Effect of high soy diet on the cerebrovasculature and endothelial nitric oxide synthase in the ovariectomized rat

Vascular Pharmacology

Volumn 52, Issue 5-6, 2010, Pages 236-242

  Schreihofer, Derek A ^a   Deutsch, Christian ^a   Lovekamp Swan, Tara ^a   Sullivan, Jennifer C ^a   Dorrance, Anne M ^b  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Estradiol; Estrogen; Middle cerebral artery; Vasodilatation; Vasoreactivity

Indexed keywords

ACETYLCHOLINE; BRADYKININ; CAVEOLIN 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; MESSENGER RNA; NITRIC OXIDE; PHENYLEPHRINE; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD VESSEL; CELL FUNCTION; CONTROLLED STUDY; DIET; ENDOTHELIUM CELL; ENZYME ACTIVITY; FEMALE; MIDDLE CEREBRAL ARTERY; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SOYBEAN;

ANIMALS; CAVEOLIN 1; DIET; ESTRADIOL; ESTROGEN RECEPTOR BETA; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; ISOFLAVONES; MIDDLE CEREBRAL ARTERY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SOYBEANS; VASODILATION;

EID: 77950918082     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vph.2010.02.003     Document Type: Article

References (62)

1. Amantea D., Russo R., Bagetta G., and Corasaniti M.T. From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens. Pharmacol. Res. 52 2 (2005) 119-132
2. An J., Tzagarakis-Foster C., Scharschmidt T.C., Lomri N., and Leitman D.C. Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens. J. Biol. Chem. 276 21 (2001) 17808-17814
3. Bain C.A., Walters M.R., Lees K.R., and Lumsden M.A. The effect of HRT on cerebral haemodynamics and cerebral vasomotor reactivity in post-menopausal women. Hum. Reprod. 19 10 (2004) 2411-2414
4. Baluchnejadmojarad T., and Roghani M. Chronic administration of genistein improves aortic reactivity of streptozotocin-diabetic rats: mode of action. Vascul. Pharmacol. 49 1 (2008) 132-135
5. Brass L.M. Hormone replacement therapy and stroke: clinical trials review. Stroke 35 11 Suppl 1 (2004) 2644-2647
6. Briones A.M., Alonso M.J., Hernanz R., Miguel M., and Salaices M. Alterations of the nitric oxide pathway in cerebral arteries from spontaneously hypertensive rats. J. Cardiovasc. Pharmacol. 39 3 (2002) 378-388
7. Bu L., and Lephart E.D. Soy isoflavones modulate the expression of BAD and neuron-specific beta III tubulin in male rat brain. Neurosci. Lett. 385 2 (2005) 153-157
8. Burguete M.C., Torregrosa G., Perez-Asensio F.J., Castello-Ruiz M., Salom J.B., Gil J.V., and Alborch E. Dietary phytoestrogens improve stroke outcome after transient focal cerebral ischemia in rats. Eur. J. NeuroSci. 23 3 (2006) 703-710
9. Catania M.A., Crupi A., Firenzuoli F., Parisi A., Sturiale A., Squadrito F., Caputi A.P., and Calapai G. Oral administration of a soy extract improves endothelial dysfunction in ovariectomized rats. Planta Med. 68 12 (2002) 1142-1144
10. Colacurci N., Chiantera A., Fornaro F., de Novellis V., Manzella D., Arciello A., Chiantera V., Improta L., and Paolisso G. Effects of soy isoflavones on endothelial function in healthy postmenopausal women. Menopause 12 3 (2005) 299-307
11. Cuevas A.M., Irribarra V.L., Castillo O.A., Yanez M.D., and Germain A.M. Isolated soy protein improves endothelial function in postmenopausal hypercholesterolemic women. Eur. J. Clin. Nutr. 57 8 (2003) 889-894
12. Duckles S.P., and Krause D.N. Cerebrovascular effects of oestrogen: multiplicity of action. Clin. Exp. Pharmacol. Physiol. 34 8 (2007) 801-808
13. Evans M., Njike V.Y., Hoxley M., Pearson M., and Katz D.L. Effect of soy isoflavone protein and soy lecithin on endothelial function in healthy postmenopausal women. Menopause 14 1 (2007) 141-149
14. Faraci F.M. Endothelium-derived vasoactive factors and regulation of the cerebral circulation. Neurosurgery 33 4 (1993) 648-658 discussion 658-9
15. Faraci F.M., and Brian Jr. J.E. Nitric oxide and the cerebral circulation. Stroke 25 3 (1994) 692-703
16. File S.E., Hartley D.E., Alom N., and Rattray M. Soya phytoestrogens change cortical and hippocampal expression of BDNF mRNA in male rats. Neurosci. Lett. 338 2 (2003) 135-138
17. Foster J.M., Carmines P.K., and Pollock J.S. PP2B-dependent NO production in the medullary thick ascending limb during diabetes. Am. J. Physiol. Ren. Physiol. 297 2 (2009) F471-F480
18. Francisco Y.A., Dantas A.P., Carvalho M.H., and Laurindo F.R. Estrogen enhances vasoconstrictive remodeling after injury in male rabbits. Braz. J. Med. Biol. Res. 38 9 (2005) 1325-1329
19. Garcia P.M., Gimenez J., Bonacasa B., Carbonell L.F., Miguel S.G., Quesada T., and Hernandez I. 17beta-estradiol exerts a beneficial effect on coronary vascular remodeling in the early stages of hypertension in spontaneously hypertensive rats. Menopause 12 4 (2005) 453-459
20. Garcia M.P., Gimenez J., Serna M., Salom M.G., Bonacasa B., Carbonell L.F., Quesada T., and Hernandez I. Effect of estrogen and angiotensin-converting enzyme inhibitor on vascular remodeling in ovariectomized spontaneously hypertensive rats. Menopause 13 3 (2006) 397-403
21. Geary G.G., Krause D.N., and Duckles S.P. Estrogen reduces myogenic tone through a nitric oxide-dependent mechanism in rat cerebral arteries. Am. J. Physiol. 275 1 Pt 2 (1998) H292-H300
22. Geary G.G., Krause D.N., and Duckles S.P. Estrogen reduces mouse cerebral artery tone through endothelial NOS- and cyclooxygenase-dependent mechanisms. Am. J. Physiol. Heart Circ. Physiol. 279 2 (2000) H511-H519
23. Gibson C.L., Gray L.J., Murphy S.P., and Bath P.M. Estrogens and experimental ischemic stroke: a systematic review. J. Cereb. Blood Flow Metab. 26 9 (2006) 1103-1113
24. Jackman K.A., Woodman O.L., Chrissobolis S., and Sobey C.G. Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries. Brain Res. 1141 (2007) 99-107
25. Katz D.L., Evans M.A., Njike V.Y., Hoxley M.L., Nawaz H., Comerford B.P., and Sarrel P.M. Raloxifene, soy phytoestrogens and endothelial function in postmenopausal women. Climacteric 10 6 (2007) 500-507
26. Kelly J.P., Kaufman D.W., Rosenberg L., Kelley K., Cooper S.G., and Mitchell A.A. Use of postmenopausal hormone therapy since the Women's Health Initiative findings. Pharmacoepidemiol. Drug Saf. 14 12 (2005) 837-842
27. Kreijkamp-Kaspers S., Kok L., Bots M.L., Grobbee D.E., Lampe J.W., and van der Schouw Y.T. Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women. Am. J. Clin. Nutr. 81 1 (2005) 189-195
28. Kuiper G.G.J.M., Lemmen J.G., Carlsson B., Corton J.C., Safe S.H., vanderSaag P.T., vanderBurg B., and Gustafsson J.-Å. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor ß. Endocrinology 139 10 (1998) 4252-4263
29. Kurzer M.S. Phytoestrogen supplement use by women. J. Nutr. 133 6 (2003) 1983S-1986S
30. Lagaud G.J., Skarsgard P.L., Laher I., and van Breemen C. Heterogeneity of endothelium-dependent vasodilation in pressurized cerebral and small mesenteric resistance arteries of the rat. J. Pharmacol. Exp. Ther. 290 2 (1999) 832-839
31. Lephart E.D., Thompson J.M., Setchell K.D., Adlercreutz H., and Weber K.S. Phytoestrogens decrease brain calcium-binding proteins but do not alter hypothalamic androgen metabolizing enzymes in adult male rats. Brain Res. 859 1 (2000) 123-131
32. Lephart E.D., Porter J.P., Hedges D.W., Lund T.D., and Setchell K.D. Phytoestrogens: implications in neurovascular research. Curr. Neurovasc. Res. 1 5 (2004) 455-464
33. Lissin L.W., Oka R., Lakshmi S., and Cooke J.P. Isoflavones improve vascular reactivity in post-menopausal women with hypercholesterolemia. Vasc. Med. 9 1 (2004) 26-30
34. Liu W.L., Guo X., and Guo Z.G. Estrogen prevents bovine aortic endothelial cells from TNF-alpha-induced apoptosis via opposing effects on p38 and p44/42 CCDPK. Acta Pharmacol. Sin. 23 3 (2002) 213-218
35. Lovekamp-Swan T., Glendenning M., and Schreihofer D.A. A high soy diet reduces programmed cell death and enhances bcl-x(L) expression in experimental stroke. Neuroscience 148 3 (2007) 644-652
36. Lovekamp-Swan T., Glendenning M.L., and Schreihofer D.A. A high soy diet enhances neurotropin receptor and Bcl-XL gene expression in the brains of ovariectomized female rats. Brain Res. 1159 (2007) 54-66
37. Lund T.D., Rhees R.W., Setchell K.D., and Lephart E.D. Altered sexually dimorphic nucleus of the preoptic area (SDN-POA) volume in adult Long-Evans rats by dietary soy phytoestrogens. Brain Res. 914 1-2 (2001) 92-99
38. Mahn K., Borras C., Knock G.A., Taylor P., Khan I.Y., Sugden D., Poston L., Ward J.P., Sharpe R.M., Vina J., Aaronson P.I., and Mann G.E. Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo. Faseb J. 19 12 (2005) 1755-1757
39. Matthan N.R., Jalbert S.M., Ausman L.M., Kuvin J.T., Karas R.H., and Lichtenstein A.H. Effect of soy protein from differently processed products on cardiovascular disease risk factors and vascular endothelial function in hypercholesterolemic subjects. Am. J. Clin. Nutr. 85 4 (2007) 960-966
40. Nagata C., Shimizu H., Takami R., Hayashi M., Takeda N., and Yasuda K. Soy product intake and serum isoflavonoid and estradiol concentrations in relation to bone mineral density in postmenopausal Japanese women. Osteoporos. Int. 13 3 (2002) 200-204
41. Newton K.M., Buist D.S., Keenan N.L., Anderson L.A., and LaCroix A.Z. Use of alternative therapies for menopause symptoms: results of a population-based survey. Obstet. Gynecol. 100 1 (2002) 18-25
42. Pan Y., Anthony M., and Clarkson T.B. Evidence for up-regulation of brain-derived neurotrophic factor mRNA by soy phytoestrogens in the frontal cortex of retired breeder female rats. Neurosci. Lett. 261 1-2 (1999) 17-20
43. Pelligrino D.A., Ye S., Tan F., Santizo R.A., Feinstein D.L., and Wang Q. Nitric-oxide-dependent pial arteriolar dilation in the female rat: effects of chronic estrogen depletion and repletion. Biochem. Biophys. Res. Commun. 269 1 (2000) 165-171
44. Rigsby C.S., Pollock D.M., and Dorrance A.M. Spironolactone improves structure and increases tone in the cerebral vasculature of male spontaneously hypertensive stroke-prone rats. Microvasc. Res. 73 3 (2007) 198-205
45. Schreihofer D.A. Transcriptional regulation by phytoestrogens in neuronal cell lines. Mol. Cell. Endocrinol. 231 1-2 (2005) 13-22
46. Schreihofer D.A., Do K.D., and Schreihofer A.M. High-soy diet decreases infarct size after permanent middle cerebral artery occlusion in female rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289 1 (2005) R103-R108
47. Setchell K.D. Soy isoflavones-benefits and risks from nature's selective estrogen receptor modulators (SERMs). J. Am. Coll. Nutr. 20 5 Suppl (2001) 354S-362S discussion 381 S-383 S
48. Setchell K.D., Brown N.M., Desai P., Zimmer-Nechemias L., Wolfe B.E., Brashear W.T., Kirschner A.S., Cassidy A., and Heubi J.E. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J. Nutr. 131 4 Suppl (2001) 1362S-1375S
49. Sobey C.G., Weiler J.M., Boujaoude M., and Woodman O.L. Effect of short-term phytoestrogen treatment in male rats on nitric oxide-mediated responses of carotid and cerebral arteries: comparison with 17beta-estradiol. J. Pharmacol. Exp. Ther. 310 1 (2004) 135-140
50. Steinberg F.M., Guthrie N.L., Villablanca A.C., Kumar K., and Murray M.J. Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women. Am. J. Clin. Nutr. 78 1 (2003) 123-130
51. Stirone C., Duckles S.P., and Krause D.N. Multiple forms of estrogen receptor-alpha in cerebral blood vessels: regulation by estrogen. Am. J. Physiol. Endocrinol. Metab. 284 1 (2003) E184-E192
52. Stirone C., Boroujerdi A., Duckles S.P., and Krause D.N. Estrogen receptor activation of phosphoinositide-3 kinase, akt, and nitric oxide signaling in cerebral blood vessels: rapid and long-term effects. Mol. Pharmacol. 67 1 (2005) 105-113
53. Tang Y.B., Wang Q.L., Zhu B.Y., Huang H.L., and Liao D.F. Phytoestrogen genistein supplementation increases eNOS and decreases caveolin-1 expression in ovariectomized rat hearts. Sheng Li Xue Bao 57 3 (2005) 373-378
54. Thigpen J.E., Setchell K.D., Ahlmark K.B., Locklear J., Spahr T., Caviness G.F., Goelz M.F., Haseman J.K., Newbold R.R., and Forsythe D.B. Phytoestrogen content of purified, open- and closed-formula laboratory animal diets. Lab. Anim. Sci. 49 5 (1999) 530-536
55. Trujillo J., Ramirez V., Perez J., Torre-Villalvazo I., Torres N., Tovar A.R., Munoz R.M., Uribe N., Gamba G., and Bobadilla N.A. Renal protection by a soy diet in obese Zucker rats is associated with restoration of nitric oxide generation. Am. J. Physiol. Ren. Physiol. 288 1 (2005) F108-F116
56. Tsang S.Y., Yao X., Chan F.L., Wong C.M., Chen Z.Y., Laher I., and Huang Y. Estrogen and tamoxifen modulate cerebrovascular tone in ovariectomized female rats. Hypertension 44 1 (2004) 78-82
57. Turner J.V., Agatonovic-Kustrin S., and Glass B.D. Molecular aspects of phytoestrogen selective binding at estrogen receptors. J. Pharm. Sci. 96 8 (2007) 1879-1885
58. Whitten P.L., and Patisaul H.B. Cross-species and interassay comparisons of phytoestrogen action. Environ. Health Perspect. 109 Suppl 1 (2001) 5-20
59. Woodman O.L., Missen M.A., and Boujaoude M. Daidzein and 17 beta-estradiol enhance nitric oxide synthase activity associated with an increase in calmodulin and a decrease in caveolin-1. J. Cardiovasc. Pharmacol. 44 2 (2004) 155-163
60. Yuan Y., Liao L., Tulis D.A., and Xu J. Steroid receptor coactivator-3 is required for inhibition of neointima formation by estrogen. Circulation 105 22 (2002) 2653-2659
61. Zhang Y., Stewart K.G., and Davidge S.T. Estrogen replacement reduces age-associated remodeling in rat mesenteric arteries. Hypertension 36 6 (2000) 970-974
62. + channel openers in cerebral arteries from diabetic rats. Circ. Res. 81 6 (1997) 996-1004