Oral drug therapy for multiple neglected tropical diseases: A systematic review

JAMA

Volumn 298, Issue 16, 2007, Pages 1911-1924

  Reddy, Madhuri ^a,b   Gill, Sudeep S ^c   Kalkar, Sunila R ^d   Wu, Wei ^d   Anderson, Peter J ^d   Rochon, Paula A ^e  

^a RESEARCH AND TRAINING INSTITUTE   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c QUEEN S UNIVERSITY   (Canada)

^d Kunin Lunenfeld Applied Research Unit and Department of Food and Nutrition Services and Baycrest Centre for Geriatric Care   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; BEPHENIUM; DIETHYLCARBAMAZINE; FLUBENDAZOLE; IVERMECTIN; LEVAMISOLE; MEBENDAZOLE; OXANTEL; PLACEBO; PRAZIQUANTEL; PYRANTEL; PYRANTEL EMBONATE; TETRAMISOLE; TIABENDAZOLE; ANTIINFECTIVE AGENT; ANTIPARASITIC AGENT;

ABDOMINAL CRAMP; ABDOMINAL DISCOMFORT; ABDOMINAL DISTENSION; ABDOMINAL PAIN; ASCARIASIS; AWARENESS; BLOODY DIARRHEA; CHEST TIGHTNESS; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; COUGHING; DIARRHEA; DIZZINESS; ELEPHANTIASIS; EPIGASTRIC PAIN; EPILEPSY; FEVER; HEADACHE; HOOKWORM INFECTION; HUMAN; LOOSE FECES; MONOTHERAPY; MORBIDITY; MYALGIA; NAUSEA; ONCHOCERCIASIS; PREVALENCE; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RASH; REVIEW; SYSTEMATIC REVIEW; THORAX PAIN; TRACHOMA; TRICHURIASIS; TROPICAL DISEASE; UNSPECIFIED SIDE EFFECT; VOMITING; CHAGAS DISEASE; DEVELOPING COUNTRY; DRACUNCULIASIS; DRUG THERAPY; ECONOMICS; LEISHMANIASIS; LEPROSY; ORAL DRUG ADMINISTRATION; PARASITOSIS; POVERTY; SCHISTOSOMIASIS; TROPICAL MEDICINE; TRYPANOSOMIASIS;

ADMINISTRATION, ORAL; ANTI-BACTERIAL AGENTS; ANTIPARASITIC AGENTS; ASCARIASIS; CHAGAS DISEASE; DEVELOPING COUNTRIES; DRACUNCULIASIS; DRUG THERAPY; ELEPHANTIASIS, FILARIAL; HOOKWORM INFECTIONS; HUMANS; LEISHMANIASIS; LEPROSY; ONCHOCERCIASIS, OCULAR; PARASITIC DISEASES; POVERTY; SCHISTOSOMIASIS; TRACHOMA; TRICHURIASIS; TROPICAL MEDICINE; TRYPANOSOMIASIS;

EID: 35448956820     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.298.16.1911     Document Type: Review

References (105)

1. World Health Organization. Control of neglected tropical diseases (NTD). http://www.who.int/neglected_diseases/en/. Accessed July 20, 2007.
2. Bill & Melinda Gates Foundation. Leading global health organizations receive $46.7 million from Gates Foundation to integrate programs fighting neglected tropical diseases. http://www.gatesfoundation.org/ GlobalHealth/Announcements/Announce-061219.htm. Accessed April 27, 2007.
3. A turning point for neglected tropical disease control [editorial]. Lancet. 2007;369(9571):1404.
4. Department of Control of Neglected Tropical Diseases, World Health Organization. Neglected tropical diseases: hidden successes, emerging opportunities. http://whqlibdoc.who.int/hq/2006/WHO_CDS_NTD_2006.2_eng.pdf. Accessed May 3, 2007.
5. World Health Organization. Trachoma. http://www.who.int/blindness/causes/ priority/en/index2.html. Accessed July 20, 2007.
6. World Health Organization. Goal 6: communicable disease prevention and control. http://www.who.int/mdg/goals/goal6/communicable_disease_ prevention/en/. Accessed August 4, 2007.
7. Hotez PJ, Brooker S, Bethony JM, et al. Hookworm infection. N Engl J Med. 2004;351(8):799-807.
8. Molyneux DH, Hotez PJ, Fenwick A. "Rapid-impact interventions": how a policy of integrated control for Africa's neglected tropical diseases could benefit the poor [published online ahead of print October 11, 2005]. PLoS Med. 2005;2(11):e336.
9. Utzinger J, de Savigny D. Control of neglected tropical diseases: integrated chemotherapy and beyond. PLoS Med. 2006;3(5):e112.
10. Fincham JE, Markus MB, Adams VJ. Could control of soil-transmitted helminthic infection influence the HIV/AIDS pandemic. Acta Trop. 2003;86(2-3): 315-333.
11. Druilhe P, Tall A, Sokhna C. Worms can worsen malaria: towards a new means to roll back malaria? Trends Parasitol. 2005;21(8):359-362.
12. Hotez PJ, Molyneux DH, Fenwick A, et al. Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria. PLoS Med. 2006;3(5):e102.
13. Rochon PA, Mashari A, Cohen A, et al. Relation between randomized controlled trials published in leading general medical journals and the global burden of disease. CMAJ. 2004;170(11):1673-1677.
14. Chirac P, Torreele E. Global framework on essential health R & D. Lancet. 2006;367(9522):1560-1561.
15. Pécoul B, Chirac P, Trouiller P, Pinel J. Access to essential drugs in poor countries: a lost battle? JAMA. 1999;281(4):361-367.
16. Global Network for Neglected Tropical Disease Control Web site. http://gnntdc.sabin.org/gnntdc_integration_pop.swf. Accessed July 30, 2007.
17. Ehrenberg JP, Ault SK. Neglected diseases of neglected populations: thinking to reshape the determinants of health in Latin America and the Caribbean. BMC Public Health. 2005;5(119).
18. Chan M. Address to the WHO global partners meeting on neglected tropical diseases. http://www.who.int/dg/speeches/2007/190407_ntds/en/index.html. Published April 19, 2007. Accessed July 30, 2007.
19. Canning D. Priority setting and the "neglected" tropical diseases. Trans R Soc Trop Med Hyg. 2006; 100(6):499-504.
20. Fenwick A, Molyneux D, Nantulya V. Achieving the Millennium Development Goals. Lancet. 2005; 365(9464):1029-1030.
21. Zu LQ, Jiang ZX, Yu SH, et al. Treatment of soil-transmitted helminth infections by anthelmintics in current use [in Chinese]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1992;10(2):95-99.
22. Xia ZH, Su YL, Yao SY, et al. Clinical observation on efficacy of ivermectin in the treatment of intestinal nematode infections [in Chinese]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1992;10(4):279-282.
23. Pène P, Vincentelli JM, Soula G, Delmont J, Rossignol JF. Treatment of intestinal nematode infections with albendazole: preliminary results [in French]. Bull Soc Pathol Exot Filiales. 1981;74(6):590-594.
24. Hoang TK, Bronshteǐn AM, Nguyen TZ, Nguyen VT, Sabgaǐda TP. The initial experience with embovin treatment in a a focus of intestinal nematode infections in the Socialist Republic of Vietnam [in Russian]. Med Parazitol (Mosk). 1993;2(2):27-28.
25. Bundy DAP, Hall A, Medly GF, et al. Evaluating measures to control intestinal parasitic infections. World Health Stat Q. 1992;45(2-3):168-179.
26. Verhagen AP, de Vet HC, de Bie RA, et al. The art of quality assessment of RCTs included in systematic reviews. J Clin Epidemiol. 2001;54(7):651-654.
27. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17 (1):1-12.
28. Jüni P, Witschi A, Bloch R, Egger M. The hazards of scoring the quality of clinical trials for meta-analysis. JAMA. 1999;282(11):1054- 1060.
29. Jüni P, Altman DG, Egger M. Systematic reviews in health care: assessing the quality of controlled clinical trials. BMJ. 2001;323(7303):42-46.
30. Jüni P, Egger M. Allocation concealment in clinical trials. JAMA. 2002;288(19):2407-2408.
31. Balk EM, Bonis PA, Moskowitz H, et al. Correlation of quality measures with estimates of treatment effect in meta-analyses of randomized controlled trials. JAMA. 2002;287(22):2973-2982.
32. Egger M, Juni P, Bartlett C, et al. How important are comprehensive literature searches and the assessment of trial quality in systematic reviews? Health Technol Assess. 2003;7(1):1-76.
33. Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995;273(5):408-412.
34. Devereaux PJ, Manns BJ, Ghali WA, et al. Physician interpretations and textbook definitions of blinding terminology in randomized controlled trials. JAMA. 2001;285(15):2000-2003.
35. Montori VM, Guyatt GH. Intention-to-treat principle. CMAJ. 2001;165(10):1339-1341.
36. Hollis S, Campbell F. What is meant by intention to treat analysis? survey of published randomised controlled trials BMJ. 1999;319(7211):670-674.
37. Beller EM, Gebski V, Keech AC. Randomisation in clinical trials. Med J Aust. 2002;177(10):565-567.
38. Gebski VJ, Beller EM, Keech AC. Randomised controlled trials: elements of a good study. Med J Aust. 2001;175(5):272-274.
39. Pildal J, Chan AW, Hrobjartsson A, Forfang E, Altman DG, Gotzsche PC. Comparison of descriptions of allocation concealment in trial protocols and the published reports: cohort study [published online ahead of print April 7, 2005]. BMJ. 2005;330(7499):1049.
40. Ioannidis JP, Lau J. Completeness of safety reporting in randomized trials: an evaluation of 7 medical areas. JAMA. 2001;285(4):437-443.
41. de Silva NR, Brooker S, Hotez PJ, et al. Soil-transmitted helminth infections: updating the global picture. Trends Parasitol. 2003;19(12):547-551.
42. Sridharan R, Lorenzo N, Ranganathan LN, Govindarajan S. Leprosy. http://www.emedicine.com/neuro/topic187.htm. Accessed April 8, 2007.
43. World Health Organization. African trypanosomiasis (sleeping sickness). http://www.who.int /mediacentre/factsheets/fs259/en/index.html. Accessed April 9, 2007.
44. Hopkins DR, Ruiz-Tiben E, Downs P, Withers PC Jr, Maguire JH. Dracunculiasis eradication: the final inch. Am J Trop Med Hyg. 2005;73(4):669-675.
45. Marti H, Haji HJ, Savioli L, et al. A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyloides stercoralis and other soil-transmitted helminth infections in children. Am J Trop Med Hyg. 1996;55(5):477-481.
46. Jongsuksuntigul P, Jeradit C, Pornpattanakul S, Charanasri U. A comparative study on the efficacy of albendazole and mebendazole in the treatment of ascariasis, hookworm infection and trichuriasis. Southeast Asian J Trop Med Public Health. 1993;24(4): 724-729.
47. Rossignol JF, Maisonneuve H. Albendazole: placebo-controlled study in 870 patients with intestinal helminthiasis. Trans R Soc Trop Med Hyg. 1983; 77(5):707-711.
48. Pene P, Mojon M, Garin JP, Coulaud JP, Rossignol JF. Albendazole: a new broad spectrum antihelminthic: double-blind, multicenter clinical trial. Am J Trop Med Hyg. 1982;31(2):263-266.
49. Yangco BG, Klein TW, Deresinski SC, et al. Flubendazole and mebendazole in the treatment of trichuriasis and other helminthiasies. Clin Ther. 1981; 4(4):285-290.
50. Jancloes MF, Cornet P, Thienpont D. Mass control of ascariasis with single oral doses of levamisole: a controlled comparison in 3,056 subjects between three incomplete population coverages. Trop Geogr Med. 1979;31(1):111-122.
51. Farahmandian I, Arfaa F, Jalali H, Reza M. Comparative studies on the evaluation of the effect of new anthelminthics on various intestinal helminthiasis in Iran: effects of anthelminthics on intestinal helminthiasis. Chemotherapy. 1977;23(2):98-105.
52. Legesse M, Erko B, Medhin G. Efficacy of alebendazole and mebendazole in the treatment of Ascaris and Trichuris infections. Ethiop Med J. 2002;40(4):335-343.
53. Fox LM, Furness BW, Haser JK, et al. Tolerance and efficacy of combined diethylcarbamazine and albendazole for treatment of Wuchereria bancrofti and intestinal helminth infections in Haitian children. Am J Trop Med Hyg. 2005;73(1):115-121.
54. Beach MJ, Streit TG, Addiss DG, et al. Assessment of combined ivermectin and albendazole for treatment of intestinal helminth and Wuchereria bancrofti infections in Haitian schoolchildren. Am J Trop Med Hyg. 1999;60(3):479-486.
55. Olds GR, King C, Hewlett J, et al. Double-blind placebo-controlled study of concurrent administration of albendazole and praziquantel in schoolchildren with schistosomiasis and geohelminths. J Infect Dis. 1999;179(4):996- 1003.
56. Albonico M, Bickle Q, Ramsan M, et al. Efficacy of mebendazole and levamisole alone or in combination against intestinal nematode infections after repeated targeted mebendazole treatment in Zanzibar. Bull World Health Organ. 2003;81(5):343-352.
57. Albonico M, Bickle Q, Haji HJ, et al. Evaluation of the efficacy of pyrantel-oxantel for the treatment of soil-transmitted nematode infections. Trans R Soc Trop Med Hyg. 2002;96(6):685-690.
58. Albonico M, Stoltzfus RJ, Savioli L, et al. A controlled evaluation of two school-based antihelminthic chemotherapy regimens on intensity of intestinal helminth infections. Int J Epidemiol. 1999;28 (3):591-596.
59. Albonico M, Smith PG, Hall A, et al. A randomized controlled trial comparing mebendazole and albendazole against Ascaris, Trichuris and hookworm infections. Trans R Soc Trop Med Hyg. 1994;88(5): 585-589.
60. Muchiri EM, Thiong'o FW, Magnussen P, Ouma JH. A comparative study of different albendazole and mebendazole regimens for the treatment of intestinal infections in school children of Usigu Division, western Kenya. J Parasitol. 2001;87(2):413-418.
61. Rahman WA. Comparative trials using albendazole and mebendazole in the treatment of soiltransmitted helminths in schoolchildren on Penang, Malaysia. Southeast Asian J Trop Med Public Health. 1996;27(4):765-767.
62. Sorensen E, Ismail M, Amarasinghe DK, Hettiarachchi I. The efficacy of three antihelminthic drugs given in a single dose. Ceylon Med J. 1996;41(2):42-45.
63. Wesche D, Barnish G. A comparative study of the effectiveness of mebendazole ( Janssen) and generically equivalent mebendazole (Nordia) in intestinal helminthiasis in Papua New Guinean children. P N G Med J. 1994;37(1):7-11.
64. Wesche D, Lutz S, Barnish G. Comparative study of chewable pyrantel pamoate: should standards for chewable tablets be revised? P N G Med J. 1994; 37(1):12-14.
65. Bartoloni A, Guglielmetti P, Cancrini G, et al. Comparative efficacy of a single 400 mg dose of albendazole or mebendazole in the treatment of nematode infections in children. Trop Geogr Med. 1993;45 (3):114-116.
66. Sinniah B, Sinniah D. The anthelmintic effects of pyrantel pamoate, oxantel-pyrantel pamoate, levamisole and mebendazole in the treatment of intestinal nematodes. Ann Trop Med Parasitol. 1981;75(3): 315-321.
67. Lucas AO, Oduntan SO. Treatment of hookworm infection and other intestinal parasites with 1-tetramisole (Ketrax). Ann Trop Med Parasitol. 1972; 66(3):391-398.
68. Charoenlarp P, Waikagul J, Muennoo C, et al. Efficacy of single-dose mebendazole, polymorphic forms A and C, in the treatment of hookworm and Trichuris infections. Southeast Asian J Trop Med Public Health. 1993;24(4):712-716.
69. Legesse M, Erko B, Medhin G. Comparative efficacy of albendazole and three brands of mebendazole in the treatment of ascariasis and trichuriasis. East Afr Med J. 2004;81(3):134-138.
70. Juan JO, Lopez Chegne N, Gargala G, Favennec L. Comparative clinical studies of nitazoxanide, albendazole and praziquantel in the treatment of ascariasis, trichuriasis and hymenolepiasis in children from Peru. Trans R Soc Trop Med Hyg. 2002;96(2):193-196.
71. Hall A, Nahar Q. Albendazole and infections with Ascaris lumbricoides and Trichuris trichiura in children in Bangladesh. Trans R Soc Trop Med Hyg. 1994; 88(1):110-112.
72. Belizario VY, Amarillo ME, de Leon WU, et al. A comparison of the efficacy of single doses of albendazole, ivermectin, and diethylcarbamazine alone or in combinations against Ascaris and Trichuris spp. Bull World Health Organ. 2003;81(1):35-42.
73. Stephenson LS, Kinoti SN, Latham MC, Kurz KM, Kyobe J. Single dose metrifonate or praziquantel treatment in Kenyan children, I: effects on Schistosoma haematobium, hookworm, hemoglobin levels, splenomegaly, and hepatomegaly.AmJ Trop Med Hyg. 1989; 41(4):436-444.
74. Greene WL, Concato J, Feinstein AR. Claims of equivalence in medical research: are they supported by the evidence? Ann Intern Med. 2000;132(9):715-722.
75. Kaul S, Diamond GA. Good enough: a primer on the analysis and interpretation of noninferiority trials. Ann Intern Med. 2006;145(1):62-69.
76. Schistosomiasis Control Initiative. Integrated mass treatment of the neglected tropical diseases in Niger. http://www.schisto.org/Niger/ NigerNTDlaunch.htm. Accessed August 4, 2007.
77. The Global Alliance to Eliminate Lymphatic Filariasis Web site. http://www.filariasis.org/. Accessed August 4, 2007.
78. Jimmy Carter and General Dr. Yakubu Gowon encourage Nigerian officials to control schistosomiasis, other diseases [press release]. February 15, 2007. The Carter Center Web site. http://www.cartercenter.org/news/pr/nigeria_021507. html. Accessed August 4, 2007.
79. Hotez PJ, Bundy DAP, Beegle K, et al. Helminth infections: soil-transmitted helminth infections and schistosomiasis. In: Jamison DT, ed. Disease Control Priorities in Developing Countries. 2nd ed. New York, NY: Oxford University Press; 2006:467-482.
80. Sachs JD. The neglected tropical diseases [abstract]. Sci Am. 2007;296(1):33A.
81. Sachs JD. The End of Poverty: Economic Possibilities for Our Time. New York, NY: Penguin Press; 2005.
82. Sachs JD, McArthur JW. The Millennium Project: a plan for meeting the Millennium Development Goals. Lancet. 2005;365(9456):347-353.
83. Kristof ND. Attack of the worms. New York Times. July 2, 2007.
84. Global Network for Neglected Tropical Disease Control. Alyssa Milano named founding ambassador of global network for neglected tropical disease control [press release]. http://gnntdc.sabin.org/files/ sabin_milano_announcement_release__06_28_07.pdf. Accessed August 4, 2007.
85. Yamey G, Hotez P. Neglected tropical diseases. BMJ. 2007;335(7614):269-270.
86. Global Network for Neglected Tropical Disease Control. Global network for neglected tropical disease control chairman and founder, Dr. Peter Hotez, named ambassador in Paul G. Rogers Society for Global Health [press release]. http://gnntdc.sabin .org/files/documents/Paul%20G%20Rogers%20- %20Hotez%20Appointment.pdf. Published November 16, 2006. Accessibility verified September 20, 2007.
87. Hotez P, Ottesen E, Fenwick A, Molyneux D. The neglected tropical diseases: the ancient afflictions of stigma and poverty and the prospects for their control and elimination. Adv Exp Med Biol. 2006;582: 23-33.
88. Global Network for Neglected Tropical Disease Control. Control of NTDs. http://gnntdc.sabin.org/what/control.html#Drug%20Donations. Accessed July 19, 2007.
89. Global Network for Neglected Tropical Diseases Web site. http://gnntdc.sabin.org/network/index.html. Accessed September 26, 2007.
90. Hotez PJ, Molyneux DH, Fenwick A, et al. Control of neglected tropical diseases. N Engl J Med. 2007; 357(10):1018-1027.
91. Lietman TM, Neuwelt MD, Gandhi NG, Dalman CA, Benitah N. Trachoma research: it takes more than a village. Lancet. 2006;367(9508):395.
92. Global Network for Neglected Tropical Diseases Web site. Neglected tropical diseases, malaria and HIV/AIDS. http://gnntdc.sabin.org/what/ntds.html. Accessed September 26, 2007.
93. World Health Organization. Report of the WHO informal consultation on the use of praziquantel during pregnancy and lactation and albendazole/mebendazole in children under 24 months, April 8-9, 2002. http://www.who.int/wormcontrol/ documents/en/pvc_20024full.pdf. Accessibility verified September 27, 2007.
94. Savioli L, Crompton DW, Neira M. Use of anthelminthic drugs during pregnancy.AmJ Obstet Gynecol. 2003;188(1):5-6.
95. World Health Organization. Report of the WHO informal consultation on hookworm infection and anaemia in girls and women: Geneva December 5-6, 1994. http://www.who.int/wormcontrol/documents/publications/en/96-1.pdf. Accessibility verified September 20, 2007.
96. World Health Organization. Preventive chemotherapy in human helminthiasis. http://whqlibdoc.who.int/publications/2006/9241547103_eng.pdf. Accessed September 9, 2007.
97. Hotez P, Bethony J, Brooker S, Albonico M. Eliminating neglected diseases in Africa. Lancet. 2005; 365(9477):2089.
98. Behnke JM, Pritchard DI, Wakelin D, et al. Effect of ivermectin on infection with gastro-intestinal nematodes in Sierra Leone. J Helminthol. 1994;68(3): 187-195.
99. Albonico M, Engels D, Savioli L. Monitoring drug efficacy and early detection of drug resistance in human soil-transmitted nematodes. Int J Parasitol. 2004; 34(11):1205-1210.
100. Albonico M, Smith PG, Ercole E, et al. Rate of reinfection with intestinal nematodes after treatment of children with mebendazole or albenadazole in a highly endemic area. Trans R Soc Trop Med Hyg. 1995; 89(5):538-541.
101. Leach AJ, Shelby-James TM, Mayo M, et al. A prospective study of the impact of community-based azithromycin treatment of trachoma on carriage and resistance of Streptococcus pneumoniae. Clin Infect Dis. 1997;24(3):356-362.
102. Sundar S, Jha TK, Thakur CP, et al. Injectable paromomycin for visceral leishmaniasis in India. N Engl J Med. 2007;356(25):2571-2581.
103. The Carter Center Web site. http://www.cartercenter.org. Accessed August 4, 2007.
104. Barry M. The tail end of guinea worm: global eradication without a drug or a vaccine. N Engl J Med. 2007;356(25):2561-2564.
105. Simeon DT, Grantham-McGregor SM, Callender JE, Wong MS. Treatment of Trichuris trichiura infections improves growth, spelling scores and school attendance in some children. J Nutr. 1995;125(7): 1875-1883.