Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 25, Issue 3, 2010, Pages 331-339

  Bag, Seema ^a   Tawari, Nilesh R ^a   Queener, Sherry F ^b   Degani, Mariam S ^a  

^a INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Biguanide; Dihydrofolate reductase; Dihydrotriazine

Indexed keywords

1 [4 (BIPHENYL 4 YLMETHOXY)PHENYL] 6,6 DIMETHYL 1,6 DIHYDRO 1,3,5 TRIAZINE 2,4 DIAMINE; ANTIFUNGAL AGENT; ANTIMYCOBACTERIAL AGENT; ANTIPROTOZOAL AGENT; BACTERIAL ENZYME; BIGUANIDE DERIVATIVE; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; FUNGAL ENZYME; LIVER ENZYME; PIRITREXIM; TRIAZINE DERIVATIVE; TRIMETHOPRIM; TRIMETREXATE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; MYCOBACTERIUM AVIUM; NONHUMAN; PNEUMOCYSTIS CARINII; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; TOXOPLASMA GONDII;

ANIMALS; BIGUANIDES; COMPUTER SIMULATION; DRUG DESIGN; FOLIC ACID ANTAGONISTS; LIVER; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM AVIUM; OPPORTUNISTIC INFECTIONS; PNEUMOCYSTIS CARINII; PROTEIN BINDING; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TOXOPLASMA; TRIAZINES; TRIMETHOPRIM; TRIMETREXATE;

MYCOBACTERIUM AVIUM; PNEUMOCYSTIS CARINII; RATTUS; TOXOPLASMA GONDII;

EID: 77951464259     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756360903179443     Document Type: Article

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