Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling

Biochemical Pharmacology

Volumn 58, Issue 7, 1999, Pages 1167-1172

  Shah, Bukhtiar H ^a   Nawaz, Zafar ^a   Pertani, Shamim A ^a   Roomi, Asad ^a   Mahmood, Hammad ^a   Saeed, Sheikh A ^a   Gilani, Anwar H ^a  

^a AGA KHAN UNIVERSITY   (Pakistan)

Author keywords

Calcium influx; Curcumin; Cyclooxygenase; Human platelets; Platelet aggregation; Thromboxane A2

Indexed keywords

ARACHIDONIC ACID; CALCIMYCIN; COLLAGEN; CURCUMIN; PROSTAGLANDIN SYNTHASE; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; THROMBOXANE A2;

ARACHIDONIC ACID METABOLISM; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; SECOND MESSENGER; THROMBOCYTE AGGLUTINATION; THROMBOCYTE AGGREGATION INHIBITION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONIC ACID; CALCIUM; CURCUMA; CURCUMIN; CYCLOOXYGENASE INHIBITORS; DRUG INTERACTIONS; HUMANS; PLANT EXTRACTS; PLATELET ACTIVATING FACTOR; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SIGNAL TRANSDUCTION; SPICES; THROMBOXANES;

EID: 0033213832     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00206-3     Document Type: Article

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