Elevated expression of hormone-regulated rat hepatocyte functions in a new serum-free hepatocyte-stromal cell coculture model

In Vitro Cellular and Developmental Biology - Animal

Volumn 36, Issue 8, 2000, Pages 502-512

  Ries, Kati ^a   Krause, Petra ^a   Solsbacher, Meike ^a   Schwartz, Peter ^a   Unthan Fechner, Kirsten ^a   Christ, Bruno ^a   Markus, Peter M ^a   Probst, Irmelin ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Coculture; Differentiation; Fenestration; Liver stromal cells; Nonparenchymal cells; Rat hepatocytes

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; GLUCAGON; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM CELL; HORMONAL REGULATION; KUPFFER CELL; LIVER CELL; MALE; NONHUMAN; RAT; STELLATE CELL; STROMA CELL;

ANIMALS; CELL ADHESION; CELL SEPARATION; CELL SURVIVAL; COCULTURE TECHNIQUES; CULTURE MEDIA, SERUM-FREE; DEXAMETHASONE; GLUCAGON; HEPATOCYTES; HUMANS; INSULIN; LIVER; MALE; MODELS, BIOLOGICAL; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); RATS; RATS, WISTAR; RNA, MESSENGER; STROMAL CELLS;

ANIMALIA;

EID: 0033653581     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1290/1071-2690(2000)036<0502:EEOHRR>2.0.CO;2     Document Type: Article

References (47)

1. Activation of Met tyrosine kinase by hepatocyte growth factor is essential for internal organogenesis in Xenopus embryo
2. 3-D coculture of hepatic sinusoidal cells with primary, hepatocytes - Design of an organotypical model
3. Negative regulation of Apo A-I gene expression by retinoic acid in rat hepatocytes maintained in a coculture system
4. Liver development: A paradigm for hepatobiliary disease in later life
5. Effect of cell-cell interactions in preservation of cellular phenotype: Cocultivation of hepatocytes and nonparenchymal cells
6. Assessment of a method of isolation, purification and cultivation of rat liver sinusoidal endothelial cells
7. Inhibition by recombinant human interleukin-6 of the glucagon-dependent induction of phosphoenolpyruvate carboxykinase and of the insulin-dependent induction of GK gene expression in cultured rat hepatocytes
8. Mechanism of the inhibiton by insulin of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures
9. A plasma membrane protein is involved in cell contact-mediated regulation of tissue-specific genes in adult hepatocytes
10. Expression of integrins during liver organogenesis in humans
11. Hepatocytes in collagen sandwich: Evidence for transcriptional and translational regulation
12. Regulation of insulin binding and glycogenesis by insulin and dexamethasone in cultured rat hepatocytes
13. The spontaneous induction of glutamine synthetase in pig hepatocytes cocultured with RL-ET-14 cells is completely inhibited by triiodothyronine and okadaic acid
14. Tissue distribution and proliferation kinetics of fat-storing cells in carbon tetrachloride injured rat liver
15. Cellular interactions promote tissue-specific function, biomatrix deposition and junctional communication of primary cultured hepatocytes
16. Maintenance and reversibility of active albumin secretion by adult rat hepatocytes cocultured with another liver epithelial cell type
17. Hepatocyte-matrix interactions
18. Maintenance of differentiated rat hepatocytes in primary culture
19. Uber die kupfferschen sternzellen und die fettspeicherungszellen (fat storing cells) in der blutkapillarwand der menschlichen leber
20. Initiation of mammalian liver development from endoderm by fibroblast growth factors
21. Induction of replicative DNA synthesis and PPAR alpha-dependent gene transcription by Wy-14643 in primary rat hepatocyte and non-parenchymal cell coculture
22. Hepatocyte-supported serumfree culture of rat liver sinusoidal endothelial cells
23. Regulation of liver metabolism by intercellular communication
24. Cultivation of rat hepatocytes on 3T3 cells: Expression of various liver differentiated function
25. A simple, rapid and sensitive DNA assay procedure
26. Hepatocellular phenotype in vitro is influenced by biophysical features of the collagenous substratum
27. Cooperation of Ito cells and hepatocytes in the deposition of an extracellular matrix in vitro
28. Rat hepatocytes prepared without collagenase: Prolonged retention of differentiated characteristics in culture
29. Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells mainrained in biological matrices in the presence of hepatocyte growth factor and epidermal growth factor
30. Redifferentiation of proliferated rat hepatocytes cultured in L15 medium supplemented with EGF and DMSO
31. Reconstruction of hepatic organoid by small hepatocytes and hepatic nonparenchymal cells
32. Long-term maintenance of hepatocyte functional activity in co-culture: Requirements for sinusoidal endothelial cells and dexamethasone
33. Evaluation of the function of primary human hepatocytes co-cultured with the human hepatic stellate cell (HSC) line LI90
34. Integration of function in the hepatic acinus: Intercellular communication in neural and humoral control of liver metabolism
35. Characterization and functional studies on rat liver fat-storing cell line and freshly isolated hepatocyte coculture system
36. Mechanism of the permissive action of dexamethasone on the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in cultured rat hepatocytes
37. On the mechanism of gluconeogenesis and its regulation
38. Stimulation of growth of primary cultured adult rat hepatocytes without growth factors by coculture with nonparenchymal cells
39. Expression of alpha2-macroglobulin by the interaction between hepatocytes and endothelial cells in coculture
40. Heterogeneity of growth potential of adult rat hepatocytes in vitro
41. Dependency of the in vitro stabilization of differentiated functions in liver parenchymal cells on the type of cell line used for co-culture
42. Coculture of primary rat hepatocytes and nonparenchymal cells permits expression of insulin-like growth factor binding protein- 3 in vitro
43. Interaction of adult rat hepatocytes and sinusoidal cells in coculture
44. Observations on the fine structure and peroxidase cytochemistry of normal rat liver Kupffer cells
45. Reciprocal regulation of prothrombin secretion and tyrosine aminotransferase induction in hepatocytes
46. Growth stimulation in a primary, culture by soluble factor(s) secreted from nonparenchymal liver cells