Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa

British Journal of Cancer

Volumn 102, Issue 8, 2010, Pages 1254-1264

  De Bruijn, M T ^a   Raats, D A E ^a   Hoogwater, F J H ^a   Van Houdt, W J ^a   Cameron, K ^b   Medema, J P ^b   Borel Rinkes, I H M ^a   Kranenburg, O ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

5 fluorouracil; Colorectal; KRAS; Noxa; Oxaliplatin; P53

Indexed keywords

FLUOROURACIL; OXALIPLATIN; PROTEIN NOXA; PROTEIN P21; PROTEIN P53; SHORT HAIRPIN RNA;

APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL CYCLE; CELL CYCLE ARREST; CELLULAR DISTRIBUTION; COLORECTAL CANCER; COLORECTAL TUMOR; CONSERVATIVE TREATMENT; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOSIS; ONCOGENE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH; VIRUS EXPRESSION; XENOGRAFT;

ANIMALS; APOPTOSIS; CELL CYCLE; COLORECTAL NEOPLASMS; FLUOROURACIL; GENES, P53; GENES, RAS; HCT116 CELLS; HUMANS; MALE; MICE; ORGANOPLATINUM COMPOUNDS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77950858034     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605633     Document Type: Article

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