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Volumn 203, Issue 3, 2009, Pages 271-280

Anti-oxidants, controversies and perspectives: How can the failure of clinical studies using anti-oxidants be explained?;Anti-oxydants, controverses et perspectives: Comment expliquer léchec des études cliniques utilisant des anti-oxydants

Author keywords

Anti oxidants; glycation; mitochondria; nutrigenomics; oxidative stress

Indexed keywords

ANTIOXIDANT; REACTIVE OXYGEN METABOLITE;

EID: 77951209708     PISSN: 12950661     EISSN: None     Source Type: Journal    
DOI: 10.1051/jbio:2009031     Document Type: Article
Times cited : (15)

References (46)
  • 3
    • 49849088441 scopus 로고    scopus 로고
    • Systematic review: Primary and secondary prevention of gastrointestinal cancers with Anti-oxidants supplements
    • Bjelakovic G., Nikolova D., Simonetti R.G., Gluud C., Systematic review: primary and secondary prevention of gastrointestinal cancers with Anti-oxidants supplements. Aliment Pharmacol Ther, 2008, 28, 689-703.
    • (2008) Aliment Pharmacol Ther , vol.28 , pp. 689-703
    • Bjelakovic, G.1    Nikolova, D.2    Simonetti, R.G.3    Gluud, C.4
  • 4
    • 84861927005 scopus 로고    scopus 로고
    • Anti-oxidants supplements for prevention of mortality in healthy participants and patients with various diseases
    • Bjelakovic G., Nikolova D., Gluud L.L., Simonetti R.G., Gluud C., Anti-oxidants supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev, 2008, 2, CD007176.
    • (2008) Cochrane Database Syst Rev , vol.2
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 6
    • 4744372695 scopus 로고    scopus 로고
    • Anti-oxidants supplements for prevention of gastrointestinal cancers: A systematic review and metaanalysis
    • Bjelakovic G., Nikolova D., Simonetti R.G., Gluud C., Anti-oxidants supplements for prevention of gastrointestinal cancers: a systematic review and metaanalysis. The Lancet, 2004, 364, 1219-1228.
    • (2004) The Lancet , vol.364 , pp. 1219-1228
    • Bjelakovic, G.1    Nikolova, D.2    Simonetti, R.G.3    Gluud, C.4
  • 7
    • 38849199866 scopus 로고    scopus 로고
    • Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice
    • Bonnard C., Durand A., Peyrol S., Chanseaume E., Chauvin M.A., Morio B., Vidal H., Rieusset J., Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J. Clin. Invest, 2008, 118, 789-800.
    • (2008) J. Clin. Invest , vol.118 , pp. 789-800
    • Bonnard, C.1    Durand, A.2    Peyrol, S.3    Chanseaume, E.4    Chauvin, M.A.5    Morio, B.6    Vidal, H.7    Rieusset, J.8
  • 9
    • 0025004502 scopus 로고
    • Flavonoids as Anti-oxidantss: Determination of radical- scavengingefficiencies
    • Bors W., Heller W., Michel C., Satan M., Flavonoids as Anti-oxidantss: determination of radical-scavengingefficiencies. Methods in Enzymology, 1990, 186, 343.
    • (1990) Methods in Enzymology , vol.186 , pp. 343
    • Bors, W.1    Heller, W.2    Michel, C.3    Satan, M.4
  • 10
    • 38949135755 scopus 로고    scopus 로고
    • Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome
    • Bugger H., Abel E.D., Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome. Clin Sci (Lond), 2008, 114, 195-210.
    • (2008) Clin Sci (Lond) , vol.114 , pp. 195-210
    • Bugger, H.1    Abel, E.D.2
  • 11
    • 33947109803 scopus 로고    scopus 로고
    • Contraintes budgétaires et choix alimentaires. Pauvreté des ménages, pauvreté de l'alimentation?
    • Caillavet F., Darmon N., Contraintes budgétaires et choix alimentaires. Pauvreté des ménages, pauvreté de l'alimentation ? Inra Sciences Sociales, 2005, 3-4.
    • (2005) Inra Sciences Sociales , pp. 3-4
    • Caillavet, F.1    Darmon, N.2
  • 12
    • 43949132151 scopus 로고    scopus 로고
    • Risk factors for cardiovascular disease in women: Relationship to lipid peroxidation and oxidative stress
    • Castelao J.E., Gago-Dominguez M., Risk factors for cardiovascular disease in women: relationship to lipid peroxidation and oxidative stress. Med Hypotheses, 2008, 71, 39-44.
    • (2008) Med Hypotheses , vol.71 , pp. 39-44
    • Castelao, J.E.1    Gago-Dominguez, M.2
  • 13
    • 0042093769 scopus 로고    scopus 로고
    • New insights on oxidative stress and diabetic complications may lead to a "causal" Anti-oxidants therapy
    • Cerellio A., New insights on oxidative stress and diabetic complications may lead to a "causal" Anti-oxidants therapy. Diabetes Care, 2003, 26, 1589-1596.
    • (2003) Diabetes Care , vol.26 , pp. 1589-1596
    • Cerellio, A.1
  • 14
    • 2442421194 scopus 로고    scopus 로고
    • Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease ? the common soil hypothesis revisited
    • Ceriello A., Motz E., Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease ? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol, 2004, 24, 816-823.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 816-823
    • Ceriello, A.1    Motz, E.2
  • 16
    • 77956308064 scopus 로고    scopus 로고
    • ÉEquilibre alimentaire : Une question d'argent ?
    • Darmon N., équilibre alimentaire : une question d'argent ? Diab́etologie et facteurs de risque, 2006, 97, 7-11.
    • (2006) Diab́etologie et Facteurs de Risque , vol.97 , pp. 7-11
    • Darmon, N.1
  • 17
    • 64749106188 scopus 로고    scopus 로고
    • Role of oxidative stress and intracellular glutathione in the sensitivity to apoptosis induced by proteasome inhibitor in thyroid cancer cells
    • Du Z.X., Zhang H.Y., Meng X., Guan Y., Wang H.Q., Role of oxidative stress and intracellular glutathione in the sensitivity to apoptosis induced by proteasome inhibitor in thyroid cancer cells. BMC Cancer, 2009, 9, 56.
    • (2009) BMC Cancer , vol.9 , pp. 56
    • Du, Z.X.1    Zhang, H.Y.2    Meng, X.3    Guan, Y.4    Wang, H.Q.5
  • 18
    • 36348992531 scopus 로고    scopus 로고
    • Mitochondrial generation of reactive oxygen species (ROS) and its targeting by Antioxidantss
    • Edeas M.A. et al., Mitochondrial generation of reactive oxygen species (ROS) and its targeting by Antioxidantss. Agro Food Industry Hi-Tech, 2007, 18, 17-22.
    • (2007) Agro Food Industry Hi-Tech , vol.18 , pp. 17-22
    • Edeas, M.A.1
  • 20
    • 77956309303 scopus 로고    scopus 로고
    • The effect of vitamin e and β-caroten on he incidence of lung cancer and other cancers in male smokers
    • Heinonen O., Albanes D., The effect of vitamin E and β-caroten on he incidence of lung cancer and other cancers in male smokers. N Engl J Med, 1996, 334, 1150-1155.
    • (1996) N Engl J Med , vol.334 , pp. 1150-1155
    • Heinonen, O.1    Albanes, D.2
  • 21
    • 33751417659 scopus 로고    scopus 로고
    • The SU.VI.MAX study, a randomized, placebo-controlled trial on the effects of Antioxidants, vitamins and minerals on health
    • Hercberg S., The SU.VI.MAX study, a randomized, placebo-controlled trial on the effects of Antioxidants, vitamins and minerals on health. Annales Pharmaceutiques Fraņcaises, 2006, 64, 397-401.
    • (2006) Annales Pharmaceutiques Fraņcaises , vol.64 , pp. 397-401
    • Hercberg, S.1
  • 23
    • 0023708392 scopus 로고
    • Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidative as the cause of protein damage in the expérimental glycation model of diabetes mellitus ang ageing
    • Hunt J.V., Dean R.T., Wolff S.P., Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidative as the cause of protein damage in the expérimental glycation model of diabetes mellitus ang ageing. Biochem J, 1988, 256, 205-212.
    • (1988) Biochem J , vol.256 , pp. 205-212
    • Hunt, J.V.1    Dean, R.T.2    Wolff, S.P.3
  • 24
    • 26844564082 scopus 로고    scopus 로고
    • Oxidative stress and the use of Anti-oxidantss in diabetes: Linking basic science to clinical practice
    • Johansen J.S., Harris A.K., Rychly D.J., Ergul A., Oxidative stress and the use of Anti-oxidantss in diabetes: linking basic science to clinical practice. Cardiovasc Diabetol, 2005, 4, 5.
    • (2005) Cardiovasc Diabetol , vol.4 , pp. 5
    • Johansen, J.S.1    Harris, A.K.2    Rychly, D.J.3    Ergul, A.4
  • 25
    • 0024784639 scopus 로고
    • Anti-oxydants function of carotenoides
    • Kinsky N., Anti-oxydants function of carotenoides. Free Rad Biol Med, 1989, 7, 617.
    • (1989) Free Rad Biol Med , vol.7 , pp. 617
    • Kinsky, N.1
  • 26
    • 30044434360 scopus 로고    scopus 로고
    • The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations
    • Loeb L.A., Wallace D.C., Martin G.M., The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations. Proc Natl Acad Sci U S A, 2005, 102, 18769-18770.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18769-18770
    • Loeb, L.A.1    Wallace, D.C.2    Martin, G.M.3
  • 29
    • 34250646620 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress and inflammation: A slalom to obesity and insulin resistance
    • Martínez J.A., Mitochondrial oxidative stress and inflammation: a slalom to obesity and insulin resistance. J Physiol Biochem 2006, 62, 303-306.
    • (2006) J Physiol Biochem , vol.62 , pp. 303-306
    • Martínez, J.A.1
  • 30
    • 18044363639 scopus 로고    scopus 로고
    • SOD, oxidative stress and human pathologies: A brief history and a future vision
    • McCord J.M., Edeas M.A., SOD, oxidative stress and human pathologies: a brief history and a future vision. Biomed Pharmacother, 2005, 59, 139-142.
    • (2005) Biomed Pharmacother , vol.59 , pp. 139-142
    • McCord, J.M.1    Edeas, M.A.2
  • 31
    • 33644837449 scopus 로고    scopus 로고
    • Oxidative stress in diabetes: A mechanistic overview of its effects on atherogenesis and myocardial dysfunction
    • Mehta J.L., Rasouli N., Sinha A.K., Molavi B., Oxidative stress in diabetes: A mechanistic overview of its effects on atherogenesis and myocardial dysfunction. Int J Biochem Cell Biol, 2006, 38, 794-803.
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 794-803
    • Mehta, J.L.1    Rasouli, N.2    Sinha, A.K.3    Molavi, B.4
  • 32
    • 12344303813 scopus 로고    scopus 로고
    • Meta-Analysis: High-Dosage vitamin e supplementation may increase all-cause mortality
    • Miller E.R. 3rd, Pastor-Barriuso R. et al., Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality. Ann Intern Med, 2004, 10.
    • (2004) Ann Intern Med , vol.10
    • Miller Iii, E.R.1    Pastor-Barriuso, R.2
  • 33
    • 23244451614 scopus 로고    scopus 로고
    • The role of oxidative stress in diabetic complications
    • Niedowicz D.M., Daleke D.L., The role of oxidative stress in diabetic complications. Cell Biochem Biophys, 2005, 43, 289-330.
    • (2005) Cell Biochem Biophys , vol.43 , pp. 289-330
    • Niedowicz, D.M.1    Daleke, D.L.2
  • 35
    • 0025774875 scopus 로고
    • Protective role of vitamin e in biological systems
    • Packer L., Protective role of vitamin E in biological systems. Am J Clin Nutr, 1991, 53, 1050S.
    • (1991) Am J Clin Nutr , vol.53
    • Packer, L.1
  • 36
    • 33748960226 scopus 로고    scopus 로고
    • Effect of advanced glycation end-products on cell proliferation and cell death
    • Peterszegi G., Molinari J., Ravelojaono V., Robert L., Effect of advanced glycation end-products on cell proliferation and cell death. Pathologie Biologie, 2006, 54, 396-404.
    • (2006) Pathologie Biologie , vol.54 , pp. 396-404
    • Peterszegi, G.1    Molinari, J.2    Ravelojaono, V.3    Robert, L.4
  • 37
    • 61649124922 scopus 로고    scopus 로고
    • Effect of broccoli intake on markers related to oxidative stress and cancer risk in healthy smokers and nonsmokers
    • Riso P., Martini D., Visioli F., Martinetti A., Porrini M., Effect of broccoli intake on markers related to oxidative stress and cancer risk in healthy smokers and nonsmokers. Nutr Cancer, 2009, 61, 232-237.
    • (2009) Nutr Cancer , vol.61 , pp. 232-237
    • Riso, P.1    Martini, D.2    Visioli, F.3    Martinetti, A.4    Porrini, M.5
  • 38
    • 33748749428 scopus 로고    scopus 로고
    • An original approach to aging: An appreciation of Fritz Verzar contribution in the light of the last 50 years of gerontological facts and thinking
    • Robert L., An original approach to aging: an appreciation of Fritz Verzar contribution in the light of the last 50 years of gerontological facts and thinking. Gerontology, 2006, 52, 268-274.
    • (2006) Gerontology , vol.52 , pp. 268-274
    • Robert, L.1
  • 39
    • 22344442393 scopus 로고    scopus 로고
    • Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation
    • Rosca M.G. et al., Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation. Am J Physiol Renal Physiol, 2005, 289, F420-30.
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Rosca, M.G.1
  • 40
    • 0025987977 scopus 로고
    • Oxidative stress: From basics research to clinical application
    • Sies H., Oxidative stress: from basics research to clinical application. Am J Med, 1991, 90, 31S-38S.
    • (1991) Am J Med , vol.90
    • Sies, H.1
  • 41
    • 21344441240 scopus 로고    scopus 로고
    • Beta-carotene breakdown products may impair mitochondrial functions- potential side effects of high-dose beta-carotene supplementation
    • Siems W., Wiswedel I., Salerno C., Beta-carotene breakdown products may impair mitochondrial functions- potential side effects of high-dose beta-carotene supplementation. J Nutr Biochem, 2005, 16, 385-397.
    • (2005) J Nutr Biochem , vol.16 , pp. 385-397
    • Siems, W.1    Wiswedel, I.2    Salerno, C.3
  • 43
    • 61449184625 scopus 로고    scopus 로고
    • Deletion of the mitochondrial superoxide sod-2 extends lifespan in Caenorhabditis elegans
    • Van Raamsdonk J.M., Hekimi S., Deletion of the mitochondrial superoxide sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet, 2009, 5, e1000361.
    • (2009) PLoS Genet , vol.5
    • Van Raamsdonk, J.M.1    Hekimi, S.2
  • 44
    • 48049106637 scopus 로고    scopus 로고
    • Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: Implications for Parkinson's disease and protection by polyphenols
    • Vauzour D., Ravaioli G., Vafeiadou K., Rodriguez-Mateos A., Angeloni C., Spencer J.P., Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols. Arch Biochem Biophys, 2008, 476, 145-51.
    • (2008) Arch Biochem Biophys , vol.476 , pp. 145-51
    • Vauzour, D.1    Ravaioli, G.2    Vafeiadou, K.3    Rodriguez-Mateos, A.4    Angeloni, C.5    Spencer, J.P.6
  • 45
    • 0347753692 scopus 로고    scopus 로고
    • Oxidative stress as a therapeutic target in diabetes: Revisiting the controversy
    • Wiernsperger N.F., Oxidative stress as a therapeutic target in diabetes: revisiting the controversy. Diabetes Metab, 2003, 29, 579-585.
    • (2003) Diabetes Metab , vol.29 , pp. 579-585
    • Wiernsperger, N.F.1
  • 46
    • 0036667555 scopus 로고    scopus 로고
    • Superoxide dismutase multigene family: A comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression
    • Zelko I.N., Mariani T.J., Folz R.J., Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Rad Biol Med, 2002, 33, 337.
    • (2002) Free Rad Biol Med , vol.33 , pp. 337
    • Zelko, I.N.1    Mariani, T.J.2    Folz, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.