Osthole suppresses seizures in the mouse maximal electroshock seizure model

European Journal of Pharmacology

Volumn 607, Issue 1-3, 2009, Pages 107-109

  Luszczki, Jarogniew J ^a,b   Andres Mach, Marta ^b   Cisowski, Wojciech ^c   Mazol, Irena ^c   Glowniak, Kazimierz ^a   Czuczwar, Stanislaw J ^a,b  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

^c WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

Maximal electroshock seizure test; Osthole

Indexed keywords

OSTHOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ELECTRIC SHOCK; EXPERIMENTAL MODEL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE; TIME;

ANIMALS; ANTICONVULSANTS; COUMARINS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSHOCK; INJECTIONS, INTRAPERITONEAL; MALE; MICE; SEIZURES; TIME FACTORS;

EID: 62149147196     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.02.022     Document Type: Article

References (20)

1. Chen J., Chiou W.F., Chen C.C., and Chen C.F. Effect of the plant-extract osthole on the relaxation of rabbit corpus cavernosum tissue in vitro. J. Urol. 163 (2000) 1975-1980
2. Chiou W.F., Huang Y.L., Chen C.F., and Chen C.C. Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum. Planta Med. 67 (2001) 282-284
3. Chou S.Y., Hsu C.S., Wang K.T., Wang M.C., and Wang C.C. Antitumor effects of osthol from Cnidium monnieri: an in vitro and in vivo study. Phytother. Res. 21 (2007) 226-230
4. Cisowski W., Sawicka U., Mardarowicz M., Asztemborska M., and Luczkiewicz M. Essential oil from herb and rhizome of Peucedanum ostruthium (L. Koch.) ex DC. Z. Naturforsch. [C] 56 (2001) 930-932
5. Cooper D.C., and White F.J. L-type calcium channels modulate glutamate-driven bursting activity in the nucleus accumbens in vivo. Brain Res. 880 (2000) 212-218
6. Fisher R.S. Animal models of the epilepsies. Brain Res. Brain Res. Rev. 14 (1989) 245-278
7. Guh J.H., Yu S.M., Ko F.N., Wu T.S., and Teng C.M. Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens. Eur. J. Pharmacol. 298 (1996) 191-197
8. Huang R.L., Chen C.C., Huang Y.L., Hsieh D.J., Hu C.P., Chen C.F., and Chang C. Osthole increases glycosylation of hepatitis B surface antigen and suppresses the secretion of hepatitis B virus in vitro. Hepatology 24 (1996) 508-515
9. Ko F.N., Wu T.S., Liou M.J., Huang T.F., and Teng C.M. Inhibition of platelet thromboxane formation and phosphoinositides breakdown by osthole from Angelica pubescens. Thromb. Haemost. 62 (1989) 996-999
10. Ko F.N., Wu T.S., Liou M.J., Huang T.F., and Teng C.M. Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens. Eur. J. Pharmacol. 219 (1992) 29-34
11. Litchfield J.T., and Wilcoxon F. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96 (1949) 99-113
12. Liu J.H., Zschocke S., Reininger E., and Bauer R. Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase. Planta Med. 64 (1998) 525-529
13. Löscher W., Fassbender C.P., and Nolting B. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II. Maximal electroshock seizure models. Epilepsy Res. 8 (1991) 79-94
14. Luszczki J.J., Glowniak K., and Czuczwar S.J. Time-course and dose-response relationships of imperatorin in the mouse maximal electroshock seizure threshold model. Neurosci. Res. 59 (2007) 18-22
15. Luszczki J.J., Glowniak K., and Czuczwar S.J. Imperatorin enhances the protective activity of conventional antiepileptic drugs against maximal electroshock-induced seizures in mice. Eur. J. Pharmacol. 574 (2007) 133-139
16. Luszczki J.J., Wojda E., Raszewski G., Glowniak K., and Czuczwar S.J. Influence of imperatorin on the anticonvulsant and acute adverse-effect potential of lamotrigine in maximal electroshock-induced seizures and chimney test in mice. Pharmacol. Rep. 60 (2008) 566-573
17. Matsuda H., Tomohiro N., Ido Y., and Kubo M. Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol. Biol. Pharm. Bull. 25 (2002) 809-812
18. Teng C.M., Lin C.H., Ko F.N., Wu T.S., and Huang T.F. The relaxant action of osthole isolated from Angelica pubescens in guinea-pig trachea. Naunyn-Schmiedeberg's Arch. Pharmacol. 349 (1994) 202-208
19. Wang S.J., Lin T.Y., Lu C.W., and Huang W.J. Osthole and imperatorin, the active constituents of Cnidium monnieri (L.) Cusson, facilitate glutamate release from rat hippocampal nerve terminals. Neurochem. Int. 53 (2008) 416-423
20. Yang L.L., Wang M.C., Chen L.G., and Wang C.C. Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines. Planta Med. 69 (2003) 1091-1095