Effect of usnic acid from the lichen Cladonia substellata on Trypanosoma cruzi in vitro: An ultrastructural study

Micron

Volumn 36, Issue 2, 2005, Pages 155-161

  De Carvalho, E A B ^a   Andrade, P P ^a   Silva, N H ^a   Pereira, E C ^b   Figueiredo, R C B Q ^c  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^b Depto Cie Geograficas Univ F   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Cladonia substellata; Trypanosoma cruzi; Ultrastructure; Usnic acid

Indexed keywords

CHAGAS' DISEASE; CYTOPLASM; MITOCHONDRIA; USNIC ACID;

BLOOD; CELL CULTURE; CHEMOTHERAPY; DISEASE CONTROL; DRUG PRODUCTS; TOXICITY;

ORGANIC ACIDS;

ANTIINFECTIVE AGENT; ANTIPROTOZOAL AGENT; BENZOFURAN DERIVATIVE; USNIC ACID;

ANIMAL; ARTICLE; CHEMISTRY; DRUG EFFECT; ELECTRON MICROSCOPY; ISOLATION AND PURIFICATION; LICHENS; MITOCHONDRION; MOUSE; PARASITOLOGY; PERITONEUM MACROPHAGE; TRYPANOSOMA CRUZI; ULTRASTRUCTURE;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTIPROTOZOAL AGENTS; BENZOFURANS; LICHENS; MACROPHAGES, PERITONEAL; MICE; MICROSCOPY, ELECTRON; MITOCHONDRIA; TRYPANOSOMA CRUZI;

CLADONIA; CLADONIA SUBSTELLATA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 11144296195     PISSN: 09684328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micron.2004.09.003     Document Type: Article

References (30)

1. A.N. Abo-Khatwa, A.A. Al-Robai, and D.A. Al-Jawhari Lichen acids as uncouplers of oxidative phosphorylation of mouse-liver mitochondria Natural Toxins 4 1996 96 102
2. T. Ahti, S. Stenroos, and L. Xavier-Filho The lichen family Cladoniaceae in Paraíba, Pernambuco and Sergipe, northeast Brazil Tropical Biology 1993 55 70
3. A.M. Al-Bekairi, S. Qureshi, M.A. Chaudhry, D.R. Krishna, and A.H. Shah Mitodepressive, clastogenic and biochemical effects of (+)-usnic acid in mice Journal of Ethnopharmacology 33 1991 217 220
4. T.C. Araujo-Jorge, E.P. Sampaio, W. De Souza, and M.N. Meirelles Trypanosoma cruzi: the effect of variations in experimental conditions on the levels of macrophage infection in vitro Parasitology Research 75 1989 257 263
5. E.M. Camargo Growth and differentiation of Trypanosoma cruzi: origin of metacyclic trypanosomes in liquid media Revista do Instituto de Medicina Tropical de São Paulo 6 1964 93 100
6. M. Cocchietto, M. Delfini, P. Ercole, A. Iacoangeli, and G. Risuleo A review on usnic acid, an interesting natural compound Naturwissenschaften 89 2002 137 146
7. S. De Castro The challenge of Chagas' disease chemotherapy: an update of drugs assayed against Trypanosoma cruzi Acta Tropica 53 1993 83 98
8. W. De Souza A short review on the morphology of Trypanosoma cruzi: from 1909 to 1999 Memórias do Instituto Oswaldo Cruz 94 1999 17 36
9. S.S. Estani, E.L. Segura, A.M. Ruiz, E. Velazquez, B.M. Porcel, and C. Yampotis Efficacy of chemotherapy with benznidazole in children in intermediate phase of Chagas' disease American Journal of Tropical Medicine and Hygiene 59 1998 526 529
10. L.S. Filardi, and A. Brenner Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas' disease Transactions of the Royal Society of Tropical Medicine and Hygiene 81 1987 755 759
11. A. Fournet, M.E. Ferreira, A. Rojas de Arias, S. Torres de Ortiz, A. Inchausti, G. Yaluff, W. Quilhot, E. Fernandez, and M.E. Hidalgo Activity of compounds isolated from Chilean lichens against experimental cutaneous leishmaniasis Comparative Biochemistry and Physiology. Part C: Pharmacology,Toxicology and Endocrinology 116 1997 51 54
12. D. Han, K. Matsumaru, D. Rettori, and N. Kaplowitz Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress Biochemical Pharmacology 67 2004 439 451
13. S. Huneck The significance of lichens and their metabolites Naturwissenschaften 86 1999 559 570
14. K. Ingolfsdottir, G.A. Chung, V.G. Skulason, S.R. Gissurarson, and M. Vilhelmsdottir Antimycobacterial activity of lichen metabolites in vitro European Journal of Pharmaceutical Science 6 1998 141 144
15. K.C. Kumar, and K. Muller Lichen metabolites, antiproliferative and cytotoxic activity of gyrophoric, usnic, and diffractaic acid on human keratinocyte growth Journal of Natural Products 62 1999 821 823
16. M. Lauterwein, M. Oethinger, K. Belsner, T. Peters, and R. Marre In vitro activities of the lichen secondary metabolites vulpinic acid, (+)-usnic acid, and (-)-usnic acid against aerobic and anaerobic microorganisms Antimicrobial Agents and Chemotherapy 39 1995 2541 2543
17. M.N. Meirelles, T. Souto-Padron, and W. De Souza Participation of cell surface anionic sites in the interaction between Trypanosoma cruzi and macrophages Journal of Submicroscopy Cytology and Pathology 16 1984 533 545
18. A. Moncayo Program Report of the UNPD/World Bank/WHO Special Program for Research and Training in Tropical Diseases (TDR) 1993 World Health Organization Geneva pp. 67-75
19. K. Muller Pharmaceutically relevant metabolites from lichens Applied Microbiology and Biotechnology 56 2001 9 16
20. Y. Nishtoba, H. Nishmura, T. Nishiyama, and J. Mizutani Lichen acids, plant growth inhibitors from Usnea longissima Phytochemistry 26 1987 3181 3185
21. H.M. Ogmundsdottir, G.M. Zoega, S.R. Gissurarson, and K. Ingolfsdottir Anti-proliferative effects of lichen-derived inhibitors of 5-lipoxygenase on malignant cell-lines and mitogen-stimulated lymphocytes Journal of Pharmacy and Pharmacology 50 1998 107 115
22. E. Okuyama, K. Umeyama, M. Yamazaki, Y. Kinoshita, and Y. Yamamoto Usnic acid and diffractaic acid as analgesic and antipyretic components of Usnea diffracta Planta Medica 61 1995 113 115
23. F.R. Opperdoes, and P.A. Michels The glycosomes of the Kinetoplastida Biochimie 75 1993 231 234
24. E.C. Pereira, S.C. Nascimento, R.M.C. Lima, N.H. Silva, A.F.M. Oliveira, M. Boitard, H. Beriel, C. Vicente, and M.E. Legaz Analysis of Usnea fasciata crude extracts with antineoplasic activity Tokai Journal of Experimental and Clinical Medicine 112 1994 47 52
25. E.C.G. Pereira, M.T. Pereyra, S.C. Matos, N.H. Silva, L. Andrade, and C. Vicente Bioproduction of usnic acid from acetate by kaolinite immobilized cells of Cladonia substellata Vainio Acta Societatis Botanicorum Poloniae 64 1995 171 174
26. P. Pramyothin, W. Janthasoot, N. Pongnimitprasert, S. Phrukudom, and N. Ruangrungsi Hepatotoxic effect of (+)usnic acid from Usnea siamensis Wainio in rats, isolated rat hepatocytes and isolated rat liver mitochondria Journal of Ethnopharmacology 90 2004 381 387
27. R.H. Schirmer, T. Schollhammer, G. Eisenbrand, and R.L. Krauth-Siegel Oxidative stress as a defense mechanism against parasitic infections Free Radical Research Communications 3 1987 3 12
28. K.O. Vartia Antibiotics in lichens V. Ahmadjian M.E. Hale third ed The Lichens 1973 Academic Press New York 547 561
29. World Health Organization Chagas' disease: frequency and geographical distribution Weekly Epidemiological Records 65 1990 257 261
30. J. Wu, M. Zhang, D. Ding, T. Tan, and B. Yan Effect of Cladonia alpestris on Trichomonas vaginalis in vitro Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 13 1995 126 129