Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin

Molecular Pharmacology

Volumn 77, Issue 4, 2010, Pages 508-516

  Hemmert, Andrew C ^b   Otto, Tamara C ^c   Wierdl, Monika ^e   Edwards, Carol C ^e   Fleming, Christopher D ^b   MacDonald, Mary ^d   Cashman, John R ^d   Potter, Philip M ^e   Cerasoli, Douglas M ^c   Redinbo, Matthew R ^a,b  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

^d HUMAN BIOMOLECULAR RESEARCH INSTITUTE   (United States)

^e ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLESTERASE; CARBOXYLESTERASE 1; CYCLOSARIN; SARIN; SOMAN; UNCLASSIFIED DRUG;

AGING; ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME REACTIVATION; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY;

CARBOXYLIC ESTER HYDROLASES; CHEMICAL WARFARE AGENTS; CRYSTALLIZATION; ENZYME INHIBITORS; HUMANS; HYDROLYSIS; MODELS, MOLECULAR; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; SARIN; STEREOISOMERISM;

EID: 77950193026     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.062356     Document Type: Article

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