Synthesis of thia-analogous indirubin n-glycosides and their influence onmelanoma cell growth and apoptosis

ChemMedChem

Volumn 5, Issue 4, 2010, Pages 534-539

  Kunz, Manfred ^a   Driller, Katrin M ^b   Hein, Martin ^b   Libnow, Stephanie ^b   Hohensee, Ina ^a   Ramer, Robert ^b   Hinz, Burkhard ^b   Berger, Anja ^c   Eberle, Jürgen ^c   Langer, Peter ^b,d  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d LEIBNIZ INSTITUT FÜR KATALYSE E V AN DER UNIVERSITÄT ROSTOCK   (Germany)

Author keywords

Antitumor agents; Apoptosis; Carbohydrates; Indirubin analogues; Kinases

Indexed keywords

3 [THIAINDAN 3' ON 2' YLIDENE] 1 (2'',3'',4'' TRI O ACETYL BETA RHAMNOPYRANOSYL)OXINDOL; 3 [THIAINDAN 3' ONE 2' YLIDENE] 1 (BETA RHAMNOPYRANOSYL)OXINDOL; 5 (4 BROMO 2 CHLOROANILINO) 4 FLUORO 1 METHYL 1H BENZIMIDAZOLE 6 CARBOHYDROXAMIC ACID 2 HYDROXYETHYL ESTER; ANTINEOPLASTIC AGENT; GLYCOSIDE; INDIRUBIN; N (BETA RHAMNOPYRANOSYL)ISATIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CATALYSIS; CONTROLLED STUDY; DEACETYLATION; DRUG SYNTHESIS; MELANOMA CELL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; GLYCOSIDES; HUMANS; INDOLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MELANOMA; PROTEIN-SERINE-THREONINE KINASES;

EID: 77950688682     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900506     Document Type: Article

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