-
1
-
-
53049107046
-
Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential
-
Salminen A., Lehtonen M., Suuronen T., Kaarniranta K., Huuskonen J. Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential. Cell. Mol. Life Sci. 2008, 65:2979-2999.
-
(2008)
Cell. Mol. Life Sci.
, vol.65
, pp. 2979-2999
-
-
Salminen, A.1
Lehtonen, M.2
Suuronen, T.3
Kaarniranta, K.4
Huuskonen, J.5
-
2
-
-
0030823162
-
Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-κB
-
Lyß G., Schmidt T.J., Merfort I., Pahl H.L. Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-κB. Biol. Chem. 1997, 378:951-961.
-
(1997)
Biol. Chem.
, vol.378
, pp. 951-961
-
-
Lyß, G.1
Schmidt, T.J.2
Merfort, I.3
Pahl, H.L.4
-
3
-
-
0031915368
-
Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκBα and IκBβ
-
Hehner S.P., Heinrich M., Bork P.M., Vogt M., Ratter F., Lehmann V., Schulze-Osthoff K., Droge W., Schmitz M.L. Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκBα and IκBβ. J. Biol. Chem. 1998, 273:1288-1297.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 1288-1297
-
-
Hehner, S.P.1
Heinrich, M.2
Bork, P.M.3
Vogt, M.4
Ratter, F.5
Lehmann, V.6
Schulze-Osthoff, K.7
Droge, W.8
Schmitz, M.L.9
-
4
-
-
0035955729
-
Cysteine 38 in p65/NF-κB plays a crucial role in DNA binding inhibition by sesquiterpene lactones
-
Garcia-Pineres A.J., Castro V., Mora G., Schmidt T.J., Strunck E., Pahl H.L., Merfort I. Cysteine 38 in p65/NF-κB plays a crucial role in DNA binding inhibition by sesquiterpene lactones. J. Biol. Chem. 2001, 276:39713-39720.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 39713-39720
-
-
Garcia-Pineres, A.J.1
Castro, V.2
Mora, G.3
Schmidt, T.J.4
Strunck, E.5
Pahl, H.L.6
Merfort, I.7
-
5
-
-
43749098070
-
NF-κB and cancer-identifying targets and mechanisms
-
Naugler W.E., Karin M. NF-κB and cancer-identifying targets and mechanisms. Curr. Opin. Genet. Dev. 2008, 18:19-26.
-
(2008)
Curr. Opin. Genet. Dev.
, vol.18
, pp. 19-26
-
-
Naugler, W.E.1
Karin, M.2
-
6
-
-
67650744586
-
The role of ubiquitin in NF-κB regulatory pathways
-
Skaug B., Jiang X., Chen Z.J. The role of ubiquitin in NF-κB regulatory pathways. Annu. Rev. Biochem. 2009, 78:769-796.
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 769-796
-
-
Skaug, B.1
Jiang, X.2
Chen, Z.J.3
-
7
-
-
0034746919
-
NF-κB: a key role in inflammatory diseases
-
Tak P.P., Firestein G.S. NF-κB: a key role in inflammatory diseases. J. Clin. Invest. 2001, 107:7-11.
-
(2001)
J. Clin. Invest.
, vol.107
, pp. 7-11
-
-
Tak, P.P.1
Firestein, G.S.2
-
8
-
-
54949147176
-
New regulators of NF-κB in inflammation
-
Ghosh S., Hayden M.S. New regulators of NF-κB in inflammation. Nat. Rev. Immunol. 2008, 8:837-848.
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 837-848
-
-
Ghosh, S.1
Hayden, M.S.2
-
9
-
-
58149202128
-
Is NF-κB a good target for cancer therapy? Hopes and pitfalls
-
Baud V., Karin M. Is NF-κB a good target for cancer therapy? Hopes and pitfalls. Nat. Rev. Drug Discov. 2009, 8:33-40.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 33-40
-
-
Baud, V.1
Karin, M.2
-
10
-
-
67650724069
-
Regulation and function of NF-κB transcription factors in the immune system
-
Vallabhapurapu S., Karin M. Regulation and function of NF-κB transcription factors in the immune system. Annu. Rev. Immunol. 2009, 27:693-733.
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 693-733
-
-
Vallabhapurapu, S.1
Karin, M.2
-
11
-
-
0033571108
-
The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-κB by targeting the IκB kinase complex
-
Hehner S.P., Hofmann T.G., Droge W., Schmitz M.L. The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-κB by targeting the IκB kinase complex. J. Immunol. 1999, 163:5617-5623.
-
(1999)
J. Immunol.
, vol.163
, pp. 5617-5623
-
-
Hehner, S.P.1
Hofmann, T.G.2
Droge, W.3
Schmitz, M.L.4
-
12
-
-
0001112989
-
The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-κB by directly targeting p65
-
Lyß G., Knorre A., Schmidt T.J., Pahl H.L., Merfort I. The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-κB by directly targeting p65. J. Biol. Chem. 1998, 273:33508-33516.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 33508-33516
-
-
Lyß, G.1
Knorre, A.2
Schmidt, T.J.3
Pahl, H.L.4
Merfort, I.5
-
13
-
-
2942618506
-
Role of cysteine residues of p65/NF-κB on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide and on its transactivating potential
-
Garcia-Pineres A.J., Lindenmeyer M.T., Merfort I. Role of cysteine residues of p65/NF-κB on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide and on its transactivating potential. Life Sci. 2004, 75:841-856.
-
(2004)
Life Sci.
, vol.75
, pp. 841-856
-
-
Garcia-Pineres, A.J.1
Lindenmeyer, M.T.2
Merfort, I.3
-
14
-
-
0025211845
-
Further helenanolides from the flowers of Arnica chamissonis subsp. foliosa
-
Willuhn G., Kresken J., Leven W. Further helenanolides from the flowers of Arnica chamissonis subsp. foliosa. Planta Med. 1990, 56:111-114.
-
(1990)
Planta Med.
, vol.56
, pp. 111-114
-
-
Willuhn, G.1
Kresken, J.2
Leven, W.3
-
15
-
-
0038179160
-
Structural analysis of pentacyclic triterpenes from the gum resin of Boswellia serrata by NMR spectroscopy
-
Belsner K., Büchele B., Werz U., Syrovets T., Simmet T. Structural analysis of pentacyclic triterpenes from the gum resin of Boswellia serrata by NMR spectroscopy. Magn. Reson. Chem. 2003, 41:115-122.
-
(2003)
Magn. Reson. Chem.
, vol.41
, pp. 115-122
-
-
Belsner, K.1
Büchele, B.2
Werz, U.3
Syrovets, T.4
Simmet, T.5
-
16
-
-
68249133136
-
Surface chemistry in SPR technology
-
Royal Society of Chemistry, Cambridge, UK, R.B.M. Schasfoort, A.J. Tudos (Eds.)
-
Gedig E.T. Surface chemistry in SPR technology. Handbook of Surface Plasmon Resonance 2008, 173-220. Royal Society of Chemistry, Cambridge, UK. R.B.M. Schasfoort, A.J. Tudos (Eds.).
-
(2008)
Handbook of Surface Plasmon Resonance
, pp. 173-220
-
-
Gedig, E.T.1
-
17
-
-
10844262511
-
Acetyl-boswellic acids inhibit lipopolysaccharide-mediated TNF-α induction in monocytes by direct interaction with IκB kinases
-
Syrovets T., Büchele B., Krauss C., Laumonnier Y., Simmet T. Acetyl-boswellic acids inhibit lipopolysaccharide-mediated TNF-α induction in monocytes by direct interaction with IκB kinases. J. Immunol. 2005, 174:498-506.
-
(2005)
J. Immunol.
, vol.174
, pp. 498-506
-
-
Syrovets, T.1
Büchele, B.2
Krauss, C.3
Laumonnier, Y.4
Simmet, T.5
-
19
-
-
14044268207
-
Inhibition of IκB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo
-
Syrovets T., Gschwend J.E., Büchele B., Laumonnier Y., Zugmaier W., Genze F., Simmet T. Inhibition of IκB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo. J. Biol. Chem. 2005, 280:6170-6180.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 6170-6180
-
-
Syrovets, T.1
Gschwend, J.E.2
Büchele, B.3
Laumonnier, Y.4
Zugmaier, W.5
Genze, F.6
Simmet, T.7
-
20
-
-
33744826819
-
MolDock: a new technique for high-accuracy molecular docking
-
Thomsen R., Christensen M.H. MolDock: a new technique for high-accuracy molecular docking. J. Med. Chem. 2006, 49:3315-3321.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 3315-3321
-
-
Thomsen, R.1
Christensen, M.H.2
-
21
-
-
0036084259
-
Efficient docking of peptides to proteins without prior knowledge of the binding site
-
Hetenyi C., Van der Spoel D. Efficient docking of peptides to proteins without prior knowledge of the binding site. Protein Sci. 2002, 11:1729-1737.
-
(2002)
Protein Sci.
, vol.11
, pp. 1729-1737
-
-
Hetenyi, C.1
Van der Spoel, D.2
-
22
-
-
0343485104
-
Helenanolide type sesquiterpene lactones: V. The role of glutathione addition under physiological conditions
-
Schmidt T.J., Lyß G., Pahl H.L., Merfort I. Helenanolide type sesquiterpene lactones: V. The role of glutathione addition under physiological conditions. Bioorg. Med. Chem. 1999, 7:2849-2855.
-
(1999)
Bioorg. Med. Chem.
, vol.7
, pp. 2849-2855
-
-
Schmidt, T.J.1
Lyß, G.2
Pahl, H.L.3
Merfort, I.4
-
23
-
-
0034902498
-
The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells
-
Heilmann J., Wasescha M.R., Schmidt T.J. The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells. Bioorg. Med. Chem. 2001, 9:2189-2194.
-
(2001)
Bioorg. Med. Chem.
, vol.9
, pp. 2189-2194
-
-
Heilmann, J.1
Wasescha, M.R.2
Schmidt, T.J.3
-
24
-
-
0027293351
-
Determination of rate and equilibrium binding constants for macromolecular interactions using surface plasmon resonance. Use of nonlinear least squares analysis methods
-
O'Shannessy D.J., Brigham-Burke M., Soneson K.K., Hensley P., Brooks I. Determination of rate and equilibrium binding constants for macromolecular interactions using surface plasmon resonance. Use of nonlinear least squares analysis methods. Anal. Biochem. 1993, 212:457-468.
-
(1993)
Anal. Biochem.
, vol.212
, pp. 457-468
-
-
O'Shannessy, D.J.1
Brigham-Burke, M.2
Soneson, K.K.3
Hensley, P.4
Brooks, I.5
-
25
-
-
38549108133
-
-/- mice
-
-/- mice. Arterioscler. Thromb. Vasc. Biol. 2008, 28:272-277.
-
(2008)
Arterioscler. Thromb. Vasc. Biol.
, vol.28
, pp. 272-277
-
-
Cuaz-Perolin, C.1
Billiet, L.2
Bauge, E.3
Copin, C.4
Scott-Algara, D.5
Genze, F.6
Büchele, B.7
Syrovets, T.8
Simmet, T.9
Rouis, M.10
-
26
-
-
70449711383
-
Targeting NF-κB with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis
-
Wang H., Syrovets T., Kess D., Büchele B., Hainzl H., Lunov O., Weiss J.M., Scharffetter-Kochanek K., Simmet T. Targeting NF-κB with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis. J. Immunol. 2009, 183:4755-4763.
-
(2009)
J. Immunol.
, vol.183
, pp. 4755-4763
-
-
Wang, H.1
Syrovets, T.2
Kess, D.3
Büchele, B.4
Hainzl, H.5
Lunov, O.6
Weiss, J.M.7
Scharffetter-Kochanek, K.8
Simmet, T.9
-
27
-
-
0030904120
-
Helenanolide-type sesquiterpene lactones: III. Rates and stereochemistry in the reaction of helenalin and related helenanolides with sulfhydryl containing biomolecules
-
Schmidt T.J. Helenanolide-type sesquiterpene lactones: III. Rates and stereochemistry in the reaction of helenalin and related helenanolides with sulfhydryl containing biomolecules. Bioorg. Med. Chem. 1997, 5:645-653.
-
(1997)
Bioorg. Med. Chem.
, vol.5
, pp. 645-653
-
-
Schmidt, T.J.1
-
28
-
-
0024456697
-
Biological interactions of α,β-unsaturated aldehydes
-
Witz G. Biological interactions of α,β-unsaturated aldehydes. Free Radic. Biol. Med. 1989, 7:333-349.
-
(1989)
Free Radic. Biol. Med.
, vol.7
, pp. 333-349
-
-
Witz, G.1
-
29
-
-
0025944815
-
Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors
-
Johnsson B., Lofas S., Lindquist G. Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors. Anal. Biochem. 1991, 198:268-277.
-
(1991)
Anal. Biochem.
, vol.198
, pp. 268-277
-
-
Johnsson, B.1
Lofas, S.2
Lindquist, G.3
-
30
-
-
4644340688
-
SPR-based interaction studies with small molecular weight ligands using hAGT fusion proteins
-
Huber W., Perspicace S., Kohler J., Muller F., Schlatter D. SPR-based interaction studies with small molecular weight ligands using hAGT fusion proteins. Anal. Biochem. 2004, 333:280-288.
-
(2004)
Anal. Biochem.
, vol.333
, pp. 280-288
-
-
Huber, W.1
Perspicace, S.2
Kohler, J.3
Muller, F.4
Schlatter, D.5
-
31
-
-
0023185042
-
Effects of glutathione depletion on the cytotoxicity of agents toward a human colonic tumour cell line
-
Jordan J., d'Arcy Doherty M., Cohen G.M. Effects of glutathione depletion on the cytotoxicity of agents toward a human colonic tumour cell line. Br. J. Cancer 1987, 55:627-631.
-
(1987)
Br. J. Cancer
, vol.55
, pp. 627-631
-
-
Jordan, J.1
d'Arcy Doherty, M.2
Cohen, G.M.3
|