Stimulation of peripheral angiogenesis by vascular endothelial growth factor (VEGF)

Vasa - Journal of Vascular Diseases

Volumn 27, Issue 4, 1998, Pages 201-206

  Baumgartner, I ^a   Isner, J M ^b  

^a Kantonsspital Frauenfeld   (Switzerland)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Critical limb ischemia; Gene therapy; Therapeutic angiogenesis; Vascular endothelial growth factor

Indexed keywords

ANGIOPOIETIN 1; FIBROBLAST GROWTH FACTOR; PLASMID DNA; PLATELET DERIVED GROWTH FACTOR; PROTEINASE; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; CLINICAL TRIAL; COLLATERAL CIRCULATION; GENE THERAPY; GENE TRANSFER; HUMAN; LIMB ISCHEMIA; NONHUMAN; REVIEW;

ANIMALS; COLLATERAL CIRCULATION; ENDOTHELIAL GROWTH FACTORS; GENE THERAPY; HUMANS; ISCHEMIA; LEG; LYMPHOKINES; MYOCARDIAL ISCHEMIA; NEOVASCULARIZATION, PHYSIOLOGIC; RECOMBINANT PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0031760572     PISSN: 03011526     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (76)

1. Aiello LP, Avery RL, Arrigg PG, Keyt BA, Janpel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE. Vascular endothelial growth factor in ocular fluids of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994; 331: 1480-1487.
2. Albers M, Fratezi AC, DeLuccia N. Assessment of quality of life of patients with severe ischemia as a result of infrainguinal arterial occlusive disease. J Vase Surg 1992; 16: 54-59.
3. AsaharaT, Chen D. Accelerated restitution of endothelial integrity and endothelium-dependent function following phVEGF165 gene transfer. Circulation 1996;94:2892-2899.
4. Asprunk DH, Folkman J. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res 1977; 14: 53-65.
5. Baffour R, Berman J, Garb JL, Rhee SW, Kaufman Jm Friedman P. Enhanced angiogenesis and growths of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a rabbit model of acute lower limb ischemia: dose-response effect of basic fibroblast growth factor. J Vase Surg 1992; 16: 181-191.
6. Banai S, Jaklitsch MT, Shou M, Lazarous DF, Scheinowitz M, Biro S, Epstein SE, Unger EF. Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs. Circulation 1994; 89: 2183-2189.
7. Baumgartner I, Pieezek A, Manor O, Blair R, Kearney M, Walsh K, Isner JM. Constitutive expression of ph VEGF165 following intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation 1998; 97: 114-1123.
8. Bauters C, Asahara T, Zheng LP, Takeshita S, Bunting S, Ferrara N, Symes J, Isner JM. Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor. Circulation 1995; 91: 2802-2809.
9. Bauters C, Asahara T, Zheng LP, Takeshita S, Bunting S, Ferrara N, Symes JF, Isner JM. Physiological assessment of augmented vascularity induced by VEGF in ischemic rabbit hindlimb. Am J Physiol 1994; 267: H1263-H1271.
10. Bauters C, Asahara T, Zheng LP, Takeshita S, Bunting S, Ferrara N, Symes JF, Isner JM. Site-specific therapeutic angiogenesis following systemic administration of vascular endothelial growth factor. J Vase Surg 1995; 21: 314-325.
11. Breier G, Albrecht U, Starrer S, Risau W. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 1992; 114:521-532.
12. Brogi E, Schatteman G, Wu T, Kim EA, Varticovski L, Keyt B, Isner JM. Hypoxia-induced paracrine regulation of VEGF receptor expression.J Clin Invest 1996; 97: 469-476.
13. Carmeliet P, Ferriera V, Brier G, Pollefeyt S, Kieckens L, Gerstenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996; 380: 435-444.
14. Cuevas P. Hypotensive activity of fibroblast growth factor. Sience 1991; 254: 1208-1210.
15. D'Amore PA, Thompson RW. Mechanisms of angiogenesis. Annu Rev Physiol 1987;49:453-164.
16. de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT. The fms-like tyrosine kinase. a receptor for vascular endothelial growth factor. Sience 1992; 255: 989-1001.
17. Dormandy J, Mahir M, Ascady G, Balsano F, De Leeuw P, Blombery P, Bousser MG, Clement D, Coffman J, Deutschinoff A, Bletry O, Hampton J, Mahler F, Ohlin P, Rieger H, Stranden E, Turpie AGG, Urai L, Verstraete M. Fate of the patient with chronic leg ischaemia. J Cardiovasc Surg 1989; 30: 50-57.
18. Dvorak HF, Brown LF, Detmar M, Dvorak AM. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Path 1995; 146: 1029-1039.
19. Eneroth M, Persson BM. Amputation for occlusive arterial disease. A prospective multicentre study of 177 amputees. International Orthopaedics 1992; 16: 382-387.
20. European Working Group on Critical Leg Ischemia. Second European consensus document on chronic critical leg ischemia. Circulation 1991; 84 (suppl IV): IV1-IV26.
21. Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O'Shea KS, Powell-Braxton L, Hillau KJ, Moore MW. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996; 380: 439-442.
22. Ferrara N, Houck K, Jakeman L, Leung DW. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev 1992; 13: 18-32.
23. Folkman J. Therapeutic angiogenesis in ischemic limbs. Circulation 1998; 97: 1108-1110.
24. Folkman J, Shing Y Angiogenesis. J Biol Chem 1992;267: 10931-10934.
25. Goldberg MA, Schneider TJ. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and crythropoletin. J Biol Chem 1994; 269:4355-4359.
26. Haimovici H. Patterns of arteriosclerotic lesions of the lower extremity. Arch Surg 1967; 95: 918-932.
27. Haimovici H, Shapiro JH, Jacobson HG. Serial feinoral arteriography in occlusive disease: Clinical-roentgenologic considerations with a new classification of occlusive patternst. Am J Roetgenol Radium Ther Nucl Med 1960; 83: 1042-1046.
28. Hariawala MD. VEGF improves myocardial blood flow but produces EDRF-mediated hypotension in porcine hearts. J Surg Res 1996; 63: 77-82.
29. Hedin U, Wahlberg E. Gene therapy and vascular disease: potential applications in vascular surgery. Eur J Vasc Endovasc Surg 1997; 13: 101-111.
30. Ikeda E, Achen MG, Breier G, Risau W. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6glioma cells. J Biol Chem 1995; 270: 19761-19766.
31. Isner JM. Therapeutic angiogenesis: a new frontier for vascular therapy. Vascular Medicine 1996; 1: 79-87.
32. Isner JM, Pieczck A, Schainfeld R, Blair R, Haley L, Asahara T, Rosenfield K, Razvi S, Walsh K, Symes JF. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischemic limb. Lancet 1996; 348: 370-374.
33. Isner JM, Walsh K, Symes JF, Piezcek A, Takeshita S, Lowry J, Rosenfield K, Weir L, Brogi E, Jurayj D. Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease. Circulation 1995; 91: 2687-2692.
34. Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, Connolly DT. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Sience 1989;246:1309-1312.
35. Klagsbrun M, D'Amore PA. Regulators of angiogenesis. Annu Rev Physiol 1991; 53: 217-239.
36. Klagsbrun M, D'Amore PA. Vascular endothelial growth factor and its receptors. Cytokine & Growth Factor Reviews 1996;7:259-270.
37. Klagsbrun M, Folkman J. Peptide growth factors and their receptors. In: Sporn, MB Roberts, AB (Hrsg), Bd. 2. New York: Springer-Verlag 1990; 459-586.
38. Koolwijk P, van Erck GM, de Vree JA, Vermeer MA, Weich HA, Hanemaaijer R, van Hinsbergh WM. Cooperative effect of TNFalpha. bFGF. and VEGF on the formation of tubular structures of human microvascular endothelial cells in a fibrin matrix. Role of urokinase activity. J Cell Biol 1996; 132: 1177-1188.
39. Kuzuya M. Induction of angiogenesis by smooth musce cell-derived factor: possible role in neovascularization in atherosclerotic plaque. J Cell Physiol 1995;164:658-667.
40. Lepantalo M, Mätzke S. Outcome of unreconstructed chronic critical leg ischaemia. Eur J Vasc Endovasc Surg 1996; 11: 153-157.
41. Levy PL, Levy NS, Goldberg MA. Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J Biol Chem 1996; 271: 2746-2753.
42. Losordo DW, Pickering JG, Takeshita S, Leclerc G, Gal D, Weir L, Kearney M, Jekanowski J, Isner, JM. Use of the rabbit ear artery to serially assess foreign protein secretion after site specific arterial gene transfer in vivo: evidence that anatomic identification of successful gene transfer may underestimate the potential magnitude of transgene expression. Circulation 1994; 89: 785-792.
43. Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, SatoTN, Yancopoulos GD. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997;277:55-60.
44. Mandriota SJ, Menoud P-A, Pepper MS. Transform ing growth factor betal down- regulates vascular endothelial growth factor receptor 2/flk-1 expression in vascular endothelial cells. J Biol Chem 1996; 271:11500-11505.
45. Manthorpe M, Cornefert-Jensen F, Hartikka J, Feigner, J. Rundell A, Margalith M, Dwanki V. Gene therapy by intramuscular injection of plasmid DNA: studies on firefly luciferase gene expression in mice. Human Gene Ther 1993;4: 419-431.
46. Millauer B, Wizigmann-Voos S, Schnurch H, Martinez R, Moller NPH, Risau W, Ulrich A. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 1993; 72: 835-846.
47. Pearlman JD, Hibberd MG, Chuang ML, Harada K, Lopez JJ, Gladston SR, Friedman M, Sellke FW, Simons M. Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis. Nature Med 1995; 1: 1085-1089.
48. Pepper MS, Ferrara N, Orci L, Montesano R. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem Biophys Res Commun 1992; 3: 211-220.
49. Pickering JG, Weir L, Jekanowski J, Kearney MA, Isner JM. Proliferative activity in peripheral and coronary atherosclerotic plaque among patients undergoing percutaneous revascularisation. J Clin Invest 1993; 91: 1469-1480.
50. Plate KH, Breier G, Weich HA, Risau W. Vascular endothelial growth factor is a potential tumor angiogenesis factor in vivo. Nature 1992; 359: 845-847.
51. Pu LQ, Sniderman AD, Brassard R. Lachapelle KJ, Graham AM, Lisbona R, Symes J. Enhanced revascularization of the ischemic limb by means of angiogenic therapy. Circulation 1993; 88: 208-215.
52. Riessen R, Rahimizadeh H, Blessing E, Takeshita S, Barry JJ, Isner JM. Arterial gene transfer using pure DNA applied directly to a hydrogel-coated angioplasty balloon. Hum Gene Ther 1993; 4: 749-758.
53. Risau W. Mechanisms of angiogenesis. Nature 1997; 386: 671-674.
54. Risau W, Sariola H, Zerwes H-G, Sasse J, Ekblom P, Kemler R, Doetschman T. Vasculogenesis and angiogenesis in embryonic stem cell-derived embryoid bodies. Development 1988; 102: 471-478.
55. Rosengart TK, Budenbender KT, Duenas M, Mack CA, Zhang Q-X, Isom OW. Therapeutic angiogenesis: comparative study of the angiogenic potential of acidic fibroblast growth factor and heparin. J Vasc Surg 1997; 26: 302-312.
56. Sumner DS, Thiele BI. The Vascular Laboratory. In: Rutherford RB (Hrsg), 4th ed. Philadelphia: Saunders 1995: 45-64.
57. Sato Y, Rifkin DB. Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1 -like molecule by plasmin during co-culture. J Cell Biol 1989; 109: 309-315.
58. Schaper W, de Brabander M, Lewi P. DNA synthesis and mitoses in coronary collateral vessels of the dog. Circ Res 1971; 28: 671-679.
59. Schaper W, Ito WD. Molecular mechanisms of coronary collateral vessel growth. Circ Res 1996; 79: 91-19.
60. Sellke FW, Harada K, Wang SY, Friedman M, Harada K, Edelman ER, Grossman W, Simons M. Basic FGF enhances endothelium-dependent relaxation of the collateral-perfused coronary microcirculation. Am J Physiol 1994; 267: H1303-H1311.
61. Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-induced angiogenesis. Nature 1992; 359: 843-845.
62. Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, Sato TN, Yancopoulos GD. Requisite role of angiopoietin-1. a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 1996; 87: 1171-1180.
63. Takashita S, Tsurumi Y, Couffinhal T, Asahara T, Bauters C, Symes J, Ferrara N, Isner JM. Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo. Lab Invest 1996; 75: 487-502.
64. Takeshita S, Kearney M, Loushin C, Brogi E, Zheng LP, Horowitz J, Ferrara N, Symes JF, Isner JM. In vivo evidence that vascular endothelial growth factor stimulates collateral formation by inducing arterial cell proliferation in a rabbit ischemic hindlimb. Am J Physiol 1994; 266: H1588-H1595.
65. Takeshita S, Pu LQ, Stein LA, Sniderman AD, Bunting S, Ferrara N, Isner JM, Symes JF. Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia. Circulation 1994; 90: 11228-11234.
66. Takeshita S, Zheng LP, Brogi E, Zeng LP, Riessen R, Bauters C, Symes JF, Ferrara N, Isner JM. Therapeutic angiogenesis: A single intra-arterial bolus of vascular endothelial growth factor augments revascularisation in a rabbit ischemic hindlimb modelt. J Clin Invest 1994; 93: 662-670.
67. Thomas KA. Vascular endothelial growth factor, a potent and selective angiogenic agent. J Biol Chem 1996; 271: 603-606.
68. Tsurumi Y, Takeshita S, Chen D, Kearney M, Rossow ST, Passeri J, Horowitz JR, Symes JF, Isner JM. Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion. Circulation 1996; 94: 3281-3290.
69. Unger EF, Banai S, Shou M, Lazarous DF, Jaklitsch MT, Schcinowitz M, Correa R, Klingbeil C, Epstein SE. Basic fibroblast growth factor enhances myocardial collateral flow in a canine model. Am J Physiol 1994; 266 (Heart Circ Physiol 35): H1588-H1595.
70. Van Leeuwen RTJ. Extracellular proteolvsis and the migrating vascular smooth muscle cell. Fibrinolysis 1996; 10: 59-74.
71. Waltenberger, Mayr U, Pentz S, Hombach V, Functional upregulation of the vascular endothelial growth factor receptor KDR by hypoxia. Circulation 1996; 94: 1647-1654.
72. Waltenberger J. Modulation of growth factor action. Implications for the treatment of cardiovascular diseases. Circulation 1997; 96: 4083-4094.
73. Wang GL, Semenza GL. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. Blood 1993; 268: 21513-21518.
74. Ware JA, Simons M. Angiogenesis in ischemic heart disease. Nature Med 1997; 3: 158-164.
75. Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, Feigner PL. Direct gene transfer into mouse muscle in vivo. Science 1990; 247: 1465-1468.
76. Ziche M, Morbidelli L, Masini E, Amerini S, Granger HJ, Maggi CA, Geppetti P, Ledda F. Nitric oxide mediales angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest 1994;94: 2036-2044.