Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 11, 2009, Pages 3019-3022

  Grey, Ron ^a   Pierce, Albert C ^a   Bemis, Guy W ^a   Jacobs, Marc D ^a   Moody, Cameron Stuver ^a   Jajoo, Rahul ^b   Mohal, Narinder ^b   Green, Jeremy ^a  

^a VERTEX PHARMACEUTICALS   (United States)

^b GVK BIOSCIENCES PVT LTD   (India)

Author keywords

Permeability; Pim 1 kinase; Pim 1 kinase inhibitors; Solubility; Triazolo 4,3 b pyridazine

Indexed keywords

3 6 AMINO TRIAZOLO[4,3 B]PYRIDAZINE INHIBITOR; ADENOSINE TRIPHOSPHATE; PROTEIN KINASE PIM 1; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING SITE; DRUG STRUCTURE; ENZYME ACTIVITY; X RAY CRYSTALLOGRAPHY;

ANIMALS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DOGS; DRUG DESIGN; PERMEABILITY; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-PIM-1; PYRIDAZINES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 65149094214     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.061     Document Type: Article

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