Ex vivo isolation and characterization of CD4(+) CD25(+) T cells with regulatory properties from human blood. J Exp Med 2001, 193:1303-1310.
44. Jonuleit H., Schmitt E., Stassen M., Tuettenberg A., Knop J., Enk A.H. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001, 193:1285-1294.
45. Thornton A.M., Shevach E.M. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998, 188:287-296.
46. Wing K., Lindgren S., Kollberg G., Lundgren A., Harris R.A., Rudin A., et al. CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells. Eur J Immunol 2003, 33:579-587.
47. Ichiyama K., Yoshida H., Wakabayashi Y., Chinen T., Saeki K., Nakaya M., et al. Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat. J Biol Chem 2008, 283:17003-17008.
48. Hara M., Chosa E., Onitsuka T. The spleen's role in transplantation immunology. Transpl Immunol 2008, 18:324-329.
49. Kopf H., de la Rosa G.M., Howard O.M., Chen X. Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. Int Immunopharmacol 2007, 7:1819-1824.