메뉴 건너뛰기




Volumn , Issue 2, 2008, Pages 115-122

Gene medicine for cancer treatment: Commercially available medicine and accumulated clinical data in China

Author keywords

Adenovirus; Cancer; Clinical trials; E1B; Gene therapy; p53

Indexed keywords

ADENOVIRUS VECTOR; ADVEXIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CISPLATIN; DOXORUBICIN; FLUOROURACIL; GENDICINE; NAVELBINE; ONCORINE; ONYX 015; UNCLASSIFIED DRUG;

EID: 77951574435     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (45)

References (63)
  • 1
    • 0037075175 scopus 로고    scopus 로고
    • Adenoviral delivery of p53 gene suppresses expression of collagenase-3 (MMP-13) in squamous carcinoma cells
    • DOI 10.1038/sj/onc/1205198
    • Ala-aho R, Grenman R, Seth P, et al. 2002. Adenoviral delivery of p53 gene suppresses expression of collagenase-3 (MMP-13) in squamous carcinoma cells. Oncogene, 21:1187-1195 (Pubitemid 34185235)
    • (2002) Oncogene , vol.21 , Issue.8 , pp. 1187-1195
    • Ala-Aho, R.1    Grenman, R.2    Seth, P.3    Kahari, V.-M.4
  • 3
    • 0029832231 scopus 로고    scopus 로고
    • In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug
    • DOI 10.1002/(SICI)1097-0215(19960729)67:3<386::AID-IJC13>3.0.CO;2-6
    • Blagosklonny MV, EL-Deiry WS. 1996. In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug. Int J Cancer, 67:386-392 (Pubitemid 26274130)
    • (1996) International Journal of Cancer , vol.67 , Issue.3 , pp. 386-392
    • Blagosklonny, M.V.1    El-Deiry, W.S.2
  • 5
    • 0034598751 scopus 로고    scopus 로고
    • Tissue and cell-specific expression of the p53 target genes: Bax, fas, mdm2 and waf1/p21, before and following ionizing irradiation in mice
    • Bouvard V, Zaitchouk T, Vacher M, et al. 2000. Tissue and cell-specific expression of the p53 target genes: bax, fas, mdm2 and waf1/p21, before and following ionizing irradiation in mice. Oncogene, 19:649-660
    • (2000) Oncogene , vol.19 , pp. 649-660
    • Bouvard, V.1    Zaitchouk, T.2    Vacher, M.3
  • 6
    • 0035319296 scopus 로고    scopus 로고
    • Introduction of mutant p53 into a wild-type p53-expressing glioma cell line confers sensitivity to Ad-p53-induced apoptosis
    • Cerrato JA, Yung WK, Liu TJ. 2001. Introduction of mutant p53 into a wild-type p53-expressing glioma cell line confers sensitivity to Ad-p53-induced apoptosis. Neuro Oncol, 3:113-122
    • (2001) Neuro Oncol , vol.3 , pp. 113-122
    • Cerrato, J.A.1    Yung, W.K.2    Liu, T.J.3
  • 7
    • 0037515740 scopus 로고    scopus 로고
    • NKG2D ligands: Unconventional MHC class I-like molecules exploited by viruses and cancer
    • DOI 10.1034/j.1399-0039.2003.00070.x
    • Cerwenka A, Lanier LL. 2003. NKG2D ligands: Unconventional MHC class I-like molecules exploited by viruses and cancer. Tissue Antigens, 61:335-343 (Pubitemid 36605666)
    • (2003) Tissue Antigens , vol.61 , Issue.5 , pp. 335-343
    • Cerwenka, A.1    Lanier, L.L.2
  • 8
    • 2342596553 scopus 로고    scopus 로고
    • Recombinant adenovirus p53 agent injection combince with radiotherapy in treatment of nasopharyngeal carcinoma: A phase II clinical trial
    • Chen C, Pan J, Xu L. 2003. Recombinant adenovirus p53 agent injection combince with radiotherapy in treatment of nasopharyngeal carcinoma: a phase II clinical trial. Zhonghua Yi Xue Za Zhi, 23:2033-2035
    • (2003) Zhonghua Yi Xue Za Zhi , vol.23 , pp. 2033-2035
    • Chen, C.1    Pan, J.2    Xu, L.3
  • 9
    • 0842278331 scopus 로고    scopus 로고
    • Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    • Chipuk JE, Kuwana T, Bouchier-H, et al. 2004. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science, 303:1010-1014
    • (2004) Science , vol.303 , pp. 1010-1014
    • Chipuk, J.E.1    Kuwana, T.2    Bouchier, H.3
  • 10
    • 4143092630 scopus 로고    scopus 로고
    • Use of replicating oncolytic adenoviruses in combination therapy for cancer
    • Chu RL, Post DE, Khuri FR, et al. 2004. Use of replicating oncolytic adenoviruses in combination therapy for cancer. Clin Cancer Res, 10:5299-5312
    • (2004) Clin Cancer Res , vol.10 , pp. 5299-5312
    • Chu, R.L.1    Post, D.E.2    Khuri, F.R.3
  • 12
    • 0028060380 scopus 로고
    • Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
    • Dameron KM, Volpert OV, Tainsky MA, et al. 1994. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science, 265:1582-1584
    • (1994) Science , vol.265 , pp. 1582-1584
    • Dameron, K.M.1    Volpert, O.V.2    Tainsky, M.A.3
  • 14
    • 10244226744 scopus 로고    scopus 로고
    • The effect of adenovirus expressing wild-type p53 on 5-fluorouracil chemosensitivity is related to p53 status in pancreatic cancer cell lines
    • Eisold S, Linnebacher M, Ryschich E, et al. 2004. The effect of adenovirus expressing wild-type p53 on 5-fluorouracil chemosensitivity is related to p53 status in pancreatic cancer cell lines. World J Gastroenterol, 10:3583-3589 (Pubitemid 39619273)
    • (2004) World Journal of Gastroenterology , vol.10 , Issue.24 , pp. 3583-3589
    • Eisold, S.1    Linnebacher, M.2    Ryschich, E.3    Antolovic, D.4    Hinz, U.5    Klar, E.6    Schmidt, J.7
  • 15
    • 0031705691 scopus 로고    scopus 로고
    • P53 and brain tumors: From gene mutations to gene therapy
    • Fulci G, Ishii N, Van Meir EG. 1998. p53 and brain tumors: from gene mutations to gene therapy. Brain Pathol, 8:599-613. (Pubitemid 28460920)
    • (1998) Brain Pathology , vol.8 , Issue.4 , pp. 599-613
    • Fulci, G.1    Ishii, N.2    Van Meir, E.G.3
  • 16
    • 24944443608 scopus 로고    scopus 로고
    • Combination therapy with recombinant adenovirus-p53 injection (rAd-p53) via transcatheter hepatic arterial chemoembolization for advanced hepatic carcinoma
    • Guan YS, Sun L, Zhou XP, et al. 2005. Combination therapy with recombinant adenovirus-p53 injection (rAd-p53) via transcatheter hepatic arterial chemoembolization for advanced hepatic carcinoma. Shijie Huaren Xiaohua Zazhi, 13:125-127
    • (2005) Shijie Huaren Xiaohua Zazhi , vol.13 , pp. 125-127
    • Guan, Y.S.1    Sun, L.2    Zhou, X.P.3
  • 17
    • 0033543077 scopus 로고    scopus 로고
    • A phase I/II study of hepatic artery infusion with wtp53-CMV-Ad in metastatic malignant liver tumours
    • DOI 10.1089/10430349950017383
    • Habib NA, Hodgson HJ, Lemoine N, et al. 1999. A phase I/II study of hepatic artery infusion with wtp53-CMV-Ad in metastatic malignant liver tumors. Hum Gene Ther, 10:2019-2034 (Pubitemid 29387916)
    • (1999) Human Gene Therapy , vol.10 , Issue.12 , pp. 2019-2034
    • Habib, N.A.1    Hodgson, H.2    Lemoine, N.3    Pignatelli, M.4
  • 19
    • 66049157186 scopus 로고    scopus 로고
    • Abscopal effect on metastatic tumor induced by oncolytic virus of H101 combining with local heating
    • Hu F, Hu X, Yu P, et al. 2006. Abscopal effect on metastatic tumor induced by oncolytic virus of H101 combining with local heating. Ai Zheng, 25:919-924
    • (2006) Ai Zheng , vol.25 , pp. 919-924
    • Hu, F.1    Hu, X.2    Yu, P.3
  • 20
    • 0034739331 scopus 로고    scopus 로고
    • Administration of wild-type p53 adenoviral vector synergistically enhances the cytotoxicity of anti-cancer drugs in human lung cancer cells irrespective of the status of p53 gene
    • DOI 10.1016/S0304-3835(00)00480-8, PII S0304383500004808
    • Inoue A, Narumi K, Matsubara N, et al. 2000. Administration of wild-type p53 adenoviral vector synergistically enhances the cytotoxicity of anticancer drugs in human lung cancer cells irrespective of the status of p53 gene. Cancer Lett, 157:105-112 (Pubitemid 30421238)
    • (2000) Cancer Letters , vol.157 , Issue.1 , pp. 105-112
    • Inoue, A.1    Narumi, K.2    Matsubara, N.3    Sugawara, S.-I.4    Saijo, Y.5    Satoh, K.6    Nukiwa, T.7
  • 21
    • 0029028881 scopus 로고
    • Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cells
    • Katayose D, Gudas J, Nguyen H, et al. 1995. Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cells. Clin Cancer Res, 1:889-897
    • (1995) Clin Cancer Res , vol.1 , pp. 889-897
    • Katayose, D.1    Gudas, J.2    Nguyen, H.3
  • 22
    • 0033799839 scopus 로고    scopus 로고
    • Multidrug resistance (MDR) in cancer: Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs
    • Krishna R, Mayer LD. 2000. Multidrug resistance (MDR) in cancer: Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur J Pharm Sci, 11:265-283
    • (2000) Eur J Pharm Sci , vol.11 , pp. 265-283
    • Krishna, R.1    Mayer, L.D.2
  • 23
    • 2342553892 scopus 로고    scopus 로고
    • Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
    • DOI 10.1038/ncb1123
    • Leu J, Dumont P, Hafey M, et al. 2004. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol, 6:443-450 (Pubitemid 38607505)
    • (2004) Nature Cell Biology , vol.6 , Issue.5 , pp. 443-450
    • Leu, J.I.-J.1    Dumont, P.2    Hafey, M.3    Murphy, M.E.4    George, D.L.5
  • 24
    • 77953679065 scopus 로고    scopus 로고
    • Radiotherapy combined with chemotherapy and intratumoral injection of EIB gene-deleted adenovirus (H101) for nasopharyngeal carcinoma
    • Lu Y, Hu X, Li F, et al. 2006. Radiotherapy combined with chemotherapy and intratumoral injection of EIB gene-deleted adenovirus (H101) for nasopharyngeal carcinoma. Zhong Liu, 26:453-455
    • (2006) Zhong Liu , vol.26 , pp. 453-455
    • Lu, Y.1    Hu, X.2    Li, F.3
  • 28
    • 12444281703 scopus 로고    scopus 로고
    • Pilot trial of intravenous infusion of a replication selective adenovirus (ONYX-015) in combination with chemotherapy or IL-2 treatment in refractory cancer patients
    • Nemunaitis J, Cunningham C, Tong AW, et al. 2003. Pilot trial of intravenous infusion of a replication selective adenovirus (ONYX-015) in combination with chemotherapy or IL-2 treatment in refractory cancer patients. Cancer Gene Ther, 10:341-352
    • (2003) Cancer Gene Ther , vol.10 , pp. 341-352
    • Nemunaitis, J.1    Cunningham, C.2    Tong, A.W.3
  • 29
    • 22244479672 scopus 로고    scopus 로고
    • Heat shock phenocopies E1B- 55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy
    • O'Shea CC, Soria C, Bagus B, et al. 2005. Heat shock phenocopies E1B- 55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. Cancer Cell, 8:61-74.
    • (2005) Cancer Cell , vol.8 , pp. 61-74
    • O'Shea, C.C.1    Soria, C.2    Bagus, B.3
  • 30
    • 0038826049 scopus 로고    scopus 로고
    • Repeated intravesical instillations of an adenoviral vector in patients with locally advanced bladder cancer: A phase I study of p53 gene therapy
    • Pagliaro LC, Keyhani A, Williams D, et al. 2003. Repeated intravesical instillations of an adenoviral vector in patients with locally advanced bladder cancer: A phase I study of p53 gene therapy. J Clin Oncol, 21:2247-2253
    • (2003) J Clin Oncol , vol.21 , pp. 2247-2253
    • Pagliaro, L.C.1    Keyhani, A.2    Williams, D.3
  • 31
    • 0035884402 scopus 로고    scopus 로고
    • Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma
    • Pal S, Datta K, Mukhopadhyay D. 2001. Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma. Cancer Res, 61:6952-6957 (Pubitemid 32896524)
    • (2001) Cancer Research , vol.61 , Issue.18 , pp. 6952-6957
    • Pal, S.1    Datta, K.2    Mukhopadhyay, D.3
  • 32
    • 4043172586 scopus 로고    scopus 로고
    • Cooperative effect of adenoviral p53 gene therapy and standard chemotherapy in ovarian cancer cells independent of the endogenous p53 status
    • Quist SR, Wang-Gohrke S, Kohler T, et al. 2004. Cooperative effect of adenoviral p53 gene therapy and standard chemotherapy in ovarian cancer cells independent of the endogenous p53 status. Cancer Gene Ther, 11:547-554
    • (2004) Cancer Gene Ther , vol.11 , pp. 547-554
    • Quist, S.R.1    Wang-Gohrke, S.2    Kohler, T.3
  • 33
    • 0036828125 scopus 로고    scopus 로고
    • Hepatic arterial infusion of a replicationselective oncolytic adenovirus (dl520): Phase II viral, immunologic, and clinical endpoints
    • Reid T, Galanis E, Abbruzzese J, et al. 2002. Hepatic arterial infusion of a replicationselective oncolytic adenovirus (dl520): Phase II viral, immunologic, and clinical endpoints. Cancer Res, 62:6070-6079
    • (2002) Cancer Res , vol.62 , pp. 6070-6079
    • Reid, T.1    Galanis, E.2    Abbruzzese, J.3
  • 34
    • 0034161976 scopus 로고    scopus 로고
    • In vivo antitumor activity of ONYX-015 is influenced by radiotherapy
    • Rogulski KR, Freytag SO, Zhang K, et al. 2000. In vivo antitumor activity of ONYX-015 is influenced by radiotherapy. Cancer Res, 60:1193-1196
    • (2000) Cancer Res , vol.60 , pp. 1193-1196
    • Rogulski, K.R.1    Freytag, S.O.2    Zhang, K.3
  • 35
    • 1642414806 scopus 로고    scopus 로고
    • CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance
    • Rosenblum MD, Olasz E, Woodliff JE, et al. 2004. CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance. Blood, 103:2691-2698
    • (2004) Blood , vol.103 , pp. 2691-2698
    • Rosenblum, M.D.1    Olasz, E.2    Woodliff, J.E.3
  • 36
    • 2442712631 scopus 로고    scopus 로고
    • Identification of Tcf-4 as a transcriptional target of p53 signalling
    • Rother K, Johne C, Spiesbach K, et al. 2004. Identification of Tcf-4 as a transcriptional target of p53 signalling. Oncogene, 23:3376-3384
    • (2004) Oncogene , vol.23 , pp. 3376-3384
    • Rother, K.1    Johne, C.2    Spiesbach, K.3
  • 37
    • 0031743945 scopus 로고    scopus 로고
    • Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells
    • Rothmann T, Hengstermann A, Whitaker NJ, et al. 1998. Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells. J Virol, 72:9470-9478
    • (1998) J Virol , vol.72 , pp. 9470-9478
    • Rothmann, T.1    Hengstermann, A.2    Whitaker, N.J.3
  • 38
    • 33644833974 scopus 로고    scopus 로고
    • P53 promotes adenoviral replication and increases late viral gene expression
    • Royds JA, Hibma M, Dix BR, et al. 2006. p53 promotes adenoviral replication and increases late viral gene expression. Oncogene, 25:1509-1520
    • (2006) Oncogene , vol.25 , pp. 1509-1520
    • Royds, J.A.1    Hibma, M.2    Dix, B.R.3
  • 39
    • 11144290579 scopus 로고    scopus 로고
    • Can China bring its own pipeline to the market?
    • Sabine L. 2004. Can China bring its own pipeline to the market? Nat Biotechnol, 22:1497-1499
    • (2004) Nat Biotechnol , vol.22 , pp. 1497-1499
    • Sabine, L.1
  • 40
    • 3042753952 scopus 로고    scopus 로고
    • Adenovirus-mediated wild type p53 radiosensitizes human tumor cells by suppressing DNA repair capacity
    • Sah NK, Munshi A, Nishikawa T, et al. 2003. Adenovirus-mediated wild type p53 radiosensitizes human tumor cells by suppressing DNA repair capacity. Mol Cancer Ther, 2:1223-1231
    • (2003) Mol Cancer Ther , vol.2 , pp. 1223-1231
    • Sah, N.K.1    Munshi, A.2    Nishikawa, T.3
  • 41
    • 0035868848 scopus 로고    scopus 로고
    • Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: Results of a multicenter phase II study
    • Schuler M, Herrman R, DE Greve JL, et al. 2001. Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: Results of a multicenter phase II study. J Clin Oncol, 19:1750-1758
    • (2001) J Clin Oncol , vol.19 , pp. 1750-1758
    • Schuler, M.1    Herrman, R.2    De Greve, J.L.3
  • 42
    • 1942506067 scopus 로고    scopus 로고
    • The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
    • Schwartzenberg-bar-Yoseph F, Armoni M, Karnieli E, 2004. The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res, 64:2627-2633
    • (2004) Cancer Res , vol.64 , pp. 2627-2633
    • Schwartzenberg-bar-Yoseph, F.1    Armoni, M.2    Karnieli, E.3
  • 43
    • 9144273328 scopus 로고    scopus 로고
    • Isolation of temperaturesensitive p53 mutations from a comprehensive missense mutation library
    • Shiraishi K, Kato S, Han SY, et al. 2004. Isolation of temperaturesensitive p53 mutations from a comprehensive missense mutation library. J Biol Chem, 279:348-355
    • (2004) J Biol Chem , vol.279 , pp. 348-355
    • Shiraishi, K.1    Kato, S.2    Han, S.Y.3
  • 44
    • 18344380088 scopus 로고    scopus 로고
    • P53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas
    • Singh B, Reddy PG, Goberdhan A, et al. 2002. p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. Genes Dev, 16:984-993
    • (2002) Genes Dev , vol.16 , pp. 984-993
    • Singh, B.1    Reddy, P.G.2    Goberdhan, A.3
  • 45
    • 77049281450 scopus 로고
    • Studies on the use of viruses in the treatment of carcinoma of the cervix
    • Smith RR, Huebner RJ, Rowe WP, et al. 1956. Studies on the use of viruses in the treatment of carcinoma of the cervix. Cancer, 9:1211-1218
    • (1956) Cancer , vol.9 , pp. 1211-1218
    • Smith, R.R.1    Huebner, R.J.2    Rowe, W.P.3
  • 46
    • 0034106051 scopus 로고    scopus 로고
    • Endogenous p53 gene status predicts the response of human squamous cell carcinomas to wild-type p53
    • St John LS, Sauter ER, Herlyn M, et al. 2000. Endogenous p53 gene status predicts the response of human squamous cell carcinomas to wild-type p53. Cancer Gene Ther, 7:749-756 (Pubitemid 30314059)
    • (2000) Cancer Gene Therapy , vol.7 , Issue.5 , pp. 749-756
    • St John, L.S.1    Sauter, E.R.2    Herlyn, M.3    Litwin, S.4    Adler-Storthz, K.5
  • 47
    • 15244360282 scopus 로고    scopus 로고
    • P53 down-regulates matrix metalloproteinase-1 by targeting the communications between AP-1 and the basal transcription complex
    • Sun Y, Zeng XR, Wenger L, et al. 2004. p53 down-regulates matrix metalloproteinase-1 by targeting the communications between AP-1 and the basal transcription complex. J Cell Biochem, 92:258-269
    • (2004) J Cell Biochem , vol.92 , pp. 258-269
    • Sun, Y.1    Zeng, X.R.2    Wenger, L.3
  • 50
    • 0042596102 scopus 로고    scopus 로고
    • Wild-type p53 gene transfer inhibits invasion and reduces matrix metalloproteinase-2 levels in p53-mutated human melanoma cells
    • DOI 10.1046/j.1523-1747.2000.00000.x
    • Toschi E, Rota R, Antonini A, et al. 2000. Wild-type p53 gene transfer inhibits invasion and reduces matrix metalloproteinase-2 levels in p53-mutated human melanoma cells. J Invest Dermatol, 114:1188-1194 (Pubitemid 30415238)
    • (2000) Journal of Investigative Dermatology , vol.114 , Issue.6 , pp. 1188-1194
    • Toschi, E.1    Rota, R.2    Antonini, A.3    Melillo, G.4    Capogrossi, M.C.5
  • 51
    • 33646415691 scopus 로고    scopus 로고
    • Administration of PUMA adenovirus increases the sensitivity of esophageal cancer cells to anticancer drugs
    • Wang H, Qian H, Yu J, et al. 2006. Administration of PUMA adenovirus increases the sensitivity of esophageal cancer cells to anticancer drugs. Cancer Biol Ther, 5:380-385
    • (2006) Cancer Biol Ther , vol.5 , pp. 380-385
    • Wang, H.1    Qian, H.2    Yu, J.3
  • 52
    • 29144499437 scopus 로고    scopus 로고
    • Current ideas about applications of heat shock proteins in vaccine design and immunotherapy
    • DOI 10.1080/02656730500226407
    • Wang XY, Li Y, Yang G, et al. 2005. Current ideas about applications of heat shock proteins in vaccine design and immunotherapy. Int J Hyperthermia, 21:717-722 (Pubitemid 41807098)
    • (2005) International Journal of Hyperthermia , vol.21 , Issue.8 , pp. 717-722
    • Wang, X.-Y.1    Li, Y.2    Yang, G.3    Subjeck, J.R.4
  • 53
    • 24944441005 scopus 로고    scopus 로고
    • Clinical trial for the treatment of advanced lung cancer by intratumoral injection of rAd p53
    • Weng Z, Qin TL, Tan SY, et al. 2004. Clinical trial for the treatment of advanced lung cancer by intratumoral injection of rAd p53. Shenzhen Zhong Xi Yi Jie He Za Zhi, 14:206-210
    • (2004) Shenzhen Zhong Xi Yi Jie He Za Zhi , vol.14 , pp. 206-210
    • Weng, Z.1    Qin, T.L.2    Tan, S.Y.3
  • 54
    • 0028087776 scopus 로고
    • Tumour biology: P53, guardian of Rb
    • White E. 1994. Tumour biology: p53, guardian of Rb. Nature, 371:21-22
    • (1994) Nature , vol.371 , pp. 21-22
    • White, E.1
  • 55
    • 28744437659 scopus 로고    scopus 로고
    • Phase III randomized clinical trial of intratumoral injection of E1B gene-deleted adenovirus (H101) combined with cisplatin-based chemotherapy in treating squamous cell cancer of head and neck or esophagus
    • Xia ZJ, Chang JH, Zhang L, et al. 2004. Phase III randomized clinical trial of intratumoral injection of E1B gene-deleted adenovirus (H101) combined with cisplatin-based chemotherapy in treating squamous cell cancer of head and neck or esophagus. Ai Zheng, 23:1666-1670
    • (2004) Ai Zheng , vol.23 , pp. 1666-1670
    • Xia, Z.J.1    Chang, J.H.2    Zhang, L.3
  • 56
    • 77953672215 scopus 로고    scopus 로고
    • Clinical observation of the effect of recombinant adenovirus- P53 plus radio-thermotherapy on soft tissue sarcoma
    • Xiao S, Liu C, Sun Y, et al. 2007. Clinical observation of the effect of recombinant adenovirus- p53 plus radio-thermotherapy on soft tissue sarcoma. Zhong Guo Zhong Liu Lin Chuang, 34:65-67
    • (2007) Zhong Guo Zhong Liu Lin Chuang , vol.34 , pp. 65-67
    • Xiao, S.1    Liu, C.2    Sun, Y.3
  • 58
    • 0026560315 scopus 로고
    • Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein
    • Yew PR, Berk AJ, 1992. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature, 357:82-85
    • (1992) Nature , vol.357 , pp. 82-85
    • Yew, P.R.1    Berk, A.J.2
  • 59
    • 0037417281 scopus 로고    scopus 로고
    • PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression
    • DOI 10.1038/nature01519
    • Yin Y, Liu YX, Jin YJ, et al. 2003. PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression. Nature, 422:527-531 (Pubitemid 36433648)
    • (2003) Nature , vol.422 , Issue.6931 , pp. 527-531
    • Yin, Y.1    Llu, Y.-X.2    Jin, Y.J.3    Hall, E.J.4    Barrett, J.C.5
  • 60
    • 0037627875 scopus 로고    scopus 로고
    • Why did p53 gene therapy fail in ovarian cancer?
    • DOI 10.1016/S1470-2045(03)01139-2
    • Zeimet AG, Marth C. 2003. Why did p53 gene therapy fail in ovarian cancer? Lancet Oncol, 4:415-422 (Pubitemid 36833683)
    • (2003) Lancet Oncology , vol.4 , Issue.7 , pp. 415-422
    • Zeimet, A.G.1    Marth, C.2
  • 62
    • 2342614946 scopus 로고    scopus 로고
    • Treatment of head and neck squamous cell carcinoma by recombinant adenovirus-p53 combined with radiotherapy: A phase II clinical trial of 42 cases
    • Zhang S, Xiao S, Liu C, et al. 2003. Treatment of head and neck squamous cell carcinoma by recombinant adenovirus-p53 combined with radiotherapy: a phase II clinical trial of 42 cases. Zhonghua Yi Xue Za Zhi, 23:2023-2028
    • (2003) Zhonghua Yi Xue Za Zhi , vol.23 , pp. 2023-2028
    • Zhang, S.1    Xiao, S.2    Liu, C.3
  • 63
    • 77953660684 scopus 로고    scopus 로고
    • Oncolytic adenovirus H101 in combination with vinorelbine/ cisplatin chemotherapy for advanced non-small cell lung cancer
    • Zhou C, Xu Y, Ni J, et al. 2006. Oncolytic adenovirus H101 in combination with vinorelbine/ cisplatin chemotherapy for advanced non-small cell lung cancer. Zhong Liu, 26:613-617
    • (2006) Zhong Liu , vol.26 , pp. 613-617
    • Zhou, C.1    Xu, Y.2    Ni, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.