Folate-Synthesizing Enzyme System as Target for Development of Inhibitors and Inhibitor Combinations against Candida albicans - Synthesis and Biological Activity of New 2,4-Diaminopyrimidines and 4′-Substituted 4-Aminodiphenyl Sulfones

Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2004, Pages 240-253

  Otzen, Thomas ^b   Wempe, Ellen G ^a   Kunz, Brigitte ^a   Bartels, Rainer ^a   Lehwark Yvetot, Gudrun ^a   Hänsel, Wolfram ^b   Schaper, Klaus Jürgen ^a   Seydel, Joachim K ^a,c  

^a RESEARCH CENTER BORSTEL   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 5 (2,6 DICHLOROBENZYLOXY)PYRIMIDINE; 2,4 DIAMINO 5 (3,4 DICHLOROBENZYLOXY)PYRIMIDINE; 2,4 DIAMINO 5 (4 METHOXYBENZYLOXY)PYRIMIDINE; 2,4 DIAMINO 5 [3 METHOXY 4 (3 PHENYLPROPOXY)BENZYLOXY]PYRIMIDINE; 2,4 DIAMINOPYRIMIDINE DERIVATIVE; 5 (2 CHLOROBENZYLOXY) 2,4 DIAMINOPYRIMIDINE; 5 (4 BENZYLOXYBENZYLOXY) 2,4 DIAMINOPYRIMIDINE; 5 (4 BROMO 1 NAPHTHYLMETHYLOXY) 2,4 DIAMINOPYRIMIDINE; 5 (4 TERT BUTYLBENZYLOXY) 2,4 DIAMINOPYRIMIDINE; 5 BENZYLOXY 2,4 DIAMINOPYRIMIDINE; CYCLOSPORIN A; DAPSONE; DIAMINO 5 (1 NAPHTHYLMETHYLOXY)PYRIMIDINE; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROIC ACID SYNTHASE; FLUCONAZOLE; FOLIC ACID; HH 133; HH 135; HH 136; HH 154; K 130; K 220; KC 1308; OXIDOREDUCTASE; RO 12 6099; RO 17 3279; SULFONE DERIVATIVE; SYNTHETASE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CELL TRANSPORT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; DRUG UPTAKE; ENZYME INHIBITION; ESCHERICHIA COLI; FUNGAL STRAIN; FUNGUS CULTURE; FUNGUS MUTANT; GENE DELETION; GENE OVEREXPRESSION; IC 50; KNOCKOUT GENE; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM; NONHUMAN; PLASMODIUM BERGHEI; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT;

AMINOPYRIDINES; ANIMALS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; DIHYDROPTEROATE SYNTHASE; DRUG COMBINATIONS; DRUG RESISTANCE, MULTIPLE, FUNGAL; FOLIC ACID ANTAGONISTS; MICROBIAL SENSITIVITY TESTS; MUTATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; SULFONES; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0346731227     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030931w     Document Type: Article

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