PKC/Raf/MEK/ERK signaling pathway modulates native-LDL-induced E2F-1 gene expression and endothelial cell proliferation

Cardiovascular Research

Volumn 59, Issue 4, 2003, Pages 934-944

  Pintus, Gianfranco ^a   Tadolini, Bruna ^a   Posadino, Anna M ^a   Sanna, Bastiano ^a   Debidda, Marcella ^a   Carru, Ciriaco ^a   Deiana, Luca ^a   Ventura, Carlo ^a  

^a UNIVERSITY OF SASSARI   (Italy)

Author keywords

Endothelial function; Gene expression; Lipoproteins; Protein kinases; Signal transduction

Indexed keywords

LOW DENSITY LIPOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; RAF PROTEIN; TRANSCRIPTION FACTOR E2F1;

ARTICLE; CELL PROLIFERATION; DNA SYNTHESIS; DOSE TIME EFFECT RELATION; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

CELL CYCLE PROTEINS; CELL DIVISION; CELLS, CULTURED; CHOLESTEROL, LDL; DNA; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; ENDOTHELIAL CELLS; GENE EXPRESSION; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-RAF; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTORS;

EID: 1642385403     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(03)00526-1     Document Type: Article

References (37)

1. Steinberg D., Witztum J.L. Lipoproteins and atherogenesis: current concepts. J. Am. Med. Assoc. 264:1990;3047-3052.
2. Scandinavian Simvastatin Survival Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study. Lancet. 344:1994;1383-1389.
3. Shepherd J., Cobbe S.M., Ford I., et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. New Engl J Med. 333:1995;1301-1307.
4. Allen S., Khan S., Al-Mohanna F., Batten P., Yacoub M. Native low density lipoprotein-induced calcium transients trigger VCAM-1 and E-selectin expression in cultured human vascular endothelial cells. J Clin Invest. 101:1998;1064-1075.
5. Smalley D.M., Lin J.H., Curtis M.L., et al. Native LDL increases endothelial cell adhesiveness by inducing intercellular adhesion molecule-1. Arterioscler Thromb Vasc Biol. 16:1996;585-590.
6. Holland J.A., Pritchard K.A., Rogers N.J., Stemerman M.B. Atherogenic levels of low-density lipoprotein increase endocytotic activity in cultured human endothelial cells. Am J Pathol. 140:1992;551-558.
7. Guretzki H.J., Gerbitz K.D., Olgemoller B., Schleicher E. Atherogenic levels of low density lipoprotein alter the permeability and composition of the endothelial barrier. Atherosclerosis. 107:1994;15-24.
8. Pritchard K.A. Jr., Schwarz S.M., Medow M.S., Stemerman M.B. Effect of low-density lipoprotein on endothelial cell membrane fluidity and mononuclear cell attachment. Am J Physiol. 260:1991;C43-49.
9. Gerrity R.G. The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. Am J Pathol. 103:1981;181-190.
10. Rosenfeld M.E., Tsukada T., Gown A.M., Ross R. Fatty streak initiation in Watanabe heritable hyperlipemic and comparably hypercholesterolemic fat-fed rabbits. Arteriosclerosis. 7:1987;9-23.
11. Stary H.C. Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis. 9:1989;I19-32.
12. Stary H.C., Blankenhorn D.H., Chandler A.B., et al. A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb. 12:1992;120-134.
13. Gibbons G.H., Dzau V.J. The emerging concept of vascular remodeling. New Engl J Med. 330:1994;1431-1438.
14. Ko Y., Totzke G., Seewald S., et al. Native low-density lipoprotein (LDL) induces the expression of the early growth response gene-1 in human umbilical arterial endothelial cells. Eur J Cell Biol. 68:1995;306-312.
15. Kent K.C., Mii S., Harrington E.O., et al. Requirement for protein kinase C activation in basic fibroblast growth factor-induced human endothelial cell proliferation. Circ Res. 77:1995;231-238.
16. Ferrell J.E. Jr. MAP kinases in mitogenesis and development. Curr Top Dev Biol. 33:1996;1-60.
17. Muller H, Helin K. The E2F transcription factors: key regulators of cell proliferation. Biochim Biophys Acta 2000;1470:M1-12.
18. Berkovich E. Gi, Ginsberg D. Ras induces elevation of E2F-1 mRNA levels. J Biol Chem. 276:2001;42851-42856.
19. Pintus G., Tadolini B., Maioli M., et al. Heparin inhibits phorbol ester-induced ornithine decarboxylase gene expression in endothelial cells. FEBS Lett. 423:1998;98-104.
20. Kent K.C., Collins L.J., Schweirn F.T., Raychowdhury M.K., Ware J.A. Identification of functional PGH2/TxA2 receptors on human endothelial cells. Circ Res. 72:1993;958-965.
21. Esterbauer H., Striegl G., Puhl H., Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun. 6:1989;67-75.
22. Pintus G., Tadolini B., Posadino A.M., et al. Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation. Eur J Biochem. 269:2002;5861-5870.
23. Debidda M, Sanna B, Cossu A, et al. NAMI-A inhibits the PMA-induced ODC gene expression in ECV304 cells: involvement of PKC/Raf/Mek/ERK signaling pathway. Int J Oncol 2003;2:477-482.
24. Pintus G., Tadolini B., Maioli M., et al. Heparin down-regulates the phorbol ester-induced protein kinase C gene expression in human endothelial cells: enzyme-mediated autoregulation of protein kinase C-alpha and -delta genes. FEBS Lett. 449:1999;135-140.
25. Willey J.C., Crawford E.L., Jackson C.M., et al. Expression measurement of many genes simultaneously by quantitative RT-PCR using standardized mixtures of competitive templates. Am J Respir Cell Mol Biol. 19:1998;6-17.
26. Ventura C., Pintus G., Fiori M.G., et al. Opioid peptide gene expression in the primary hereditary cardiomyopathy of the Syrian hamster. I. Regulation of prodynorphin gene expression by nuclear protein kinase C. J Biol Chem. 272:1997;6685-6692.
27. Ogata N., Yamamoto H., Kugiyama K., Yasue H., Miyamoto E. Involvement of protein kinase C in superoxide anion-induced activation of nuclear factor-kappa B in human endothelial cells. Cardiovasc Res. 45:2000;513-521.
28. Moulton K.S. Plaque angiogenesis and atherosclerosis. Curr Atheroscler Rep. 3:2001;225-233.
29. Gousseva N., Kugathasan K., Chesterman C.N., Khachigian L.M. Early growth response factor-1 mediates insulin-inducible vascular endothelial cell proliferation and regrowth after injury. J Cell Biochem. 81:2001;523-534.
30. Clemens M.J., Trayner I., Menaya J. The role of protein kinase C isoenzymes in the regulation of cell proliferation and differentiation. J Cell Sci. 103:1992;881-887.
31. Berra E., Diaz-Meco M.T., Lozano J., et al. Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta. EMBO J. 14:1992;6157-6163.
32. Sugden P.H., Clerk A. Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors. Cell Signal. 9:1997;337-351.
33. Zhou W., Takuwa N., Kumada M., Takuwa Y. E2F1, B-myb and selective members of cyclin/cdk subunits are targets for protein kinase C-mediated bimodal growth regulation in vascular endothelial cells. Biochem Biophys Res Commun. 199:1994;191-198.
34. Bennett M.R., Macdonald K., Chan S.W., Boyle J., Weissberg P.L. Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques. Circ Res. 82:1998;704-712.
35. Wang A., Nomura M., Patan S., Ware J.A. Inhibition of protein kinase C alpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo. Circ Res. 90:2002;609-616.
36. Haneda M., Koya D., Kikkawa R. Cellular mechanisms in the development and progression of diabetic nephropathy: activation of the DAG-PKC-ERK pathway. Am J Kidney Dis. 38:2001;S178-181.
37. Kruth H.S., Huang W., Ishii I., Zhang W.Y. Macrophage foam cell formation with native low density lipoprotein. J Biol Chem. 277:2002;34573- 34580.