Interaction between serotonin 5-HT2A receptor gene and dopamine transporter (DAT1) gene polymorphisms influences personality trait of persistence in Austrian Caucasians

World Journal of Biological Psychiatry

Volumn 11, Issue 2 PART 2, 2010, Pages 417-424

  Schosser, Alexandra ^a   Fuchs, Karoline ^a   Scharl, Theresa ^b   Schloegelhofer, Monika ^a   Kindler, Jochen ^a   Mossaheb, Nilufar ^a   Kaufmann, Rainer M ^a   Leisch, Friedrich ^c   Kasper, Siegfried ^a   Sieghart, Werner ^a   Aschauer, Harald N ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

5HT2A; DAT1; DRD3; Personality; TCI

Indexed keywords

DOPAMINE 3 RECEPTOR; DOPAMINE TRANSPORTER; SEROTONIN 2A RECEPTOR;

ADULT; ARTICLE; AUSTRIA; CAUCASIAN; DNA POLYMORPHISM; EXON; FEMALE; GENE AMPLIFICATION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MALE; NORMAL HUMAN; PERSISTENT PERSONALITY; PERSONALITY; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; TEMPERAMENT; VARIABLE NUMBER OF TANDEM REPEAT;

ADULT; ALLELES; AUSTRIA; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; EUROPEAN CONTINENTAL ANCESTRY GROUP; EXPLORATORY BEHAVIOR; FEMALE; GENOTYPE; HARM REDUCTION; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MALE; MINISATELLITE REPEATS; PERSONALITY; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, DOPAMINE D3; SEX FACTORS; STATISTICS, NONPARAMETRIC;

EID: 77950845391     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622970801935586     Document Type: Article

References (54)

1. Bannon MJ, Michelhaugh SK, Wang J, Sacchetti P. 2001. The human dopamine transporter gene: gene organization, transcriptional regulation, and potential involvement in neuropsychiatric disorders. Eur Neuropsychopharmacol 11:449-455.
2. Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH. 1996. Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking. Nat Genet 12:81-84.
3. Bouchard TJJ. 1994. Genes, environment, and personality. Science 264:1700-1701.
4. Cloninger CR, Svrakic DM, Przybeck TR. 1993. A psychobiological model of temperament and character. Arch Gen Psychiatry 50:975-990.
5. Czermak C, Lehofer M, Renger H, Wagner EM, Lemonis L, Rohrhofer A, et al. 2004. Dopamine receptor D3 mRNA expression in human lymphocytes is negatively correlated with the personality trait of persistence. J Neuroimmunol 150:145-149.
6. Doucette-Stamm LA, Blakely DJ, Tian J, Mockus S, Mao JI. 1995. Population genetic study of the human dopamine transporter gene (DAT1). Genet Epidemiol 12:303-308.
7. Du L, Bakish D, Lapierre YD, Ravindran AV, Hrdina PD. 2000. Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. Am J Med Genet 96:56-60.
8. Duaux E, Gorwood P, Griffon N, Bourdel M-C, Sautel F, Sokoloff P, et al. 1998. Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence. Mol Psychiatry 3:33-336.
9. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blaine D, et al. 1996. Dopamine D4 receptor (DRD4) exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet 12:78-80.
10. Ebstein RP, Segman R, Benjamin J, Osher Y, Nemanov L, Belmaker RH. 1997. 5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms. Am J Med Genet 74:65-72.
11. Eley TC, Sugden K, Corsico A, Gregory AM, Sham P, McGuffin P, et al. 2004. Gene-environment interaction analysis of serotonin system markers with adolescent depression. Mol Psychiatry 9:908-915.
12. Gebhardt C, Leisch F, Schussler P, Fuchs K, Stompe T, Sieghart W, et al. 2000. Non-association of dopamine D4 and D2 receptor genes with personality in healthy individuals. Psychiatr Genet 10:131-137.
13. Geijer T, Frisch A, Persson ML, Wasserman D, Rockah R, Michaelovsky E, et al. 2000. Search for association between suicide attempt and serotonergic polymorphisms. Psychiatr Genet 10:19-26.
14. Gelernter J, Kranzler H, Lacobelle J. 1998. Population studies of polymorphisms at loci of neuropsychiatric interest (tryptophan hydroxylase (TPH), dopamine transporter protein (SLC6A3), D3 dopamine receptor (DRD3), apolipoprotein E (APOE), mu opioid receptor (OPRMI), and ciliary neurotrophic factor (CNTF). Genomics 52:289-297.
15. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG. 1996. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379:606-612.
16. Greenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, et al. 2000. Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet 96:202-216.
17. Heath AC, Cloninger CR, Martin NG. 1994. Testing a model for the genetic structure of personality: A comparison of the personality systems of Cloninger and Eysenck. J Pers Soc Psychol 66:762-775.
18. Henderson AS, Korten AE, Jorm AF, Jacomb PA, Christensen H, Rodgers B, et al. 2000. COMT and DRD3 polymorphisms, environmental exposures, and personality traits related to common mental disorders. Am J Med Genet 96:102-107.
19. Jönsson EG, Burgert E, Crocq MA, Gustavsson JP, Forslund K, Mattila-Evenden M, et al. 2003. Association study between dopamine D3 receptor gene variant and personality traits. Am J Med Gent 117B:61-65. (Pubitemid 37059362)
20. Jorm AF, Henderson AS, Jacomb PA, Christensen H, Korten AE, Rodgers B, et al. 2000. Association of smoking and personality with a polymorphism of the dopamine transporter gene: results from a community survey. Am J Med Genet 96:331-334. (Pubitemid 30390128)
21. Joyce PR, McHugh PC, McKenzie JM, Sullivan PF, Mulder RT, Luty SE, et al. 2006. A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients. Psychol Med 36:807-813.
22. Kelsoe JR, Sadovnick AD, Kristbjarnarson H, Bergesch P, Mroczkowski-Parker Z, Drennan M, et al. 1996. Possible locus for bipolar disorder near the dopamine transporter on chromosome 5. Am J Medl Genet 67:533-540.
23. Kim SJ, Kim YS, Lee HS, Kim SY, Kim C-H. 2006. An interaction between the serotonin transporter promoter region and dopamine transporter polymorphisms contributes to harm avoidance and reward dependence traits in normal healthy subjects. J Neural Transm 113:877-886.
24. Kim DJ, Park BL, Yoon S, Lee H-K, Joe K-H, Cheon Y-H, et al. 2007. 5UTR polymorphism of dopamine receptor D1 (DRD1) associated with severity and temperament of alcoholism. Biochem Biophys Res Commun 357:1135-1141. (Pubitemid 46722580)
25. Koob GF, Riley SJ, Smith SC, Robbins TW. 1978. Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity, and amphetamine anorexia in the rat. J Comp Physiol Psychol 92:917- 927.
26. Kusumi I, Koyama T, Yamashita I. 1991. Serotonin-stimulated Ca2- response is increased in the blood platelets of depressed patients. Biol Psychiatry 30:310-312.
27. Kusumi I, Koyama T, Yamashita I. 1994. Serotonin-induced platelet intracellular calcium mobilization in depressed patients. Psychopharmacology (Berlin) 113:322-327. (Pubitemid 24150475)
28. Kusumi I, Suziki K, Sasaki Y, Kameda K, Sasaki T, Koyama T. 2002. Serotonin 5-HT2A receptor gene polymorphism, 5-HT2A receptor function and personality traits in healthy subjects: a negative study. J Affect Disord 68:235-241. (Pubitemid 34628330)
29. Lander ES, Schorck RJ. 1994. Genetic dissection of complex traits. Science 365:2037-2048.
30. Lannfelt L, Sokoloff P, Martres M, Pilon C, Giros B, Jonsson E, et al. 1992. Amino-acid substitution in the dopamine D3 receptor as a useful polymorphism for investigating psychiatric disorders. Psychiatr Genet 2:249-256.
31. Lerer B, Segman RH, Fangerau H, Daly AK, Basile VS, Cavallaro R, et al. 2002. Pharmacogenetics of tardive dyskinesia: Combined analysis of 780 patients supports association with dopamine D3 receptor gene Ser9Gly polymorphism. Neuropsychopharmacology 27:105-119. (Pubitemid 34626747)
32. Lerer B, Segman RH, Tan EC, Basile VS, Cavallaro R, Aschauer HN, et al. 2005. Combined analysis of 635 patients confirms an age-related association of the serotonin 2A receptor gene with tardive dyskinesia and specificity for the non-orofacial subtype. Int J Neuropsychopharmacol 8:411-425. (Pubitemid 41002495)
33. Lorenzo CV, Baca-Garcia E, Diaz-Hernandez M, Botillo-Martin C, Perez-Rodriguez M, Fernandez-Ramos C. 2006. Association between the T102C polymorphism of the serotonin-2A receptor gene and schizophrenia. Prog Neuro-Psychopharmacol Biol Psychiatry 30:1136-1138. (Pubitemid 44202367)
34. Meszaros K, Lenzinger E, Hornik K, Fureder T, Stompe T, Willinger U. 2000. Assoziation study of schizophrenia spectrum disorders and dopamine D3 receptor gene: is schizoaffective disorder special? Psychiatry Res 96:179-183.
35. Mill J, Asherson P, Browes C, D'Souza U, Craig I. 2002. Expression of the dopamine transporter gene is regulated by the 3-UTR VNTR: evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet 114:975-979.
36. Nilsson KW, Damberg M, .Ö hrvik J, Leppert J, Lindström L, Anckarsäter H, et al. 2007. Genes encoding for AP-2ß and the serotonin transporter are associated with the personality character spiritual acceptance. Neurosci Lett 411:233-237. (Pubitemid 44828284)
37. Noble EP, Ozkaragoz TZ, Ritchie TL, Zhang X, Belin TR, Sparkes RS. 1998. D2 and D4 dopamine receptor polymorphisms and personality. Am J Med Genet 81:257-267.
38. R Development Core Team. 2007. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-00-3, URL: http://www.R-project.org.
39. Rhule-Louie DM, McMahon RJ. 2007. Problem behavior and romantic relationships: assortative mating, behavior contagion, and desistance. Clin Child Fam Psychol Rev 10:53-100.
40. Sabol SZ, Nelson ML, Fisher C, Gunzerath L, Brody CL, Hu S, et al. 1999. A genetic association for cigarette smoking behavior. Health Psychol 18:7-13. (Pubitemid 29047354)
41. Samochowiec J, Rybakowski F, Czerski P, Zakrzewska M, Stepien G, Pelka-Wysiecka J, et al. 2001. Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers. Neuropsychobiology 43:248-253. (Pubitemid 32467698)
42. Serretti A, Macciardi F, Cusin C, Lattuada E, Souery D, Lipp O, et al. 2000. Linkage of mood disorders with D2, D3 and TH genes: a multicenter study. J Affect Disord 58:51-61. (Pubitemid 30173211)
43. Spurlock G, Williams J, McGuffin P, Aschauer HN, Lenzinger E, Fuchs K, et al. 1998. European Multicentre Association Study of Schizophrenia: A study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms. Am J Med Genet (Neuropsychiatr Genet) 81:24-28.
44. Stallings MC, Hewitt JK, Cloninger CR, Heath AC. 1996. Genetic and environmental structure of the tridimensional personality questionnaire: Three or four temperament dimensions? J Pers Soc Psychol 70:127-140.
45. Staner L, Hilger C, Hentges F, Monreal J, Hoffmann A, Couturier M, et al. 1998. Association between novelty-seeking and the dopamine D3 receptor gene in bipolar patients: a preliminary report. Am J Med Genet 81:192-194.
46. Sullivan PF, Fifield WJ, Kennedy MA, Mulder RT, Sellman JD, Joyce PR. 1997. Novelty seeking and a dopamine transporter gene polymorphism (DAT1). Biol Psychiatry 42:1070-1072.
47. Thapar A, Holmes J, Poulton K, Harrington R. 1999. Genetic basis of attention deficit and hyperactivity. Br J Psychiatry 174:105-111.
48. Thierry N, Willeit M, Praschak-Rieder N, Zill P, Hornik K, Neumeister A, et al. 2004. Serotonin transporter promoter gene polymorphic region (5-HTTLPR) and personality in female patients with seasonal affective disorder and in healthy controls. Eur Neuropsychopharmacol 14:53-58.
49. Thome J, Weijers H-G, Wiesbeck GA, Sian J, Nara K, Bönig J, et al. 1999. Dopamine D3 receptor gene polymorphism and alcohol dependence: relation to personality rating. Psychiatr Genet 9:17-21.
50. Turecki G, Sequeira A, Gingras Y, Seguin M, Lesage A, Tousignant M, et al. 2003. Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers. Am J Med Genet 118B:36-40.
51. Wiesbeck GA, Weijers HG, Wodarz N, Keller HK, Michel TM, Hermann MJ, et al. 2004. Serotonin transporter gene polymorphism and personality traits in primary alcohol dependence. World J Biol Psychiatry 5:45-48.
52. Williams J, Spurlock G, McGuffin P, Mallet J, Nöthen MM, Gill M, et al. 1996. Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. European Multicentre Association Study of Schizophrenia (EMASS) Group. Lancet 347:1294-1296.
53. Williams J, Spurlock G, Holmans P, Mant R, Murphy K, Jones L, et al. 1998. A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia. Mol Psychiatry 3:141-149. (Pubitemid 28149555)
54. Yang B, Chan RC, Jing J, Li T, Sham P, Chen RY. 2007. A metaanalysis of association studies between the 10 repeat allele of a VNTR polymorphism in the 3 UTR of dopamine transporter gene and attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 144(4):541-550.