Curcumin inhibits GPVI-mediated platelet activation by interfering with the kinase activity of Syk and the subsequent activation of PLC2

Platelets

Volumn 21, Issue 3, 2010, Pages 211-220

  Mayanglambam, Azad ^a   Dangelmaier, Carol A ^b,c   Thomas, Dafydd ^b   Damodar Reddy, C ^a   Daniel, James L ^b,c   Kunapuli, Satya P ^a,b,c  

^a TEMPLE UNIVERSITY   (United States)

^b Departments of Molecular Pharmacology   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Curcumin; GPVI; Platelet activation; PLC2; Syk

Indexed keywords

ADAPTOR PROTEIN; COLLAGEN; CONVULXIN; CURCUMIN; GLYCOPROTEIN VI; PHOSPHOLIPASE C GAMMA2; PROTEIN KINASE SYK; THROMBOXANE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE RELEASE REACTION;

BLOOD PLATELETS; CROTALID VENOMS; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LECTINS, C-TYPE; PHOSPHOLIPASE C GAMMA; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN-TYROSINE KINASES; SECRETORY VESICLES; STRUCTURE-ACTIVITY RELATIONSHIP;

CURCUMA LONGA;

EID: 77951285470     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.3109/09537100903528269     Document Type: Article

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