Mechanism for the stabilization in vivo of the aziridine precursor 2-(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride by serum proteins

Biochemical Pharmacology

Volumn 53, Issue 2, 1997, Pages 189-197

  Louw, Ann ^a   Swart, Pieter ^a   De Kock, Schalk S ^a   Van Der Merwe, Kirsten J ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

adrenal steroidogenesis; aziridines; corticosteroid binding globulin; oestrus cycle; P450c11; rats; Salsola tuberculatiformis Botsch.; sex hormone binding globulin

Indexed keywords

2 (4 ACETOXYPHENYL) 2 CHLORO N METHYLETHYLAMMONIUM CHLORIDE; CYTOCHROME P450 ISOENZYME; QUATERNARY AMMONIUM DERIVATIVE; SEX HORMONE BINDING GLOBULIN; TRANSCORTIN; UNCLASSIFIED DRUG;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTRACEPTION; CONTROLLED STUDY; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; ENZYME INHIBITION; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; MASS SPECTROMETRY; NONHUMAN; ORAL DRUG ADMINISTRATION; PLASMA; PRIORITY JOURNAL; PROTEIN BINDING; RAT; SHEEP;

ACETATES; ALDOSTERONE SYNTHASE; ANIMALS; BLOOD PROTEINS; CONTRACEPTIVES, ORAL; DESOXYCORTICOSTERONE; DRUG STABILITY; ETHYLAMINES; FEMALE; MASS SPECTROMETRY; RATS; RATS, WISTAR; SEX HORMONE-BINDING GLOBULIN; TRANSCORTIN;

EID: 0031012174     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00661-2     Document Type: Article

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