-
1
-
-
33750518467
-
Designing drugs for parasitic diseases of the developing world
-
McKerrow JH. Designing drugs for parasitic diseases of the developing world. PLoS Med 2005; 2: 712-714
-
(2005)
PLoS Med
, vol.2
, pp. 712-714
-
-
McKerrow, J.H.1
-
3
-
-
35448956820
-
Oral drug therapy for multiple neglected tropical diseases: A systematic review
-
Reddy M, Gill SS, Kalkar SR, et al. Oral drug therapy for multiple neglected tropical diseases: a systematic review. JAMA 2007; 298: 1911-1924
-
(2007)
JAMA
, vol.298
, pp. 1911-1924
-
-
Reddy, M.1
Gill, S.S.2
Kalkar, S.R.3
-
4
-
-
0142165164
-
Functional genomics: Identifying drug targets for parasitic diseases
-
Cowman AF, Crabb BS. Functional genomics: identifying drug targets for parasitic diseases. Trends Parasitol 2003; 19: 538-543
-
(2003)
Trends Parasitol
, vol.19
, pp. 538-543
-
-
Cowman, A.F.1
Crabb, B.S.2
-
5
-
-
0142165173
-
Drugs for the control of parasitic diseases: Current status and development
-
Watkins BM. Drugs for the control of parasitic diseases: current status and development. Trends Parasitol 2003; 19: 477-478
-
(2003)
Trends Parasitol
, vol.19
, pp. 477-478
-
-
Watkins, B.M.1
-
6
-
-
33750531864
-
Innovative lead discovery strategies for tropical diseases
-
Nwaka S, Hudson A. Innovative lead discovery strategies for tropical diseases. Nat Rev Drug Discov 2006; 5: 941-955
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 941-955
-
-
Nwaka, S.1
Hudson, A.2
-
7
-
-
0033927095
-
Target-based drug discovery for malaria, leishmaniasis, and trypanosomiasis
-
Werbovetz KA. Target-based drug discovery for malaria, leishmaniasis, and trypanosomiasis. Curr Med Chem 2000; 7: 835-860
-
(2000)
Curr Med Chem
, vol.7
, pp. 835-860
-
-
Werbovetz, K.A.1
-
8
-
-
9444230640
-
The life and times of ivermectin - A success story
-
Omura S, Crump A. The life and times of ivermectin - a success story. Nat Rev Microbiol 2004; 2: 984-989
-
(2004)
Nat Rev Microbiol
, vol.2
, pp. 984-989
-
-
Omura, S.1
Crump, A.2
-
9
-
-
0242687126
-
Parasite mitochondria as drug target: Diversity and dynamic changes during the life cycle
-
Kita K, Nihei C, Tomitsuka E. Parasite mitochondria as drug target: diversity and dynamic changes during the life cycle. Curr Med Chem 2003; 10: 2535-2548
-
(2003)
Curr Med Chem
, vol.10
, pp. 2535-2548
-
-
Kita, K.1
Nihei, C.2
Tomitsuka, E.3
-
11
-
-
0034791244
-
Unique aspects of mitochondrial biogenesis in try-panosomatids
-
Schneider A. Unique aspects of mitochondrial biogenesis in try-panosomatids. Int J Parasitol 2001; 31: 1403-1415
-
(2001)
Int J Parasitol
, vol.31
, pp. 1403-1415
-
-
Schneider, A.1
-
12
-
-
0031735879
-
Symbiosis between methanogenic archaea and delta-proteobacteria as the origin of eukaryotes: The syntrophic hypothesis
-
Moreira D, Lopez-Garcia P. Symbiosis between methanogenic archaea and delta-proteobacteria as the origin of eukaryotes: the syntrophic hypothesis. J Mol Evol 1998; 47: 517-530
-
(1998)
J Mol Evol
, vol.47
, pp. 517-530
-
-
Moreira, D.1
Lopez-Garcia, P.2
-
13
-
-
0033897694
-
Origins of hydrogenosomes and mitochondria: Evolution and organelle biogenesis
-
Dyall SD, Johnson PJ. Origins of hydrogenosomes and mitochondria: evolution and organelle biogenesis. Curr Opin Microbiol 2000; 3: 404-411
-
(2000)
Curr Opin Microbiol
, vol.3
, pp. 404-411
-
-
Dyall, S.D.1
Johnson, P.J.2
-
15
-
-
0347052859
-
Oxidative phosphorylation and rotenone-insensitive malate-and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ
-
Uyemura SA, Luo S, Vieira M, Moreno SN, Docampo R. Oxidative phosphorylation and rotenone-insensitive malate-and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ. J Biol Chem 2004; 279: 385-393
-
(2004)
J Biol Chem
, vol.279
, pp. 385-393
-
-
Uyemura, S.A.1
Luo, S.2
Vieira, M.3
Moreno, S.N.4
Docampo, R.5
-
16
-
-
0035684435
-
Purification and enzymatic activity of an NADH-fumarate reductase and other mitochondrial activities of Leishmania parasites
-
Chen M, Bennedsen M, Zhai L, Kharazmi A. Purification and enzymatic activity of an NADH-fumarate reductase and other mitochondrial activities of Leishmania parasites. APMIS 2001; 109: 801-808
-
(2001)
APMIS
, vol.109
, pp. 801-808
-
-
Chen, M.1
Bennedsen, M.2
Zhai, L.3
Kharazmi, A.4
-
17
-
-
1642565134
-
Mitochondrial and plastid functions as antimalarial drug targets
-
Vaidya AB. Mitochondrial and plastid functions as antimalarial drug targets. Curr Drug Targets Infect Disord 2004; 4: 11-23.
-
(2004)
Curr Drug Targets Infect Disord
, vol.4
, pp. 11-23
-
-
Vaidya, A.B.1
-
18
-
-
0041883796
-
Unique properties of respiratory chain in Plasmodium falciparum mitochondria
-
Mi-Ichi F, Takeo S, Takashima E, et al. Unique properties of respiratory chain in Plasmodium falciparum mitochondria. Adv Exp Med Biol 2003; 531: 117-133
-
(2003)
Adv Exp Med Biol
, vol.531
, pp. 117-133
-
-
Mi-Ichi, F.1
Takeo, S.2
Takashima, E.3
-
19
-
-
0026099675
-
Mitochondria of mammalian Plasmodium spp
-
Fry M, Beesley JE. Mitochondria of mammalian Plasmodium spp. Parasitology 1991; 102 Pt 1: 17-26.
-
(1991)
Parasitology
, vol.102
, Issue.PART 1
, pp. 17-26
-
-
Fry, M.1
Beesley, J.E.2
-
20
-
-
0027327005
-
Plasmodium berghei: Partial purification and characterization of the mitochondrial cyto- chrome c oxidase
-
Krungkrai J, Krungkrai SR, Bhumiratana A. Plasmodium berghei: partial purification and characterization of the mitochondrial cyto- chrome c oxidase. Exp Parasitol 1993; 77: 136-146
-
(1993)
Exp Parasitol
, vol.77
, pp. 136-146
-
-
Krungkrai, J.1
Krungkrai, S.R.2
Bhumiratana, A.3
-
21
-
-
0034522518
-
Leishmania tarento-lae: A parallel isolation of cytochrome bc(1) and cytochrome c oxidase
-
Horvath A, Berry EA, Huang LS, Maslov DA. Leishmania tarento-lae: a parallel isolation of cytochrome bc(1) and cytochrome c oxidase. Exp Parasitol 2000; 96: 160-167
-
(2000)
Exp Parasitol
, vol.96
, pp. 160-167
-
-
Horvath, A.1
Berry, E.A.2
Huang, L.S.3
Maslov, D.A.4
-
22
-
-
0024672514
-
Characterization of a protein fraction containing cytochromes b and c1 from mitochondria of Leishmania tarentolae
-
Shaw JM, Simpson L. Characterization of a protein fraction containing cytochromes b and c1 from mitochondria of Leishmania tarentolae. Exp Parasitol 1989; 68: 443-449
-
(1989)
Exp Parasitol
, vol.68
, pp. 443-449
-
-
Shaw, J.M.1
Simpson, L.2
-
23
-
-
28044459892
-
Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani
-
Mukherjee A, Padmanabhan PK, Sahani MH, Barrett MP, Madhubala R. Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani. Mol Biochem Parasitol 2006; 145: 1-10.
-
(2006)
Mol Biochem Parasitol
, vol.145
, pp. 1-10
-
-
Mukherjee, A.1
Padmanabhan, P.K.2
Sahani, M.H.3
Barrett, M.P.4
Madhubala, R.5
-
24
-
-
8144229994
-
The multiple roles of the mitochondrion of the malarial parasite
-
Krungkrai J. The multiple roles of the mitochondrion of the malarial parasite. Parasitology 2004; 129: 511-524
-
(2004)
Parasitology
, vol.129
, pp. 511-524
-
-
Krungkrai, J.1
-
25
-
-
0036076250
-
Characterisation of atovaquone resistance in Leishmania infantum promastigotes
-
Cauchetier E, Loiseau PM, Lehman J, et al. Characterisation of atovaquone resistance in Leishmania infantum promastigotes. Int J Parasitol 2002; 32: 1043-1051
-
(2002)
Int J Parasitol
, vol.32
, pp. 1043-1051
-
-
Cauchetier, E.1
Loiseau, P.M.2
Lehman, J.3
-
26
-
-
0034049451
-
Antimycin A resistance in a mutant Leishmania tarentolae strain is correlated to a point mutation in the mitochondrial apocytochrome b gene
-
Schnaufer A, Sbicego S, Blum B. Antimycin A resistance in a mutant Leishmania tarentolae strain is correlated to a point mutation in the mitochondrial apocytochrome b gene. Curr Genet 2000;37: 234-241
-
(2000)
Curr Genet
, vol.37
, pp. 234-241
-
-
Schnaufer, A.1
Sbicego, S.2
Blum, B.3
-
27
-
-
0037351752
-
Programmed cell death in trypanosomatids and other unicellular organisms
-
Debrabant A, Lee N, Bertholet S, Duncan R, Nakhasi HL. Programmed cell death in trypanosomatids and other unicellular organisms. Int J Parasitol 2003; 33: 257-267
-
(2003)
Int J Parasitol
, vol.33
, pp. 257-267
-
-
Debrabant, A.1
Lee, N.2
Bertholet, S.3
Duncan, R.4
Nakhasi, H.L.5
-
29
-
-
0023009615
-
Purification and properties of the bovine liver mitochondrial dihydroorotate dehydrogenase
-
Hines V, Keys LD, III, Johnston M. Purification and properties of the bovine liver mitochondrial dihydroorotate dehydrogenase. J Biol Chem 1986; 261: 11386-11392
-
(1986)
J Biol Chem
, vol.261
, pp. 11386-11392
-
-
Hines, V.1
Keys Iii, L.D.2
Johnston, M.3
-
30
-
-
0030761388
-
Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides
-
Loffler M, Jockel J, Schuster G, Becker C. Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides. Mol Cell Biochem 1997; 174: 125-129
-
(1997)
Mol Cell Biochem
, vol.174
, pp. 125-129
-
-
Loffler, M.1
Jockel, J.2
Schuster, G.3
Becker, C.4
-
31
-
-
0036830528
-
Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity
-
Baldwin J, Farajallah AM, Malmquist NA, Rathod PK, Phillips MA. Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity. J Biol Chem 2002; 277: 41827-41834
-
(2002)
J Biol Chem
, vol.277
, pp. 41827-41834
-
-
Baldwin, J.1
Farajallah, A.M.2
Malmquist, N.A.3
Rathod, P.K.4
Phillips, M.A.5
-
32
-
-
33847398001
-
Specific role of mitochondrial electron transport in blood-stage Plasmodium falci-parum
-
Painter HJ, Morrisey JM, Mather MW, Vaidya AB. Specific role of mitochondrial electron transport in blood-stage Plasmodium falci-parum. Nature 2007; 446: 88-91.
-
(2007)
Nature
, vol.446
, pp. 88-91
-
-
Painter, H.J.1
Morrisey, J.M.2
Mather, M.W.3
Vaidya, A.B.4
-
34
-
-
9144231229
-
Direct evidence for cyanide-insensitive quinol oxidase (alternative oxidase) in apicom- plexan parasite Cryptosporidium parvum: Phylogenetic and therapeutic implications
-
Suzuki T, Hashimoto T, Yabu Y, et al. Direct evidence for cyanide-insensitive quinol oxidase (alternative oxidase) in apicom- plexan parasite Cryptosporidium parvum: phylogenetic and therapeutic implications. Biochem Biophys Res Commun 2004; 313: 1044-1052
-
(2004)
Biochem Biophys Res Commun
, vol.313
, pp. 1044-1052
-
-
Suzuki, T.1
Hashimoto, T.2
Yabu, Y.3
-
35
-
-
0033198384
-
Preliminary evidence for a mitochondrion in Cryptosporidium par-vum: Phylogenetic and therapeutic implications
-
Riordan CE, Langreth SG, Sanchez LB, Kayser O, Keithly JS. Preliminary evidence for a mitochondrion in Cryptosporidium par-vum: phylogenetic and therapeutic implications. J Eukaryot Microbiol 1999; 46: 52S-5S.
-
(1999)
J Eukaryot Microbiol
, vol.46
-
-
Riordan, C.E.1
Langreth, S.G.2
Sanchez, L.B.3
Kayser, O.4
Keithly, J.S.5
-
36
-
-
0024419431
-
Respiration of bloodstream forms of the parasite Trypanosoma brucei brucei is dependent on a plant-like alternative oxidase
-
Clarkson AB, Jr., Bienen EJ, Pollakis G, Grady RW. Respiration of bloodstream forms of the parasite Trypanosoma brucei brucei is dependent on a plant-like alternative oxidase. J Biol Chem 1989; 264: 17770-17776
-
(1989)
J Biol Chem
, vol.264
, pp. 17770-17776
-
-
Clarkson Jr., A.B.1
Bienen, E.J.2
Pollakis, G.3
Grady, R.W.4
-
37
-
-
0021266034
-
2;-fixing activity in Plasmodium falciparum grown in vitro in human erythrocytes
-
2;-fixing activity in Plasmodium falciparum grown in vitro in human erythrocytes. J Protozool 1984; 31: 167-169
-
(1984)
J Protozool
, vol.31
, pp. 167-169
-
-
Blum, J.J.1
Ginsburg, H.2
-
38
-
-
0344908963
-
14;C)glucose into the soluble metabolic intermediates of malaria parasites
-
14;C)glucose into the soluble metabolic intermediates of malaria parasites. Am J Trop Med Hyg 1964; 13: 515-519
-
(1964)
Am J Trop Med Hyg
, vol.13
, pp. 515-519
-
-
Bryant, C.1
Voller, A.2
Smith, M.J.3
-
39
-
-
0028362570
-
Detection of ubiquinone in parasitic and free-living protozoa, including species devoid of mitochondria
-
Ellis JE, Setchell KD, Kaneshiro ES. Detection of ubiquinone in parasitic and free-living protozoa, including species devoid of mitochondria. Mol Biochem Parasitol 1994; 65: 213-224
-
(1994)
Mol Biochem Parasitol
, vol.65
, pp. 213-224
-
-
Ellis, J.E.1
Setchell, K.D.2
Kaneshiro, E.S.3
-
40
-
-
0030801546
-
Schistosoma mansoni sporocysts contain rhodoquinone and produce succinate by fumarate reduction
-
van Hellemond JJ, Van Remoortere A, Tielens AG. Schistosoma mansoni sporocysts contain rhodoquinone and produce succinate by fumarate reduction. Parasitology 1997; 115 ( Pt 2): 177-182
-
(1997)
Parasitology
, vol.115
, Issue.PART 2
, pp. 177-182
-
-
Van Hellemond, J.J.1
Van Remoortere, A.2
Tielens, A.G.3
-
41
-
-
1042267385
-
Rhodoquinone reaction site of mitochondrial complex I, in parasitic helminth, Ascaris suum
-
Yamashita T, Ino T, Miyoshi H, et al. Rhodoquinone reaction site of mitochondrial complex I, in parasitic helminth, Ascaris suum. Biochim Biophys Acta 2004; 1608: 97-103.
-
(2004)
Biochim Biophys Acta
, vol.1608
, pp. 97-103
-
-
Yamashita, T.1
Ino, T.2
Miyoshi, H.3
-
42
-
-
0028943370
-
Purification, characterization and localization of mitochondrial dihydroorotate dehydrogenase in Plasmodium falciparum, human malaria parasite
-
Krungkrai J. Purification, characterization and localization of mitochondrial dihydroorotate dehydrogenase in Plasmodium falciparum, human malaria parasite. Biochim Biophys Acta 1995; 1243: 351-360
-
(1995)
Biochim Biophys Acta
, vol.1243
, pp. 351-360
-
-
Krungkrai, J.1
-
43
-
-
0030581109
-
Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis
-
Rock CO, Cronan JE. Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis. Biochim Biophys Acta 1996; 1302: 1-16.
-
(1996)
Biochim Biophys Acta
, vol.1302
, pp. 1-16
-
-
Rock, C.O.1
Cronan, J.E.2
-
44
-
-
12344322412
-
Strange organelles-Plasmodium mitochondria lack a pyruvate dehydrogenase complex
-
Ralph SA. Strange organelles-Plasmodium mitochondria lack a pyruvate dehydrogenase complex. Mol Microbiol 2005; 55: 1-4.
-
(2005)
Mol Microbiol
, vol.55
, pp. 1-4
-
-
Ralph, S.A.1
-
46
-
-
1942444611
-
Enzymes for heme biosynthesis are found in both the mitochondrion and plastid of the malaria parasite Plasmodium falciparum
-
Sato S, Clough B, Coates L, Wilson RJ. Enzymes for heme biosynthesis are found in both the mitochondrion and plastid of the malaria parasite Plasmodium falciparum. Protist 2004; 155: 117-125
-
(2004)
Protist
, vol.155
, pp. 117-125
-
-
Sato, S.1
Clough, B.2
Coates, L.3
Wilson, R.J.4
-
47
-
-
38049121219
-
Unique properties of Plasmodium falciparum porphobilinogen deaminase
-
Nagaraj VA, Arumugam R, Gopalakrishnan B, et al. Unique properties of Plasmodium falciparum porphobilinogen deaminase. J Biol Chem 2008; 283: 437-444
-
(2008)
J Biol Chem
, vol.283
, pp. 437-444
-
-
Nagaraj, V.A.1
Arumugam, R.2
Gopalakrishnan, B.3
-
48
-
-
0034665704
-
Suppression of mutations in mitochondrial DNA by tRNAs imported from the cytoplasm
-
Kolesnikova OA, Entelis NS, Mireau H, et al. Suppression of mutations in mitochondrial DNA by tRNAs imported from the cytoplasm. Science 2000; 289: 1931-1933
-
(2000)
Science
, vol.289
, pp. 1931-1933
-
-
Kolesnikova, O.A.1
Entelis, N.S.2
Mireau, H.3
-
49
-
-
0028336726
-
Mitochondrial topoisomerase II activity is essential for kinetoplast DNA minicircle segregation
-
Shapiro TA. Mitochondrial topoisomerase II activity is essential for kinetoplast DNA minicircle segregation. Mol Cell Biol 1994; 14: 3660-3667
-
(1994)
Mol Cell Biol
, vol.14
, pp. 3660-3667
-
-
Shapiro, T.A.1
-
50
-
-
34249723729
-
Toxic effects of albendazole on adenosine triphosphatase activity and ultrastructure in Eisenia fetida
-
Gao Y, Sun Z, Sun X, Sun Y, Shi W. Toxic effects of albendazole on adenosine triphosphatase activity and ultrastructure in Eisenia fetida. Ecotoxicol Environ Saf 2007; 67: 378-384
-
(2007)
Ecotoxicol Environ Saf
, vol.67
, pp. 378-384
-
-
Gao, Y.1
Sun, Z.2
Sun, X.3
Sun, Y.4
Shi, W.5
-
51
-
-
0035037934
-
Antileishmanial activity of an indole alkaloid from Peschiera australis
-
Delorenzi JC, Attias M, Gattass CR, et al. Antileishmanial activity of an indole alkaloid from Peschiera australis. Antimicrob Agents Chemother 2001; 45: 1349-1354
-
(2001)
Antimicrob Agents Chemother
, vol.45
, pp. 1349-1354
-
-
Delorenzi, J.C.1
Attias, M.2
Gattass, C.R.3
-
53
-
-
0036174597
-
Ultrastructural alterations induced by nifur-timox and another nitro derivative on epimastigotes of Trypano-soma cruzi
-
Muelas-Serrano S, Perez-Serrano J, Gomez-Barrio A, Aran VJ, Rodriguez-Caabeiro F. Ultrastructural alterations induced by nifur-timox and another nitro derivative on epimastigotes of Trypano-soma cruzi. Parasitol Res 2002; 88: 97-101.
-
(2002)
Parasitol Res
, vol.88
, pp. 97-101
-
-
Muelas-Serrano, S.1
Perez-Serrano, J.2
Gomez-Barrio, A.3
Aran, V.J.4
Rodriguez-Caabeiro, F.5
-
54
-
-
10844234671
-
Therapeutic potential of new Pt(II) and Ru(III) triazole-pyrimidine complexes against Leishmania donovani
-
Magan R, Marin C, Rosales MJ, Salas JM, Sanchez-Moreno M. Therapeutic potential of new Pt(II) and Ru(III) triazole-pyrimidine complexes against Leishmania donovani. Pharmacology 2005; 73: 41-48
-
(2005)
Pharmacology
, vol.73
, pp. 41-48
-
-
Magan, R.1
Marin, C.2
Rosales, M.J.3
Salas, J.M.4
Sanchez-Moreno, M.5
-
55
-
-
33846632321
-
Novel inhibitors of the trypanosome alternative oxidase inhibit Trypanosoma brucei brucei growth and respiration
-
Ott R, Chibale K, Anderson S, et al. Novel inhibitors of the trypanosome alternative oxidase inhibit Trypanosoma brucei brucei growth and respiration. Acta Trop 2006; 100: 172-184
-
(2006)
Acta Trop
, vol.100
, pp. 172-184
-
-
Ott, R.1
Chibale, K.2
Anderson, S.3
-
56
-
-
0034951496
-
Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones
-
Chen M, Zhai L, Christensen SB, Theander TG, Kharazmi A. Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones. Antimicrob Agents Chemother 2001; 45: 2023-2029
-
(2001)
Antimicrob Agents Chemother
, vol.45
, pp. 2023-2029
-
-
Chen, M.1
Zhai, L.2
Christensen, S.B.3
Theander, T.G.4
Kharazmi, A.5
-
57
-
-
34249698953
-
Efficacy of atova-quone-proguanil for treatment of acute multidrug-resistant Plasmodium falciparum malaria in Thailand
-
Krudsood S, Patel SN, Tangpukdee N, et al. Efficacy of atova-quone-proguanil for treatment of acute multidrug-resistant Plasmodium falciparum malaria in Thailand. Am J Trop Med Hyg 2007; 76: 655-658
-
(2007)
Am J Trop Med Hyg
, vol.76
, pp. 655-658
-
-
Krudsood, S.1
Patel, S.N.2
Tangpukdee, N.3
-
59
-
-
20444412699
-
Efficacy of atovaquone and sulfadiazine in the treatment of mice infected with Toxoplasma gondii strains isolated in Brazil
-
Alves CF, Vitor RW. Efficacy of atovaquone and sulfadiazine in the treatment of mice infected with Toxoplasma gondii strains isolated in Brazil. Parasite 2005; 12: 171-177
-
(2005)
Parasite
, vol.12
, pp. 171-177
-
-
Alves, C.F.1
Vitor, R.W.2
-
60
-
-
42449112113
-
Acridinediones: Selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex
-
Biagini GA, Fisher N, Berry N, et al. Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex. Mol Pharmacol 2008; 73: 1347-1355
-
(2008)
Mol Pharmacol
, vol.73
, pp. 1347-1355
-
-
Biagini, G.A.1
Fisher, N.2
Berry, N.3
-
61
-
-
40649111683
-
Antimalarial quinolones: Synthesis, potency, and mechanistic studies
-
Winter RW, Kelly JX, Smilkstein MJ, et al. Antimalarial quinolones: synthesis, potency, and mechanistic studies. Exp Parasitol 2008; 118: 487-497
-
(2008)
Exp Parasitol
, vol.118
, pp. 487-497
-
-
Winter, R.W.1
Kelly, J.X.2
Smilkstein, M.J.3
-
62
-
-
0035214127
-
New trends in extraction, identification and quantification of artemisinin and its derivatives
-
Christen P, Veuthey JL. New trends in extraction, identification and quantification of artemisinin and its derivatives. Curr Med Chem 2001; 8: 1827-1839
-
(2001)
Curr Med Chem
, vol.8
, pp. 1827-1839
-
-
Christen, P.1
Veuthey, J.L.2
-
63
-
-
0242406992
-
Antimalarial drug discovery: Old and new approaches
-
Rosenthal PJ. Antimalarial drug discovery: old and new approaches. J Exp Biol 2003; 206: 3735-3744
-
(2003)
J Exp Biol
, vol.206
, pp. 3735-3744
-
-
Rosenthal, P.J.1
-
65
-
-
0037181479
-
Inhibition of mitochondrial and plastid activity of Plasmodium falciparum by minocycline
-
Lin Q, Katakura K, Suzuki M. Inhibition of mitochondrial and plastid activity of Plasmodium falciparum by minocycline. FEBS Lett 2002; 515: 71-74
-
(2002)
FEBS Lett
, vol.515
, pp. 71-74
-
-
Lin, Q.1
Katakura, K.2
Suzuki, M.3
-
66
-
-
33947319001
-
-
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
-
Xiao SU, Utzinger J, Shen BG, Tanner M, Chollet J. Ultrastructural alterations of adult Schistosoma haematobium harbored in mice following artemether administration. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2006; 24: 321-328
-
(2006)
Ultrastructural Alterations of Adult Schistosoma Haematobium Harbored in Mice Following Artemether Administration
, vol.24
, pp. 321-328
-
-
Xiao, S.U.1
Utzinger, J.2
Shen, B.G.3
Tanner, M.4
Chollet, J.5
-
67
-
-
0034101928
-
Effects of dihydroartemisinin on fine structure of erythrocytic stages of Plasmodium berghei ANKA strain
-
Chen PQ, Yuan J, Du QY, et al. Effects of dihydroartemisinin on fine structure of erythrocytic stages of Plasmodium berghei ANKA strain. Acta Pharmacol Sin 2000; 21: 234-238
-
(2000)
Acta Pharmacol Sin
, vol.21
, pp. 234-238
-
-
Chen, P.Q.1
Yuan, J.2
Du, Q.Y.3
-
68
-
-
0036194878
-
Antischistosomal bioactivity of isoflavonoids from Millettia thonningii (Leguminosae)
-
Lyddiard JR, Whitfield PJ, Bartlett A. Antischistosomal bioactivity of isoflavonoids from Millettia thonningii (Leguminosae). J Parasi-tol 2002; 88: 163-170
-
(2002)
J Parasi-tol
, vol.88
, pp. 163-170
-
-
Lyddiard, J.R.1
Whitfield, P.J.2
Bartlett, A.3
-
69
-
-
0035793109
-
An anthelmintic compound, nafuredin, shows selective inhibition of complex i in helminth mitochondria
-
Omura S, Miyadera H, Ui H, et al. An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria. Proc Natl Acad Sci USA 2001; 98: 60-62
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 60-62
-
-
Omura, S.1
Miyadera, H.2
Ui, H.3
-
70
-
-
2142695761
-
Fungus-elicited metabolites from plants as an enriched source for new leishmanicidal agents: Antifungal phenyl-phenalenone phytoalexins from the banana plant (Musa acuminata) target mitochondria of Leishmania donovani promastigotes
-
Luque-Ortega JR, Martinez S, Saugar JM, et al. Fungus-elicited metabolites from plants as an enriched source for new leishmanicidal agents: antifungal phenyl-phenalenone phytoalexins from the banana plant (Musa acuminata) target mitochondria of Leishmania donovani promastigotes. Antimicrob Agents Chemother 2004; 48: 1534-1540
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 1534-1540
-
-
Luque-Ortega, J.R.1
Martinez, S.2
Saugar, J.M.3
-
71
-
-
0037866531
-
The efficacy of ascofuranone in a consecutive treatment on Trypanosoma brucei brucei in mice
-
Yabu Y, Yoshida A, Suzuki T, et al. The efficacy of ascofuranone in a consecutive treatment on Trypanosoma brucei brucei in mice. Parasitol Int 2003; 52: 155-164
-
(2003)
Parasitol Int
, vol.52
, pp. 155-164
-
-
Yabu, Y.1
Yoshida, A.2
Suzuki, T.3
-
72
-
-
33947102605
-
Miltefosine induces apoptosis in arsenite-resistant Leishmania donovani promastigotes through mitochondrial dysfunction
-
Verma NK, Singh G, Dey CS. Miltefosine induces apoptosis in arsenite-resistant Leishmania donovani promastigotes through mitochondrial dysfunction. Exp Parasitol 2007; 116: 1-13.
-
(2007)
Exp Parasitol
, vol.116
, pp. 1-13
-
-
Verma, N.K.1
Singh, G.2
Dey, C.S.3
-
73
-
-
15244342930
-
Programmed cell death in Trypanosoma cruzi induced by Bothrops jararaca venom
-
Deolindo P, Teixeira-Ferreira AS, Melo EJ, et al. Programmed cell death in Trypanosoma cruzi induced by Bothrops jararaca venom. Mem Inst Oswaldo Cruz 2005; 100: 33-38
-
(2005)
Mem Inst Oswaldo Cruz
, vol.100
, pp. 33-38
-
-
Deolindo, P.1
Teixeira-Ferreira, A.S.2
Melo, E.J.3
-
75
-
-
4644332709
-
DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharo- myces cerevisiae
-
Lanteri CA, Trumpower BL, Tidwell RR, Meshnick SR. DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharo- myces cerevisiae. Antimicrob Agents Chemother 2004; 48: 3968-3974
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 3968-3974
-
-
Lanteri, C.A.1
Trumpower, B.L.2
Tidwell, R.R.3
Meshnick, S.R.4
-
76
-
-
40549136475
-
The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei
-
Lanteri CA, Tidwell RR, Meshnick SR. The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei. Antimicrob Agents Chemother 2008; 52: 875-882
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 875-882
-
-
Lanteri, C.A.1
Tidwell, R.R.2
Meshnick, S.R.3
-
77
-
-
33745825571
-
Activity of and initial mechanistic studies on a novel antileishmanial agent identified through in silico pharmacophore development and database searching
-
Delfin DA, Bhattacharjee AK, Yakovich AJ, Werbovetz KA. Activity of and initial mechanistic studies on a novel antileishmanial agent identified through in silico pharmacophore development and database searching. J Med Chem 2006; 49: 4196-4207
-
(2006)
J Med Chem
, vol.49
, pp. 4196-4207
-
-
Delfin, D.A.1
Bhattacharjee, A.K.2
Yakovich, A.J.3
Werbovetz, K.A.4
-
78
-
-
18044369645
-
Differential effects of polyamine derivative compounds against Leishmania infantum promastigotes and axenic amastigotes
-
Tavares J, Ouaissi A, Lin PK, Tomas A, Cordeiro-da-Silva A. Differential effects of polyamine derivative compounds against Leishmania infantum promastigotes and axenic amastigotes. Int J Parasitol 2005; 35: 637-646
-
(2005)
Int J Parasitol
, vol.35
, pp. 637-646
-
-
Tavares, J.1
Ouaissi, A.2
Lin, P.K.3
Tomas, A.4
Cordeiro-Da-Silva, A.5
-
79
-
-
0036251457
-
Trypanocidal action of 2, 4-dichloro-6-phenylphenoxyethyl diethylamine hydrobromide (Lilly 18947) on Trypanosoma cruzi
-
Bernacchi AS, Franke DC, Castro JA. Trypanocidal action of 2, 4-dichloro-6-phenylphenoxyethyl diethylamine hydrobromide (Lilly 18947) on Trypanosoma cruzi. Acta Pharmacol Sin 2002; 23: 399-404.
-
(2002)
Acta Pharmacol Sin
, vol.23
, pp. 399-404
-
-
Bernacchi, A.S.1
Franke, D.C.2
Castro, J.A.3
-
80
-
-
14744267865
-
Synthesis and an-tileishmanial activities of novel 3-substituted quinolines
-
Tempone AG, da Silva AC, Brandt CA. et al. Synthesis and an-tileishmanial activities of novel 3-substituted quinolines. Antimi- crob Agents Chemother 2005; 49: 1076-1080
-
(2005)
Antimi- Crob Agents Chemother
, vol.49
, pp. 1076-1080
-
-
Tempone, A.G.1
Da Silva, A.C.2
Brandt, C.A.3
-
81
-
-
33644514339
-
Multiple synergistic interactions between atovaquone and antifolates against Plasmodium falciparum in vitro: A rational basis for combination therapy
-
Nduati EW, Kamau EM. Multiple synergistic interactions between atovaquone and antifolates against Plasmodium falciparum in vitro: a rational basis for combination therapy. Acta Trop 2006; 97: 357-363
-
(2006)
Acta Trop
, vol.97
, pp. 357-363
-
-
Nduati, E.W.1
Kamau, E.M.2
-
82
-
-
1242292989
-
Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon
-
Meaney M, Fairweather I, Brennan GP, Forbes AB. Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res 2004; 92: 232-241
-
(2004)
Parasitol Res
, vol.92
, pp. 232-241
-
-
Meaney, M.1
Fairweather, I.2
Brennan, G.P.3
Forbes, A.B.4
-
83
-
-
0034529985
-
Mode of action of cyclosporin A against Hymenolepis microstoma (Cestoda): Relationship between cyclophilin binding and drug-induced damage
-
McLauchlan PE, Roberts HC, Chappell LH. Mode of action of cyclosporin A against Hymenolepis microstoma (Cestoda): relationship between cyclophilin binding and drug-induced damage. Parasitology 2000; 121 Pt 6: 661-670
-
(2000)
Parasitology
, vol.121
, Issue.PART 6
, pp. 661-670
-
-
McLauchlan, P.E.1
Roberts, H.C.2
Chappell, L.H.3
-
84
-
-
5644269099
-
Effect of cyclosporin A on the survival and ultrastructure of Echinococcus granulosus protoscoleces in vitro
-
Colebrook AL, Jenkins DJ, Jones MK, Tatarczuch L, Lightowlers MW. Effect of cyclosporin A on the survival and ultrastructure of Echinococcus granulosus protoscoleces in vitro. Parasitology 2004; 129: 497-504.
-
(2004)
Parasitology
, vol.129
, pp. 497-504
-
-
Colebrook, A.L.1
Jenkins, D.J.2
Jones, M.K.3
Tatarczuch, L.4
Lightowlers, M.W.5
-
85
-
-
8844278360
-
Effects of phytochemicals of Flemingia vestita (Fabaceae) on glucose 6-phosphate dehydrogenase and enzymes of gluconeogenesis in a cestode (Raillietina echinobothrida)
-
Das B, Tandon V, Saha N. Effects of phytochemicals of Flemingia vestita (Fabaceae) on glucose 6-phosphate dehydrogenase and enzymes of gluconeogenesis in a cestode (Raillietina echinobothrida). Comp Biochem Physiol C Toxicol Pharmacol 2004; 139: 141-146
-
(2004)
Comp Biochem Physiol C Toxicol Pharmacol
, vol.139
, pp. 141-146
-
-
Das, B.1
Tandon, V.2
Saha, N.3
-
86
-
-
44949133077
-
Human antimicrobial peptide histatin 5 is a cell-penetrating peptide targeting mitochondrial ATP synthesis in Leishmania
-
Luque-Ortega JR, van't Hof W, Veerman EC, Saugar JM, Rivas L. Human antimicrobial peptide histatin 5 is a cell-penetrating peptide targeting mitochondrial ATP synthesis in Leishmania. FASEB J 2008; 22: 1817-1828
-
(2008)
FASEB J
, vol.22
, pp. 1817-1828
-
-
Luque-Ortega, J.R.1
Van'T Hof, W.2
Veerman, E.C.3
Saugar, J.M.4
Rivas, L.5
-
87
-
-
0036194878
-
Antischistosomal bioactivity of isoflavonoids from Millettia thonningii (Leguminosae)
-
Lyddiard JR, Whitfield PJ, Bartlett A. Antischistosomal bioactivity of isoflavonoids from Millettia thonningii (Leguminosae). J Parasitol 2002;163-170
-
(2002)
J Parasitol
, pp. 163-170
-
-
Lyddiard, J.R.1
Whitfield, P.J.2
Bartlett, A.3
-
88
-
-
18844381913
-
Anti-proliferative synergy of lysophospholipid analogues and keto-conazole against Trypanosoma cruzi (Kinetoplastida: Trypanoso-matidae): Cellular and ultrastructural analysis
-
Santa-Rita RM, Lira R, Barbosa HS, Urbina JA, de Castro SL. Anti-proliferative synergy of lysophospholipid analogues and keto-conazole against Trypanosoma cruzi (Kinetoplastida: Trypanoso-matidae): cellular and ultrastructural analysis. J Antimicrob Chemother 2005; 55: 780-784
-
(2005)
J Antimicrob Chemother
, vol.55
, pp. 780-784
-
-
Santa-Rita, R.M.1
Lira, R.2
Barbosa, H.S.3
Urbina, J.A.4
De Castro, S.L.5
-
89
-
-
1942446017
-
The mitochondrial ribosome of the protozoan Acanthamoeba castellanii is the target for macrolide antibiotics
-
Mathis A, Wild P, Deplazes P, Boettger EC. The mitochondrial ribosome of the protozoan Acanthamoeba castellanii is the target for macrolide antibiotics. Mol Biochem Parasitol 2004; 135: 225-229
-
(2004)
Mol Biochem Parasitol
, vol.135
, pp. 225-229
-
-
Mathis, A.1
Wild, P.2
Deplazes, P.3
Boettger, E.C.4
-
90
-
-
29444438029
-
Effect of a beta-lapachone-derived naphthoimidazole on Trypanosoma cruzi: Identification of target organelles
-
Menna-Barreto RF, Henriques-Pons A, Pinto AV, et al. Effect of a beta-lapachone-derived naphthoimidazole on Trypanosoma cruzi: identification of target organelles. J Antimicrob Chemother 2005; 56: 1034-1041
-
(2005)
J Antimicrob Chemother
, vol.56
, pp. 1034-1041
-
-
Menna-Barreto, R.F.1
Henriques-Pons, A.2
Pinto, A.V.3
-
91
-
-
34547775867
-
Mitochondrial disruption and DNA fragmentation in Trypanosoma cruzi induced by naphthoimidazoles synthesized from beta-lapachone
-
Menna-Barreto RF, Correa JR, Pinto AV, Soares MJ, de Castro SL. Mitochondrial disruption and DNA fragmentation in Trypanosoma cruzi induced by naphthoimidazoles synthesized from beta-lapachone. Parasitol Res 2007; 101: 895-905.
-
(2007)
Parasitol Res
, vol.101
, pp. 895-905
-
-
Menna-Barreto, R.F.1
Correa, J.R.2
Pinto, A.V.3
Soares, M.J.4
De Castro, S.L.5
-
92
-
-
34547814680
-
Ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo and in vitro drug treatment with nitroxynil (Trodax)
-
McKinstry B, Brennan GP, Halferty L, Forbes AB, Fairweather I. Ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo and in vitro drug treatment with nitroxynil (Trodax). Parasitol Res 2007; 101: 929-941
-
(2007)
Parasitol Res
, vol.101
, pp. 929-941
-
-
McKinstry, B.1
Brennan, G.P.2
Halferty, L.3
Forbes, A.B.4
Fairweather, I.5
-
93
-
-
36348933352
-
Sterol methenyl transferase inhibitors alter the ultrastructure and function of the Leishmania amazonensis mitochondrion leading to potent growth inhibition
-
Rodrigues JC, Bernardes CF, Visbal G, et al. Sterol methenyl transferase inhibitors alter the ultrastructure and function of the Leishmania amazonensis mitochondrion leading to potent growth inhibition. Protist 2007; 158: 447-456
-
(2007)
Protist
, vol.158
, pp. 447-456
-
-
Rodrigues, J.C.1
Bernardes, C.F.2
Visbal, G.3
-
94
-
-
11144296195
-
Effect of usnic acid from the lichen Cladonia substellata on Trypanosoma cruzi in vitro: An ultrastructural study
-
De Carvalho EA, Andrade PP, Silva NH, Pereira EC, Figueiredo RC. Effect of usnic acid from the lichen Cladonia substellata on Trypanosoma cruzi in vitro: an ultrastructural study. Micron 2005; 36: 155-161
-
(2005)
Micron
, vol.36
, pp. 155-161
-
-
De Carvalho, E.A.1
Andrade, P.P.2
Silva, N.H.3
Pereira, E.C.4
Figueiredo, R.C.5
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