Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 22, 2007, Pages 6138-6141

  Podeszwa, B ^a   Niedbala, H ^a   Polanski, J ^a   Musiol, R ^a   Tabak, D ^a   Finster, J ^a   Serafin, K ^a   Milczarek, M ^b   Wietrzyk, J ^b   Boryczka, S ^c   Mol, W ^c   Jampilek, J ^d,e   Dohnal, J ^d,e   Kalinowski, D S ^f   Richardson, D R ^f  

^a UNIVERSITY OF SILESIA   (Poland)

^b INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^c MEDICAL UNIVERSITY OF SILESIA   (Poland)

^d Zentiva Prague   (Czech Republic)

^e UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

^f UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Antiproliferative activity; Quinoline 5,8 diones; Quinolinecarboxylic acid

Indexed keywords

CISPLATIN; QUINOLINE DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROPHOBICITY; LEUKEMIA P 388; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NEUROEPITHELIOMA; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBOXYLIC ACIDS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; MOLECULAR STRUCTURE; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35148854089     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.09.040     Document Type: Article

References (17)

1. Rao, K. V. Cancer Chemother. Rep. Part 2 1974, 4, 11.
2. Behforouz M., Haddad J., Cai W., Arnold M.B., Mohammadi F., Sousa A.C., and Horn M.A. J. Org. Chem. 61 (1996) 6552
3. Behforouz M., Cai W., Mohammadi F., Stocksdale M.G., Gu Zh., Ahmadian M., Baty D.E., Etling M.R., Al-Anzi Ch.H., Swiftney T.M., Tanzer L.R., Merriman R.L., and Behforouz N.C. Bioorg. Med. Chem. 15 (2007) 495
4. Behforouz M., Cai W., Stocksdale M.G., Lucas J.S., Jung J.Y., Briere D., Wang A., Katen K.S., and Behforouz N.C. J. Med. Chem. 46 (2003) 5773
5. Behforouz M., Gu Z., Cai W., Horn M.A., and Ahmadian M. J. Org. Chem. 58 (1993) 7089
6. Balitz D.M., Bush J.A., Bradner W.T., Doyle T.W., O'Herron F.A., and Nettleton D.E. J. Antibiot. (Tokyo) 35 (1982) 259
7. Abe N., Nakakita Y., Nakamura T., Enoki N., Uchida H., Takeo S., and Munekata M. J. Antibiot. (Tokyo) 46 (1993) 1672
8. Fang Y., Linardic C.M., Richardson D.A., Cai W., Behforouz M., and Abraham R.T. Mol. Cancer Ther. 2 (2003) 517
9. Doyle T.W., Balitz D.M., Grulich R.E., Nettleton D.E., Gould S.J., Tann C.-H., and Meows A.E. Tetrahedron Lett. 22 (1981) 4595
10. Hackethal C.A., Golbey R.B., Tan C.T.C., Karnofsky D.A., and Burchenal J.H. Antibiot. Chemother. 11 (1961) 178
11. Boger D.L., Yasuda M., Mitscher L.A., Drake S.D., Kitos P.A., and Thompson S.C. J. Med. Chem. 30 (1987) 1918
12. Wilson W.L., Labra C., and Barrist E. Antibiot. Chemother. 11 (1961) 147
13. Musiol R., Podeszwa B., Finster J., Niedbala H., and Polanski J. Monatsh. Chem. 137 (2006) 1211
14. Musiol R., Jampilek J., Kralova K., Richardson D.R., Kalinowski D.S., Podeszwa B., Finster J., Niedbala H., Palka A., and Polanski J. Bioorg. Med. Chem. 15 (2007) 1280
15. 50 values. Each concentration of each individual compound was tested in triplicate in a single experiment, with each experiment being repeated 3-7 times. After 72 h of incubation with tested compounds, 20 μL of MTT solution (MTT: stock solution: 5 mg/mL) was added to each well and incubated for 4 h at 37 °C. After this incubation, 80 μL of the lysis mixture was added to each well (lysis mixture: 225 mL dimethylformamide, 67.5 g sodium dodecyl sulphate, and 275 mL of distilled water). The optical densities of the samples were read after an incubation of 24 h at 570 nm.
16. Polanski J., Niedbala H., Musiol R., Podeszwa B., Tabak D., Palka A., Mencel A., Mouscadet J.-F., and Le Bret M. Lett. Drug Des. Discov. 4 (2007) 99
17. Polanski J., Niedbala H., Musiol R., Tabak D., Podeszwa B., Gieleciak R., Bak A., Palka A., and Magdziarz T. Acta Pol. Pharm., Drug Res. 61 (2004) 3