Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 9, 2010, Pages 2801-2805

  Sliman, Faten ^a   Blairvacq, Mélina ^b   Durieu, Emilie ^b   Meijer, Laurent ^b   Rodrigo, Jordi ^a   Desmaële, Didier ^a  

^a UNIVERSITÉ PARIS SUD   (France)

^b Protein Phosphorylation and Human Disease Group   (France)

Author keywords

Inhibitors; Molecular docking; Pim 1 kinase; Quinoline 2 carboxamides; Styrylquinolines

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; MOLECULAR SCAFFOLD; PROTEIN KINASE PIM 1; PROTEIN SERINE THREONINE KINASE INHIBITOR;

ARTICLE; BINDING SITE; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

EID: 77950955443     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.061     Document Type: Article

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