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Volumn 161, Issue 1-3, 2010, Pages 97-105

Rikkunshito and 5-HT2C receptor antagonist improve cisplatin-induced anorexia via hypothalamic ghrelin interaction

Author keywords

Cisplatin; Ghrelin; GHS R1a; Hypothalamus; RKT

Indexed keywords

6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; CISPLATIN; GHRELIN; GHRELIN RECEPTOR; GRANISETRON; HERBACEOUS AGENT; HESPERIDIN; ISOLIQUIRITIGENIN; MESSENGER RNA; ONDANSETRON; RIKKUNSHITO; UNCLASSIFIED DRUG;

EID: 77950338637     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2010.02.003     Document Type: Article
Times cited : (67)

References (48)
  • 1
    • 36049025554 scopus 로고    scopus 로고
    • New anti-emetic treatments
    • Roila F., Garassio M., Fatigon S. New anti-emetic treatments. Ann Oncol 2007, 18(Supplement 9):43-47.
    • (2007) Ann Oncol , vol.18 , Issue.9 SUPPL. , pp. 43-47
    • Roila, F.1    Garassio, M.2    Fatigon, S.3
  • 2
    • 0038728753 scopus 로고    scopus 로고
    • Addition of the neurokinin 1 receptor antagonist aprepitant to standard antiemetic therapy improves control of chemotherapy-induced nausea and vomiting. Results from a randomized, double-blind, placebo-controlled trial in Latin America
    • Poli-Bigelli S., Rodrigues-Pereira J., Carides A.D. Addition of the neurokinin 1 receptor antagonist aprepitant to standard antiemetic therapy improves control of chemotherapy-induced nausea and vomiting. Results from a randomized, double-blind, placebo-controlled trial in Latin America. Cancer 2003, 97:2931-2947.
    • (2003) Cancer , vol.97 , pp. 2931-2947
    • Poli-Bigelli, S.1    Rodrigues-Pereira, J.2    Carides, A.D.3
  • 3
    • 64449086749 scopus 로고    scopus 로고
    • A questionnaire study of the approach to the anorexia-cachexia syndrome in patients with cancer by staff in a district general hospital
    • Churm D., Andrew I.M., Holden K., Hildreth A.J., Hawkins C. A questionnaire study of the approach to the anorexia-cachexia syndrome in patients with cancer by staff in a district general hospital. Support Care Cancer 2009, 17:503-507.
    • (2009) Support Care Cancer , vol.17 , pp. 503-507
    • Churm, D.1    Andrew, I.M.2    Holden, K.3    Hildreth, A.J.4    Hawkins, C.5
  • 4
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402:656-660.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 6
    • 0036073405 scopus 로고    scopus 로고
    • Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure
    • Banks W.A., Tschop M., Robinson S.M., Heiman M.L. Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther 2002, 302:822-827.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 822-827
    • Banks, W.A.1    Tschop, M.2    Robinson, S.M.3    Heiman, M.L.4
  • 10
    • 11244319495 scopus 로고    scopus 로고
    • Circulating ghrelin levels and central GHS-R1a expression are elevated in response to food deprivation in a season mammal (Holdups sungorus)
    • Tups A., Helwig M., Khorooshi R.M.H., Archer Z.A., Klingensport M., Mercer J.G. Circulating ghrelin levels and central GHS-R1a expression are elevated in response to food deprivation in a season mammal (Holdups sungorus). J Neuroendocrinol 2004, 16:922-928.
    • (2004) J Neuroendocrinol , vol.16 , pp. 922-928
    • Tups, A.1    Helwig, M.2    Khorooshi, R.M.H.3    Archer, Z.A.4    Klingensport, M.5    Mercer, J.G.6
  • 11
    • 4644249772 scopus 로고    scopus 로고
    • Regulation of growth hormone secretagogue receptor gene expression in the arcurate nuclei of the rats by leptin and ghrelin
    • Nogueiras R., Tovar S., Mitchell S.E., Rayner D.V., Archer Z.A., Dieguez C., Williams L.M. Regulation of growth hormone secretagogue receptor gene expression in the arcurate nuclei of the rats by leptin and ghrelin. Diabetes 2004, 53:2552-2558.
    • (2004) Diabetes , vol.53 , pp. 2552-2558
    • Nogueiras, R.1    Tovar, S.2    Mitchell, S.E.3    Rayner, D.V.4    Archer, Z.A.5    Dieguez, C.6    Williams, L.M.7
  • 12
    • 0034098562 scopus 로고    scopus 로고
    • Regulation of pituitary growth hormone-secretagogue and growth hormone-releasing hormone receptor RNA expression in young Dwarf rats
    • Hirokawa R., Tachibana T., Katsumata N. Regulation of pituitary growth hormone-secretagogue and growth hormone-releasing hormone receptor RNA expression in young Dwarf rats. Endocr J 2000, 47:S53-S56. Suppl.
    • (2000) Endocr J , vol.47 , Issue.SUPPL
    • Hirokawa, R.1    Tachibana, T.2    Katsumata, N.3
  • 13
    • 44649158443 scopus 로고    scopus 로고
    • Rikkunshito, a herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT 2 receptor antagonism
    • Takeda H., Sadakane C., Hattori T., Katsurada T., Ohkawara T., Nagai K., Asaka M. Rikkunshito, a herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT 2 receptor antagonism. Gastroenterology 2008, 134:2004-2013.
    • (2008) Gastroenterology , vol.134 , pp. 2004-2013
    • Takeda, H.1    Sadakane, C.2    Hattori, T.3    Katsurada, T.4    Ohkawara, T.5    Nagai, K.6    Asaka, M.7
  • 16
    • 13144258739 scopus 로고    scopus 로고
    • 5-hydroxytryptamine(5-HT) concentrations in the hippocampus, the hypothalamus and the medulla oblongata related to cisplatin-induced PICA of rats
    • Liu Y., Hamaue N., Endo T., Hirafuji M., Minami M. 5-hydroxytryptamine(5-HT) concentrations in the hippocampus, the hypothalamus and the medulla oblongata related to cisplatin-induced PICA of rats. Res Commun Mol Pathol Pharmacol 2003, 113:97-113.
    • (2003) Res Commun Mol Pathol Pharmacol , vol.113 , pp. 97-113
    • Liu, Y.1    Hamaue, N.2    Endo, T.3    Hirafuji, M.4    Minami, M.5
  • 17
    • 0034000526 scopus 로고    scopus 로고
    • Effects of selected serotonin 5-HT1 and 5-HT2 receptor agonists on feeding behavior: possible mechanisms of action
    • De Vry J., Schreiber R. Effects of selected serotonin 5-HT1 and 5-HT2 receptor agonists on feeding behavior: possible mechanisms of action. Neurosci Biobehav Rev 2000, 24:341-353.
    • (2000) Neurosci Biobehav Rev , vol.24 , pp. 341-353
    • De Vry, J.1    Schreiber, R.2
  • 18
    • 0034536796 scopus 로고    scopus 로고
    • Effects of serotonin 1/2 receptor agonists on dark-phase food and water intake in rats
    • Schreiber R., Selbach K., Asmussen M., Hesse D., De Vry J. Effects of serotonin 1/2 receptor agonists on dark-phase food and water intake in rats. Pharmacol Biochem Behav 2000, 67:291-305.
    • (2000) Pharmacol Biochem Behav , vol.67 , pp. 291-305
    • Schreiber, R.1    Selbach, K.2    Asmussen, M.3    Hesse, D.4    De Vry, J.5
  • 20
    • 35548988366 scopus 로고    scopus 로고
    • Serotonin and the orchestration of energy balance
    • Tecott L.H. Serotonin and the orchestration of energy balance. Cell Metab 2007, 6:352-361.
    • (2007) Cell Metab , vol.6 , pp. 352-361
    • Tecott, L.H.1
  • 21
    • 35648977537 scopus 로고    scopus 로고
    • Ghrelin and feedback system
    • Nonogaki K. Ghrelin and feedback system. Vitam Horm 2007, 77:150-170.
    • (2007) Vitam Horm , vol.77 , pp. 150-170
    • Nonogaki, K.1
  • 22
    • 63449106102 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2C receptor and acyl ghrelin
    • 1
    • Fujitsuka N., Asakawa A., Hayashi M., Sameshima M., Amitani H., Kojima S., Fujimiya M., Inui A. Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2C receptor and acyl ghrelin. Biol Psychiatr 2009, 65(9):748-759. 1.
    • (2009) Biol Psychiatr , vol.65 , Issue.9 , pp. 748-759
    • Fujitsuka, N.1    Asakawa, A.2    Hayashi, M.3    Sameshima, M.4    Amitani, H.5    Kojima, S.6    Fujimiya, M.7    Inui, A.8
  • 23
    • 73649123558 scopus 로고    scopus 로고
    • Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibition
    • Takeda H., Muto S., Hattori T., Sadakane C., Tsuchiya K., Katsurada T., Ohkawara T., Oridate N., Asaka M. Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibition. Endocrinology 2010, 151(1):244-252.
    • (2010) Endocrinology , vol.151 , Issue.1 , pp. 244-252
    • Takeda, H.1    Muto, S.2    Hattori, T.3    Sadakane, C.4    Tsuchiya, K.5    Katsurada, T.6    Ohkawara, T.7    Oridate, N.8    Asaka, M.9
  • 24
    • 1642414933 scopus 로고    scopus 로고
    • The herbal medicine Rikkunshi-to stimulates and coordinates the gastric myoelectric activity in post-operative dyspeptic children after gastrointestinal surgery
    • Yagi M., Homma S., Kubota M., Iinuma Y., Kanada S., Kinoshita Y., Ohtaki M., Yamazaki S., Murata H. The herbal medicine Rikkunshi-to stimulates and coordinates the gastric myoelectric activity in post-operative dyspeptic children after gastrointestinal surgery. Pediatr Surg Int 2004, 19:760-765.
    • (2004) Pediatr Surg Int , vol.19 , pp. 760-765
    • Yagi, M.1    Homma, S.2    Kubota, M.3    Iinuma, Y.4    Kanada, S.5    Kinoshita, Y.6    Ohtaki, M.7    Yamazaki, S.8    Murata, H.9
  • 25
    • 0027219966 scopus 로고
    • Effect of treatment with liu-jun-zi-tang(TJ-43) on gastric emptying and gastrointestinal symptoms in dyspeptic patients
    • Tatsuta M., Iishi H. Effect of treatment with liu-jun-zi-tang(TJ-43) on gastric emptying and gastrointestinal symptoms in dyspeptic patients. Aliment Pharmacol Ther 1993, 7:459-462.
    • (1993) Aliment Pharmacol Ther , vol.7 , pp. 459-462
    • Tatsuta, M.1    Iishi, H.2
  • 26
    • 32644454595 scopus 로고
    • Clinical evaluation of the efficacy of TJ-43 Tsumura Rikkunshito on chronic gastritis with abdominal symptom-multicenter groups study in comparison with cisapride
    • Miyoshi A., Yachi A., Masamune O., Ishikawa M. Clinical evaluation of the efficacy of TJ-43 Tsumura Rikkunshito on chronic gastritis with abdominal symptom-multicenter groups study in comparison with cisapride. Prog Med 1991, 11:1605-1631.
    • (1991) Prog Med , vol.11 , pp. 1605-1631
    • Miyoshi, A.1    Yachi, A.2    Masamune, O.3    Ishikawa, M.4
  • 27
    • 67650489294 scopus 로고    scopus 로고
    • Japanese herbal medicine in functional gastrointestinal disorders
    • Suzuki H., Inadomi J.M., Hibi T. Japanese herbal medicine in functional gastrointestinal disorders. Neurogastroenterol Motil 2009, 21:688-696.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 688-696
    • Suzuki, H.1    Inadomi, J.M.2    Hibi, T.3
  • 28
    • 33748338959 scopus 로고    scopus 로고
    • Successful antiemetic treatment of Tsumura Rikkunshito extract granules for ethical use in addition to other antiemetic agents in neoadjuvant chemotherapy for an advanced breast cancer patient
    • Tomono H., Ito Y., Watanabe T. Successful antiemetic treatment of Tsumura Rikkunshito extract granules for ethical use in addition to other antiemetic agents in neoadjuvant chemotherapy for an advanced breast cancer patient. Jpn J Cancer Chemother 2006, 33:1129-1131.
    • (2006) Jpn J Cancer Chemother , vol.33 , pp. 1129-1131
    • Tomono, H.1    Ito, Y.2    Watanabe, T.3
  • 29
    • 15044340115 scopus 로고    scopus 로고
    • Agonist diversity in 5-HT2C receptor-mediated weight control in rats
    • Hayashi A., Suzuki M., Sasamata M., Miyata K. Agonist diversity in 5-HT2C receptor-mediated weight control in rats. Psychopharmacology 2005, 178:241-249.
    • (2005) Psychopharmacology , vol.178 , pp. 241-249
    • Hayashi, A.1    Suzuki, M.2    Sasamata, M.3    Miyata, K.4
  • 30
    • 0036314871 scopus 로고    scopus 로고
    • Stimulation of 5-hydroxytryptamine (5-HT2c) receptors in the ventrotegmental area inhibits stress-induced but not basal dopamine release in the rat prefrontal cortex
    • Pozzi L., Acconcia S., Ceglia I., Invernizzi R.W., Samani R. Stimulation of 5-hydroxytryptamine (5-HT2c) receptors in the ventrotegmental area inhibits stress-induced but not basal dopamine release in the rat prefrontal cortex. J Neurochem 2002, 82:93-100.
    • (2002) J Neurochem , vol.82 , pp. 93-100
    • Pozzi, L.1    Acconcia, S.2    Ceglia, I.3    Invernizzi, R.W.4    Samani, R.5
  • 31
    • 0036223046 scopus 로고    scopus 로고
    • Involvement of 5-HT1A and 5-H1B serotonergic receptor subtypes in sexual arousal in male mice
    • Popova N.K., Amstislavskaya T.G. Involvement of 5-HT1A and 5-H1B serotonergic receptor subtypes in sexual arousal in male mice. Psychoneuroendocrinology 2002, 27:609-618.
    • (2002) Psychoneuroendocrinology , vol.27 , pp. 609-618
    • Popova, N.K.1    Amstislavskaya, T.G.2
  • 32
    • 67349157186 scopus 로고    scopus 로고
    • Effects of reducing hypothalamic ghrelin receptor gene expression on energy balance
    • Shrestha Y.B., Wickwire K., Giraudo S. Effects of reducing hypothalamic ghrelin receptor gene expression on energy balance. Peptides 2009, 30:1336-1341.
    • (2009) Peptides , vol.30 , pp. 1336-1341
    • Shrestha, Y.B.1    Wickwire, K.2    Giraudo, S.3
  • 34
    • 1842480284 scopus 로고    scopus 로고
    • Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    • Sun Y., Wang P., Zheng H., Smith R.G. Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci USA 2004, 30:4679-4684.
    • (2004) Proc Natl Acad Sci USA , vol.30 , pp. 4679-4684
    • Sun, Y.1    Wang, P.2    Zheng, H.3    Smith, R.G.4
  • 36
    • 67649449241 scopus 로고    scopus 로고
    • Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice
    • Nonogaki K., Kaji T., Ohba Y., Sumii M., Wakameda M., Tamari T. Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice. Biochem Biophys Res Commun 2009, 386:311-315.
    • (2009) Biochem Biophys Res Commun , vol.386 , pp. 311-315
    • Nonogaki, K.1    Kaji, T.2    Ohba, Y.3    Sumii, M.4    Wakameda, M.5    Tamari, T.6
  • 37
    • 39149129347 scopus 로고    scopus 로고
    • Autoradiographic analysis of ghrelin receptors in the rat hypothalamus
    • Harrold J.A., Dovey T., Cai X.-J., Halford J.C.G., Pinkney J. Autoradiographic analysis of ghrelin receptors in the rat hypothalamus. Brain Res 2008, 1196:59-64.
    • (2008) Brain Res , vol.1196 , pp. 59-64
    • Harrold, J.A.1    Dovey, T.2    Cai, X.-J.3    Halford, J.C.G.4    Pinkney, J.5
  • 39
    • 67649208320 scopus 로고    scopus 로고
    • Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene
    • Nonogaki K., Ohba Y., Wakameda M., Tamari T. Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene. Int J Neuropsychopharmacol 2009, 12:547-552.
    • (2009) Int J Neuropsychopharmacol , vol.12 , pp. 547-552
    • Nonogaki, K.1    Ohba, Y.2    Wakameda, M.3    Tamari, T.4
  • 40
    • 44549089064 scopus 로고    scopus 로고
    • Adaptive upregulation of gastric and hypothalamic GHS-R1as and increased plasma ghrelin in a model of cancer chemotherapy-induced dyspepsia
    • Malik N.M., Moore G.B.T., Kaur R., Liu Y.L., Wood S.L., Morrow R.W., Sanger G.J., Andrews P.L. Adaptive upregulation of gastric and hypothalamic GHS-R1as and increased plasma ghrelin in a model of cancer chemotherapy-induced dyspepsia. Regul Pept 2008, 148:33-38.
    • (2008) Regul Pept , vol.148 , pp. 33-38
    • Malik, N.M.1    Moore, G.B.T.2    Kaur, R.3    Liu, Y.L.4    Wood, S.L.5    Morrow, R.W.6    Sanger, G.J.7    Andrews, P.L.8
  • 41
    • 0034077279 scopus 로고    scopus 로고
    • New insights into sympathetic regulation of glucose and fat metabolism
    • Nonogaki K. New insights into sympathetic regulation of glucose and fat metabolism. Diabetologia 2000, 43:533-549.
    • (2000) Diabetologia , vol.43 , pp. 533-549
    • Nonogaki, K.1
  • 42
    • 0029904648 scopus 로고    scopus 로고
    • Differential effects of the 5-HT1B/2C receptor agonist mCPP and 5-HT1A agonist flesinoxan on hypothalamic neuropeptide Y in the rat: evidence that NPY may mediate serotonin's effects on food intake
    • Dryden S., Wang Q., Frankishu H.M., Williams G. Differential effects of the 5-HT1B/2C receptor agonist mCPP and 5-HT1A agonist flesinoxan on hypothalamic neuropeptide Y in the rat: evidence that NPY may mediate serotonin's effects on food intake. Peptides 1996, 17:943-949.
    • (1996) Peptides , vol.17 , pp. 943-949
    • Dryden, S.1    Wang, Q.2    Frankishu, H.M.3    Williams, G.4
  • 43
    • 0036092341 scopus 로고    scopus 로고
    • Evidence for an interaction between neuropeptide Y and the melanocortin-4 receptor on feeding in the rat
    • Hansen M.J., Morris M.J. Evidence for an interaction between neuropeptide Y and the melanocortin-4 receptor on feeding in the rat. Neuropharmacology 2002, 42:792-797.
    • (2002) Neuropharmacology , vol.42 , pp. 792-797
    • Hansen, M.J.1    Morris, M.J.2
  • 44
    • 0030894709 scopus 로고    scopus 로고
    • Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti syndrome
    • Kesterson R.A., Huszar D., Lynch C.A., Simerly R.B., Cone R.D. Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti syndrome. Mol Endocrinol 1997, 11:630-637.
    • (1997) Mol Endocrinol , vol.11 , pp. 630-637
    • Kesterson, R.A.1    Huszar, D.2    Lynch, C.A.3    Simerly, R.B.4    Cone, R.D.5
  • 45
    • 0003279556 scopus 로고    scopus 로고
    • Anatomy of an endogenous antagonist: relationship between Agoti-related protein and proopiomelanocortin in the brain
    • Bagrol I.D., Lu X.Y., Kaelin C.B., Day H.E., Ollmann M., Gan E.I., Akil H., Marsh G.S., Watson S.J. Anatomy of an endogenous antagonist: relationship between Agoti-related protein and proopiomelanocortin in the brain. J Neurosci 1999, 18:1-7.
    • (1999) J Neurosci , vol.18 , pp. 1-7
    • Bagrol, I.D.1    Lu, X.Y.2    Kaelin, C.B.3    Day, H.E.4    Ollmann, M.5    Gan, E.I.6    Akil, H.7    Marsh, G.S.8    Watson, S.J.9
  • 46
    • 1542343913 scopus 로고    scopus 로고
    • Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ
    • Inui A., Asakawa A., Bowers C.Y., Mantovani G., Laviano A., Meguid M.M., Fujimiya M. Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J 2004, 18:439-456.
    • (2004) FASEB J , vol.18 , pp. 439-456
    • Inui, A.1    Asakawa, A.2    Bowers, C.Y.3    Mantovani, G.4    Laviano, A.5    Meguid, M.M.6    Fujimiya, M.7
  • 47
    • 35648985567 scopus 로고    scopus 로고
    • The growth hormone secretagogue receptor
    • Cruse C.R.Y., Smith R.G. The growth hormone secretagogue receptor. Vitam Horm 2007, 77:89-119.
    • (2007) Vitam Horm , vol.77 , pp. 89-119
    • Cruse, C.R.Y.1    Smith, R.G.2


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