Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes

Journal of Molecular Endocrinology

Volumn 44, Issue 4, 2010, Pages 225-236

  Jun, Dong Jae ^a   Na, Kyung Yoon ^a   Kim, Wanil ^a   Kwak, Dongoh ^a   Kwon, Eun Jeong ^a   Yoon, Jong Hyuk ^a   Yea, Kyungmoo ^a   Lee, Hyeongji ^a   Kim, Jaeyoon ^a   Suh, Pann Gill ^a   Ryu, Sung Ho ^a   Kim, Kyong Tai ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; CORTICOTROPIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; I KAPPA B KINASE; INTERLEUKIN 6; MELANOCORTIN; MELANOCORTIN 2 RECEPTOR; MELANOCORTIN 5 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EPIDIDYMIS FAT; GENE EXPRESSION; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADIPOCYTES; ADRENOCORTICOTROPIC HORMONE; ALPHA-MSH; ANIMALS; CELL DIFFERENTIATION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION; I-KAPPA B KINASE; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MELANOCORTINS; MICE; MICE, INBRED C57BL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTOR, MELANOCORTIN, TYPE 2; RECEPTORS, MELANOCORTIN; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 77950221237     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1677/JME-09-0161     Document Type: Article

References (54)

1. Ajuwon KM & Spurlock ME 2005 Palmitate activates the NF-κB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes. Journal of Nutrition 135 1841-1846.
2. An J, Sun Y, Sun R & Rettig MB 2003 Kaposi's sarcoma-associated herpesvirus encoded vFLIP induces cellular IL-6 expression: the role of the NF-κB and JNK/AP1 pathways. Oncogene 22 3371-3385.
3. An JJ, Rhee Y, Kim SH, Kim DM, Han DH, Hwang JH, Jin YJ, Cha BS, Baik JH, Lee WT et al. 2007 Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle. Journal of Biological Chemistry 282 2862-2870.
4. Antunes TT, Gagnon A, Chen B, Pacini F, Smith TJ & Sorisky A 2006 Interleukin-6 release from human abdominal adipose cells is regulated by thyroid-stimulating hormone: effect of adipocyte differentiation and anatomic depot. American Journal of Physiology. Endocrinology and Metabolism 290 E1140-E1144.
5. Antunes TT, Gagnon A, Langille ML & Sorisky A 2008 Thyroid-stimulating hormone induces interleukin-6 release from human adipocytes through activation of the nuclear factor-κB pathway. Endocrinology 149 3062-3066.
6. Bohm M, Luger TA, Tobin DJ & Garcia-Borron JC 2006 Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. Journal of Investigative Dermatology 126 1966-1975.
7. Boston BA 1999 The role of melanocortins in adipocyte function. Annals of the New York Academy of Sciences 885 75-84.
8. Brown BL, Albano JD, Ekins RP & Sgherzi AM 1971 A simple and sensitive saturation assay method for the measurement of adenosine 3′:5′-cyclic monophosphate. Biochemical Journal 121 561-562.
9. Butler AA, Marks DL, FanW, Kuhn CM, BartolomeM& Cone RD 2001 Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nature Neuroscience 4 605-611.
10. Chen W, Kelly MA, Opitz-Araya X, Thomas RE, Low MJ & Cone RD 1997 Exocrine gland dysfunction in MC5-R-deficientmice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides. Cell 91 789-798.
11. Chen BC, Liao CC, Hsu MJ, Liao YT, Lin CC, Sheu JR & Lin CH 2006 Peptidoglycan-induced IL-6 production in RAW264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B kinase, and NF-κB. Journal of Immunology 177 681-693.
12. Cone RD 2006 Studies on the physiological functions of the melanocortin system. Endocrine Reviews 27 736-749.
13. Diya Z, Lili C, Shenglai L, Zhiyuan G & Jie Y 2008 Lipopolysaccharide (LPS) of Porphyromonas gingivalis induces IL-1beta, TNF-alpha and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS. Innate Immunity 14 99-107.
14. Fang X, Yu S, Bast RC, Liu S, Xu HJ, Hu SX, LaPushin R, Claret FX, Aggarwal BB, Lu Y et al. 2004 Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells. Journal of Biological Chemistry 279 9653-9661.
15. Fasshauer M, Kralisch S, Klier M, Lossner U, Bluher M, Klein J & Paschke R 2003 Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications 301 1045-1050.
16. Fernandez-Real JM & Ricart W 2003 Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocrine Reviews 24 278-301.
17. Franchimont N, Durant D, Rydziel S & Canalis E 1999 Platelet-derived growth factor induces interleukin-6 transcription in osteoblasts through the activator protein-1 complex and activating transcription factor-2. Journal of Biological Chemistry 274 6783-6789.
18. Fried SK, Bunkin DA & Greenberg AS 1998 Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. Journal of Clinical Endocrinology and Metabolism 83 847-850.
19. Gohil BC, Rosenblum LA, Coplan JD & Kral JG 2001 Hypothalamic- pituitary-adrenal axis function and the metabolic syndrome X of obesity. CNS Spectrums 6 581-586 (589).
20. Harmer SC, Pepper DJ, Cooke K, Bennett HP & Bicknell AB 2008 Evidence of a possible role for Lys-gamma3-MSH in the regulation of adipocyte function. Journal of Endocrinology 196 149-158.
21. Hoch M, Hirzel E, Lindinger P, Eberle AN, Linscheid P, Martin I, Peters T & Peterli R 2008 Weak functional coupling of the melanocortin-1 receptor expressed in human adipocytes. Journal of Receptors and Signal Transduction 28 485-504.
22. Hoggard N, Hunter L, Duncan JS & Rayner DV 2004 Regulation of adipose tissue leptin secretion by alpha-melanocyte-stimulating hormone and agouti-related protein: further evidence of an interaction between leptin and the melanocortin signalling system. Journal of Molecular Endocrinology 32 145-153.
23. Holz GG, Kang G, Harbeck M, Roe MW & Chepurny OG 2006 Cell physiology of cAMP sensor Epac. Journal of Physiology 577 5-15.
24. Iwen KA, Senyaman O, Schwartz A, Drenckhan M, Meier B, Hadaschik D & Klein J 2008 Melanocortin crosstalk with adipose functions: ACTH directly induces insulin resistance, promotes a proinflammatory adipokine profile and stimulates UCP-1 in adipocytes. Journal of Endocrinology 196 465-472.
25. Jun DJ, Lee JH, Choi BH, Koh TK, Ha DC, Jeong MW & Kim KT 2006 Sphingosine-1-phosphate modulates both lipolysis and leptin production in differentiated rat white adipocytes. Endocrinology 147 5835-5844.
26. Kamimura D, Ishihara K & Hirano T 2003 IL-6 signal transduction and its physiological roles: the signal orchestration model. Reviews of Physiology, Biochemistry and Pharmacology 149 1-38.
27. Kaufman D, Banerji MA, Shorman I, Smith EL, Coplan JD, Rosenblum LA & Kral JG 2007 Early-life stress and the development of obesity and insulin resistance in juvenile bonnet macaques. Diabetes 56 1382-1386.
28. Khorram O, Bedran de Castro JC & McCann SM 1985 Stress-induced secretion of alpha-melanocyte-stimulating hormone and its physiological role in modulating the secretion of prolactin and luteinizing hormone in the female rat. Endocrinology 117 2483-2489.
29. Kiecolt-Glaser JK, Preacher KJ, MacCallum RC, Atkinson C, Malarkey WB & Glaser R 2003 Chronic stress and age-related increases in the proinflammatory cytokine IL-6. PNAS 100 9090-9095.
30. Kristiansen OP & Mandrup-Poulsen T 2005 Interleukin-6 and diabetes: the good, the bad, or the indifferent? Diabetes 54 S114-S124.
31. Lagathu C, Bastard JP, Auclair M, Maachi M, Capeau J & Caron M 2003 Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochemical and Biophysical Research Communications 311 372-379.
32. Legrand-Poels S, Schoonbroodt S & Piette J 2000 Regulation of interleukin-6 gene expression by pro-inflammatory cytokines in a colon cancer cell line. Biochemical Journal 349 765-773.
33. Libermann TA & Baltimore D 1990 Activation of interleukin-6 gene expression through the NF-κB transcription factor. Molecular and Cellular Biology 10 2327-2334.
34. Liu XH, Kirschenbaum A, Yao S & Levine AC 2005 Cross-talk between the interleukin-6 and prostaglandin E(2) signaling systems results in enhancement of osteoclastogenesis through effects on the osteoprotegerin/receptor activator of nuclear factor-κB (RANK) ligand/RANK system. Endocrinology 146 1991-1998.
35. Liu J, Garza JC, Truong HV, Henschel J, Zhang W & Lu XY 2007 The melanocortinergic pathway is rapidly recruited by emotional stress and contributes to stress-induced anorexia and anxiety-like behavior. Endocrinology 148 5531-5540.
36. Livak KJ & Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(KDelta Delta C(T)) method. Methods 25 402-408.
37. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, Klein S & Coppack SW 1997 Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. Journal of Clinical Endocrinology and Metabolism 82 4196-4200.
38. Mohamed-Ali V, Flower L, Sethi J, Hotamisligil G, Gray R, Humphries SE, York DA & Pinkney J 2001 β-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies. Journal of Clinical Endocrinology and Metabolism 86 5864-5869.
39. Niederberger E & Geisslinger G 2008 The IKK-NF-κB pathway: a source for novel molecular drug targets in pain therapy? FASEB Journal 22 3432-3442.
40. Norman D, Isidori AM, Frajese V, Caprio M, Chew SL, Grossman AB, Clark AJ, MichaelBesser G & Fabbri A 2003 ACTH and alpha-MSH inhibit leptin expression and secretion in 3T3-L1 adipocytes: model for a central-peripheral melanocortin-leptin pathway. Molecular and Cellular Endocrinology 200 99-109.
41. Persson E, Voznesensky OS, Huang YF & Lerner UH 2005 Increased expression of interleukin-6 by vasoactive intestinal peptide is associated with regulation of CREB, AP-1 and C/EBP, but not NF-κB, in mouse calvarial osteoblasts. Bone 37 513-529. (Pubitemid 41317325)
42. Rotter V, Nagaev I & Smith U 2003 Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. Journal of Biological Chemistry 278 45777-45784.
43. Saha RN, Jana M & Pahan K 2007 MAPK p38 regulates transcriptional activity of NF-κB in primary human astrocytes via acetylation of p65. Journal of Immunology 179 7101-7109.
44. Schaffler A, Scholmerich J & Buechler C 2006 The role of 'adipotropins' and the clinical importance of a potential hypothalamic- pituitary-adipose axis. Nature Clinical Practice. Endocrinology and Metabolism 2 374-383.
45. Seres J, Bornstein SR, Seres P, Willenberg HS, Schulte KM, Scherbaum WA & Ehrhart-Bornstein M 2004 Corticotropin-releasing hormone system in human adipose tissue. Journal of Clinical Endocrinology and Metabolism 89 965-970.
46. Shi H, Tzameli I, Bjorbaek C & Flier JS 2004 Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling. Journal of Biological Chemistry 279 34733-34740.
47. Tan KS, Nackley AG, Satterfield K, Maixner W, Diatchenko L & Flood PM 2007 Beta2 adrenergic receptor activation stimulates proinflammatory cytokine production in macrophages via PKA- and NF-κB-independent mechanisms. Cellular Signalling 19 251-260.
48. Tang CH, Chiu YC, Tan TW, Yang RS & Fu WM 2007 Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-κB pathway. Journal of Immunology 179 5483-5492.
49. Tuyt LM, Dokter WH, Birkenkamp K, Koopmans SB, Lummen C, KruijerW& Vellenga E 1999 Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-κB-dependent IL-6 expression in human monocytes. Journal of Immunology 162 4893-4902.
50. Verhasselt V, Buelens C, Willems F, De Groote D, Haeffner-Cavaillon N & Goldman M 1997 Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway. Journal of Immunology 158 2919-2925.
51. Wikberg JE & Mutulis F 2008 Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction. Nature Reviews. Drug Discovery 7 307-323.
52. Yang YK & Harmon CM 2003 Recent developments in our understanding of melanocortin system in the regulation of food intake. Obesity Reviews 4 239-248.
53. Yoon SW, Goh SH, Chun JS, Cho EW, Lee MK, Kim KL, Kim JJ, Kim CJ & Poo H 2003 a-Melanocyte-stimulating hormone inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in leukocytes by modulating protein kinase A, p38 kinase, and nuclear factor κB signaling pathways. Journal of Biological Chemistry 278 32914-32920.
54. Zhao W, Liu M & Kirkwood KL 2008 p38alpha stabilizes interleukin-6 mRNA via multiple AU-rich elements. Journal of Biological Chemistry 283 1778-1785.