Artificial cell microencapsulated stem cells in regenerative medicine, tissue engineering and cell therapy

Advances in Experimental Medicine and Biology

Volumn 670, Issue , 2010, Pages 68-79

  Liu, Zun Chang ^b   Chang, Thomas Ming Swi ^a  

^a MCGILL UNIVERSITY   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOSUPPRESSIVE AGENT;

ARTICLE; ARTIFICIAL CELL; BIOCOMPATIBILITY; BIOTECHNOLOGY; CELL ADHESION; CELL DENSITY; CELL DIFFERENTIATION; CELL ENCAPSULATION; CELL FUNCTION; CELL GROWTH; CELL LINEAGE; CELL PROLIFERATION; CELL RENEWAL; CELL SURVIVAL; CELL VIABILITY; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMOBILIZED CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER FAILURE; LIVER REGENERATION; LIVER TRANSPLANTATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MICROENCAPSULATION; NONHUMAN; PRIORITY JOURNAL; REGENERATIVE MEDICINE; SURVIVAL TIME; TISSUE ENGINEERING; ADULT STEM CELL; ANIMAL; ARTIFICIAL MEMBRANE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CYTOLOGY; DRUG FORMULATION; LIVER; MESENCHYMAL STEM CELL; METHODOLOGY; PHYSIOLOGY; REVIEW; TRANSPLANTATION;

RATTUS;

ADULT STEM CELLS; ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL LINEAGE; CELL SURVIVAL; DRUG COMPOUNDING; HEPATOCYTES; HUMANS; LIVER; MEMBRANES, ARTIFICIAL; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; REGENERATIVE MEDICINE; TISSUE ENGINEERING;

EID: 77951640822     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-5786-3_7     Document Type: Article

References (109)

1. Tuan RS, Boland G, Tuli R. Adult mesenchymal stem cells and cell-based tissue engineering. Arthritis Res Ther 2003; 5:32-45. (Pubitemid 36849748)
2. Chang TM. Semipermeable Microcapsules. Science 1964; 146:524-525.
3. Chang TMS, Mason SG. Semipermeable aqueous microcapsules: I. Preparation and properties. Can J Physiol Pharmacol 1966; 44:115-128.
4. Chang TMS. Monograph on "Artificial Cells". Springfield, Illinois, USA: Charles C. Thomas, Publisher, (available for free online viewing at www.artcell.mcgill.ca) 1972.
5. Chang TM. Therapeutic applications of polymeric artificial cells. Nat Rev Drug Discov 2005; 4:221-235. (Pubitemid 40372556)
6. Lim F, Sun AM. Microencapsulated islets as bioartificial endocrine pancreas. Science 1980; 210:908-910. (Pubitemid 11169847)
7. Orive G, Hernandez RM, Gascon AR et al. Cell encapsulation: Promise and progress. Nat Med 2003; 9:104-107. (Pubitemid 36098269)
8. Wong H, Chang TM. Bioartificial liver: Implanted artificial cells microencapsulated living hepatocytes increases survival of liver failure rats. Int J Artif Organs 1986; 9:335-336. (Pubitemid 17213373)
9. Wong H, Chang TM. The viability and regeneration of artificial cell microencapsulated rat hepatocyte xenograft transplants in mice. Biomater Artif Cells Artif Organs 1988; 16:731-739.
10. Kashani SA, Chang TM. Physicochemical characteristics of hepatic stimulatory factor prepared from cell free supernatant of hepatocyte cultures. Biomater Artif Cells Immobilization Biotechnol 1991; 19:579-598.
11. Bruni S, Chang TM. Hepatocytes immobilised by microencapsulation in artificial cells: Effects on hyperbilirubinemia in Gunn rats. Biomater Artif Cells Artif Organs 1989; 17:403-411. (Pubitemid 19264325)
12. Bruni S, Chang TM. Encapsulated hepatocytes for controlling hyperbilirubinemia in Gunn rats. Int J Artif Organs 1991; 14:239-241.
13. Bruni S, Chang TM. Kinetic analysis of UDP-glucuronosyltransferase in bilirubin conjugation by encapsulated hepatocytes for transplantation into Gunn rats. Artif Organs 1995; 19:449-457.
14. Liu ZC, Chang TM. Coencapsulation of hepatocytes and bone marrow stem cells: In vitro conversion of ammonia and in vivo lowering of bilirubin in hyperbilirubemia Gunn rats. Int J Artif Organs 2003; 26:491-497. (Pubitemid 36916699)
15. Liu ZC, Chang TM. Transdifferentiation of bioencapsulated bone marrow cells into hepatocyte-like cells in the 90% hepatectomized rat model. Liver Transpl 2006; 12:566-572.
16. Soon-Shiong P, Heintz RE, Merideth N et al. Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation. Lancet 1994; 343:950-951. (Pubitemid 24117231)
17. Sun Y, Ma X, Zhou D et al. Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression. J Clin Invest 1996; 98:1417-1422. (Pubitemid 26322067)
18. Calafiore R, Basta G, Luca G et al. Transplantation of pancreatic islets contained in minimal volume microcapsules in diabetic high mammalians. Ann N Y Acad Sci 1999; 875:219-232. (Pubitemid 29349074)
19. de Vos P, Hamel AF, Tatarkiewicz K. Considerations for successful transplantation of encapsulated pancreatic islets. Diabetologia 2002; 45:159-173. (Pubitemid 34208378)
20. Prakash S, Chang TM. Microencapsulated genetically engineered live E. coli DH5 cells administered orally to maintain normal plasma urea level in uremic rats. Nat Med 1996; 2:883-887. (Pubitemid 26296758)
21. Al-Hendy A, Hortelano G, Tannenbaum GS et al. Growth retardation-an unexpected outcome from growth hormone gene therapy in normal mice with microencapsulated myoblasts. Hum Gene Ther 1996; 7:61-70. (Pubitemid 26119484)
22. Basic D, Vacek I, Sun AM. Microencapsulation and transplantation of genetically engineered cells: A new approach to somatic gene therapy. Artif Cells Blood Substit Immobil Biotechnol 1996; 24:219-255. (Pubitemid 26195715)
23. Koo J, Chang TM. Secretion of erythropoietin from microencapsulated rat kidney cells: Preliminary results. Int J Artif Organs 1993; 16:557-560. (Pubitemid 23272976)
24. Saitoh Y, Taki T, Arita N et al. Cell therapy with encapsulated xenogeneic tumor cells secreting beta-endorphin for treatment of peripheral pain. Cell Transplant 1995;(4 Suppl 1):S13-17.
25. Xu W, Liu L, Charles IG. Microencapsulated iNOS-expressing cells cause tumor suppression in mice. FASEB J 2002; 16:213-215.
26. Garofalo FA, Chang TM. Effects of mass transfer and reaction kinetics on serum cholesterol depletion rates of free and immobilized Pseudomonas pictorum. Appl Biochem Biotechnol 1991; 27:75-91.
27. Aebischer P, Pochon NA, Heyd B et al. Gene therapy for amyotrophic lateral sclerosis (ALS) using a polymer encapsulated xenogenic cell line engineered to secrete hCNTF. Hum Gene Ther 1996; 7:851-860. (Pubitemid 26146442)
28. Bloch J, Bachoud-Levi AC, Deglon N et al. Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: Results of a phase I study. Hum Gene Ther 2004; 15:968-975. (Pubitemid 39372573)
29. Theise ND. Gastrointestinal Stem Cells. III. Emergent themes of liver stem cell biology: Niche, quiescence, self-renewal and plasticity. Am J Physiol Gastrointest Liver Physiol 2006; 290:G189-193.
30. Liu Z, Chang TM. Effects of bone marrow cells on hepatocytes: When cocultured or co-encapsulated together. Artif Cells Blood Substit Immobil Biotechnol 2000; 28:365-374. (Pubitemid 30463720)
31. Liu ZC, Chang TM. Increased viability of transplanted hepatocytes when hepatocytes are co-encapsulated with bone marrow stem cells using a novel method. Artif Cells Blood Substit Immobil Biotechnol 2002; 30:99-112. (Pubitemid 34507456)
32. Graf T. Differentiation plasticity of hematopoietic cells. Blood 2002; 99:3089-3101. (Pubitemid 34525285)
33. Le Blanc K, Pittenger M. Mesenchymal stem cells: Progress toward promise. Cytotherapy 2005; 7:36-45. (Pubitemid 40542402)
34. Korbling M, Estrov Z, Champlin R. Adult stem cells and tissue repair. Bone Marrow Transplant 2003; 32(Suppl 1):S23-24. (Pubitemid 37069504)
35. Goessler UR, Hormann K, Riedel F. Tissue engineering with adult stem cells in reconstructive surgery (review). Int J Mol Med 2005; 15:899-905.
36. Thorgeirsson SS. Hematopoietic cells as hepatocyte stem cells: A critical review of the evidence. Hepatology 2006:2-8. (Pubitemid 43733584)
37. Friedenstein AJ, Petrakova KV, Kurolesova AI et al. Heterotopic of bone marrow.Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 1968; 6:230-247.
38. Owen M, Friedenstein AJ. Stromal stem cells: Marrow-derived osteogenic precursors. Ciba Foundation Symposium 1988; 136:42-60.
39. Friedenstein AJ. Precursor cells of mechanocytes. Int Rev Cytol 1976; 47:327-359.
40. Friedenstein AJ, Chailakhyan RK, Gerasimov UV. Bone marrow osteogenic stem cells: In vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet 1987; 20:263-272.
41. Vaananen HK. Mesenchymal stem cells. Ann Med 2005; 37:469-479. (Pubitemid 41693577)
42. Beyer Nardi N, da Silva Meirelles L. Mesenchymal stem cells: Isolation, in vitro expansion and characterization. Handb Exp Pharmacol 2006:249-282.
43. Petersen BE. Bone marrow as a potential source of hepatic oval cells. Science 1999; 284:1168.
44. Alison MR. Hepatocytes from nonhepatic adult stem cells. Nature 2000; 406:257. (Pubitemid 30604395)
45. Theise ND, Badve S, Saxena R et al. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology 2000; 31:235-240. (Pubitemid 30033713)
46. Mezey E, Key S, Vogelsang G et al. Transplanted bone marrow generates new neurons in human brains. Proc Natl Acad Sci USA 2003; 100:1364-1369. (Pubitemid 36184007)
47. Brazelton TR, Rossi FM, Keshet GI et al. From marrow to brain: Expression of neuronal phenotypes in adult mice. Science 2000; 290:1775-1779. (Pubitemid 32004810)
48. Azizi SA, Stokes D, Augelli BJ et al. Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats-similarities to astrocyte grafts. Proc Natl Acad Sci USA 1998; 95:3908-3913. (Pubitemid 28173227)
49. Kopen GC, Prockop DJ, Phinney DG. Marrow stromal cells migrate throughout forebrain and cerebellum and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA 1999; 96:10711.
50. Orlic D, Kajstura J, Chimenti S et al. Bone marrow cells regenerate infracted myocardium. Nature 2001; 410:701-705. (Pubitemid 32290358)
51. Fukuda K. Molecular characterization of regenerated cardiomyocytes derived from adult mesenchymal stem cells. Congenit Anom (Kyoto) 2002; 42:1-9. (Pubitemid 34589283)
52. Makino S, Fukuda K, Miyoshi S et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999; 103:697-705. (Pubitemid 29122423)
53. Fukuda K. Development of regenerative cardiomyocytes from mesenchymal stem cells for cardiovascular tissue engineering. Artif Organs 2001; 25:187-193. (Pubitemid 32852966)
54. Poulsom R, Alison MR, Cook T et al. Bone marrow stem cells contribute to healing of the kidney. J Am Soc Nephrol 2003; 14(Suppl 1):S48-54. (Pubitemid 36687040)
55. Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284:143-147. (Pubitemid 29282067)
56. Bianco P, Costantini M, Dearden LC et al. Alkaline phosphatase positive precursors of adipocytes in the human bone marrow. Br J Haematol 1988; 68:401-403.
57. Johnstone B, Hering TM, Caplan AI et al. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 1998; 238:265-272. (Pubitemid 28366150)
58. Mackay AM, Beck SC, Murphy JM et al. Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow. Tissue Eng 1998; 4:415-428. (Pubitemid 28553528)
59. Yoo JU, Barthel TS, Nishimura K et al. The chondrogenic potential of human bone-marrow-derived mesenchymal progenitor cells. J Bone Joint Surg Am 1998; 80:1745-1757. (Pubitemid 29013807)
60. Ito T, Suzuki A, Okabe M et al. Application of bone marrow-derived stem cells in experimental nephrology. Exp Nephrol 2001; 9:444-450. (Pubitemid 33036008)
61. Ferrari G, Cusella-De Angelis G, Coletta M et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 1998; 279:1528-1530. (Pubitemid 28217075)
62. Wakitani S, Saito T, Caplan AI. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 1995; 18:1417-1426.
63. Bruder SP, Jaiswal N, Haynesworth SE. Growth kinetics, self-renewal and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biochem 1997; 64:278-294. (Pubitemid 27065442)
64. Owen M, Friedenstein AJ. Stromal stem cells: Marrow-derived osteogenic precursors. Ciba Found Symp 1988; 136:42-60.
65. Jaiswal N, Haynesworth SE, Caplan AI et al. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem 1997; 64:295-312. (Pubitemid 27065443)
66. Mao JJ. Stem-cell-driven regeneration of synovial joints. Biol Cell 2005; 97:289-301. (Pubitemid 40668200)
67. Haynesworth SE, Goshima J, Goldberg VM et al. Characterization of cells with osteogenic potential from human marrow. Bone 1992; 13:81-88.
68. Castro-Malaspina H, Gay RE, Resnick G et al. Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny. Blood 1980; 56:289-301. (Pubitemid 10043431)
69. Simmons PJ, Torok-Storb B. Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood 1991; 78:55-62.
70. Jones EA, Kinsey SE, English A et al. Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. Arthritis Rheum 2002; 46:3349-3360. (Pubitemid 35453547)
71. Digirolamo CM, Stokes D, Colter D et al. Propagation and senescence of human marrow stromal cells in culture: A simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate. Br J Haematol 1999; 107:275-281. (Pubitemid 29530211)
72. Sekiya I, Larson BL, Smith JR et al. Expansion of human adult stem cells from bone marrow stroma: Conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells 2002; 20:530-541. (Pubitemid 35463066)
73. Koc ON, Peters C, Aubourg P et al. Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases. Exp Hematol 1999; 27:1675-1681. (Pubitemid 29526752)
74. Bianco P, Robey PG. Stem cells in tissue engineering. Nature 2001; 414:118-121. (Pubitemid 33041636)
75. Liu ZC, Chang TM. Transplantation of bioencapsulated bone marrow stem cells improves hepatic regeneration and survival of 90% hepatectomized rats: A preliminary report. Artif Cells Blood Substit Immobil Biotechnol 2005; 33:405-410. (Pubitemid 41659165)
76. Ma HL, Hung SC, Lin SY et al. Chondrogenesis of human mesenchymal stem cells encapsulated in alginate beads. J Biomed Mater Res A 2003; 64:273-281.
77. Batorsky A, Liao J, Lund AW et al. Encapsulation of adult human mesenchymal stem cells within collagen-agarose microenvironments. Biotechnol Bioeng 2005; 92:492-500. (Pubitemid 41737240)
78. Sakai D, Mochida J, Iwashina T et al. Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc. Biomaterials 2006; 27:335-345. (Pubitemid 41457236)
79. Morishita T, Honoki K, Ohgushi H et al. Tissue engineering approach to the treatment of bone tumors: Three cases of cultured bone grafts derived from patients' mesenchymal stem cells. Artif Organs 2006; 30:115-118.
80. Uematsu K, Hattori K, Ishimoto Y et al. Cartilage regeneration using mesenchymal stem cells and a three-dimensional poly-lactic-glycolic acid (PLGA) scaffold. Biomaterials 2005; 26:4273-4279. (Pubitemid 40430855)
81. Wang Y, Kim UJ, Blasioli DJ et al. In vitro cartilage tissue engineering with 3D porous aqueous-derived silk scaffolds and mesenchymal stem cells. Biomaterials 2005; 26:7082-7094. (Pubitemid 41095530)
82. Juncosa-Melvin N, Boivin GP, Gooch C et al. The effect of autologous mesenchymal stem cells on the biomechanics and histology of gel-collagen sponge constructs used for rabbit patellar tendon repair. Tissue Eng 2006; ;12(2):369-79.
83. Meinel L, Karageorgiou V, Hofmann S et al. Engineering bone-like tissue in vitro using human bone marrow stem cells and silk scaffolds. J Biomed Mater Res A 2004; 71:25-34. (Pubitemid 39244392)
84. Kramer J, Bohrnsen F, Lindner U et al. In vivo matrix-guided human mesenchymal stem cells. Cell Mol Life Sci 2006; 63:616-626.
85. Cui JH, Park K, Park SR et al. Effects of low-intensity ultrasound on chondrogenic differentiation of mesenchymal stem cells embedded in polyglycolic acid-an in vivo study. Tissue Eng 2006 Jan;12(1):75-82.
86. Wang Y, Singh A, Xu P et al. Expansion and osteogenic differentiation of bone marrow-derived mesenchymal stem cells on a vitamin C functionalized polymer. Biomaterials 2006; 27:3265-3273. (Pubitemid 43344338)
87. Peterson ET, Papautsky I. Microtextured polydimethylsiloxane substrates for culturing mesenchymal stem cells. Methods Mol Biol 2006; 321:179-197.
88. Li WJ, Tuli R, Okafor C et al. A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials 2005; 26:599-609. (Pubitemid 38988302)
89. Li WJ, Tuli R, Huang X et al. Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold. Biomaterials 2005; 26:5158-5166. (Pubitemid 40387839)
90. Cassiede P, Dennis JE, Ma F et al. Osteochondrogenic potential of marrow mesenchymal progenitor cells exposed to TGF-beta 1 or PDGF-BB as assayed in vivo and in vitro. J Bone Miner Res 1996; 11:1264-1273. (Pubitemid 26282527)
91. Thomas CH, Collier JH, Sfeir CS et al. Engineering gene expression and protein synthesis by modulation of nuclear shape. Proc Natl Acad Sci USA 2002; 99:1972-1977. (Pubitemid 34168999)
92. McBeath R, Pirone DM, Nelson CM et al. Cell shape, cytoskeletal tension and RhoA regulate stem cell lineage commitment. Dev Cell 2004; 6:483-495. (Pubitemid 38456178)
93. Katsura N, Ikai I, Mitaka T et al. Long-term culture of primary human hepatocytes with preservation of proliferative capacity and differentiated functions. J Surg Res 2002; 106:115-123.
94. Clement B, Guguen-Guillouzo C, Campion JP et al. Long-term cocultures of adult human hepatocytes with rat liver epithelial cells: Modulation of albumin secretion and accumulation of extracellular material. Hepatology 1984; 4:373-380. (Pubitemid 14116634)
95. Ries K, Krause P, Solsbacher M et al. Elevated expression of hormone-regulated rat hepatocyte functions in a new serum-free hepatocyte-stromal cell coculture model. In Vitro Cell Dev Biol Anim 2000; 36:502-512.
96. Kaihara S, Kim S, Kim BS et al. Survival and function of rat hepatocytes cocultured with nonparenchymal cells or sinusoidal endothelial cells on biodegradable polymers under flow conditions. J Pediatr Surg 2000; 35:1287-1290.
97. Makowka L, Falk RE, Rotstein LE et al. Cellular transplantation in the treatment of experimental hepatic failure. Science 1980; 210:901-903. (Pubitemid 11169845)
98. Neuss S, Becher E, Woltje M et al. Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair and wound healing. Stem Cells 2004; 22:405-414. (Pubitemid 38736624)
99. Takai K, Hara J, Matsumoto K et al. Hepatocyte growth factor is constitutively produced by human bone marrow stromal cells and indirectly promotes hematopoiesis. Blood 1997; 89:1560-1565. (Pubitemid 27097448)
100. Chen X, Katakowski M, Li Y et al. Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: Growth factor production. J Neurosci Res 2002; 69:687-691. (Pubitemid 34966882)
101. Chen X, Li Y, Wang L et al. Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Neuropathology 2002; 22:275-279. (Pubitemid 36142758)
102. Ogura Y, Hamanoue M, Tanabe G et al. Hepatocyte growth factor promotes liver regeneration and protein synthesis after hepatectomy in cirrhotic rats. Hepatogastroenterology 2001; 48:545-549. (Pubitemid 32391608)
103. Hayashi H, Nagaki M, Imose M et al. Normal liver regeneration and liver cell apoptosis after partial hepatectomy in tumor necrosis factor-alpha- deficient mice. Liver Int 2005; 25:162-170. (Pubitemid 40298259)
104. Nagao M, Isaji S, Iwata M et al. The remnant liver dysfunction after 84% hepatectomy in dogs. Hepatogastroenterology 2000; 47:1564-1569.
105. Hasegawa S, Kubota T, Fukuyama N et al. Apoptosis of hepatocytes is a main cause of inducing lethal hepatic failure after excessive hepatectomy in rats. Transplant Proc 1999; 31:558-559. (Pubitemid 29127573)
106. Morita T, Togo S, Kubota T et al. Mechanism of postoperative liver failure after excessive hepatectomy investigated using a cDNA microarray. J Hepatobiliary Pancreat Surg 2002; 9:352-359. (Pubitemid 35000478)
107. Schulze-Bergkamen H, Brenner D, Krueger A et al. Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt. Hepatology 2004; 39:645-654. (Pubitemid 38337644)
108. Forte G, Minieri M, Cossa P et al. Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells: Proliferation, Migration and Differentiation. Stem Cells 2005; 24(1):23-33.
109. Oh SH, Miyazaki M, Kouchi H et al. Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro. Biochem Biophys Res Commun 2000; 279:500-504. (Pubitemid 32016744)