The human α11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-β1 in a Smad- and Sp1-dependent manner

Matrix Biology

Volumn 29, Issue 3, 2010, Pages 166-176

  Lu, Ning ^a   Carracedo, Sergio ^a   Ranta, Jonna ^b   Heuchel, Rainer ^c   Soininen, Raija ^b   Gullberg, Donald ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b UNIVERSITY OF OULU   (Finland)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Ectomesenchyme; Fibroblast specific; Integrin 11; ITGA11 promoter; LacZ reporter; Smad; Sp1; TGF ; Transgenic mice

Indexed keywords

ALPHA11 INTEGRIN; BETA GALACTOSIDASE; INTEGRIN; RNA; SMAD PROTEIN; SMAD2 PROTEIN; SMAD7 PROTEIN; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; ALPHA INTEGRIN; ITGA11 PROTEIN, HUMAN;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; ANIMAL; CHEMISTRY; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

MUS MUSCULUS;

ANIMALS; CELL LINE, TUMOR; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FIBROBLASTS; HUMANS; INTEGRIN ALPHA CHAINS; MICE; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SMAD PROTEINS; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77950860603     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.matbio.2009.11.003     Document Type: Article

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