메뉴 건너뛰기




Volumn 60, Issue 5, 2000, Pages 1193-1196

In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; COBALT 60; FLUOROURACIL; PROTEIN P53;

EID: 0034161976     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (186)

References (21)
  • 2
    • 0030917202 scopus 로고    scopus 로고
    • ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
    • Heise, C., Sampson-Johannes, A., Williams, A., McCormick, F., Von Hoff, D. D., and Kirn, D. H. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat. Med., 3: 639-645, 1997.
    • (1997) Nat. Med. , vol.3 , pp. 639-645
    • Heise, C.1    Sampson-Johannes, A.2    Williams, A.3    McCormick, F.4    Von Hoff, D.D.5    Kirn, D.H.6
  • 3
    • 0032503659 scopus 로고    scopus 로고
    • A novel three-pronged approach to kill cancer cells selectively: Concomitant viral, double suicide gene, and radiotherapy
    • Freytag, S. O., Rogulski, K. R., Paielli, D. L., Gilbert, J. D., and Kim, J. H. A novel three-pronged approach to kill cancer cells selectively: concomitant viral, double suicide gene, and radiotherapy. Hum. Gene Ther., 9: 1323-1333, 1998.
    • (1998) Hum. Gene Ther. , vol.9 , pp. 1323-1333
    • Freytag, S.O.1    Rogulski, K.R.2    Paielli, D.L.3    Gilbert, J.D.4    Kim, J.H.5
  • 4
    • 0026560315 scopus 로고
    • Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein
    • Lond.
    • Yew, P. R., and Burke, A. J. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature (Lond.), 357: 82-85, 1992.
    • (1992) Nature , vol.357 , pp. 82-85
    • Yew, P.R.1    Burke, A.J.2
  • 6
    • 0028875410 scopus 로고
    • Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy
    • Bergh, J., Norberg, T., Siogren, S., Lindgren, A., and Holmberg, L. Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy. Nat. Med., 1: 1029-1034, 1995.
    • (1995) Nat. Med. , vol.1 , pp. 1029-1034
    • Bergh, J.1    Norberg, T.2    Siogren, S.3    Lindgren, A.4    Holmberg, L.5
  • 7
    • 0031060333 scopus 로고    scopus 로고
    • The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle
    • Goodrum, F., and Ornelles, D. The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle. J. Virol., 71: 548-561, 1997.
    • (1997) J. Virol. , vol.71 , pp. 548-561
    • Goodrum, F.1    Ornelles, D.2
  • 8
    • 0031798440 scopus 로고    scopus 로고
    • p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection
    • Goodrum, F., and Ornelles, D. p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection. J. Virol., 72: 9479-9490, 1998.
    • (1998) J. Virol. , vol.72 , pp. 9479-9490
    • Goodrum, F.1    Ornelles, D.2
  • 9
    • 0031743945 scopus 로고    scopus 로고
    • Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells
    • Rothmann, T., Hengstermann, N., Whitaker, M., Sheffner, M., and Hausen, H. Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells. J. Virol., 72: 9470-9478, 1998.
    • (1998) J. Virol. , vol.72 , pp. 9470-9478
    • Rothmann, T.1    Hengstermann, N.2    Whitaker, M.3    Sheffner, M.4    Hausen, H.5
  • 10
    • 0031697770 scopus 로고    scopus 로고
    • p53-dependent cell death/apoptosis is required for a productive adenovirus infection
    • Hall, A. R., Dix, B. R., O'Carroll, S. J., and Braithwaite, A. W. p53-dependent cell death/apoptosis is required for a productive adenovirus infection. Nat. Med., 4: 1068-1072, 1998.
    • (1998) Nat. Med. , vol.4 , pp. 1068-1072
    • Hall, A.R.1    Dix, B.R.2    O'Carroll, S.J.3    Braithwaite, A.W.4
  • 11
    • 0033011866 scopus 로고    scopus 로고
    • The replicative capacities of large E1B-null group A and C adenoviruses are independent of host cell p53 status
    • Turnell, A., Grand, R., and Gallimore, P. The replicative capacities of large E1B-null group A and C adenoviruses are independent of host cell p53 status. J. Virol., 73: 2074-2083, 1999.
    • (1999) J. Virol. , vol.73 , pp. 2074-2083
    • Turnell, A.1    Grand, R.2    Gallimore, P.3
  • 12
    • 0033022039 scopus 로고    scopus 로고
    • p53-independent, and -dependent requirements for E1B-55K in adenovirus type 5 replication
    • Harada, J., and Berk, A. p53-independent, and -dependent requirements for E1B-55K in adenovirus type 5 replication. J. Virol., 73: 5333-5344, 1999.
    • (1999) J. Virol. , vol.73 , pp. 5333-5344
    • Harada, J.1    Berk, A.2
  • 14
    • 0030666029 scopus 로고    scopus 로고
    • Pronounced antitumor effects and tumor radiosensitization of double suicide gene therapy
    • Rogulski, K. R., Zhang, K., Kolozsvary, A., Kim, J. H., and Freytag, S. O. Pronounced antitumor effects and tumor radiosensitization of double suicide gene therapy. Clin. Cancer Res., 3: 2081-2088, 1997.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 2081-2088
    • Rogulski, K.R.1    Zhang, K.2    Kolozsvary, A.3    Kim, J.H.4    Freytag, S.O.5
  • 15
    • 0018182623 scopus 로고
    • An in situ method for estimating cell survival in a solid tumor
    • Alfieri, A. A., and Hahn, E. W. An in situ method for estimating cell survival in a solid tumor. Cancer Res., 38: 3006-3011, 1978.
    • (1978) Cancer Res. , vol.38 , pp. 3006-3011
    • Alfieri, A.A.1    Hahn, E.W.2
  • 16
    • 0003096712 scopus 로고
    • The physics and chemistry of radiation absorption
    • E. J. Hall (ed.), Philadelphia: Lipponcott Co.
    • Hall, E. J. The physics and chemistry of radiation absorption. In: E. J. Hall (ed.), Radiobiology for the Radiobiologist, pp. 17-38. Philadelphia: Lipponcott Co., 1994.
    • (1994) Radiobiology for the Radiobiologist , pp. 17-38
    • Hall, E.J.1
  • 18
    • 0002138012 scopus 로고    scopus 로고
    • A phase 1 clinical trial with ONYX-015 (a selectively replicating adenovirus) administered by intratumoral injection in patients with recurrent head and neck cancer
    • Kirn, D., Ganley, I., Nemunaitis, J., Otto, R., Soutar, D., Kuhn, J., Heise, C., Propst, M., Maack, C., Eckhardt, G., Kaye, S., and Von Hoff, D. A. A Phase 1 clinical trial with ONYX-015 (a selectively replicating adenovirus) administered by intratumoral injection in patients with recurrent head and neck cancer. Cancer Gene Ther., 49 (Suppl.): S13, 1997.
    • (1997) Cancer Gene Ther. , vol.49 , Issue.SUPPL.
    • Kirn, D.1    Ganley, I.2    Nemunaitis, J.3    Otto, R.4    Soutar, D.5    Kuhn, J.6    Heise, C.7    Propst, M.8    Maack, C.9    Eckhardt, G.10    Kaye, S.11    Von Hoff, D.A.12
  • 19
    • 0003324586 scopus 로고    scopus 로고
    • Intratumoral injection of ONYX-015 for gastrointestinal tumors metastatic to the liver: A phase 1 trial
    • Bergsland, E., Mani, S., Kirn, D., Fell, S., Heise, C., Maack, C., and Venook, A. Intratumoral injection of ONYX-015 for gastrointestinal tumors metastatic to the liver: a Phase 1 trial. Proc. Am. Soc. Clin. Oncol., 117: 211A, 1998.
    • (1998) Proc. Am. Soc. Clin. Oncol. , vol.117
    • Bergsland, E.1    Mani, S.2    Kirn, D.3    Fell, S.4    Heise, C.5    Maack, C.6    Venook, A.7
  • 20
    • 0031024794 scopus 로고    scopus 로고
    • Glioma cells transduced with an E. coli CD/HSV-I TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity
    • Rogulski, K., Kim, J. H., Kim, S. H., and Freytag, S. Glioma cells transduced with an E. coli CD/HSV-I TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity. Hum. Gene Ther., 8: 73-85, 1997.
    • (1997) Hum. Gene Ther. , vol.8 , pp. 73-85
    • Rogulski, K.1    Kim, J.H.2    Kim, S.H.3    Freytag, S.4
  • 21
    • 0033984339 scopus 로고    scopus 로고
    • Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radiosensitization
    • Rogulski, K. R., Wing, M., Paielli, D. L., Gilbert, J. D., Kim, J. H., and Freytag, S. O. Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radiosensitization. Hum. Gene Ther., 11: 67-76, 2000.
    • (2000) Hum. Gene Ther. , vol.11 , pp. 67-76
    • Rogulski, K.R.1    Wing, M.2    Paielli, D.L.3    Gilbert, J.D.4    Kim, J.H.5    Freytag, S.O.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.