Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound A

Journal of Biological Chemistry

Volumn 285, Issue 11, 2010, Pages 8061-8075

  Robertson, Steven ^a   Allie Reid, Fatima ^a   Vanden Berghe, Wim ^b   Visser, Koch ^a   Binder, Anke ^a   Africander, Donita ^a   Vismer, Michael ^a   De Bosscher, Karolien ^c   Hapgood, Janet ^b   Haegeman, Guy ^a   Louw, Ann ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b GHENT UNIVERSITY   (Belgium)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOCORTICOTROPIC HORMONES; AMINOTRANSFERASE; CO-IMMUNOPRECIPITATIONS; DEXAMETHASONES; FLUORESCENCE RESONANCE ENERGY TRANSFER; GLUCOCORTICOID RECEPTOR; HEPG2 CELL LINE; HORMONE LEVELS; NUCLEAR LOCALIZATION; NUCLEAR TRANSLOCATIONS; REPORTER ASSAY; TRANSACTIVATION; TRANSCRIPTIONAL REGULATION; TRANSREPRESSION; WHOLE CELL; WILD TYPES;

AMINO ACIDS; BINDING ENERGY; CELL CULTURE; DRUG PRODUCTS; ENERGY TRANSFER; FLUORESCENCE; MODULATION; PHOSPHATASES;

DIMERIZATION;

2 (4 ACETOXYPHENYL) 2 CHLORO NITRO METHYLETHYLAMMONIUM CHLORIDE; CORTICOTROPIN; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ANTAGONIST; HISTONE H3; LUTEINIZING HORMONE; TRANSCORTIN; TYROSINE AMINOTRANSFERASE; UNCLASSIFIED DRUG; ADENINE; CITRIC ACID; CPDA SOLUTIONS; DIAGNOSTIC AGENT; GLUCOCORTICOID; GLUCOSE; PHOSPHATE; SERPINA6 PROTEIN, RAT; TRITIUM;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL STRAIN HEPG2; CONTROLLED STUDY; DIMERIZATION; DRUG RECEPTOR BINDING; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE CONSTRUCT; HORMONE INHIBITION; HORMONE RECEPTOR INTERACTION; HORMONE TRANSPORT; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROMOTER REGION; RAT; TRANSACTIVATION; TRANSCRIPTION REGULATION; WILD TYPE; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION; GENETICS; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; MOUSE; MUTAGENESIS; NERVE CELL; PHYSIOLOGY; REPORTER GENE; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION INITIATION; TUMOR CELL LINE; WISTAR RAT;

RATTUS;

ADENINE; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; CITRATES; COS CELLS; DEXAMETHASONE; DIMERIZATION; GENE EXPRESSION; GENES, REPORTER; GLUCOCORTICOIDS; GLUCOSE; HUMANS; LIVER NEOPLASMS; MICE; MUTAGENESIS; NEURONS; PHOSPHATES; PROMOTER REGIONS, GENETIC; RATS; RATS, WISTAR; RECEPTORS, GLUCOCORTICOID; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCORTIN; TRANSCRIPTIONAL ACTIVATION; TRITIUM; TYROSINE TRANSAMINASE;

EID: 77950892860     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.087866     Document Type: Article

References (68)

1. Swart, P., Swart, A. C., Louw, A., and van der Merwe, K. J. (2003) Bioessays 25, 612-619
2. Louw, A., Swart, P., de Kock, S. S., and van der Merwe, K. J. (1997) Biochem. Pharmacol. 53, 189-197
3. Louw, A., Allie, F., Swart, A. C., and Swart, P. (2000) Endocr. Res. 26, 729-736
4. Louw, A., Swart, P., and Allie, F. (2000) Biochem. Pharmacol. 59, 167-175
5. Louw, A., and Swart, P. (1999) Endocrinology 140, 2044-2053
6. De Bosscher, K., Vanden Berghe, W., Beck, I. M., Van Molle, W., Hennuyer, N., Hapgood, J., Libert, C., Staels, B., Louw, A., and Haegeman, G. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 15827-15832
7. Beato, M., Truss, M., and Chávez, S. (1996) Ann. N.Y. Acad. Sci. 784, 93-123
8. Beato, M., and Klug, J. (2000) Hum. Reprod. Update 6, 225-236
9. Newton, R. (2000) Thorax 55, 603-613
10. De Bosscher, K., Vanden Berghe, W., and Haegeman, G. (2003) Endocr. Rev. 24, 488-522
11. Zhou, J., and Cidlowski, J. A. (2005) Steroids 70, 407-417
12. Adcock, I. M. (2000) Pulm. Pharmacol. Ther. 13, 115-126
13. McEwan, I. J., Wright, A. P., and Gustafsson, J. A. (1997) Bioessays 19, 153-160
14. Webster, J. C., and Cidlowski, J. A. (1999) Trends Endocrinol. Metab. 10, 396-402
15. Hayashi, R., Wada, H., Ito, K., and Adcock, I. M. (2004) Eur. J. Pharmacol. 500, 51-62
16. Reichardt, H. M., Tuckermann, J. P., Göttlicher, M., Vujic, M., Weih, F., Angel, P., Herrlich, P., and Schütz, G. (2001) EMBO J. 20, 7168-7173
17. Underhill, D. A., and Hammond, G. L. (1995) Gene 162, 205-211
18. Chandran, U. R., Warren, B. S., Baumann, C. T., Hager, G. L., and DeFranco, D. B. (1999) J. Biol. Chem. 274, 2372-2378
19. Therrien, M., and Drouin, J. (1993) Mol. Cell. Biol. 13, 2342-2353
20. Miesfeld, R., Rusconi, S., Godowski, P. J., Maler, B. A., Okret, S., Wikström, A. C., Gustafsson, J. A., and Yamamoto, K. R. (1986) Cell 46, 389-399
21. Schaaf, M. J., and Cidlowski, J. A. (2003) Mol. Cell. Biol. 23, 1922-1934
22. Waddell, D. S., Baehr, L. M., van den Brandt, J., Johnsen, S. A., Reichardt, H. M., Furlow, J. D., and Bodine, S. C. (2008) Am. J. Physiol. Endocrinol. Metab. 295, E785-E797
23. Savory, J. G., Préfontaine, G. G., Lamprecht, C., Liao, M., Walther, R. F., Lefebvre, Y. A., and Haché, R. J. (2001) Mol. Cell. Biol. 21, 781-793
24. Harnish, D. C., Scicchitano, M. S., Adelman, S. J., Lyttle, C. R., and Karathanasis, S. K. (2000) Endocrinology 141, 3403-3411
25. Kastner, P., Bocquel, M. T., Turcotte, B., Garnier, J. M., Horwitz, K. B., Chambon, P., and Gronemeyer, H. (1990) J. Biol. Chem. 265, 12163-12167
26. Brinkmann, A. O., Faber, P. W., van Rooij, H. C., Kuiper, G. G., Ris, C., Klaassen, P., van der Korput, J. A., Voorhorst, M. M., van Laar, J. H., and Mulder, E. (1989) J. Steroid Biochem. 34, 307-310
27. De Bosscher, K., Vanden Berghe, W., Vermeulen, L., Plaisance, S., Boone, E., and Haegeman, G. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 3919-3924
28. Dewint, P., Gossye, V., De Bosscher, K., Vanden Berghe, W., Van Beneden, K., Deforce, D., Van Calenbergh, S., Müller-Ladner, U., Vander Cruyssen, B., Verbruggen, G., Haegeman, G., and Elewaut, D. (2008) J. Immunol. 180, 2608-2615
29. Sui, X., Bramlett, K. S., Jorge, M. C., Swanson, D. A., von Eschenbach, A. C., and Jenster, G. (1999) J. Biol. Chem. 274, 9449-9454
30. Weatherman, R. V., Chang, C. Y., Clegg, N. J., Carroll, D. C., Day, R. N., Baxter, J. D., McDonnell, D. P., Scanlan, T. S., and Schaufele, F. (2002) Mol. Endocrinol. 16, 487-496
31. Vanden Berghe, W., Plaisance, S., Boone, E., De Bosscher, K., Schmitz, M. L., Fiers, W., and Haegeman, G. (1998) J. Biol. Chem. 273, 3285-3290
32. Ronacher, K., Hadley, K., Avenant, C., Stubsrud, E., Simons, S. S., Jr., Louw, A., and Hapgood, J. P. (2009) Mol. Cell. Endocrinol. 299, 219-231
33. Sadie, H., Styger, G., and Hapgood, J. (2003) Endocrinology 144, 1958-1971
34. Diamondstone, T. I. (1966) Anal. Biochem. 16, 395-401
35. Trón, L., Szöllósi, J., Damjanovich, S., Helliwell, S. H., Arndt-Jovin, D. J., and Jovin, T. M. (1984) Biophys. J. 45, 939-946
36. Drouin, J., Trifiro, M. A., Plante, R. K., Nemer, M., Eriksson, P., and Wrange, O. (1989) Mol. Cell. Biol. 9, 5305-5314
37. Adelman, J. P., Mason, A. J., Hayflick, J. S., and Seeburg, P. H. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 179-183
38. Coghlan, M. J., Jacobson, P. B., Lane, B., Nakane, M., Lin, C. W., Elmore, S. W., Kym, P. R., Luly, J. R., Carter, G. W., Turner, R., Tyree, C. M., Hu, J., Elgort, M., Rosen, J., and Miner, J. N. (2003) Mol. Endocrinol. 17, 860-869
39. Schäcke, H., Döcke, W. D., and Asadullah, K. (2002) Pharmacol. Ther. 96, 23-43
40. Savory, J. G., Hsu, B., Laquian, I. R., Giffin, W., Reich, T., Haché, R. J., and Lefebvre, Y. A. (1999) Mol. Cell. Biol. 19, 1025-1037
41. Neubig, R. R., Spedding, M., Kenakin, T., and Christopoulos, A. (2003) Pharmacol. Rev. 55, 597-606
42. Verrijdt, G., Haelens, A., Schoenmakers, E., Rombauts, W., and Claessens, F. (2002) Biochem. J. 361, 97-103
43. Barnes, P. J. (2006) Eur. J. Pharmacol. 533, 2-14
44. Schäcke, H., and Rehwinkel, H. (2004) Curr. Opin. Investig. Drugs 5, 524-528
45. Barnes, P. J. (2006) Eur. Respir. J. 27, 413-426
46. Schäcke, H., Schottelius, A., Döcke, W. D., Strehlke, P., Jaroch, S., Schmees, N., Rehwinkel, H., Hennekes, H., and Asadullah, K. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 227-232
47. Black, P. H., and Garbutt, L. D. (2002) J. Psychosom. Res. 52, 1-23
48. Beishuizen, A., Thijs, L. G., and Vermes, I. (2001) Intensive Care Med. 27, 1584-1591
49. Ingenbleek, Y., and Bernstein, L. (1999) Nutrition 15, 305-320
50. Rigaud, G., Roux, J., Pictet, R., and Grange, T. (1991) Cell 67, 977-986
51. Yemelyanov, A., Czwornog, J., Gera, L., Joshi, S., Chatterton, R. T., Jr., and Budunova, I. (2008) Cancer Res. 68, 4763-4773
52. Reichardt, H. M., Tuckermann, J. P., Bauer, A., and Schütz, G. (2000) Z. Rheumatol. 59, Suppl. 2, II/1-II/5
53. Schoneveld, O. J., Gaemers, I. C., and Lamers, W. H. (2004) Biochim. Biophys. Acta 1680, 114-128
54. De Bosscher, K., and Haegeman, G. (2009) Mol. Endocrinol. 23, 281-291
55. Schäcke, H., Hennekes, H., Schottelius, A., Jaroch, S., Lehmann, M., Schmees, N., Rehwinkel, H., and Asadullah, K. (2002) Ernst. Schering. Res. Found. Workshop 357-371
56. Deak, T., Meriwether, J. L., Fleshner, M., Spencer, R. L., Abouhamze, A., Moldawer, L. L., Grahn, R. E., Watkins, L. R., and Maier, S. F. (1997) Am. J. Physiol. Regul. Integr. Comp. Physiol. 273, R1998-R2004
57. Smith, C. L., and Hammond, G. L. (1992) Endocrinology 130, 2245-2251
58. Martens, C., Bilodeau, S., Maira, M., Gauthier, Y., and Drouin, J. (2005) Mol. Endocrinol. 19, 885-897
59. Bilodeau, S., Vallette-Kasic, S., Gauthier, Y., Figarella-Branger, D., Brue, T., Berthelet, F., Lacroix, A., Batista, D., Stratakis, C., Hanson, J., Meij, B., and Drouin, J. (2006) Genes Dev. 20, 2871-2886
60. Tanner, T. M., Verrijdt, G., Rombauts, W., Louw, A., Hapgood, J. P., and Claessens, F. (2003) Mol. Cell. Endocrinol. 201, 155-164
61. Jacobsen, B. M., Jambal, P., Schittone, S. A., and Horwitz, K. B. (2009) Mol. Endocrinol. 23, 989-1000
62. So, A. Y., Cooper, S. B., Feldman, B. J., Manuchehri, M., and Yamamoto, K. R. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 5745-5749
63. So, A. Y., Chaivorapol, C., Bolton, E. C., Li, H., and Yamamoto, K. R. (2007) PLoS Genet. 3, e94
64. Radoja, N., Komine, M., Jho, S. H., Blumenberg, M., and Tomic-Canic, M. (2000) Mol. Cell. Biol. 20, 4328-4339
65. Stöcklin, E., Wissler, M., Gouilleux, F., and Groner, B. (1996) Nature 383, 726-728
66. Zhang, Z., Zhang, Z. Y., and Schluesener, H. J. (2009) J. Immunol. 183, 3081-3091
67. Carrigan, A., Walther, R. F., Salem, H. A., Wu, D., Atlas, E., Lefebvre, Y. A., and Haché, R. J. G. (2007) J. Biol. Chem. 282, 10963-10971
68. Cheng, Y., and Prusoff, W. H. (1973) Biochem. Pharmacol. 22, 3099-3108