Glucocorticoid receptor homodimers and glucocorticoid-mineralocorticoid receptor heterodimers form in the cytoplasm through alternative dimerization interfaces

Molecular and Cellular Biology

Volumn 21, Issue 3, 2001, Pages 781-793

  Savory, J G A ^a   Prefontaine G G ^a   Lamprecht, C ^a   Liao, M ^a   Walther, R F ^a   Lefebvre, Y A ^a   Hache R J G ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR; STEROID RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOPLASM; DIMERIZATION; DNA RESPONSIVE ELEMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PROTEIN INTERACTION; SOLVATION; TRANSCRIPTION REGULATION;

ANIMALS; BINDING SITES; CELL LINE; CELL NUCLEUS; COS CELLS; CYTOPLASM; DIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; RATS; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; RECOMBINANT FUSION PROTEINS; SOLUTIONS; TWO-HYBRID SYSTEM TECHNIQUES;

ANIMALIA;

EID: 0035135217     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.3.781-793.2001     Document Type: Article

References (68)

1. Steroid hormone receptors: Many actors in search of a plot
2. 11-beta-hydroxysteroid dehydrogenases: Tissue-specific dictators of glucocorticoid action
3. AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor
4. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha
5. Molecular basis of agonism and antagonism in the oestrogen receptor
6. Androgen and glucocorticoid receptor heterodimer formation. A possible mechanism for mutual inhibition of transcriptional activity
7. Ligand- and DNA-induced dissociation of RXR tetramers
8. Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha
9. RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1
10. Protein-protein interactions facilitate DNA binding by the glucocorticoid receptor DNA-binding domain
11. Interaction of the glucocorticoid receptor DNA-binding domain with DNA as a dimer is mediated by a short segment of five amino acids
12. Determinants of high-affinity DNA binding by the glucocorticoid receptor: Evaluation of receptor domains outside the DNA-binding domain
13. Nucleocytoplasmic shuttling of steroid receptors
14. Brain corticosteroid receptor balance in health and disease
15. Dimerization of mammalian progesterone receptors occurs in the absence of DNA and is related to the release of the 90-kDa heat shock protein
16. Translation of glucocorticoid receptor mRNA in vitro yields a nonactivated protein
17. Homodimer formation is rate-limiting for high affinity DNA binding by glucocorticoid receptor
18. Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor
19. In vitro transcription enhancement by purified derivatives of the glucocorticoid receptor
20. Glucocorticoid and mineralocorticoid receptors: Biology and clinical relevance
21. Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix
22. Genetic dissection of the signaling domain of a mammalian steroid receptor in yeast
23. Mechanisms of nuclear localization of the progesterone receptor: Evidence for interaction between monomers
24. Nucleocytoplasmic trafficking of steroid-free glucocorticoid receptor
25. Specific hydroxylations determine selective corticosteroid recognition by human glucocorticoid and mineralocorticoid receptors
26. Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins
27. Steroid hormones and excitability in the mammalian brain
28. Long-term exposure to high corticosterone levels attenuates serotonin responses in rat hippocampal CA1 neurons
29. Effect of long-term elevated corticosteroid levels on field responses to synaptic stimulation, in the rat CA1 hippocampal area
30. Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor
31. The type I and type II 11beta-hydroxysteroid dehydrogenase enzymes
32. Evidence for an antiparallel orientation of the ligand-activated human androgen receptor dimer
33. Molybdate inhibition of glucocorticoid receptor inactivation and transformation
34. Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions
35. Formation of retinoid X receptor homodimers leads to repression of T3 response: Hormonal cross talk by ligand-induced squelching
36. Physical measurements of the liver glucocorticoid receptor
37. Steroid receptor heterodimerization demonstrated in vitro and in vivo
38. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
39. The RXR heterodimers and orphan receptors
40. The nuclear receptor superfamily: The second decade
41. Demonstration by confocal microscopy that unliganded overexpressed glucocorticoid receptors are distributed in a nonrandom manner throughout all planes of the nucleus
42. The nuclear receptor ligand-binding domain: Structure and function
43. The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action
44. FTZ-F1 beta, a novel member of the Drosophila nuclear receptor family
45. Steroid receptor interactions with heat shock protein and immunophilin chaperones
46. Recruitment of octamer transcription factors to DNA by glucocorticoid receptor
47. Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor
48. Determinants of subcellular distribution of the glucocorticoid receptor
49. Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90
50. Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor
51. Mammalian glucocorticoid receptor derivatives enhance transcription in yeast
52. High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier
53. Glucocorticosteroid receptor dimerization investigated by analysis of receptor binding to glucocorticosteroid responsive elements using a monomer-dimer equilibrium model
54. A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
55. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains
56. A role for HDJ-2/HSDJ in correcting subnuclear trafficking, transactivation, and transrepression defects of a glucocorticoid receptor zinc finger mutant
57. Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo
58. Hinge and amino-terminal sequences contribute to solution dimerization of human progesterone receptor
59. Heterodimerization between mineralocorticoid and glucocorticoid receptor: A new principle of glucocorticoid action in the CNS
60. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
61. Functional interaction of hybrid response elements with wild-type and mutant steroid hormone receptors
62. Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation
63. Partial colocalization of glucocorticoid and mineralocorticoid receptors in discrete compartments in nuclei of rat hippocampus neurons
64. Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding
65. Atomic structure of progesterone complexed with its receptor
66. The purified activated glucocorticoid receptor is a homodimer
67. Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors