DNA diagnostics: Nanotechnology-enhanced electrochemical detection of nucleic acids

Pediatric Research

Volumn 67, Issue 5, 2010, Pages 458-468

  Wei, Fang ^a   Lillehoj, Peter B ^a   Ho, Chih Ming ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; NUCLEIC ACID;

DNA DETERMINATION; ELECTROCHEMICAL DETECTION; HUMAN; MOLECULAR RECOGNITION; NANOFABRICATION; NANOSENSOR; POINT OF CARE TESTING; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

BIOSENSING TECHNIQUES; DNA; DNA MUTATIONAL ANALYSIS; ELECTROCHEMICAL TECHNIQUES; EQUIPMENT DESIGN; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; HUMANS; NANOMEDICINE; NANOTECHNOLOGY; POINT-OF-CARE SYSTEMS; PREDICTIVE VALUE OF TESTS; SENSITIVITY AND SPECIFICITY;

EID: 77951449533     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e3181d361c3     Document Type: Review

References (127)

1. Yang S, Rothman RE 2004 PCR-based diagnostics for infectious diseases: uses, limitations, and future applications in acute-care settings. Lancet Infect Dis 4:337-348 (Pubitemid 38692698)
2. Beaudet AL, Belmont JW 2008 Array-based DNA diagnostics: let the revolution begin. Annu Rev Med 59:113-129
3. Roberts DG, Morrison TB, Liu-Cordero SN, Cho J, Garcia J, Kanigan TS, Munnelly K, Brenan CJ 2009 A nanoliter fluidic platform for large-scale single nucleotide polymorphism genotyping. Biotechniques 46:IX-XIII
4. Tost J, Gut IG 2005 Genotyping single nucleotide polymorphisms by MALDI mass spectrometry in clinical applications. Clin Biochem 38:335-350 (Pubitemid 40342864)
5. Murphy KM, Berg KD 2003 Mutation and single nucleotide polymorphism detection using temperature gradient capillary electrophoresis. Expert Rev Mol Diagn 3:811-818
6. Zhang J, Wan Y, Wang LH, Song SP, Fan CH 2007 The electrochemical DNA biosensor. Progr Chem 19:1576-1584
7. Cagnin S, Caraballo M, Guiducci C, Martini P, Ross M, SantaAna M, Danley D, West T, Lanfranchi G 2009 Overview of electrochemical DNA biosensors: new approaches to detect the expression of life. Sensors 9:3122-3148
8. Ahmed MU, Hossain MM, Tamiya E 2008 Electrochemical biosensors for medical and food applications. Electroanalysis 20:616-626
9. Ricci F, Bonham AJ, Mason AC, Reich NO, Plaxco KW 2009 Reagentless, electrochemical approach for the specific detection of double-and single-stranded DNA binding proteins. Anal Chem 81:1608-1614
10. Wei F, Patel P, Liao W, Chaudhry K, Zhang L, Arellano-Garcia M, Hu S, Elashoff D, Zhou H, Shukla S, Shah F, Ho CM, Wong DT 2009 Electrochemical sensor for multiplex biomarkers detection. Clin Cancer Res 15:4446-4452
11. Wei F, Wang JH, Liao W, Zimmermann BG, Wong DT, Ho CM 2008 Electrochemical detection of low-copy number salivary RNA based on specific signal amplification with a hairpin probe. Nucleic Acids Res 36:e65 (Pubitemid 351917548)
12. Gau V, Wong D 2007 Oral fluid nanosensor test (OFNASET) with advanced electrochemical-based molecular analysis platform. Ann NY Acad Sci 1098:401-410 (Pubitemid 47092526)
13. Liepold P, Wieder H, Hillebrandt H, Friebel A, Hartwich G 2005 DNA-arrays with electrical detection: a label-free low cost technology for routine use in life sciences and diagnostics. Bioelectrochemistry 67:143-150 (Pubitemid 41191209)
14. Lucarelli F, Capponcelli S, Marrazza G, Sangiorgi L, Mascini M 2009 Split hybridisation probes for electrochemical typing of single-nucleotide polymorphisms. Analyst 134:52-59
15. Pohlmann C, Wang YR, Humenik M, Heidenreich B, Gareis M, Sprinzl M 2009 Rapid, specific and sensitive electrochemical detection of foodborne bacteria. Biosens Bioelectron 24:2766-2771
16. Wakai J, Takagi A, Nakayama M, Miya T, Miyahara T, Iwanaga T, Takenaka S, Ikeda Y, Amano M 2004 A novel method of identifying genetic mutations using an electrochemical DNA array. Nucleic Acids Res 32:e141
17. Zhang J, Song SP, Zhang LY, Wang LH, Wu HP, Pan D, Fan C 2006 Sequence-specific detection of femtomolar DNA via a chronocoulometric DNA sensor (CDS): effects of nanoparticle-mediated amplification and nanoscale control of DNA assembly at electrodes. J Am Chem Soc 128:8575-8580
18. Lord H, Kelley SO 2009 Nanomaterials for ultrasensitive electrochemical nucleic acids biosensing. J Mater Chem 19:3127-3134
19. Radwan SH, Azzazy HM 2009 Gold nanoparticles for molecular diagnostics. Expert Rev Mol Diagn 9:511-524
20. Wei F, Liao W, Xu Z, Yang Y, Wong DT, Ho CM 2009 Bio/abiotic interface constructed from nanoscale DNA dendrimer and conducting polymer for ultrasensitive biomolecular diagnosis. Small 5:1784-1790
21. Pandey P, Datta M, Malhotra BD 2008 Prospects of nanomaterials in biosensors. Anal Lett 41:159-209 (Pubitemid 351238309)
22. Kerman K, Morita Y, Takamura Y, Ozsoz M, Tamiya E 2004 Modification of Escherichia coli single-stranded DNA binding protein with gold nanoparticles for electrochemical detection of DNA hybridization. Anal Chim Acta 510:169-174 (Pubitemid 38510126)
23. Liao WC, Ho JA 2009 Attomole DNA electrochemical sensor for the detection of Escherichia coli O157. Anal Chem 81:2470-2476
24. Ozsoz M, Erdem A, Kerman K, Ozkan D, Tugrul B, Topcuoglu N, Ekren H, Taylan M 2003 Electrochemical genosensor based on colloidal gold nanoparticles for the detection of Factor V Leiden mutation using disposable pencil graphite electrodes. Anal Chem 75:2181-2187
25. Castaneda MT, Merkoci A, Pumera M, Alegret S 2007 Electrochemical genosen-sors for biomedical applications based on gold nanoparticles. Biosens Bioelectron 22:1961-1967
26. Mao X, Liu GD 2008 Nanomaterial based electrochemical DNA biosensors and bioassays. J Biomed Nanotechnol 4:419-431
27. Wang F, Hu SS 2009 Electrochemical sensors based on metal and semiconductor nanoparticles. Mikrochim Acta 165:1-22
28. Xu K, Huang JR, Ye ZZ, Ying YB, Li YB 2009 Recent development of nano-materials used in DNA biosensors. Sensors 9:5534-5557
29. Ferguson BS, Buchsbaum SF, Swensen JS, Hsieh K, Lou XH, Soh HT 2009 Integrated microfluidic electrochemical DNA sensor. Anal Chem 81:6503-6508
30. Pedrero M, Campuzano S, Pingarron JM 2009 Electroanalytical sensors and devices for multiplexed detection of foodborne pathogen microorganisms. Sensors 9:5503-5520
31. Kallioniemi OP 2001 Biochip technologies in cancer research. Ann Med 33:142-147
32. Pavlovic E, Lai RY, Wu TT, Ferguson BS, Sun R, Plaxco KW, Soh HT 2008 Microfluidic device architecture for electrochemical patterning and detection of multiple DNA sequences. Langmuir 24:1102-1107
33. Pohanka M, Skladai P 2008 Electrochemical biosensors\principles and applications. J Appl Biomed 6:57-64
34. Bard AJ, Faulkner LR 1980 Electrochemical Methods: Fundamentals and Applications. John Wiley & Sons, New York, pp 1-44, 137-156
35. Wei F, Sun B, Guo Y, Zhao XS 2003 Monitoring DNA hybridization on alkyl modified silicon surface through capacitance measurement. Biosens Bioelectron 18:1157-1163
36. Sadik OA, Aluoch AO, Zhou AL 2009 Status of biomolecular recognition using electrochemical techniques. Biosens Bioelectron 24:2749-2765
37. Wang J 1999 Towards genoelectronics: electrochemical biosensing of DNA hybridization. Chem Eur J 5:1681-1685
38. Jin Y 2009 Label-free monitoring of site-specific DNA cleavage by EcoRI endo-nuclease using cyclic voltammetry and electrochemical impedance. Anal Chim Acta 634:44-48
39. Tang H, Yang X, Wang K, Tan W, Li H, He L, Liu B 2008 RNA-templated single-base mutation detection based on T4 DNA ligase and reverse molecular beacon. Talanta 75:1388-1393
40. Heaton RJ, Peterson AW, Georgiadis RM 2001 Electrostatic surface plasmon resonance: direct electric field-induced hybridization and denaturation in mono-layer nucleic acid films and label-free discrimination of base mismatches. Proc Natl Acad Sci USA 98:3701-3704
41. Wei F, Chen CL, Zhai L, Zhang N, Zhao XS 2005 Recognition of single nucleotide polymorphisms using scanning potential hairpin denaturation. J Am Chem Soc 127:5306-5307
42. Neugebauer S, Zimdars A, Liepold P, Gebala M, Schuhmann W, Hartwich G 2009 Optimization of an electrochemical DNA assay by using a 48-electrode array and redox amplification studies by means of scanning electrochemical microscopy. Chembiochem 10:1193-1199
43. Kuramitz H 2009 Magnetic microbead-based electrochemical immunoassays. Anal Bioanal Chem 394:61-69
44. Loaiza OA, Campuzano S, Pedrero M, Pividori MI, Garcia P, Pingarron JM 2008 Disposable magnetic DNA sensors for the determination at the attomolar level of a specific enterobacteriaceae family gene. Anal Chem 80:8239-8245
45. Fan CH, Plaxco KW, Heeger AJ 2003 Electrochemical interrogation of conforma-tional changes as a reagentless method for the sequence-specific detection of DNA. Proc Natl Acad Sci USA 100:9134-9137
46. Lai RY, Plaxco KW, Heeger AJ 2007 Aptamer-based electrochemical detection of picomolar platelet-derived growth factor directly in blood serum. Anal Chem 79:229-233
47. Chua JH, Chee RE, Agarwal A, Wong SM, Zhang GJ 2009 Label-free electrical detection of cardiac biomarker with complementary metal-oxide semiconductor-compatible silicon nanowire sensor arrays. Anal Chem 81:6266-6271
48. Maehashi K, Matsumoto K 2009 Label-free electrical detection using carbon nanotube-based biosensors. Sensors 9:5368-5378
49. Daniels JS, Pourmand N 2007 Label-free impedance biosensors: opportunities and challenges. Electroanalysis 19:1239-1257
50. Pohlmann C, Humenik M, Sprinzl M 2009 Detection of bacterial 16S rRNA using multivalent dendrimer-reporter enzyme conjugates. Biosens Bioelectron 24:3383-3386
51. Millan KM, Mikkelsen SR 1993 Sequence-selective biosensor for DNA-based on electroactive hybridization indicators. Anal Chem 65:2317-2323
52. Wang J, Rivas G, Cai X, Palecek E, Nielsen P, Shiraishi H, Dontha N, Luo D, Parrado C, Chicharro M, Farias PA, Valera FS, Grant DH, Ozsoz M, Flair MN 1997 DNA electrochemical biosensors for environmental monitoring. A review. Anal Chim Acta 347:1-8
53. Erdem A, Kerman K, Meric B, Akarca US, Ozsoz M 1999 DNA electrochemical biosensor for the detection of short DNA sequences related to the hepatitis B virus. Electroanalysis 11:586-588
54. Mascini M, Palchetti I, Marrazza G 2001 DNA electrochemical biosensors. Frese-nius J Anal Chem 369:15-22
55. Belluzo MS, Ribone ME, Lagier CM 2008 Assembling amperometric biosensors for clinical diagnostics. Sensors 8:1366-1399
56. Hajdukiewicz J, Boland S, Kavanagh P, Nowicka A, Stojek Z, Leech D 2009 Enzyme-amplified amperometric detection of DNA using redox mediating films on gold microelectrodes. Electroanalysis 21:342-350
57. Wang K, Chen JH, Chen J, Liu AL, Li GW, Luo HB, Lin XH, Chen YZ 2009 A sandwich-type electrochemical biosensor for detection of BCR/ABL fusion gene using locked nucleic acids on gold electrode. Electroanalysis 21:1159-1166
58. Zuo X, Xiao Y, Plaxco K 2009 High specificity, electrochemical sandwich assays based on single aptamer sequences and suitable for the direct detection of small-molecule targets in blood and other complex matrices. J Am Chem Soc 131:6944-6945
59. Zhou N, Yang T, Jiang C, Du M, Jiao K 2009 Highly sensitive electrochemical impedance spectroscopic detection of DNA hybridization based on Au-nano-CNT/PAN(nano) films. Talanta 77:1021-1026
60. Liao W, Randall BA, Alba NA, Cui XT 2008 Conducting polymer-based impedi-metric aptamer biosensor for in situ detection. Anal Bioanal Chem 392:861-864
61. Liao W, Cui XT 2007 Reagentless aptamer based impedance biosensor for monitoring a neuro-inflammatory cytokine PDGF. Biosens Bioelectron 23:218-224
62. Vamvakaki V, Chaniotakis NA 2008 DNA stabilization and hybridization detection on porous silicon surface by EIS and total reflection FT-IR spectroscopy. Electro-analysis 20:1845-1850
63. Suni II 2008 Impedance methods for electrochemical sensors using nanomaterials. Trends Anal Chem 27:604-611
64. Feng Y, Yang T, Zhang W, Jiang C, Jiao K 2008 Enhanced sensitivity for deoxyribonucleic acid electrochemical impedance sensor: gold nanoparticle/polyaniline nanotube membranes. Anal Chim Acta 616:144-151
65. K'Owino IO, Sadik OA 2005 Impedance spectroscopy: a powerful tool for rapid biomolecular screening and cell culture monitoring. Electroanalysis 17:2101-2113
66. Li J, Koehne JE, Cassell AM, Chen H, Ng HT, Ye Q, Fan W, Han J, Meyyappan M 2005 Inlaid multi-walled carbon nanotube nanoelectrode arrays for electroanaly-sis. Electroanalysis 17:15-27
67. Tiwari A, Gong SQ 2009 Electrochemical detection of a breast cancer susceptible gene using cDNA immobilized chitosan-co-polyaniline electrode. Talanta 77:1217-1222
68. Deng CY, Chen JH, Nie Z, Wang MD, Chu XC, Chen XL, Xiao XL, Lei CY, Yao SZ 2009 Impedimetric aptasensor with femtomolar sensitivity based on the enlargement of surface-charged gold nanoparticles. Anal Chem 81:739-745
69. Li G, Li X, Wan J, Zhang S 2009 Dendrimers-based DNA biosensors for highly sensitive electrochemical detection of DNA hybridization using reporter probe DNA modified with Au nanoparticles. Biosens Bioelectron 24:3281-3287
70. Pan C, Guo M, Nie Z, Xiao X, Yao S 2009 Aptamer-based electrochemical sensor for label-free recognition and detection of cancer cells. Electroanalysis 21:1321-1326
71. Zhang Z, Yang W, Wang J, Yang C, Yang F, Yang X 2009 A sensitive impedi-metric thrombin aptasensor based on polyamidoamine dendrimer. Talanta 78:1240-1245
72. Dong H, Cao XD, Li CM, Hu WH 2008 An in situ electrochemical surface plasmon resonance immunosensor with polypyrrole propylic acid film: comparison between SPR and electrochemical responses from polymer formation to protein immuno-sensing. Biosens Bioelectron 23:1055-1062
73. Lucarelli F, Tombelli S, Minunni M, Marrazza G, Mascini M 2008 Electrochemical and piezoelectric DNA biosensors for hybridisation detection. Anal Chim Acta 609:139-159
74. Stelzle M, Durr M, Cieplik M, Nisch W 2001 On-chip electrophoretic accumulation of DNA oligomers and streptavidin. Fresenius J Anal Chem 371:112-119
75. Hestekin CN, Jakupciak JP, Chiesl TN, Kan CW, O'Connell CD, Barron AE 2006 An optimized microchip electrophoresis system for mutation detection by tandem SSCP and heteroduplex analysis for p53 gene exons 5-9. Electrophoresis 27:3823-3835
76. Griess GA, Hardies SC, Serwer P 2005 Matrix conditioning for lengthened capillary DNA sequencing. Electrophoresis 26:102-111
77. Nagarajan R, Liu W, Kumar J, Tripathy SK, Bruno FF, Samuelson LA 2001 Manipulating DNA conformation using intertwined conducting polymer chains. Macromolecules 34:3921-3927
78. Han FT, Huynh BH, Ma YF, Lin BC 1999 High efficiency DNA separation by capillary electrophoresis in a polymer solution with ultralow viscosity. Anal Chem 71:2385-2389
79. Lubin AA, Hunt BV, White RJ, Plaxco KW 2009 Effects of probe length, probe geometry, and redox-tag placement on the performance of the electrochemical E-DNA sensor. Anal Chem 81:2150-2158
80. Liu C, De Palma R, Reekmans G, Laureyn W, Stakenborg T, Lagae L 2009 Discrimination of specific and non-specific bindings by dielectrophoretic repulsion in on-chip magnetic bio-assays. Biosens Bioelectron 24:2294-2297
81. Wang TH, Peng YH, Zhang CY, Wong PK, Ho CM 2005 Single-molecule tracing on a fluidic microchip for quantitative detection of low-abundance nucleic acids. J Am Chem Soc 127:5354-5359
82. Kelley SO, Barton JK, Jackson NM, McPherson LD, Potter AB, Spain EM, Allen MJ, Hill MG 1998 Orienting DNA helices on gold using applied electric fields. Langmuir 14:6781-6784
83. Sin ML, Gau V, Liao JC, Haake DA, Wong PK 2009 Active manipulation of quantum dots using AC electrokinetics. J Phys Chem C 113:6561-6565
84. Wei F, Qu P, Zhai L, Chen CL, Wang HF, Zhao XS 2006 Electric potential induced dissociation of hybridized DNA with hairpin motif immobilized on silicon surface. Langmuir 22:6280-6285
85. Suzuki H 2000 Advances in the microfabrication of electrochemical sensors and systems. Electroanalysis 12:703-715
86. Zhang S, Wright G, Yang Y 2000 Materials and techniques for electrochemical biosensor design and construction. Biosens Bioelectron 15:273-282
87. Becker H, Gartner C 2008 Polymer microfabrication technologies for microfluidic systems. Anal Bioanal Chem 390:89-111
88. Gao Z, Agarwal A, Trigg AD, Singh N, Fang C, Tung CH, Fan Y, Buddharaju KD, Kong J 2007 Silicon nanowire arrays for label-free detection of DNA. Anal Chem 79:3291-3297
89. Hahm J, Lieber CM 2004 Direct ultrasensitive electrical detection of DNA and DNA sequence variations using nanowire nanosensors. Nano Lett 4:51-54
90. Li Z, Chen Y, Li X, Kamins TI, Nauka K, Williams RS 2004 Sequence-specific label-free DNA sensors based on silicon nanowires. Nano Lett 4:245-247 (Pubitemid 38292895)
91. Lee H, Park J, Kim J, Jung H, Kawai T 2006 Well-oriented nanowell array metrics for integrated digital nanobiosensors. Appl Phys Lett 89:113901
92. Yang M, Yau H, Chan H 1998 Adsorption kinetics and ligand-binding properties of thiol-modified double-stranded DNA on a gold surface. Langmuir 14:6121-6129
93. Yang W, Gerasimov JY, Lai RY 2009 Folding-based electrochemical DNA sensor fabricated on a gold-plated screen-printed carbon electrode. Chem Commun (Camb) 2902-2904
94. Wu JT, Yin H, Zhou JZ, Jin L, Lin ZH 1997 Electrochemical behaviors of DNA at mercury film electrode. Bioelectrochem Bioenerg 44:151-154
95. Wang X, Ozkan CS 2008 Multisegment nanowire sensors for the detection of DNA molecules. Nano Lett 8:398-404
96. Lapierre-Devlin MA, Asher CL, Taft BJ, Gasparac R, Roberts MA, Kelley SO 2005 Amplified electrocatalysis at DNA-modified nanowires. Nano Lett 5:1051-1055
97. Chang H, Yuan Y, Shi N, Guan Y 2007 Electrochemical DNA biosensor based on conducting polyaniline nanotube array. Anal Chem 79:5111-5115
98. Baughman RH, Zakhidov AA, de Heer WA 2002 Carbon nanotubes\the route toward applications. Science 297:787-792
99. Iijima S, Ichihashi T 1993 Single-shell carbon nanotubes of 1-nm diameter. Nature 363:603-605
100. He P, Dai L 2004 Aligned carbon nanotube-DNA electrochemical sensors. Chem Commun (Camb) 348-349
101. Wang SG, Wang RL, Sellin PJ, Zhang Q 2004 DNA biosensors based on self-assembled carbon nanotubes. Biochem Biophys Res Commun 325:1433-1437
102. Heller I, Kong J, Heering HA, Williams KA, Lemay SG, Dekker C 2005 Individual single-walled carbon nanotubes as nanoelectrodes for electrochemistry. Nano Lett 5:137-142 (Pubitemid 40168916)
103. Koehne J, Chen H, Li J, Cassell AM, Ye Q, Ng HT, Han J, Meyyappan M 2003 Ultrasensitive label-free DNA analysis using an electronic chip based on carbon nanotube nanoelectrode arrays. Nanotechnology 14:1239-1245
104. Li J, Ng HT, Cassell A, Fan W, Chen H, Ye Q, Koehne J, Han J, Meyyappan M 2003 Carbon nanotube nanoelectrode array for ultrasensitive DNA detection. Nano Lett 3:597-602
105. Azek F, Grossiord C, Joannes M, Limoges B, Brossier P 2000 Hybridization assay at a disposable electrochemical biosensor for the attomole detection of amplified human cytomegalovirus DNA. Anal Biochem 284:107-113
106. Wang J, Rivas G, Ozsos M, Grant DH, Cai XH, Parrado C 1997 Microfabricated electrochemical sensor for the detection of radiation-induced DNA damage. Anal Chem 69:1457-1460
107. Wang J, Cai XH, Rivas G, Shiraishi H, Farias PA, Dontha N 1996 DNA electrochemical biosensor for the detection of short DNA sequences related to the human immunodeficiency virus. Anal Chem 68:2629-2634
108. Ye Y, Ju H 2005 Rapid detection of ssDNA and RNA using multi-walled carbon nanotubes modified screen-printed carbon electrode. Biosens Bioelectron 21:735-741
109. Cai H, Cao XN, Jiang Y, He PG, Fang YZ 2003 Carbon nanotube-enhanced electrochemical DNA biosensor for DNA hybridization detection. Anal Bioanal Chem 375:287-293
110. Yang Y, Wang Z, Yang M, Li J, Zheng F, Shen G, Yu R 2007 Electrical detection of deoxyribonucleic acid hybridization based on carbon-nanotubes/nano zirconium dioxide/chitosan-modified electrodes. Anal Chim Acta 584:268-274
111. Zhu NN, Chang Z, He PG, Fang YZ 2005 Electrochemical DNA biosensors based on platinum nanoparticles combined carbon nanotubes. Anal Chim Acta 545:21-26
112. Jiang C, Yang T, Jiao K, Gao H 2008 A DNA electrochemical sensor with poly-L-lysine/single-walled carbon nanotubes films and its application for the highly sensitive EIS detection of PAT gene fragment and PCR amplification of NOS gene. Electrochim Acta 53:2917-2924
113. Ramanavicius A, Ramanaviciene A, Malinauskas A 2006 Electrochemical sensors based on conducting polymer\polypyrrole. Electrochim Acta 51:6025-6037
114. Shen Q, Wang X, Fu D 2008 The amplification effect of functionalized gold nanoparticles on the binding of anticancer drug dacarbazine to DNA and DNA bases. Appl Surf Sci 255:577-580
115. Pinijsuwan S, Rijiravanich P, Somasundrum M, Surareungchai W 2008 Sub-femtomolar electrochemical detection of DNA hybridization based on latex/gold nanoparticle-assisted signal amplification. Anal Chem 80:6779-6784
116. Rijiravanich P, Somasundrum M, Surareungchai W 2008 Femtomolar electrochemical detection of DNA hybridization using hollow polyelectrolyte shells bearing silver nanoparticles. Anal Chem 80:3904-3909
117. Malinowski DP 2007 Multiple biomarkers in molecular oncology. II. Molecular diagnostics applications in breast cancer management. Expert Rev Mol Diagn 7:269-280
118. Malinowski DP 2007 Multiple biomarkers in molecular oncology. I. Molecular diagnostics applications in cervical cancer detection. Expert Rev Mol Diagn 7:117-131
119. Liao JC, Mastali M, Li Y, Gau V, Suchard MA, Babbitt J, Gornbein J, Landaw EM, McCabe ER, Churchill BM, Haake DA 2007 Development of an advanced electrochemical DNA biosensor for bacterial pathogen detection. J Mol Diagn 9:158-168
120. Soper SA, Brown K, Ellington A, Frazier B, Garcia-Manero G, Gau V, Gutman SI, Hayes DF, Korte B, Landers JL, Larson D, Ligler F, Majumdar A, Mascini M, Nolte D, Rosenzweig Z, Wang J, Wilson D 2006 Point-of-care biosensor systems for cancer diagnostics/prognostics. Biosens Bioelectron 21:1932-1942
121. Nel A, Xia T, Madler L, Li N 2006 Toxic potential of materials at the nanolevel. Science 311:622-627
122. Singh N, Manshian B, Jenkins GJ, Griffiths SM, Williams PM, Maffeis TG, Wright CJ, Doak SH 2009 NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. Biomaterials 30:3891-3914
123. Variola F, Vetrone F, Richert L, Jedrzejowski P, Yi JH, Zalzal S, Clair S, Sarkissian A, Perepichka DF, Wuest JD, Rosei F, Nanci A 2009 Improving biocompatibitity of implantable metals by nanoscale modification of surfaces: an overview of strategies, fabrication methods, and challenges. Small 5:996-1006
124. Zhou Y 2008 Lipid nanotubes: formation, templating nanostructures and drug nanocarriers. Crit Rev Solid State Mater Sci 33:183-196
125. Bianco A, Kostarelos K, Prato M 2008 Opportunities and challenges of carbon-based nanomaterials for cancer therapy. Expert Opin Drug Deliv 5:331-342
126. Rodriguez-Cabello JC, Prieto S, Reguera J, Arias FJ, Ribeiro A 2007 Biofunctional design of elastin-like polymers for advanced applications in nanobiotechnology. J Biomater Sci Polym Ed 18:269-286
127. Banta S, Megeed Z, Casali M, Rege K, Yarmush ML 2007 Engineering protein and peptide building blocks for nanotechnology. J Nanosci Nanotechnol 7:387-401