Treatment with a soluble receptor for activin improves bone mass and structure in the axial and appendicular skeleton of female cynomolgus macaques (Macaca fascicularis)

Bone

Volumn 46, Issue 1, 2010, Pages 64-71

  Fajardo, Roberto José ^a   Manoharan, Rajaram K ^a   Pearsall, R Scott ^b   Davies, Monique V ^b   Marvell, Tod ^b   Monnell, Travis E ^b   Ucran, Jeffrey A ^b   Pearsall, Amelia E ^b   Khanzode, Deepali ^b   Kumar, Ravindra ^b   Underwood, Kathryn W ^b   Roberts, Benjamin ^a   Seehra, Jasbir ^b   Bouxsein, Mary L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Acceleron Pharma   (United States)

Author keywords

Activin inhibition; Anabolic agent; Bone mass; Bone strength; Osteoporosis

Indexed keywords

ACE 011; ACTIVIN; ACTIVIN RECEPTOR 2; ACTIVIN TYPE 2A RECEPTOR FC FUSION PROTEIN; ANABOLIC AGENT; HYBRID PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MASS; BONE METABOLISM; BONE MINERALIZATION; BONE STRENGTH; BONE STRUCTURE; CANCELLOUS BONE; CONTROLLED STUDY; CORTICAL BONE; DOSE RESPONSE; DRUG CLEARANCE; DRUG HALF LIFE; DRUG TOLERANCE; FEMALE; FEMUR; LUMBAR VERTEBRA; MACACA; MALE; NONHUMAN; OSSIFICATION; SHORT COURSE THERAPY; TRABECULAR BONE;

ACTIVIN RECEPTORS, TYPE II; ANIMALS; BONE AND BONES; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; FEMALE; HUMANS; MACACA FASCICULARIS;

EID: 72049109947     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.09.018     Document Type: Article

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