Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence

Molecular Psychiatry

Volumn 3, Issue 4, 1998, Pages 333-336

  Duaux, E ^a   Gorwood, P ^b   Griffon, N ^c   Bourdel, M C ^a   Sautel, F ^c   Sokoloff, P ^c   Schwartz, J C ^c   Ades, J ^b   Loo H ^a   Poirier, M F ^a  

^a CENTRE HOSPITALIER SAINTE ANNE   (France)

^b HÔPITAL LOUIS MOURIER   (France)

^c CENTRE PAUL BROCA   (France)

Author keywords

Association study; Drug dependence; Impulsiveness; Sensation seeking

Indexed keywords

DOPAMINE 3 RECEPTOR; DOPAMINE 2 RECEPTOR; DRD3 PROTEIN, HUMAN; ENDODEOXYRIBONUCLEASE BALI; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE;

ADULT; ARTICLE; CONTROLLED STUDY; GENETIC POLYMORPHISM; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; NORMAL HUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; RECEPTOR GENE; FRANCE; GENETICS; HOMOZYGOTE; MALE; MORBIDITY; PERSONALITY; POLYMERASE CHAIN REACTION; REFERENCE VALUE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; FRANCE; GENOTYPE; HOMOZYGOTE; HUMANS; MALE; MORBIDITY; OPIOID-RELATED DISORDERS; PERSONALITY; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; REFERENCE VALUES;

EID: 7344262909     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000409     Document Type: Article

References (32)

1. Rounsaville BJ, Kosten TR, Weissman MMPB, Pauls D, Anton SF, Merikangas K. Psychiatric disorders in the relatives of probands with opiate addiction. Arch Gen Psychiatry 1991; 488: 33-42.
2. Pickens RW, Svikis DS. Genetic influences in human substance abuse. Arch Gen Psychiatry 1991; 10: 202-213.
3. Cadoret RJ, Yates WR, Troughton E, Woodworth G, Stewart MA. Adoption studies demonstrating two genetic pathways to drug abuse. Arch Gen Psychiatry 1995; 52: 42-52.
4. Di Chiara G, Imperato A. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 1988; 85: 5274-5278.
5. 3) as a target for neuroleptics. Nature 1990; 347: 146-151.
6. 3 receptor functional test in vitro predicts potencies of dopamine agonists to reduce cocaine self-administration. Neuroreport 1997; 8: 2373-2377.
7. 3 agonist 7-OH-DPAT in rhesus monkeys is modified by prior cocaine exposure. Neuropsychopharmacology 1996; 125: 12-22.
8. 3 receptor agonists partially reproduce the discriminative stimulus effects of cocaine in squirrel monkeys. J Pharmacol Exp Ther 1996; 278: 1128-1137.
9. 3 receptor as a mechanism of behavioral sensitization to levodopa. Proc Natl Acad Sci USA 1997; 94: 3363-3367.
10. 3 dopamine receptors in the brain reward circuits of human cocaine fatalities. J. Neurosci 1996; 16: 6100-6106.
11. 3 dopamine receptor mRNA in the nucleus accumbens of human cocaine fatalities. Mol Brain Res 1997; 45: 335-339.
12. Zückerman M, Link K. Construct, validity of the sensation seeking scale. J Consult Clin Psychol 1968; 32: 420-426.
13. 3 receptor as a useful polymorphism for investigating psychiatric disorders. Psychiatric Genet 1992; 2: 249-256.
14. Dubertret C, Gorwood P, Ades J, Feingold J, Schwartz JC, Sokoloff P. A meta-analysis of DRD3 gene and schizophrenia: ethnic heterogeneity and significant association in Caucasians. Am J Med Genet (Neuropsych Genet) (in press).
15. 3 dopamine receptor (DRD3) alleles and cocaine dependence. Addiction Biol 1996; 1: 281-287.
16. Palmer MS, Dryden AJ, Hughes JT, Collinge J. Homozygous prion protein genotype predisposes to sporadic Creutfeldt-Jakob disease. Nature 1991; 352: 340-342.
17. Kilpatrick DG, Sutker PB, Smith AD. Deviant drug and alcohol use: the role of anxiety, sensation seeking and other personality variables. In: Zuckerman M, Spielberger CD (eds). Emotions and Anxiety: New Concepts, Methods and Applications. Erlbaum: Hillsdale, NJ, 1976, pp 247-278.
18. Piazza PV, Deminière JM, Le Moal M, Simon H. Factors that predict individual vulnerability to amphetamine self-administration. Science 1989; 145: 1511-1513.
19. 3 receptor gene is associated with hyperactivity in mice. Proc Natl Acad Sci USA 1396; 93: 1945-1949.
20. 3 receptor antagonist, activates locomotion in rodents. J Pharmacol Exp Ther 1995; 275: 1239-1246.
21. 3 receptor: a postsynaptic receptor inhibitory on rat locomotor activity. J Neural Transm [Gen Sect] 1993; 94: 11-19.
22. Carol EN, Zückerman M. Psychopathology and sensation seeking in 'downers', 'speeder' and 'tripers': a study on the relationships between personality and drug choice. Int J Addictions 1977; 12: 591-601.
23. Spotts JW, Shontz FC. Drugs and personality: dependence of findings on methods. Am J Drugs AIc Abuse 1986; 12: 355-382.
24. Sachs O. Awakenings. EP Dutton: New York, 1983.
25. 4 receptor exon III polymorphism associated with the human personality trait of Novelty Seeking. Nature Gen 1996; 12: 78-84.
26. 3 dopamine receptor gene in three independent samples. Am J Med Genet 1995; 60: 529-531.
27. 3 receptor genes in alcohol dependence. Psychiatric Genet 1935; 5: 171-176.
28. Galizio M, Gerstenharber L, Friedensen F. Correlates of sensation seeking in alcoholics. Int J Addictions 1985; 20: 1479-1493.
29. Regier DA, Farmer ME, Rae DS. Comorbidity of mental disorders with alcohol and other drug abuse - results from the epidemiologic catchment area (EGA) study. JAMA 1990; 264: 2511-2518.
30. Boutros N, Bonnet K, Mak T. Drug abuse: a significant variable in schizophrenia research. Biol Psychiatry 1996; 39: 1053-1054.
31. 3 receptor gene variants and substance abuse in schizophrenia. Mol Psychiatry 1998; 3: 337-341.
32. Barrat E. Anxiety and impulsiveness related to psychomotor efficiency. Perceptual and Motor Skills 1959; 9: 191-198.