Use of Manometric Temperature Measurements (MTM) to characterize the freeze-drying behavior of amorphous protein formulations

Journal of Pharmaceutical Sciences

Volumn 99, Issue 6, 2010, Pages 2863-2873

  Johnson, Robert E ^a   Oldroyd, Megan E ^a   Ahmed, Saleem S ^a   Gieseler, Henning ^b   Lewis, Lavinia M ^a  

^a PFIZER INC   (United States)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Cycle optimization; Freeze drying; Manometric temperature measurements; Microcollapse; Product resistance; Proteins

Indexed keywords

ARTICLE; CONTROLLED STUDY; FREEZE DRYING; MANOMETRIC TEMPERATURE MEASUREMENT; MANOMETRY; PROTEIN PROCESSING; SCANNING ELECTRON MICROSCOPY;

EID: 77951619639     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22031     Document Type: Article

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