Effect of product temperature during primary drying on the long-term stability of lyophilized proteins

Pharmaceutical Development and Technology

Volumn 12, Issue 6, 2007, Pages 543-553

  Passot, Stéphanie ^a   Fonseca, Fernanda ^a   Barbouche, Naziha ^a   Marin, Michèle ^a   Alarcon Lorca, Muriel ^b   Rolland, Dominique ^b   Rapaud, Michel ^c  

^a CEMAGREF   (France)

^b Immunoassays and Proteomic R and D   (France)

^c Clinical Development Department   (France)

Author keywords

Freeze drying; Glass transition; Long term stability; Protein

Indexed keywords

BULKING AGENT; CRYSTALLIN; PROTEIN; TOXIN;

ANTIGENICITY; ARTICLE; FREEZE DRYING; GLASS TRANSITION TEMPERATURE; LYOPHILISATE; PRIORITY JOURNAL; PROTEIN STABILITY; SHELF LIFE; STORAGE; VISCOSITY;

BACTERIAL PROTEINS; BACTERIAL TOXINS; CALORIMETRY, DIFFERENTIAL SCANNING; CLOSTRIDIUM DIFFICILE; CRYSTALLIZATION; DRUG STABILITY; DRUG STORAGE; ENTEROTOXINS; FREEZE DRYING; PHASE TRANSITION; TECHNOLOGY, PHARMACEUTICAL; TRANSITION TEMPERATURE;

EID: 37549065553     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450701563459     Document Type: Article

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