DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 17, 2008, Pages 6314-6319

  Hastak, Kedar ^a   Paul, Rajib K ^a   Agarwal, Mukesh K ^c   Thakur, Vijay S ^a   Amin, A R M Ruhul ^a   Agrawal, Sudesh ^c   Sramkoski, R Michael ^b   Jacobberger, James W ^b   Jackson, Mark W ^b,c   Stark, George R ^a,b,c   Agarwal, Munna L ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Macrophage inhibitory cytokine 1; N (phosphonacetyl) L aspartate; p21; S phase

Indexed keywords

ATR PROTEIN; CHECKPOINT KINASE 1; CYTOKINE; HISTONE H2AX; MACROPHAGE INHIBITORY CYTOKINE 1; PROTEIN P21; PROTEIN P53; PYRIMIDINE NUCLEOTIDE; SPARFOSIC ACID; ASPARTIC ACID; ATM PROTEIN; ATR PROTEIN, HUMAN; CELL CYCLE PROTEIN; DNA; DNA BINDING PROTEIN; DRUG DERIVATIVE; NUCLEOTIDE; PHOSPHONOACETIC ACID; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; PYRIMIDINE; PYRIMIDINE DERIVATIVE; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL SURVIVAL; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA SYNTHESIS; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; ULTRAVIOLET RADIATION; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL LINE; DRUG EFFECT; METABOLISM; PHOSPHORYLATION;

ASPARTIC ACID; CELL CYCLE PROTEINS; CELL LINE; DNA; DNA DAMAGE; DNA-BINDING PROTEINS; HUMANS; MODELS, BIOLOGICAL; NUCLEOTIDES; PHOSPHONOACETIC ACID; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; S PHASE; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 44049086505     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802080105     Document Type: Article

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