The evaluation of quinonoid compounds against Trypanosoma cruzi: Synthesis of imidazolic anthraquinones, nor-β-lapachone derivatives and β-lapachone-based 1,2,3-triazoles

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 9, 2010, Pages 3224-3230

  da Silva Júnior, Eufrânio N ^a,b   Guimarães, Tiago T ^a   Menna Barreto, Rubem F S ^c   Pinto, Maria do Carmo F R ^a   de Simone, Carlos A ^d,e   Pessoa, Claudia ^g   Cavalcanti, Bruno C ^g   Sabino, José R ^f   Andrade, Carlos Kleber Z ^b   Goulart, Marilia O F ^d   de Castro, Solange L ^c   Pinto, Antônio V ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSITY OF BRASILIA   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

^d FEDERAL UNIVERSITY OF ALAGOAS   (Brazil)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

^f FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^g FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Chagas' disease; Experimental chemotherapy; Naphthoquinones; Nor lapachone; Trypanosoma cruzi

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; 1,4 NAPHTHOQUINONE DERIVATIVE; 2 BIPHENYL 4 YL 1H ANTHRA[1,2 D]IMIDAZOLE 6,11 DIONE; 2 NAPTHALEN 1 YL 1H ANTHRA[1,2 D]IMIDAZOLE 6,11 DIONE; 2,2 DIMETHYL 3 (2,4 DIBROMOPHENYLAMINO) 2,3 DIHYDRO NAPHTHO[1,2B]FURAN 4,5 DIONE; 3 BROMO 2,2 DIMETHYL 4 (4 PHENYL 1,2,3 TRIAZOL 1 YL) 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; 3 BROMO 4 [4 (4 FLUOROPHENYL) 1,2,3 TRIAZOL 1 YL] 2,2 DIMETHYL 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; 3 BROMO 4 [4 (4 METHOXYPHENYL) 1,2,3 TRIAZOL 1 YL] 2,2 DIMETHYL 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; 4 AZIDO 3 BROMO 2,2 DIMETHYL 3,4 DIHYDRO 2H BENZO[G]CHROMENE 5,10 DIONE; 4 AZIDO 3 BROMO 2,2 DIMETHYL 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; 4 BROMO 4 [4 (4 BROMOPHENYL) 1,2,3 TRIAZOL 1 YL] 2,2 DIMETHYL 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; ANTHRAQUINONE DERIVATIVE; BENZNIDAZOLE; BETA LAPACHONE; LAPACHOL; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL PROLIFERATION; CHAGAS DISEASE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; INHIBITION KINETICS; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTHRAQUINONES; ANTIPARASITIC AGENTS; CRYSTALLOGRAPHY, X-RAY; IMIDAZOLES; MICE; MOLECULAR STRUCTURE; NAPHTHOQUINONES; PARASITIC SENSITIVITY TESTS; QUINONES; TRIAZOLES; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 77951209292     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.029     Document Type: Article

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