Synthesis of indirubin-N′-glycosides and their anti-proliferative activity against human cancer cell lines

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 10, 2008, Pages 5570-5583

  Libnow, Stefanie ^a   Methling, Karen ^b   Hein, Martin ^a   Michalik, Dirk ^c   Harms, Manuela ^b   Wende, Kristian ^b   Flemming, Anke ^a   Köckerling, Martin ^a   Reinke, Helmut ^a   Bednarski, Patrick J ^b   Lalk, Michael ^b   Langer, Peter ^a,c  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

^c LEIBNIZ INSTITUT FÜR KATALYSE E V AN DER UNIVERSITÄT ROSTOCK   (Germany)

Author keywords

Anti proliferative activity; Carbohydrates; Indirubin; N heterocycles

Indexed keywords

4',6' DIMETHYL 1' BETA LEVO RHAMNOPYRANOSYLINDIRUBIN; GLYCOSIDE; INDIRUBIN; INDIRUBIN N' GLYCOSIDE; INDIRUBIN N' RHAMNOSIDE; INDOLE DERIVATIVE; INDOXYL DERIVATIVE; ISATIN DERIVATIVE; ISATIN N' GLYCOSIDE; N' BETA DEXTRO GALACTOPYRANOSYLINDIRUBIN; N' BETA DEXTRO GLUCOPYRANOSYLINDIRUBIN; N' BETA DEXTRO MANNOPYRANOSYLINDIRUBIN; N' BETA LEVO RHAMNOPYRANOSYLINDIRUBIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN MCF 7; CONTROLLED STUDY; CULTURE MEDIUM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NEOPLASM; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; GLYCOSIDES; HUMANS; INDOLES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 43749101513     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.04.003     Document Type: Article

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