Cyclosporin versus tacrolimus as primary immunosuppressant after liver transplantation: A meta-analysis

American Journal of Transplantation

Volumn 6, Issue 7, 2006, Pages 1578-1585

  McAlister, V C ^a   Haddad, E ^a   Renouf, E ^a   Malthaner, R A ^a   Kjaer, M S ^b   Gluud, L L ^b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b Cochrane Hepato Biliary Group ^*  (Denmark)

Author keywords

Calcineurin; Immunosuppression; Liver transplantation; Meta analysis

Indexed keywords

CYCLOSPORIN; TACROLIMUS;

ACUTE GRAFT REJECTION; ARTICLE; CLINICAL TRIAL; COCHRANE LIBRARY; CONFIDENCE INTERVAL; DIABETES MELLITUS; DIALYSIS; EMBASE; GRAFT FAILURE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIVER TRANSPLANTATION; LYMPHOPROLIFERATIVE DISEASE; MEDLINE; META ANALYSIS; MORTALITY; PRIORITY JOURNAL; RISK FACTOR; SYSTEMATIC REVIEW;

ACUTE DISEASE; CYCLOSPORINE; FOLLOW-UP STUDIES; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LIVER TRANSPLANTATION; RISK FACTORS; TACROLIMUS;

EID: 33745336579     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2006.01360.x     Document Type: Article

References (32)

1. Starzl TE Iwatsuki S Shaw BW Jr. Gordon RD Esquivel CO. Immunosuppression and other nonsurgical factors in the improved results of liver transplantation. Semin Liver Dis 1985 5: 334 343.
2. European FK506 Multicentre Liver Study Group. Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. Lancet 1994 344: 423 428.
3. The US Multicentre FK506 Study Group. A comparison of tacrolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation. N Engl J Med 1994 331: 1110 1115.
4. Siekierka JJ Sigal NH. FK-506 and cyclosporin A: Immunosuppressive mechanism of action and beyond. Curr Opin Immunol 1992 4: 548 552.
5. O'Grady JG Burroughs A Hardy P Elbourne D Truesdale A, The UK and Republic of Ireland Liver Transplant Study Group. Tacrolimus versus microemulsified ciclosporin in liver transplantation: The TMC randomised controlled trial. Lancet 2002 360: 1119 1125.
6. Knoll GA Bell RC Knoll GA Bell RC. Tacrolimus versus cyclosporin for immunosuppression in renal transplantation: meta-analysis of randomised trials. BMJ 1999 318: 1104 1107.
7. Webster AC Woodroffe RC Taylor RS Chapman JR Craig JC. Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: Meta-analysis and meta-regression of randomised trial data. BMJ 2005 331: 810 821.
8. Haddad EM McAlister VC Renouf E Malthaner R Kjaer MS Gluud LL. Cyclosporin versus tacrolimus for liver transplanted patients. In: Cochrane Database of Systematic Reviews 2005, Issue 1 CD005161.
9. Kjaergard LL Villumsen J Gluud C. Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses. Ann Intern Med 2001 135: 982 989.
10. Arnold JC Theilmann L. Vergleich zwischen Tacrolimus (FK 506) und Cyclosporin in der immunosuppressiven Therapie nach Lebertransplantation [Comparison between tacrolimus (FK 506) and cyclosporin in immunosuppressive therapy after liver transplantation]. Zeitschrift fur Gastroenterologie 1995 33: 624 625.
11. Loinaz C Marin LM Gonzalez-Pinto I Gomez R Jimenez C Moreno E. A single-centre experience with cyclosporine microemulsion versus tacrolimus in 100 ransomized liver transplant recipients: Midterm efficacy and safety. Transplant Proc 2001 33: 3439 3441.
12. Ericzon B Eusufzai S Soderdahl G Duraj F Einarsson K Angelin B. Secretion and composition of bile after human liver transplantation. Transplantation 1997 63: 74 80.
13. Trull A Hughes V Cooper D et al. Influence of albumin supplementation on tacrolimus and cyclosporine therapy early after liver transplantation. Liver Transpl 2002 8: 224 232.
14. Timmermann W Erhard J Lange R et al. A randomised trial comparing the efficacy and safety of tacrolimus with microemulsified cyclosporine after liver transplantation. Transplant Proc 2002 34: 1516 1518.
15. Stegall M Wachs ME Everson G et al. Prednisone withdrawal 14 days after liver transplantation with mycophenolate: A prospective trial of cyclosporine and tacrolimus. Transplantation 1997 64: 1755 1760.
16. Fisher RA Ham JM Marcos A et al. A prospective randomized trial of mycophenolate mofetil with neoral or tacrolimus after orthotopic transplantation. Transplantation 1998 66: 1616 1621.
17. Fung J Abu-Elmagd K Jain A et al. A randomized trial of primary liver transplantation under immunosuppression with FK 506 vs cyclosporine. Transplant Proc 1991 23: 2977 2983.
18. Grazi GL Levy G Wu Y et al. 12-month follow-up data from a randomized multicentre, prospective study of cyclosporine C2 monitoring versus tacrolimus in liver transplantation (LIS2T). Am J Transplant 2004 4 ( Suppl 8 268.
19. Greig P Lilly L Scudamore C et al. Early steroid withdrawal after liver transplantation: The Canadian tacrolimus versus microemulsion cyclosporin a trial: 1-year follow-up. Liver Transpl 2003 9: 587 595.
20. Klupp J Glanemann M Bechstein WO et al. Mycophenolate mofetil in combination with tacrolimus versus neoral after liver transplantation. Transplant Proc 1999 31: 1113 1114.
21. Therapondos G Flapan AD Dollinger MM Garden OJ Plevris JN Hayes PC. Cardiac function after orthotopic liver transplantation and the effects of immunosuppression: a prospective randomized trial comparing cyclosporin (neoral) and tacrolimus. Liver Transpl 2002 8: 690 700.
22. Kelly D Jara P Rodeck B et al. Tacrolimus and steroids versus ciclosporin microemulsion, steroids, and azathioprine in children undergoing liver transplantation: Randomised European multicentre trial. Lancet 2004 364: 1054 1061.
23. Martin P Busuttil RW Goldstein RM et al. Impact of tacrolimus versus cyclosporine in hepatitis C virus-infected liver transplant recipients on recurrent hepatitis: a prospective randomized trial. Liver Transpl 2004 10: 1258 1262.
24. Muhlbacher F. European Liver Transplantation Tacrolimus vs Cyclosporin Microemulsion Study Group. Tacrolimus versus cyclosporin microemulsion in liver transplantation: results of a 3-month study. Transpl Proc 2001 33: 1339 1340.
25. Rolles K Davidson BR Burroughs AK. A pilot study of immunosuppressive monotherapy in liver transplantation: Tacrolimus versus microemulsified cyclosporin. Transplantation 1999 68: 1195 1209.
26. Zervos XA Weppler D Fragulidis GP et al. Comparison of tacrolimus with microemulsion cyclosporine as primary immunosuppression in hepatitis C patients after liver transplantation. Transplantation 1998 65: 1044 1046.
27. Fung JJ Eliasziw M Todo S et al. The Pittsburgh randomized trial of tacrolimus compared to cyclosporine for hepatic transplantation. J Am Coll Surg 1996 183: 117 125.
28. Fisher RA Stone JJ Wolfe LG et al. Four-year follow-up of a prospective randomized trial of mycophenolate mofetil with cyclosporine microemulsion or tacrolimus following liver transplantation. Clin Transplant 2004 18: 463 472.
29. Muehlbacher FF. for the European Liver Transplantation Tacrolimus vs Cyclosporin Microemulsion Study Group. Tacrolimus versus cyclosporin microemulsion in liver transplantation: results of one-year follow-up. In: 10th ESOT & 12th ETCO Congress 2001, October 6-11, 2001, Lisboa, Portugal. 2001.
30. Levy G Villamil F Samuel D et al. LIS2T Study Group. Results of lis2t, a multicenter, randomized study comparing cyclosporine microemulsion with C2 monitoring and tacrolimus with C0 monitoring in de novo liver transplantation. Transplantation 2004 77: 1632 1638.
31. Higgins JP Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002 21: 1539 1558.
32. Starzl TE Donner A Eliasziw M et al. Randomised trialomania? The multicentre liver transplant trials of tacrolimus. Lancet 1995 346: 1346 1350.