Cytometric analysis of cytotoxicity of polyphenols and related phenolics to rat thymocytes: Potent cytotoxicity of resveratrol to normal cells

Basic and Clinical Pharmacology and Toxicology

Volumn 104, Issue 6, 2009, Pages 455-462

  Fujimoto, Aya ^a   Sakanashi, Yoko ^a   Matsui, Hiroko ^b   Oyama, Toshihisa ^c   Nishimura, Yumiko ^c   Masuda, Toshiya ^a   Oyama, Yasuo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 GINGEROL; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CAFFEIC ACID; CATECHIN; CHLOROGENIC ACID; DNA; EUGENOL; PHENOL DERIVATIVE; POLYPHENOL; RESVERATROL; ROSMARINIC ACID; SESAMOL; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL POPULATION; CELL SIZE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DIPLOIDY; FLOW CYTOMETRY; INCUBATION TEMPERATURE; INCUBATION TIME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THYMOCYTE; TOXICITY TESTING;

ANIMALS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; FLOW CYTOMETRY; MALE; PHENOLS; RATS; RATS, WISTAR; STILBENES; THYMUS GLAND;

RATTUS;

EID: 65549089618     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2009.00386.x     Document Type: Article

References (33)

1. Schilter B, Andersson C, Anton R, Constable A, Kleiner J, O'Brien J et al. Guidance for the safety assessment of botanicals and botanical preparations for use in food and food supplements. Food Chem Toxicol 2003 41 : 1625 49. (Pubitemid 37249332)
2. Lambert JD, Yang CS. Cancer chemopreventive activity and bioavailability of tea and tea polyphenols. Mutat Res 2003 523-4 : 201 8. (Pubitemid 36293247)
3. Arts IC, Hollman PC. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 2005 81 : S317 25.
4. Yang CS, Sang S, Lambert JD, Lee MJ. Bioavailability issues in studying the health effects of plant polyphenolic compounds. Mol Nutr Food Res 2008 52 : S139 51.
5. Galati G, Teng S, Moridani MY, Chan TS, O'Brien PJ. Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolics. Drug Metabol Drug Interact 2000 17 : 311 49. (Pubitemid 32047540)
6. Nichenametla SN, Taruscio TG, Barney DL, Exon JH. A review of the effects and mechanisms of polyphenolics in cancer. Crit Rev Food Sci Nutr 2006 46 : 161 83. (Pubitemid 43315924)
7. McConkey DJ, Jondal M, Orrenius S. The regulation of apoptosis in thymocytes. Biochem Soc Trans 1994 22 : 606 10. (Pubitemid 24272773)
8. Quaglino D, Ronchetti IP. Cell death in the rat thymus: A minireview. Apoptosis 2001 6 : 389 401. (Pubitemid 32910880)
9. Nakao, Umebayashi C, Nakata M, Nishizaki Y, Noda K, Okano Y et al. Formaldehyde-induced shrinkage of rat thymocytes. J Pharmacol Sci 2003 91 : 83 6. (Pubitemid 36575558)
10. Iwase K, Tatsuishi T, Nishimura Y, Yamaguchi JY, Oyama Y, Miyoshi N et al. Cytometric analysis of adverse action of diphenyl ditelluride on rat thymocytes: Cell shrinkage as a cytotoxic parameter. Environ Toxicol 2004 19 : 614 9. (Pubitemid 39552272)
11. Tiso M, Gangemi R, Bargellesi-Severi A, Pizzolitto S, Fabbi M, Risso A. Spontaneous apoptosis in human thymocytes. Am J Pathol 1995 147 : 434 44.
12. Rinner I, Felsner P, Hofer D, Globerson A, Schauenstein K. Characterization of the spontaneous apoptosis of rat thymocytes in vitro. Int Arch Allergy Immunol 1996 111 : 230 7. (Pubitemid 26345380)
13. 2-induced changes in cell viability and cellular nonprotein thiol level of dissociated rat thymocytes. Jpn J Pharmacol 1996 71 : 299 305. (Pubitemid 26308295)
14. Oyama Y, Noguchi S, Nakata M, Okada Y, Yamazaki Y, Funai M et al. Exposure of rat thymocytes to hydrogen peroxide increases annexin V binding to membranes: Inhibitory actions of deferoxamine and quercetin. Eur J Pharmacol 1999 384 : 47 52.
15. Wolf CM, Reynolds JE, Morana SJ, Eastman A. The temporal relationship between protein phosphatase, ICE/CED-3 proteases, intracellular acidification, and DNA fragmentation in apoptosis. Exp Cell Res 1997 230 : 22 7. (Pubitemid 27187535)
16. Hughes FM, Cidlowski JA. Glucocorticoid-induced thymocyte apoptosis: Protease-dependent activation of cell shrinkage and DNA degradation. J Steroid Biochem Mol Biol 1998 65 : 207 17. (Pubitemid 28335608)
17. Cohen GM. Caspases: The executioners of apoptosis. Biochem J 1997 326 : 1 16. (subitemid 27386911)
18. Van Noorden CJ. The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition. Acta Histochem 2001 103 : 241 51. (Pubitemid 32624783)
19. Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, van Oers MH. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 1994 84 : 1415 20. (Pubitemid 24273007)
20. Athar M, Back JH, Tang X, Kim KH, Kopelovich L, Bickers DR et al. Resveratrol: A review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol 2007 224 : 274 83. (Pubitemid 47575677)
21. Lu R, Serrero G. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J Cell Physiol 1999 179 : 297 304. (Pubitemid 29203154)
22. Delmas D, Rébé C, Lacour S, Filomenko R, Athias A, Gambert P et al. Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells. J Biol Chem 2003 278 : 41482 90. (Pubitemid 37280977)
23. Zhou HB, Yan Y, Sun YN, Zhu JR. Resveratrol induces apoptosis in human esophageal carcinoma cells. World J Gastroenterol 2003 9 : 408 11. (Pubitemid 36372096)
24. Niles RM, McFarland M, Weimer MB, Redkar A, Fu YM, Meadows GG. Resveratrol is a potent inducer of apoptosis in human melanoma cells. Cancer Lett 2003 190 : 157 63. (Pubitemid 36136014)
25. Ahn CH, Choi WC, Kong JY. Chemosensitizing activity of caffeic acid in multidrug-resistant MCF-7/Dox human breast carcinoma cells. Anticancer Res 1997 17 : 1913 7. (Pubitemid 2732096)
26. Lee YJ, Kuo HC, Chu CY, Wang CJ, Lin WC, Tseng TH. Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells. Biochem Pharmacol 2003 66 : 2281 9.
27. Nagaoka T, Banskota AH, Tezuka Y, Saiki I, Kadota S. Selective antiproliferative activity of caffeic acid phenethyl ester analogues on highly liver-metastatic murine colon 26-L5 carcinoma cell line. Bioorg Med Chem 2002 10 : 3351 9.
28. Scheckel KA, Degner SC, Romagnolo DF. Rosmarinic Acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. J Nutr 2008 138 : 2098 105.
29. Osakabe N, Yasuda A, Natsume M, Yoshikawa T. Rosmarinic acid inhibits epidermal inflammatory responses: Anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model. Carcinogenesis 2004 25 : 549 57. (Pubitemid 38499943)
30. Lee WJ, Zhu BT. Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols. Carcinogenesis 2006 27 : 269 77. (Pubitemid 43159879)
31. Nwankwo JO. Anti-metastatic activities of all-trans retinoic acid, indole-3-carbinol and (+)-catechin in Dunning rat invasive prostate adenocarcinoma cells. Anticancer Res 2002 22 : 4129 35. (Pubitemid 36134444)
32. Lee HS, Seo EY, Kang NE, Kim WK. [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. J Nutr Biochem 2008 19 : 313 9.
33. Kim SS, Oh O-J, Min H-Y, Park E-J, Kim Y, Park HJ et al. Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. Life Sci 2003 73 : 337 48. (Pubitemid 36579176)