Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3-d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 24, 2006, Pages 8341-8351

  Gangjee, Aleem ^a   Yang, Jie ^a   Queener, Sherry F ^b  

^a DUQUESNE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 5 (2 METHYL 2 PHENYL)ETHYLPYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 [2 METHYL 2 (2 FLUORENYL)]ETHYLPYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 [2 METHYL 2 (2 NAPHTHYL)]ETHYLPYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 [2 METHYL 2 (2,5 DIMETHOXYPHENYL)]ETHYLPYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 [2 METHYL 2 (3,4,5 TRIMETHOXYPHENYL)]ETHYLPYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 [2 METHYL 2 (4 BIPHENYL)]ETHYLPYRROLO[2,3 D]PYRIMIDINE; 2,4,6 TRIAMINOPYRIMIDINE; ACETONE; ALKENE DERIVATIVE; DIHYDROFOLATE REDUCTASE INHIBITOR; KETONE DERIVATIVE; METHYL GROUP; PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG SELECTIVITY; DRUG SYNTHESIS; MICHAEL ADDITION; MYCOBACTERIUM AVIUM; NONHUMAN; PNEUMOCYSTIS CARINII; RAT; TOXOPLASMA GONDII;

ANIMALS; ENZYME INHIBITORS; FEMALE; INHIBITORY CONCENTRATION 50; LIVER; MOLECULAR STRUCTURE; MYCOBACTERIUM AVIUM; PNEUMOCYSTIS CARINII; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TOXOPLASMA;

MYCOBACTERIUM AVIUM; PNEUMOCYSTIS CARINII; TOXOPLASMA GONDII;

EID: 33750493900     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.09.008     Document Type: Article

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