Erythropoietin Secretion and Physiological Effect in Mouse after Intramuscular Plasmid DNA Electrotransfer

Journal of Gene Medicine

Volumn 1, Issue 4, 1999, Pages 245-250

  Kreiss, P ^a   Bettan, M ^b   Crouzet, J ^c   Scherman, D ^b  

^a PSL RESEARCH UNIVERSITY   (France)

^b CRVA   (France)

^c INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Electrotransfer; Erythropoietin; Gene therapy; Muscle gene transfer; Plasmid

Indexed keywords

MURINAE;

DNA; ERYTHROPOIETIN;

ANIMAL; ARTICLE; C57BL MOUSE; COMPARATIVE STUDY; ELECTROSTIMULATION; GENE TRANSFER; GENETICS; HEMATOCRIT; INTRAMUSCULAR DRUG ADMINISTRATION; KINETICS; METABOLISM; MOUSE; PHYSIOLOGY; PLASMID; SECRETION; SKELETAL MUSCLE;

ANIMALS; DNA; ELECTRIC STIMULATION; ERYTHROPOIETIN; GENE TRANSFER TECHNIQUES; HEMATOCRIT; INJECTIONS, INTRAMUSCULAR; KINETICS; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; PLASMIDS;

EID: 0033154484     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-2254(199907/08)1:4<245::AID-JGM49>3.0.CO;2-G     Document Type: Article

References (25)

1. Graber S, Krantz S. Erythropoietin and the control of red cell production. Annu Rev Med 1978; 29: 51-66.
2. Shanks J, Hill C, Lappin T, Maxwell A. Localization of erythropoietin gene expression in proximal renal tubular cells detected by digoxigenin-labelled oligonucleotide probes. J Pathol 1996; 179: 283-287.
3. Goodnough L, Monk T, Andriole G. Erythropoietin therapy. N Engl J Med 1997; 336: 933-938.
4. Henry D. Recombinant human erythropoietin treatment of anemic cancer patients. Cancer Pract 1996; 4: 180-184.
5. Perrella O, Finelli E, Perrella A, Tartaglia G, Scognamiglio P, Scalera G. Combined therapy with zidovudine, recombinant granulocyte colony stimulating factors and erythropoietin in asymptomatic HIV patients. J Chemother 1996; 8: 63-66.
6. Eschbach J, Egrie J, Downing M, Browne J, Adamson J. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial. N Engl J Med 1987; 316: 73-78.
7. Sytkowski A, Lunn E, Davis K, Feldman L, Siekman S. Human erythropoietin dimers with markedly enhanced in vivo activity. Proc Natl Acad Sci USA 1998; 95: 1184-1188.
8. Tripathy S, Goldwasser E, Lu M, Barr E, Leiden J. Stable delivery of physiologic levels of recombinant erythropoietin to the systemic circulation by intramuscular injection of replication-defective adenovirus. Proc Natl Acad Sci U S A 1994; 91: 11557-11561.
9. Naffakh N, Henri A, Villeval J, Rouyer FP, Moullier P, Blumenfeld N, et al. Sustained delivery of erythropoietin in mice by genetically modified skin fibroblasts. Proc Natl Acad Sci U S A 1995; 92: 3194-3198.
10. Rinsch C, Regulier E, Deglon N, Dalle B, Beuzard Y, Aebischer P. A gene therapy approach to regulated delivery of erythropotetin as a function of oxygen tension. Hum Gene Ther 1997; 8: 1881-1889.
11. Régulier E, Schneider B, Déglon N, Beuzard Y, Aebischer P. Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts. Gene Ther 1998; 5: 1014-1022.
12. Kessler P, Podsakoff G, Chen X, McQuiston S, Colosi P, Matelis L, et al. Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein. Proc Natl Acad Sci U S A 1996; 93: 14082-14087.
13. Zhou S, Murphy J, Escobedo J, Dwarki V. Adeno-associated virus-mediated delivery of erythropoietin leads to sustained elevation of hematocrit in nonhuman primates. Gene Ther 1998; 5, 665-670.
14. Tripathy S, Svensson E, Black H, Goldwasser E, Margalith M, Hobart P, et al. Long-term expression of erythropoietin in the systemic circulation of mice after intramuscular injection of a plasmid DNA vector. Proc Natl Acad Sci U S A 1996; 93: 10876-10880.
15. Mir L, Bureau M, Gehl J, Rangara R, Rouy D, Caillaud J, et. al. High efficiency gene transfer into skeletal muscle mediated by electric pulses. Proc. NatL Acad. Science. USA 1999; 96: 4262-4267.
16. Mir L, Bureau M, Rangara R, Schwartz B, Scherman D. Long-term, high level in vivo gene expression after electric pulse-mediated gene transfer into skeletal muscle. C R Acad. Sci Paris 1998; 321: 893-899.
17. Aihara H, Miyazaki J. Gene transfer into muscle by electroporation in vivo. Nat Biotechnol 1998; 16: 867-870.
18. Mathiesen I. Electropermeabilization of skeletal muscle enhances gene transfer in vivo. Gene Ther 1999; 6: 508-514.
19. Sambrook J, Fritsh E, Maniatis T. Molecular Cloning: a Laboratory Manual. 2nd Ed. Cold Spring Harbor NY: Cold Spring Harbor, 1989.
20. Soubrier F, Cameron B, Manse B, Somarriba S, Dubertret C, Jaslin G, et al. pCOR: a new design of plasmid vectors for non viral gene therapy. Gene Ther in press.
21. Shoemaker C, Mitsock L. Murine erythropoietin gene: cloning, expression, and human gene homology. Mol Cell Biol 1986; 6: 849-858.
22. Normanly J, Masson J, Kleina L, Abelson J, Miller J. Construction of two Escherichia coli amber suppressor genes: tRNAPheCUA and tRNACysCUA. Proc Natl Acad Sci U S A 1986; 83: 6548-6552.
23. Bayston K, Cohen J. Bacterial endotoxin and current concepts in the diagnosis and treatment of endotoxaemia. J Med Microbiol 1990; 31: 73-83.
24. Koepke J. Microhematocrit method. In Practical Laboratory Hematology. New York: Churchill Livingstone, 1991; 112-114.
25. Wolff J, Williams P, Acsadi G, Jiao S, Jani A, Chong W. Conditions affecting direct gene transfer into rodent muscle in vivo. Biotechniques 1991; 11: 474-485.